-
1
-
-
0035210770
-
Stabilization of immobilized enzymes against water-soluble organic cosolvents and generation of hyper-hydrophilic microenvironments surrounding enzyme molecules
-
Abian C, Mateo C, Fernández-Lorente G, Palomo JM, Fernández-Lafuente R, Guisán JM (2001) Stabilization of immobilized enzymes against water-soluble organic cosolvents and generation of hyper-hydrophilic microenvironments surrounding enzyme molecules. Biocatal Biotransform 19:489-503
-
(2001)
Biocatal Biotransform
, vol.19
, pp. 489-503
-
-
Abian, C.1
Mateo, C.2
Fernández-Lorente, G.3
Palomo, J.M.4
Fernández-Lafuente, R.5
Guisán, J.M.6
-
2
-
-
85036703536
-
-
International Patent Application WO 01/29202
-
Acebal C, Arroyo M, Torres-Bacete J, Castillón MP, de la Mata I, Torres-Guzmán R (2001) Method for immobilizing a novel penicillin V acylase of Streptomyces lavendulae for obtaining 6-amino penicillanic acid. International Patent Application WO 01/29202
-
(2001)
Method for Immobilizing a Novel Penicillin V Acylase of Streptomyces lavendulae for Obtaining 6-Amino Penicillanic Acid
-
-
Acebal, C.1
Arroyo, M.2
Torres-Bacete, J.3
Castillón, M.P.4
De La Mata, I.5
Torres-Guzmán, R.6
-
3
-
-
0036844577
-
Effect of cosolvent and pH on the kinetically controlled synthesis of cephalexin with immobilized penicillin acylase
-
Aguirre C, Toledo M, Medina V, Illanes A (2002) Effect of cosolvent and pH on the kinetically controlled synthesis of cephalexin with immobilized penicillin acylase. Process Biochem 38:351-360
-
(2002)
Process Biochem
, vol.38
, pp. 351-360
-
-
Aguirre, C.1
Toledo, M.2
Medina, V.3
Illanes, A.4
-
4
-
-
0034462589
-
Characterization of the β-lactam binding site of penicillin acylase of Escherichia coli by structural and site-directed mutagenesis studies
-
Alkema WBL, Hensgens CMH, Kroezinga EH, de Vries E, Floris R, Van der Laan JM, Dijkstra BW, Janssen DB (2000) Characterization of the β-lactam binding site of penicillin acylase of Escherichia coli by structural and site-directed mutagenesis studies. Protein Eng 13:857-863
-
(2000)
Protein Eng
, vol.13
, pp. 857-863
-
-
Alkema, W.B.L.1
Hensgens, C.M.H.2
Kroezinga, E.H.3
De Vries, E.4
Floris, R.5
Van Der Laan, J.M.6
Dijkstra, B.W.7
Janssen, D.B.8
-
5
-
-
0036237518
-
The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase
-
Alkema WBL, Dijkhuis AJ, de Vries E, Janssen DB (2002) The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase. Eur J Biochem 269:2093-2100
-
(2002)
Eur J Biochem
, vol.269
, pp. 2093-2100
-
-
Alkema, W.B.L.1
Dijkhuis, A.J.2
De Vries, E.3
Janssen, D.B.4
-
6
-
-
0033180046
-
Interaction of penicillin V acylase with organic solvents. Catalytic activity modulation on the hydrolysis of penicillin V
-
Arroyo M, Torres R, de la Mata I, Castillón MP, Acebal C (1999) Interaction of penicillin V acylase with organic solvents. Catalytic activity modulation on the hydrolysis of penicillin V. Enzyme Microb Technol 25:378-383
-
(1999)
Enzyme Microb Technol
, vol.25
, pp. 378-383
-
-
Arroyo, M.1
Torres, R.2
De La Mata, I.3
Castillón, M.P.4
Acebal, C.5
-
7
-
-
0034041263
-
Activation and stabilization of penicillin V acylase from Streptomyces lavendulae in the presence of glycerol and glycols
-
Arroyo M, Torres-Guzmán R, de la Mata I, Castillón MP, Acebal C (2000a) Activation and stabilization of penicillin V acylase from Streptomyces lavendulae in the presence of glycerol and glycols. Biotechnol Prog 16:368-371
-
(2000)
Biotechnol Prog
, vol.16
, pp. 368-371
-
-
Arroyo, M.1
Torres-Guzmán, R.2
De La Mata, I.3
Castillón, M.P.4
Acebal, C.5
-
8
-
-
0034237189
-
Prediction of penicillin V acylase stability in water-organic cosolvent monophasic systems as a function of solvent composition
-
Arroyo M, Tortes R, de la Mata I, Castillón MP, Acebal C (2000b) Prediction of penicillin V acylase stability in water-organic cosolvent monophasic systems as a function of solvent composition. Enzyme Microb Technol 27:122-126
-
(2000)
Enzyme Microb Technol
, vol.27
, pp. 122-126
-
-
Arroyo, M.1
Tortes, R.2
De La Mata, I.3
Castillón, M.P.4
Acebal, C.5
-
9
-
-
0035812378
-
Kinetic mechanism of penicillin V acylase activation by short-chain alcohols
-
Arroyo M, Torres-Guzmán R, Torres-Bacete J, de la Mata I, Castillón MP, Acebal C (2001) Kinetic mechanism of penicillin V acylase activation by short-chain alcohols. Enzyme Microb Technol 29:312-318
-
(2001)
Enzyme Microb Technol
, vol.29
, pp. 312-318
-
-
Arroyo, M.1
Torres-Guzmán, R.2
Torres-Bacete, J.3
De La Mata, I.4
Castillón, M.P.5
Acebal, C.6
-
10
-
-
0036317712
-
Chromogenic analogues of penicillin dihydroF and penicillin K for the continuous spectrophotometric determination of aliphatic penicillin acylase activity
-
Arroyo M, Torres-Guzmán R, Torres-Bacete J, de la Mata I, Castillón MP, Acebal C (2002a) Chromogenic analogues of penicillin dihydroF and penicillin K for the continuous spectrophotometric determination of aliphatic penicillin acylase activity. Biotechnol Lett 24:1045-1048
-
(2002)
Biotechnol Lett
, vol.24
, pp. 1045-1048
-
-
Arroyo, M.1
Torres-Guzmán, R.2
Torres-Bacete, J.3
De La Mata, I.4
Castillón, M.P.5
Acebal, C.6
-
11
-
-
0036176917
-
A kinetic examination of penicillin acylase stability in water-organic solvent systems at different temperatures
-
Arroyo M, Torres-Guzmán R, de la Mata I, Castillón MP, Acebal C (2002b) A kinetic examination of penicillin acylase stability in water-organic solvent systems at different temperatures. Biocatal Biotransform 20:53-56
-
(2002)
Biocatal Biotransform
, vol.20
, pp. 53-56
-
-
Arroyo, M.1
Torres-Guzmán, R.2
De La Mata, I.3
Castillón, M.P.4
Acebal, C.5
-
12
-
-
0034607766
-
D-Phenylglycine and D-4-hydroxyphenylglycine methyl esters via penicillin G acylase catalysed resolution in organic solvents
-
Basso A, Braiuca P, De Martin L, Ebert C, Gardossi L, Linda P (2000) D-Phenylglycine and D-4-hydroxyphenylglycine methyl esters via penicillin G acylase catalysed resolution in organic solvents. Tetrahedron Asym 11:1789-1796
-
(2000)
Tetrahedron Asym
, vol.11
, pp. 1789-1796
-
-
Basso, A.1
Braiuca, P.2
De Martin, L.3
Ebert, C.4
Gardossi, L.5
Linda, P.6
-
13
-
-
0035814178
-
Selectivity of penicillin G acylase towards phenylacetic acid derivatives in amide bond synthesis in toluene
-
Basso A, De Martin L, Ebert C, Gardossi L, Linda P (2001) Selectivity of penicillin G acylase towards phenylacetic acid derivatives in amide bond synthesis in toluene. J Mol Catal B 16:73-80
-
(2001)
J Mol Catal B
, vol.16
, pp. 73-80
-
-
Basso, A.1
De Martin, L.2
Ebert, C.3
Gardossi, L.4
Linda, P.5
-
15
-
-
0000927125
-
Application of immobilised enzymes in the manufacture of beta-lactam antibiotics
-
Bianchi D, Bartolo R, Olini P, Cesti P (1998) Application of immobilised enzymes in the manufacture of beta-lactam antibiotics. Chim Ind Milan 80:879-885
-
(1998)
Chim Ind Milan
, vol.80
, pp. 879-885
-
-
Bianchi, D.1
Bartolo, R.2
Olini, P.3
Cesti, P.4
-
16
-
-
0032553508
-
Production of D-phenylglycine from racemic (D,L)-phenylglycine via isoelectrically-trapped penicillin G acylase
-
Bossi A, Cretich M, Righetti PG (1998) Production of D-phenylglycine from racemic (D,L)-phenylglycine via isoelectrically-trapped penicillin G acylase. Biotechnol Bioeng 60:454-461
-
(1998)
Biotechnol Bioeng
, vol.60
, pp. 454-461
-
-
Bossi, A.1
Cretich, M.2
Righetti, P.G.3
-
17
-
-
0000862981
-
Biocatalysis and process integration in synthesis of semi-synthetic antibiotics
-
Bruggink A (1996) Biocatalysis and process integration in synthesis of semi-synthetic antibiotics. Chimia 50:431-432
-
(1996)
Chimia
, vol.50
, pp. 431-432
-
-
Bruggink, A.1
-
18
-
-
0001081201
-
Penicillin acylase in industrial production of β-lactam antibiotics
-
Bruggink A, Ross EC, de Vroom E (1998) Penicillin acylase in industrial production of β-lactam antibiotics. Org Process Res Dev 2:128-133
-
(1998)
Org Process Res Dev
, vol.2
, pp. 128-133
-
-
Bruggink, A.1
Ross, E.C.2
De Vroom, E.3
-
19
-
-
0030882447
-
Penicillin G acylase mediated synthesis of the enantiopure (S)-3-amino-azetidin-2-one
-
Cainelli F, Giacomini D, Galletti P, DaCol M (1997) Penicillin G acylase mediated synthesis of the enantiopure (S)-3-amino-azetidin-2-one. Tetrahedron Asym 8:3231-3235
-
(1997)
Tetrahedron Asym
, vol.8
, pp. 3231-3235
-
-
Cainelli, F.1
Giacomini, D.2
Galletti, P.3
DaCol, M.4
-
21
-
-
0034682159
-
Cross-linked enzyme aggregates: A simple and effective method for the immobilization of penicillin acylase
-
Cao L, Van Rantwijk F, Sheldon RA (2000b) Cross-linked enzyme aggregates: a simple and effective method for the immobilization of penicillin acylase. Org Lett 2:1361-1364
-
(2000)
Org Lett
, vol.2
, pp. 1361-1364
-
-
Cao, L.1
Van Rantwijk, F.2
Sheldon, R.A.3
-
22
-
-
0035931490
-
Cross-linked aggregates of penicillin acylase: Robust catalysts for the synthesis of β-lactam antibiotics
-
Cao L, Van Langen LM, Van Rantwijk F, Sheldon RA (2001) Cross-linked aggregates of penicillin acylase: robust catalysts for the synthesis of β-lactam antibiotics. J Mol Catal B 11:665-670
-
(2001)
J Mol Catal B
, vol.11
, pp. 665-670
-
-
Cao, L.1
Van Langen, L.M.2
Van Rantwijk, F.3
Sheldon, R.A.4
-
23
-
-
0029959625
-
Enzymatic resolution of a-alkyl β-amino acids using immobilized penicillin G acylase
-
Cardillo G, Tolomelli A, Tomasini C (1996) Enzymatic resolution of a-alkyl β-amino acids using immobilized penicillin G acylase. J Org Chem 61:8651-8654
-
(1996)
J Org Chem
, vol.61
, pp. 8651-8654
-
-
Cardillo, G.1
Tolomelli, A.2
Tomasini, C.3
-
24
-
-
0034548901
-
Genetic strategies to enhance penicillin acylase production in Escherichia coli
-
Chou CP, Lin WJ, Kuo BY, Yu CC (2000a) Genetic strategies to enhance penicillin acylase production in Escherichia coli. Enzyme Microb Technol 27:766-773
-
(2000)
Enzyme Microb Technol
, vol.27
, pp. 766-773
-
-
Chou, C.P.1
Lin, W.J.2
Kuo, B.Y.3
Yu, C.C.4
-
25
-
-
0034129596
-
An approach for enhancing heterologous production of Providencia rettgeri penicillin acylase in Escherichia coli
-
Chou CP, Wang WC, Lin MI (2000b) An approach for enhancing heterologous production of Providencia rettgeri penicillin acylase in Escherichia coli. Biotechnol Prog 16:315-318
-
(2000)
Biotechnol Prog
, vol.16
, pp. 315-318
-
-
Chou, C.P.1
Wang, W.C.2
Lin, M.I.3
-
26
-
-
0034305155
-
Small bugs, big business: The economic power of the microbe
-
Demain AL (2000) Small bugs, big business: the economic power of the microbe. Biotechnol Adv 18:499-514
-
(2000)
Biotechnol Adv
, vol.18
, pp. 499-514
-
-
Demain, A.L.1
-
29
-
-
0033236418
-
The central role of penicillin acylase in antibiotics production
-
De Vroom E (1999) The central role of penicillin acylase in antibiotics production. Chimica Oggi 17:65-68
-
(1999)
Chimica Oggi
, vol.17
, pp. 65-68
-
-
De Vroom, E.1
-
31
-
-
0034333350
-
Course of pH during the formation of amoxicillin by a suspension-to-suspension reaction
-
Diender MB, Straathof AJJ, van der Does T, Zomerdijk M, Heijnen JJ (2000) Course of pH during the formation of amoxicillin by a suspension-to-suspension reaction. Enzyme Microb Technol 27:576-582
-
(2000)
Enzyme Microb Technol
, vol.27
, pp. 576-582
-
-
Diender, M.B.1
Straathof, A.J.J.2
Van Der Does, T.3
Zomerdijk, M.4
Heijnen, J.J.5
-
32
-
-
0028857547
-
Penicillin acylase has a single amino-acid catalytic centre
-
Duggleby HJ, Tolley SP, Hill CP, Dodson EJ, Dodson G, Moody PCE (1995) Penicillin acylase has a single amino-acid catalytic centre. Nature 373:264-268
-
(1995)
Nature
, vol.373
, pp. 264-268
-
-
Duggleby, H.J.1
Tolley, S.P.2
Hill, C.P.3
Dodson, E.J.4
Dodson, G.5
Moody, P.C.E.6
-
33
-
-
33748644020
-
Efficient chemoenzymatic synthesis of (2S,3S)-3-hydroxyleucine mediated by immobilized penicillin G acylase
-
Fadnavis NW, Sharfuddin M, Vadivel SK, Bhalerao UT (1997) Efficient chemoenzymatic synthesis of (2S,3S)-3-hydroxyleucine mediated by immobilized penicillin G acylase. J Chem Soc Perkin Trans 1:3577-3578
-
(1997)
J Chem Soc Perkin Trans
, vol.1
, pp. 3577-3578
-
-
Fadnavis, N.W.1
Sharfuddin, M.2
Vadivel, S.K.3
Bhalerao, U.T.4
-
34
-
-
0026262142
-
Enzyme reaction engineering: Synthesis of antibiotics catalysed by stabilised penicillin G acylase in the presence of organic cosolvents
-
Fernández-Lafuente R, Rosell CM, Guisán JM (1991a) Enzyme reaction engineering: synthesis of antibiotics catalysed by stabilised penicillin G acylase in the presence of organic cosolvents. Enzyme Microb Technol 13:898-905
-
(1991)
Enzyme Microb Technol
, vol.13
, pp. 898-905
-
-
Fernández-Lafuente, R.1
Rosell, C.M.2
Guisán, J.M.3
-
35
-
-
0002991576
-
Equilibrium controlled synthesis of cephalotin in monophasic water-organic cosolvent systems catalyzed by stabilized derivatives of penicillin G acylase
-
Fernández-Lafuente R, Rosell CM, Caanan-Haden L, Rodes L, Guisán JM (1991b) Equilibrium controlled synthesis of cephalotin in monophasic water-organic cosolvent systems catalyzed by stabilized derivatives of penicillin G acylase. Appl Biochem Biotechnol 27:75-84
-
(1991)
Appl Biochem Biotechnol
, vol.27
, pp. 75-84
-
-
Fernández-Lafuente, R.1
Rosell, C.M.2
Caanan-Haden, L.3
Rodes, L.4
Guisán, J.M.5
-
36
-
-
0028835759
-
The use of stabilised penicillin acylase derivatives improves the design of kinetically controlled synthesis
-
Fernández-Lafuente R, Rosell CM, Guisán JM (1995) The use of stabilised penicillin acylase derivatives improves the design of kinetically controlled synthesis. J Mol Catal A 101:91-97
-
(1995)
J Mol Catal A
, vol.101
, pp. 91-97
-
-
Fernández-Lafuente, R.1
Rosell, C.M.2
Guisán, J.M.3
-
37
-
-
0029760450
-
Dynamic reaction design of enzymic biotransformations in organic media: Equilibrium-controlled synthesis of antibiotics by penicillin G acylase
-
Fernández-Lafuente R, Rosell CM, Guisán JM (1996a) Dynamic reaction design of enzymic biotransformations in organic media: equilibrium-controlled synthesis of antibiotics by penicillin G acylase. Biotechnol Appl Biochem 24:139-143
-
(1996)
Biotechnol Appl Biochem
, vol.24
, pp. 139-143
-
-
Fernández-Lafuente, R.1
Rosell, C.M.2
Guisán, J.M.3
-
38
-
-
0343446120
-
Synthesis of antibiotics (cephaloglycin) catalyzed by penicillin G acylase. Evaluation and optimization of different synthetic approaches
-
Fernández-Lafuente R, Rosell CM, Piatkowska B, Guisán JM (1996b) Synthesis of antibiotics (cephaloglycin) catalyzed by penicillin G acylase. Evaluation and optimization of different synthetic approaches. Enzyme Microb Technol 19:9-14
-
(1996)
Enzyme Microb Technol
, vol.19
, pp. 9-14
-
-
Fernández-Lafuente, R.1
Rosell, C.M.2
Piatkowska, B.3
Guisán, J.M.4
-
39
-
-
0032890111
-
Facile synthesis of artificial enzyme nano-environments via solid-phase chemistry of immobilized derivatives: Dramatic stabilization of penicillin acylase versus organic solvents
-
Fernández-Lafuente R, Rosell CM, Caanan-Haden L, Rodes L, Guisán JM (1999) Facile synthesis of artificial enzyme nano-environments via solid-phase chemistry of immobilized derivatives: dramatic stabilization of penicillin acylase versus organic solvents. Enzyme Microb Technol 24:96-103
-
(1999)
Enzyme Microb Technol
, vol.24
, pp. 96-103
-
-
Fernández-Lafuente, R.1
Rosell, C.M.2
Caanan-Haden, L.3
Rodes, L.4
Guisán, J.M.5
-
40
-
-
0022458485
-
Immobilized penicillin acylase: Application to the synthesis of the dipeptide aspartame
-
Fuganti C, Grasselli P, Casati P (1986a) Immobilized penicillin acylase: application to the synthesis of the dipeptide aspartame. Tetrahedron Lett 27:3191-3194
-
(1986)
Tetrahedron Lett
, vol.27
, pp. 3191-3194
-
-
Fuganti, C.1
Grasselli, P.2
Casati, P.3
-
41
-
-
0022651317
-
Immobilized benzylpenicillin acylase: Application to the synthesis of optically active forms of carnitin and propranalol
-
Fuganti C, Grasselli P, Seneci PF, Servi S, Casati P (1986b) Immobilized benzylpenicillin acylase: application to the synthesis of optically active forms of carnitin and propranalol. Tetrahedron Lett 27:2061-2062
-
(1986)
Tetrahedron Lett
, vol.27
, pp. 2061-2062
-
-
Fuganti, C.1
Grasselli, P.2
Seneci, P.F.3
Servi, S.4
Casati, P.5
-
42
-
-
0035813519
-
Cloning and expression of the penicillin acylase gene (pac) from E. coli ATCC 11105
-
Gümüsel F, Öztürk SI, Korkut NK, Gelegen C, Bermek E (2001) Cloning and expression of the penicillin acylase gene (pac) from E. coli ATCC 11105. Enzyme Microb Technol 29:499-505
-
(2001)
Enzyme Microb Technol
, vol.29
, pp. 499-505
-
-
Gümüsel, F.1
Öztürk, S.I.2
Korkut, N.K.3
Gelegen, C.4
Bermek, E.5
-
43
-
-
0035806466
-
Highly efficient and enantioselective enzymatic acylation of amines in aqueous medium
-
Guranda DT, van Langen LM, Van Rantwijk F, Sheldon RA, Svedas VK. (2001) Highly efficient and enantioselective enzymatic acylation of amines in aqueous medium. Tetrahedron Asym 12:1645-1650
-
(2001)
Tetrahedron Asym
, vol.12
, pp. 1645-1650
-
-
Guranda, D.T.1
Van Langen, L.M.2
Van Rantwijk, F.3
Sheldon, R.A.4
Svedas, V.K.5
-
44
-
-
0037506386
-
Evaluation of different enzymes as catalysts for the production of β-lactam antibiotics following a kinetically controlled strategy
-
Hernández-Justiz O, Terreni M, Pagani G, García JL, Guisán JM, Fernández-Lafuente R (1999) Evaluation of different enzymes as catalysts for the production of β-lactam antibiotics following a kinetically controlled strategy. Enzyme Microb Technol 25:336-343
-
(1999)
Enzyme Microb Technol
, vol.25
, pp. 336-343
-
-
Hernández-Justiz, O.1
Terreni, M.2
Pagani, G.3
García, J.L.4
Guisán, J.M.5
Fernández-Lafuente, R.6
-
45
-
-
84952891609
-
Cleavage and formation of amide bonds
-
Kelly DR (ed). Wiley-VCH, Weinheim
-
Hoople D (1998) Cleavage and formation of amide bonds. In: Kelly DR (ed) Biotechnology, vol 8a. Biotransformations I. Wiley-VCH, Weinheim, pp 243-275
-
(1998)
Biotechnology, Vol 8a. Biotransformations I
, vol.8 A
, pp. 243-275
-
-
Hoople, D.1
-
46
-
-
0031062859
-
Immobilization of whole-cell penicillin G acylase by entrapping within polymethacrylamide beads
-
Hsiau L-T, Lee W-C, Wang F-S (1997) Immobilization of whole-cell penicillin G acylase by entrapping within polymethacrylamide beads. Appl Biochem Biotechnol 62:303-315
-
(1997)
Appl Biochem Biotechnol
, vol.62
, pp. 303-315
-
-
Hsiau, L.-T.1
Lee, W.-C.2
Wang, F.-S.3
-
47
-
-
0035988113
-
Effect of pH on high-temperature production of bacterial penicillin acylase in Escherichia coli
-
Huang SW, Lin YH, Chin HL, Wang WC, Kuo BY, Chou CP (2002) Effect of pH on high-temperature production of bacterial penicillin acylase in Escherichia coli. Biotechnol Prog 18:668-671
-
(2002)
Biotechnol Prog
, vol.18
, pp. 668-671
-
-
Huang, S.W.1
Lin, Y.H.2
Chin, H.L.3
Wang, W.C.4
Kuo, B.Y.5
Chou, C.P.6
-
48
-
-
0035931395
-
Kinetically controlled synthesis of ampicillin with immobilized penicillin acylase in the presence of organic cosolvents
-
Illanes A, Fajardo A (2001) Kinetically controlled synthesis of ampicillin with immobilized penicillin acylase in the presence of organic cosolvents. J Mol Catal B 11:587-595
-
(2001)
J Mol Catal B
, vol.11
, pp. 587-595
-
-
Illanes, A.1
Fajardo, A.2
-
49
-
-
0036219285
-
Optimization of yield in the kinetically controlled synthesis of ampicillin with immobilized penicillin acylase in organic media
-
Illanes A, Anjarí S, Arrieta R, Aguirre C (2002) Optimization of yield in the kinetically controlled synthesis of ampicillin with immobilized penicillin acylase in organic media. Appl Biochem Biotechnol 97:165-179
-
(2002)
Appl Biochem Biotechnol
, vol.97
, pp. 165-179
-
-
Illanes, A.1
Anjarí, S.2
Arrieta, R.3
Aguirre, C.4
-
50
-
-
0037141606
-
Evaluation of the performance of immobilized penicillin G acylase using active-site titration
-
Janssen MHA, Van Langen LM, Pereira SRM, Van Rantwijk F, Sheldon RA (2002) Evaluation of the performance of immobilized penicillin G acylase using active-site titration. Biotechnol Bioeng 78:425-432
-
(2002)
Biotechnol Bioeng
, vol.78
, pp. 425-432
-
-
Janssen, M.H.A.1
Van Langen, L.M.2
Pereira, S.R.M.3
Van Rantwijk, F.4
Sheldon, R.A.5
-
52
-
-
0022630151
-
Mechanism and yields in enzyme catalysed equilibrium and kinetically controlled synthesis of β-lactam antibiotics, peptides and other condensation products
-
Kasche V (1986) Mechanism and yields in enzyme catalysed equilibrium and kinetically controlled synthesis of β-lactam antibiotics, peptides and other condensation products. Enzyme Microb Technol 8:4-16
-
(1986)
Enzyme Microb Technol
, vol.8
, pp. 4-16
-
-
Kasche, V.1
-
53
-
-
0032795578
-
Intramolecular autoproteolysis initiates the maturation of penicillin amidase from E. coli
-
Kasche V, Lummer K, Nurk A, Piotraschke E, Rieks A, Stoeva S, Voelter W (1999) Intramolecular autoproteolysis initiates the maturation of penicillin amidase from E. coli. Biochim Biophys Acta 1433:76-86
-
(1999)
Biochim Biophys Acta
, vol.1433
, pp. 76-86
-
-
Kasche, V.1
Lummer, K.2
Nurk, A.3
Piotraschke, E.4
Rieks, A.5
Stoeva, S.6
Voelter, W.7
-
54
-
-
0034274420
-
Eupergit C, a carrier for immobilization of enzymes of industrial potential
-
Katchalski-Katzir E, Kraemer DM (2000) Eupergit C, a carrier for immobilization of enzymes of industrial potential. J Mol Catal B 10:157-176
-
(2000)
J Mol Catal B
, vol.10
, pp. 157-176
-
-
Katchalski-Katzir, E.1
Kraemer, D.M.2
-
55
-
-
0030568517
-
Penicillin acylase-catalyzed synthesis of pivampicillin: Effect of reaction variables and organic cosolvents
-
Kim MG, Lee SB (1996) Penicillin acylase-catalyzed synthesis of pivampicillin: effect of reaction variables and organic cosolvents. J Mol Catal B 1:71-80
-
(1996)
J Mol Catal B
, vol.1
, pp. 71-80
-
-
Kim, M.G.1
Lee, S.B.2
-
56
-
-
0031071314
-
Practical catalysis with enzyme crystals
-
Lalonde J (1997) Practical catalysis with enzyme crystals. Chem Tech 27:38-45
-
(1997)
Chem Tech
, vol.27
, pp. 38-45
-
-
Lalonde, J.1
-
57
-
-
0033974892
-
Immobilization of cell-associated enzyme by entrapping in gluten matrix
-
Long J-C, Lee W-C, Guo S-H (2000) Immobilization of cell-associated enzyme by entrapping in gluten matrix. Biocatal Biotransform 17:431-443
-
(2000)
Biocatal Biotransform
, vol.17
, pp. 431-443
-
-
Long, J.-C.1
Lee, W.-C.2
Guo, S.-H.3
-
58
-
-
0030185060
-
Novel crystalline catalysts
-
Margolin A (1996) Novel crystalline catalysts. Trends Biotechnol 14:223-230
-
(1996)
Trends Biotechnol
, vol.14
, pp. 223-230
-
-
Margolin, A.1
-
59
-
-
0034111128
-
Increase in conformational stability of enzymes immobilized on epoxy-activated supports by favoring additional multipoint covalent attachment
-
Mateo C, Abian O, Fernández-Lafuente R, Guisán JM (2000) Increase in conformational stability of enzymes immobilized on epoxy-activated supports by favoring additional multipoint covalent attachment. Enzyme Microb Technol 26:509-515
-
(2000)
Enzyme Microb Technol
, vol.26
, pp. 509-515
-
-
Mateo, C.1
Abian, O.2
Fernández-Lafuente, R.3
Guisán, J.M.4
-
60
-
-
0035988098
-
Epoxy sepabeads: A novel epoxy support for stabilization of industrial enzymes via very intense multipoint covalent attachment
-
Mateo C, Abian O, Fernández-Lorente G, Pedroche J, Fernández-Lafuente R, Guisán JM, Tam A, Daminati M (2002) Epoxy sepabeads: a novel epoxy support for stabilization of industrial enzymes via very intense multipoint covalent attachment. Biotechnol Prog 18:629-634
-
(2002)
Biotechnol Prog
, vol.18
, pp. 629-634
-
-
Mateo, C.1
Abian, O.2
Fernández-Lorente, G.3
Pedroche, J.4
Fernández-Lafuente, R.5
Guisán, J.M.6
Tam, A.7
Daminati, M.8
-
61
-
-
0035850792
-
Crystal structures of penicillin acylase-substrate complexes: Structural insights into the catalytic mechanism
-
McVey CE, Walsh MA, Dodson GG, Wilson KS, Brannigan JA (2001) Crystal structures of penicillin acylase-substrate complexes: structural insights into the catalytic mechanism. J Mol Biol 313:139-150
-
(2001)
J Mol Biol
, vol.313
, pp. 139-150
-
-
McVey, C.E.1
Walsh, M.A.2
Dodson, G.G.3
Wilson, K.S.4
Brannigan, J.A.5
-
64
-
-
0034495297
-
Structural comparison of Ntn-hydrolases
-
Oinonen C, Rouvinen J (2000) Structural comparison of Ntn-hydrolases. Protein Sci 9:2329-2337
-
(2000)
Protein Sci
, vol.9
, pp. 2329-2337
-
-
Oinonen, C.1
Rouvinen, J.2
-
66
-
-
0034697231
-
Penicillin acylase-catalyzed synthesis of cefazolin in water-solvent mixtures: Enhancement effect of ethyl acetate and carbon tetrachloride on the synthetic yield
-
Park CB, Lee SB, Ryu DDY (2000) Penicillin acylase-catalyzed synthesis of cefazolin in water-solvent mixtures: enhancement effect of ethyl acetate and carbon tetrachloride on the synthetic yield. J Mol Catal B 9:275-281
-
(2000)
J Mol Catal B
, vol.9
, pp. 275-281
-
-
Park, C.B.1
Lee, S.B.2
Ryu, D.D.Y.3
-
67
-
-
0034234028
-
Advances in enzymatic transformation of penicillins to 6-aminopenicillanic acid (6-APA)
-
Parmar A, Kumar H, Marwaha SS, Kennedy JF (2000) Advances in enzymatic transformation of penicillins to 6-aminopenicillanic acid (6-APA). Biotechnol Adv 18:289-301
-
(2000)
Biotechnol Adv
, vol.18
, pp. 289-301
-
-
Parmar, A.1
Kumar, H.2
Marwaha, S.S.3
Kennedy, J.F.4
-
68
-
-
0035988032
-
Penicillin G acylase-fatty lipid biocomposite films show excellent catalytic activity and long term stability/reusability
-
Phadtare S, Parekh P, Gole A, Patis M, Pundle A, Prabhune A, Sastry M (2002) Penicillin G acylase-fatty lipid biocomposite films show excellent catalytic activity and long term stability/reusability. Biotechnol Prog 18:483-488
-
(2002)
Biotechnol Prog
, vol.18
, pp. 483-488
-
-
Phadtare, S.1
Parekh, P.2
Gole, A.3
Patis, M.4
Pundle, A.5
Prabhune, A.6
Sastry, M.7
-
69
-
-
0036644256
-
Influence of the enzyme derivative preparation and substrate structure on the enantioselectivity of penicillin acylase
-
Rocchietti S, San Vicente A, Pregnolato M, Tagliani A, Guisán JM, Fernández-Lafuente R, Terreni M (2002) Influence of the enzyme derivative preparation and substrate structure on the enantioselectivity of penicillin acylase. Enzyme Microb Technol 31:88-93
-
(2002)
Enzyme Microb Technol
, vol.31
, pp. 88-93
-
-
Rocchietti, S.1
San Vicente, A.2
Pregnolato, M.3
Tagliani, A.4
Guisán, J.M.5
Fernández-Lafuente, R.6
Terreni, M.7
-
70
-
-
0033531990
-
Enantioselective acylation of β-amino esters using penicillin G acylase in organic solvents
-
Roche D, Prasad K, Repic O (1999) Enantioselective acylation of β-amino esters using penicillin G acylase in organic solvents. Tetrahedron Lett 40:3665-3668
-
(1999)
Tetrahedron Lett
, vol.40
, pp. 3665-3668
-
-
Roche, D.1
Prasad, K.2
Repic, O.3
-
72
-
-
0032922615
-
Thermodynamically controlled synthesis of β-lactam antibiotics. Equilibrium concentrations and side-chain properties
-
Schroën CGPH, Nierstrasz V, Kroon PJ, Bosma R, Janssen AEM, Beeftink HH, Tramper J (1999) Thermodynamically controlled synthesis of β-lactam antibiotics. Equilibrium concentrations and side-chain properties. Enzyme Microb Technol 24:498-506
-
(1999)
Enzyme Microb Technol
, vol.24
, pp. 498-506
-
-
Schroën, C.G.P.H.1
Nierstrasz, V.2
Kroon, P.J.3
Bosma, R.4
Janssen, A.E.M.5
Beeftink, H.H.6
Tramper, J.7
-
73
-
-
0035501626
-
Cephalexin synthesis by immobilized penicillin G acylase under non-isothermal conditions: Reduction of diffusion limitation
-
Schröen CGPH, Mohy Eldin M, Janssen A, Mita G, Tramper J (2001) Cephalexin synthesis by immobilized penicillin G acylase under non-isothermal conditions: reduction of diffusion limitation. J Mol Catal B 15:163-172
-
(2001)
J Mol Catal B
, vol.15
, pp. 163-172
-
-
Schröen, C.G.P.H.1
Mohy Eldin, M.2
Janssen, A.3
Mita, G.4
Tramper, J.5
-
75
-
-
0000903228
-
Penicillin acylase: Enzyme production and its application in the manufacture of 6-APA
-
Shewale JG, SivaRaman H (1989) Penicillin acylase: enzyme production and its application in the manufacture of 6-APA. Process Biochem 24:146-154
-
(1989)
Process Biochem
, vol.24
, pp. 146-154
-
-
Shewale, J.G.1
SivaRaman, H.2
-
76
-
-
0031149064
-
Penicillin V acylase: Its potential in the production of 6-amino penicillanic acid
-
Shewale JG, Sudhakaran VK (1997) Penicillin V acylase: its potential in the production of 6-amino penicillanic acid. Enzyme Microb Technol 20:402-410
-
(1997)
Enzyme Microb Technol
, vol.20
, pp. 402-410
-
-
Shewale, J.G.1
Sudhakaran, V.K.2
-
77
-
-
0022296094
-
Microbial transformation of β-lactam antibiotics: Enzymes from bacteria, sources and study - A summary
-
Sudhakaran VK, Borkar PS (1985a) Microbial transformation of β-lactam antibiotics: enzymes from bacteria, sources and study - a summary. Hind Antibiot Bull 27:63-119
-
(1985)
Hind Antibiot Bull
, vol.27
, pp. 63-119
-
-
Sudhakaran, V.K.1
Borkar, P.S.2
-
78
-
-
0022296403
-
Phenoxymethyl penicillin acylases: Sources and study - A summary
-
Sudhakaran VK, Borkar PS (1985b) Phenoxymethyl penicillin acylases: sources and study - a summary. Hind Antibiot Bull 27:44-62
-
(1985)
Hind Antibiot Bull
, vol.27
, pp. 44-62
-
-
Sudhakaran, V.K.1
Borkar, P.S.2
-
79
-
-
0032915960
-
Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members
-
Suresh CG, Pundle AV, SivaRaman H, Rao KN, Brannigan JA, McVey CE, Verma CS, Dauter Z, Dodson EJ, Dodson GG (1999) Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members. Nat Struct Biol 6:414-416
-
(1999)
Nat Struct Biol
, vol.6
, pp. 414-416
-
-
Suresh, C.G.1
Pundle, A.V.2
SivaRaman, H.3
Rao, K.N.4
Brannigan, J.A.5
McVey, C.E.6
Verma, C.S.7
Dauter, Z.8
Dodson, E.J.9
Dodson, G.G.10
-
81
-
-
0033179684
-
Immobilized enzymes: Crystals or carriers?
-
Tischer W, Kasche V (1999) Immobilized enzymes: crystals or carriers? Trends Biotechnol 17:326-334
-
(1999)
Trends Biotechnol
, vol.17
, pp. 326-334
-
-
Tischer, W.1
Kasche, V.2
-
82
-
-
0032874447
-
Use of enzyme penicillin acylase in selective amidation/amide hydrolysis to resolve ethyl 3-amino-4-pentynoate isomers
-
Topgi RS, Ng JS, Landis B, Wang P, Behling JR (1999) Use of enzyme penicillin acylase in selective amidation/amide hydrolysis to resolve ethyl 3-amino-4-pentynoate isomers. Bioorg Med Chem 7:2221-2229
-
(1999)
Bioorg Med Chem
, vol.7
, pp. 2221-2229
-
-
Topgi, R.S.1
Ng, J.S.2
Landis, B.3
Wang, P.4
Behling, J.R.5
-
83
-
-
0033491935
-
Enhanced production of penicillin V acylase from Streptomyces lavendulae
-
Torres R, Ramön F, de la Mata I, Castillön MP, Acebal C (1999) Enhanced production of penicillin V acylase from Streptomyces lavendulae. Appl Microbiol Biotechnol 53:81-84
-
(1999)
Appl Microbiol Biotechnol
, vol.53
, pp. 81-84
-
-
Torres, R.1
Ramön, F.2
De La Mata, I.3
Castillön, M.P.4
Acebal, C.5
-
84
-
-
0033914091
-
Covalent immobilization of penicillin acylase from Streptomyces lavendulae
-
Torres-Bacete J, Arroyo M, Torres-Guzmán R, de la Mata I, Castillón MP, Acebal C (2000a) Covalent immobilization of penicillin acylase from Streptomyces lavendulae. Biotechnol Lett 22:1011-1014
-
(2000)
Biotechnol Lett
, vol.22
, pp. 1011-1014
-
-
Torres-Bacete, J.1
Arroyo, M.2
Torres-Guzmán, R.3
De La Mata, I.4
Castillón, M.P.5
Acebal, C.6
-
85
-
-
0034527110
-
Optimization of 6-APA production by using a new immobilized penicillin acylase
-
Torres-Bacete J, Arroyo M, Torres-Guzmán R, de la Mata I, Castillón MP, Acebal C (2000b) Optimization of 6-APA production by using a new immobilized penicillin acylase. Biotechnol Appl Biochem 32:173-177
-
(2000)
Biotechnol Appl Biochem
, vol.32
, pp. 173-177
-
-
Torres-Bacete, J.1
Arroyo, M.2
Torres-Guzmán, R.3
De La Mata, I.4
Castillón, M.P.5
Acebal, C.6
-
86
-
-
12244250179
-
Stabilization of penicillin acylase from Streptomyces lavendulae by covalent immobilization
-
Torres-Bacete J, Arroyo M, Torres-Guzmán R, de la Mata I, Castillón MP, Acebal C (2001) Stabilization of penicillin acylase from Streptomyces lavendulae by covalent immobilization. J Chem Technol Biotechnol 76:1-4
-
(2001)
J Chem Technol Biotechnol
, vol.76
, pp. 1-4
-
-
Torres-Bacete, J.1
Arroyo, M.2
Torres-Guzmán, R.3
De La Mata, I.4
Castillón, M.P.5
Acebal, C.6
-
87
-
-
0035202670
-
The kinetic mechanism of penicillin V acylase from Streptomyces lavendulae
-
Torres-Guzmán R, de la Mata I, Arroyo M, Torres-Bacete J, Castillón MP, Acebal C (2000) The kinetic mechanism of penicillin V acylase from Streptomyces lavendulae. Biocatal Biotransform 19:301-311
-
(2000)
Biocatal Biotransform
, vol.19
, pp. 301-311
-
-
Torres-Guzmán, R.1
De La Mata, I.2
Arroyo, M.3
Torres-Bacete, J.4
Castillón, M.P.5
Acebal, C.6
-
88
-
-
0035923380
-
Chemical mechanism of penicillin V acylase from Streptomyces lavendulae: pH dependence of kinetic parameters
-
Torres-Guzmán R, de la Mata I, Torres-Bacete J, Arroyo M, Castillón MP, Acebal C (2001) Chemical mechanism of penicillin V acylase from Streptomyces lavendulae: pH dependence of kinetic parameters. J Mol Catal B 16:33-41
-
(2001)
J Mol Catal B
, vol.16
, pp. 33-41
-
-
Torres-Guzmán, R.1
De La Mata, I.2
Torres-Bacete, J.3
Arroyo, M.4
Castillón, M.P.5
Acebal, C.6
-
89
-
-
0036293840
-
Substrate specificity of penicillin acylase from Streptomyces lavendulae
-
Torres-Guzmán R, de la Mata I, Torres-Bacete J, Arroyo M, Castillón MP, Acebal C (2002) Substrate specificity of penicillin acylase from Streptomyces lavendulae. Biochem Biophys Res Commun 291:593-597
-
(2002)
Biochem Biophys Res Commun
, vol.291
, pp. 593-597
-
-
Torres-Guzmán, R.1
De La Mata, I.2
Torres-Bacete, J.3
Arroyo, M.4
Castillón, M.P.5
Acebal, C.6
-
91
-
-
0032787978
-
Enzymatic synthesis of β-lactam antibiotics using penicillin G acylase in frozen media
-
Van Langen LM, De Vroom E, Van Rantwijk F, Sheldon RA (1999) Enzymatic synthesis of β-lactam antibiotics using penicillin G acylase in frozen media. FEBS Lett 456:89-92
-
(1999)
FEBS Lett
, vol.456
, pp. 89-92
-
-
Van Langen, L.M.1
De Vroom, E.2
Van Rantwijk, F.3
Sheldon, R.A.4
-
92
-
-
0344002700
-
Penicillin acylase-catalyzed peptide synthesis: A chemoenzymatic route to stereoisomers of 3,6-diphenylpiperazine-2,5-dione
-
Van Langen LM, Van Rantwijk F, Svedas VK, Sheldon RA (2000a) Penicillin acylase-catalyzed peptide synthesis: a chemoenzymatic route to stereoisomers of 3,6-diphenylpiperazine-2,5-dione. Tetrahedron Asym 11:1077-1083
-
(2000)
Tetrahedron Asym
, vol.11
, pp. 1077-1083
-
-
Van Langen, L.M.1
Van Rantwijk, F.2
Svedas, V.K.3
Sheldon, R.A.4
-
93
-
-
0034680482
-
Penicillin acylase-catalyzed resolution of amines in aqueous organic solvents
-
Van Langen LM, Oosthoek NHP, Guranda DT, Van Rantwijk F, Svedas VK, Sheldon RA (2000b) Penicillin acylase-catalyzed resolution of amines in aqueous organic solvents. Tetrahedron Asym 11:4593-4600
-
(2000)
Tetrahedron Asym
, vol.11
, pp. 4593-4600
-
-
Van Langen, L.M.1
Oosthoek, N.H.P.2
Guranda, D.T.3
Van Rantwijk, F.4
Svedas, V.K.5
Sheldon, R.A.6
-
94
-
-
12244272706
-
-
International Patent Application WO 02/20821 to DSM N.V. (The Netherlands)
-
Van Rantwijk F, Sheldon RA, Van Langen LM, Khimiouk AI, Guranda DT, Svedas VK (2002) Process for the preparation of enantiomerically enriched amines. International Patent Application WO 02/20821 to DSM N.V. (The Netherlands)
-
(2002)
Process for the Preparation of Enantiomerically Enriched Amines
-
-
Van Rantwijk, F.1
Sheldon, R.A.2
Van Langen, L.M.3
Khimiouk, A.I.4
Guranda, D.T.5
Svedas, V.K.6
-
97
-
-
0037023939
-
Penicillin acylase-catalyzed ampicillin synthesis using a pH gradient: A new approach to optimization
-
Youshko MI, Van Langen LM, De Vroom E, Van Rantwijk F, Sheldon RA, Svedas VK (2002) Penicillin acylase-catalyzed ampicillin synthesis using a pH gradient: a new approach to optimization. Biotechnol Bioeng 78:589-593
-
(2002)
Biotechnol Bioeng
, vol.78
, pp. 589-593
-
-
Youshko, M.I.1
Van Langen, L.M.2
De Vroom, E.3
Van Rantwijk, F.4
Sheldon, R.A.5
Svedas, V.K.6
-
98
-
-
0026100874
-
Enantioselective acylation of a β-lactam intermediate in the synthesis of loracarbef using penicillin G amidase
-
Zmijewski MJ, Briggs BS, Thompson AR, Wright IG (1991) Enantioselective acylation of a β-lactam intermediate in the synthesis of loracarbef using penicillin G amidase. Tetrahedron Lett 32:1621-1622
-
(1991)
Tetrahedron Lett
, vol.32
, pp. 1621-1622
-
-
Zmijewski, M.J.1
Briggs, B.S.2
Thompson, A.R.3
Wright, I.G.4
|