-
1
-
-
0031918742
-
The mitochondrial death/life regulator in apoptosis and necrosis
-
DOI 10.1146/annurev.physiol.60.1.619
-
Kroemer G, Dallaporta B, Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 1998; 60: 619-42; PMID: 9558479; h t t p://d x. d oi.or g/10.114 6/a n nu re v. physiol.60.1.619 (Pubitemid 28157889)
-
(1998)
Annual Review of Physiology
, vol.60
, pp. 619-642
-
-
Kroemer, G.1
Dallaporta, B.2
Resche-Rigon, M.3
-
2
-
-
0033971898
-
Mitochondria and neu-ronal survival
-
PMID: 10617771
-
Nicholls DG, Budd SL. Mitochondria and neu-ronal survival. Physiol Rev 2000; 80: 315-60; PMID: 10617771
-
(2000)
Physiol Rev
, vol.80
, pp. 315-360
-
-
Nicholls, D.G.1
Budd, S.L.2
-
3
-
-
67651119928
-
Mitochondria: Determinants of stem cell fate?
-
PMID 19563264
-
Parker GC, Acsadi G, Brenner CA. Mitochondria: determinants of stem cell fate? Stem Cells Dev 2009; 18: 803-6; PMID: 19563264; http://dx.doi.org/10.1089/ scd.2009.1806.edi
-
(2009)
Stem Cells Dev
, vol.18
, pp. 803-806
-
-
Parker, G.C.1
Acsadi, G.2
Brenner, C.A.3
-
4
-
-
27744491193
-
Emerging functions of mammalian mitochondrial fusion and fission
-
DOI 10.1093/hmg/ddi270
-
Chen H, Chan DC. Emerging functions of mammalian mitochondrial fusion and fission. Hum Mol Genet 2005; 14 Spec No. 2:R283-9; PMID: 16244327; http://dx.doi.org/10.1093/hmg/ddi270 (Pubitemid 41631897)
-
(2005)
Human Molecular Genetics
, vol.14
, Issue.SUPPL. 2
-
-
Chen, H.1
Chan, D.C.2
-
5
-
-
67651159365
-
Transcriptional control of mito-chondrial biogenesis and function
-
PMID: 19575678
-
Hock MB, Kralli A. Transcriptional control of mito-chondrial biogenesis and function. Annu Rev Physiol 2009; 71: 177-203; PMID: 19575678; http://dx.doi.org/10.114 6/annurev.physiol.010908.163119
-
(2009)
Annu Rev Physiol
, vol.71
, pp. 177-203
-
-
Hock, M.B.1
Kralli, A.2
-
6
-
-
84871005673
-
The pathways of mitophagy for quality control and clearance of mitochondria
-
PMID: 22743996
-
Ashrafi G, Schwarz TL. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ 2013; 20: 31-42; PMID: 22743996; http://dx.doi.org/10.1038/cdd.2012.81
-
(2013)
Cell Death Differ
, vol.20
, pp. 31-42
-
-
Ashrafi, G.1
Schwarz, T.L.2
-
7
-
-
41749114288
-
Autophagy: Basic principles and relevance to disease
-
DOI 10.1146/annurev.pathmechdis.2.010506.091842
-
Kundu M, Thompson CB. Autophagy: basic principles and relevance to disease. Annu Rev Pathol 2008; 3: 427-55; PMID: 18039129; http://dx.doi.org/10. 1146/annurev.pathmechdis.2.010506.091842 (Pubitemid 351488288)
-
(2008)
Annual Review of Pathology: Mechanisms of Disease
, vol.3
, pp. 427-455
-
-
Kundu, M.1
Thompson, C.B.2
-
8
-
-
35448981935
-
Autophagy: From phenomenology to molecular understanding in less than a decade
-
DOI 10.1038/nrm2245, PII NRM2245
-
Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007; 8: 931-7; PMID: 17712358; http://dx.doi.org/10.1038/nrm2245 (Pubitemid 47622558)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.11
, pp. 931-937
-
-
Klionsky, D.J.1
-
9
-
-
67649467294
-
Dynamics and diversity in autophagy mechanisms: Lessons from yeast
-
PMID: 19491929
-
Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y. Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol 2009; 10: 458-67; PMID: 19491929; http://dx.doi.org/10.1038/nrm2708
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 458-467
-
-
Nakatogawa, H.1
Suzuki, K.2
Kamada, Y.3
Ohsumi, Y.4
-
10
-
-
77956404377
-
Eaten alive: A history of macroautophagy
-
PMID: 20811353
-
Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nat Cell Biol 2010; 12: 814-22; PMID: 20811353; http://dx.doi.org/10.1038/ncb0910-814
-
(2010)
Nat Cell Biol
, vol.12
, pp. 814-822
-
-
Yang, Z.1
Klionsky, D.J.2
-
11
-
-
78649338141
-
Autophagy and the integrated stress response
-
PMID: 20965422
-
Kroemer G, Mariño G, Levine B. Autophagy and the integrated stress response. Mol Cell 2010; 40: 280-93; PMID: 20965422; http://dx.doi.org/10.1016/ j. molcel.2010.09.023
-
(2010)
Mol Cell
, vol.40
, pp. 280-293
-
-
Kroemer, G.1
Mariño, G.2
Levine, B.3
-
12
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
PMID: 18191218
-
Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132: 27-42; PMID: 18191218; http://dx.doi.org/10.1016/j.cell.2007.12.018
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
13
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
DOI 10.1038/nature06639, PII NATURE06639
-
Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451: 1069-75; PMID: 18305538; http://dx.doi.org/10.1038/nature06639 (Pubitemid 351317450)
-
(2008)
Nature
, vol.451
, Issue.7182
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
14
-
-
76249127368
-
Loss of auto-phagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo
-
PMID: 20080761
-
Mortensen M, Ferguson DJ, Edelmann M, Kessler B, Morten KJ, Komatsu M, Simon AK. Loss of auto-phagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci U S A 2010; 107: 832-7; PMID: 20080761; http://dx.doi.org/10.1073/pnas.0913170107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 832-837
-
-
Mortensen, M.1
Ferguson, D.J.2
Edelmann, M.3
Kessler, B.4
Morten, K.J.5
Komatsu, M.6
Simon, A.K.7
-
15
-
-
79952728102
-
The auto-phagy protein Atg7 is essential for hematopoietic stem cell maintenance
-
PMID: 21339326
-
Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Glanville J, Knight S, Jacobsen SE, et al. The auto-phagy protein Atg7 is essential for hematopoietic stem cell maintenance. J Exp Med 2011; 208: 455-67; PMID: 21339326; http://dx.doi.org/10.1084/jem. 20101145
-
(2011)
J Exp Med
, vol.208
, pp. 455-467
-
-
Mortensen, M.1
Soilleux, E.J.2
Djordjevic, G.3
Tripp, R.4
Lutteropp, M.5
Sadighi-Akha, E.6
Stranks, A.J.7
Glanville, J.8
Knight, S.9
Jacobsen, S.E.10
-
16
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
DOI 10.1038/nature02517
-
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004; 429: 417-23; PMID: 15164064; http://dx.doi.org/10.1038/nature02517 (Pubitemid 38715133)
-
(2004)
Nature
, vol.429
, Issue.6990
, pp. 417-423
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
Spelbrink, J.N.4
Rovio, A.T.5
Bruder, C.E.6
Bohlooly-Y, M.7
Gldlof, S.8
Oldfors, A.9
Wibom, R.10
Tornell, J.11
Jacobs, H.T.12
Larsson, N.-G.13
-
17
-
-
22344456832
-
Medicine: Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
-
DOI 10.1126/science.1112125
-
Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemut h SE, Hofer T, Seo AY, Sullivan R, Jobling WA, et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005; 309: 481-4; PMID: 16020738; http://dx.doi.org/10.1126/science.1112125 (Pubitemid 40994689)
-
(2005)
Science
, vol.309
, Issue.5733
, pp. 481-484
-
-
Kujoth, C.C.1
Hiona, A.2
Pugh, T.D.3
Someya, S.4
Panzer, K.5
Wohlgemuth, S.E.6
Hofer, T.7
Seo, A.Y.8
Sullivan, R.9
Jobling, W.A.10
Morrow, J.D.11
Van Remmen, H.12
Sedivy, J.M.13
Yamasoba, T.14
Tanokura, M.15
Weindruch, R.16
Leeuwenburgh, C.17
Prolla, T.A.18
-
18
-
-
77950236668
-
Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction
-
PMID: 19734452
-
Chen ML, Logan TD, Hochberg ML, Shelat SG, Yu X, Wilding GE, Ta n W, Kujoth GC, Prolla TA, Selak MA, et al. Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction. Blood 2009; 114: 4045-53; PMID: 19734 452; http://dx.doi.org/10.1182/blood-2008-08- 169474
-
(2009)
Blood
, vol.114
, pp. 4045-4053
-
-
Chen, M.L.1
Logan, T.D.2
Hochberg, M.L.3
Shelat, S.G.4
Yu, X.5
Wilding, G.E.6
Tan, W.7
Kujoth, G.C.8
Prolla, T.A.9
Selak, M.A.10
-
19
-
-
84868632060
-
A PML -PPAR- d pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
-
PMID: 22902876
-
Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, Schafer ZT, Evans RM, Suda T, Lee CH, et al. A PML -PPAR- d pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med 2012; 18: 1350-8; PMID: 22902876; http://dx.doi.org/10.1038/nm.2882
-
(2012)
Nat Med
, vol.18
, pp. 1350-1358
-
-
Ito, K.1
Carracedo, A.2
Weiss, D.3
Arai, F.4
Ala, U.5
Avigan, D.E.6
Schafer, Z.T.7
Evans, R.M.8
Suda, T.9
Lee, C.H.10
-
20
-
-
77956205122
-
The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
-
PMID: 20804973
-
Simsek T, Kocabas F, Zheng J, Deberardinis RJ, Mahmoud AI, Olson EN, Schneider JW, Zhang CC, Sadek HA. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell 2010; 7: 380-90; PMID: 20804973; http://dx.doi.org/10.1016/j. stem.2010.07.011
-
(2010)
Cell Stem Cell
, vol.7
, pp. 380-390
-
-
Simsek, T.1
Kocabas, F.2
Zheng, J.3
Deberardinis, R.J.4
Mahmoud, A.I.5
Olson, E.N.6
Schneider, J.W.7
Zhang, C.C.8
Sadek, H.A.9
-
21
-
-
22544446192
-
Characterization of mitochondrial and extra-mitochondrial oxygen consuming reactions in human hematopoietic stem cells: Novel evidence of the occurrence of NAD(P)H oxidase activity
-
DOI 10.1074/jbc.M500047200
-
Piccoli C, Ria R, Scrima R, Cela O, D'Apr ile A, Boffoli D, Falzetti F, Tabilio A, Capitanio N. Characterization of mitochondrial and extra-mito-chondrial oxygen consuming reactions in human hematopoietic stem cells. Novel evidence of the occurrence of NAD(P)H oxidase activity. J Biol Chem 2005; 280: 26467-76; PMID: 15 8 8316 3; http://dx.doi.org/10.1074/jbc. M500047200 (Pubitemid 41022243)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.28
, pp. 26467-26476
-
-
Piccoli, C.1
Ria, R.2
Scrima, R.3
Cela, O.4
D'Aprile, A.5
Boffoli, D.6
Falzetti, F.7
Tabilio, A.8
Capitanio, N.9
-
22
-
-
77953632556
-
Upregulation of nascent mitochondrial biogenesis in mouse hematopoietic stem cells parallels upregulation of CD34 and loss of pluripotency: A potential strategy for reducing oxidative risk in stem cells
-
PMID: 20495374
-
Mantel C, Messina-Graham S, Broxmeyer HE. Upregulation of nascent mitochondrial biogenesis in mouse hematopoietic stem cells parallels upregulation of CD34 and loss of pluripotency: a potential strategy for reducing oxidative risk in stem cells. Cell Cycle 2010; 9: 2008-17; PMID: 20495374; http://dx.doi.org/10.4161/cc.9.10.11733
-
(2010)
Cell Cycle
, vol.9
, pp. 2008-2017
-
-
Mantel, C.1
Messina-Graham, S.2
Broxmeyer, H.E.3
-
23
-
-
79955698235
-
Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging
-
PMID: 215 49 326
-
Norddahl GL, Pronk CJ, Wahlestedt M, Sten G, Nygren JM, Ugale A, Sigvardsson M, Bryder D. Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging. Cell Stem Cell 2 011; 8: 499-510; PMID: 215 49 3 2 6; http://dx.doi.org/10.1016/j.stem.2011.03.009
-
(2011)
Cell Stem Cell
, vol.8
, pp. 499-510
-
-
Norddahl, G.L.1
Pronk, C.J.2
Wahlestedt, M.3
Sten, G.4
Nygren, J.M.5
Ugale, A.6
Sigvardsson, M.7
Bryder, D.8
-
24
-
-
84858782079
-
AMPK: A nutrient and energy sensor that maintains energy homeo-stasis
-
PMID: 22436748
-
Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeo-stasis. Nat Rev Mol Cell Biol 2012; 13: 251-62; PMID: 22436748; http://dx.doi.org/10.1038/nrm3311
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
25
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
DOI 10.1073/pnas.0308061100
-
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A 2004; 101: 3329-35; PMID: 14985505; http://dx.doi.org/10.1073/pnas. 0308061100 (Pubitemid 38338195)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.10
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
Cantley, L.C.7
-
26
-
-
67749111502
-
The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
-
PMID: 19629071
-
Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 2009; 9: 563-75; PMID: 19629071; http://dx.doi.org/10.1038/nrc2676
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 563-575
-
-
Shackelford, D.B.1
Shaw, R.J.2
-
27
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
-
PMID: 14511394
-
Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2003; 2: 28; PMID: 14511394; http://dx.doi.org/10.1186/ 1475-4924-2-28
-
(2003)
J Biol
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Mäkelä, T.P.6
Alessi, D.R.7
Hardie, D.G.8
-
28
-
-
12144287284
-
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
-
DOI 10.1038/sj.emboj.7600110
-
Lizcano JM, Göransson O, To t h R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 2004; 23: 833-43; PMID: 14976552; http://dx.doi.org/10.1038/sj.emboj.7600110 (Pubitemid 38418750)
-
(2004)
EMBO Journal
, vol.23
, Issue.4
, pp. 833-843
-
-
Lizcano, J.M.1
Goransson, O.2
Toth, R.3
Deak, M.4
Morrice, N.A.5
Boudeau, J.6
Hawley, S.A.7
Udd, L.8
Makela, T.P.9
Hardie, D.G.10
Alessi, D.R.11
-
29
-
-
78649811793
-
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
-
PMID: 211 2 4 45 0
-
Nakada D, Saunders TL, Morrison SJ. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 2010; 468: 653-8; PMID: 211 2 4 45 0; http://dx.doi.org/10.1038/nature09571
-
(2010)
Nature
, vol.468
, pp. 653-658
-
-
Nakada, D.1
Saunders, T.L.2
Morrison, S.J.3
-
30
-
-
78649874959
-
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
-
PMID: 21124456
-
Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, et al. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 2010; 468: 701-4; PMID: 21124456; http://dx.doi.org/10.1038/nature09595
-
(2010)
Nature
, vol.468
, pp. 701-704
-
-
Gan, B.1
Hu, J.2
Jiang, S.3
Liu, Y.4
Sahin, E.5
Zhuang, L.6
Fletcher-Sananikone, E.7
Colla, S.8
Wang, Y.A.9
Chin, L.10
-
31
-
-
78649851511
-
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
-
PMID: 21124451
-
Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusu f RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, et al. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 2010; 468: 659-63; PMID: 2112 4 451; http://dx.doi.org/10.1038/nature09572
-
(2010)
Nature
, vol.468
, pp. 659-663
-
-
Gurumurthy, S.1
Xie, S.Z.2
Alagesan, B.3
Kim, J.4
Yusuf, R.Z.5
Saez, B.6
Tzatsos, A.7
Ozsolak, F.8
Milos, P.9
Ferrari, F.10
-
32
-
-
77957608608
-
A general introduction to the biochemistry of mitochondrial fatty acid ß-oxidation
-
PMID: 20195903
-
Houten SM, Wa nders RJ. A general introduction to the biochemistry of mitochondrial fatty acid ß-oxidation. J Inherit Metab Dis 2010; 33: 469-77; PMID: 20195903; http://dx.doi.org/10.1007/s10545-010-9061-2
-
(2010)
J Inherit Metab Dis
, vol.33
, pp. 469-477
-
-
Houten, S.M.1
Wanders, R.J.2
-
33
-
-
34547136480
-
New therapeutic target for metabolic syndrome: PPARδ
-
DOI 10.1507/endocrj.KR-99
-
Takahashi S, Tanaka T, Sakai J. New therapeutic target for metabolic syndrome: PPARdelta. Endocr J 2007; 54: 347-57; PMID: 17409576; http://dx.doi.org/10.1507/endocrj.KR-99 (Pubitemid 47105421)
-
(2007)
Endocrine Journal
, vol.54
, Issue.3
, pp. 347-357
-
-
Takahashi, S.1
Tanaka, T.2
Sakai, J.3
-
34
-
-
76449100708
-
PPARs: Diverse regulators in energy metabolism and metabolic diseases
-
PMID: 20101262
-
Wa n g YX. PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Res 2010; 20: 124-37; PMID: 20101262; http://dx.doi.org/10.1038/ cr.2010.13
-
(2010)
Cell Res
, vol.20
, pp. 124-137
-
-
Wang, Y.X.1
-
35
-
-
84872037830
-
Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation
-
PMID: 23290137
-
Yu WM, Liu X, Shen J, Jovanovic O, Pohl EE, Gerson SL, Finkel T, Broxmeyer HE, Qu CK. Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell 2013; 12: 62-74; PMID: 23290137; http://dx.doi.org/10.1016/j.stem.2012.11.022
-
(2013)
Cell Stem Cell
, vol.12
, pp. 62-74
-
-
Yu, W.M.1
Liu, X.2
Shen, J.3
Jovanovic, O.4
Pohl, E.E.5
Gerson, S.L.6
Finkel, T.7
Broxmeyer, H.E.8
Qu, C.K.9
-
36
-
-
79958780643
-
Superoxide flashes reactive oxygen species and the mitochondrial permeability transition pore: Potential implications for hematopoietic stem cell function
-
PMID: 215 3 7169
-
Mantel C, Messina-Graham SV, Broxmeyer HE. Superoxide flashes, reactive oxygen species, and the mitochondrial permeability transition pore: potential implications for hematopoietic stem cell function. Curr Opin Hematol 2011; 18: 208-13; PMID: 215 3 7 16 9; http://dx.doi.org/10.1097/MOH.0b013e3283475ffe
-
(2011)
Curr Opin Hematol
, vol.18
, pp. 208-213
-
-
Mantel, C.1
Messina-Graham, S.V.2
Broxmeyer, H.E.3
-
37
-
-
0033135256
-
Hematopoietic growth factors signal through the formation of reactive oxygen species
-
Sattler M, Winkler T, Verma S, Byrne CH, Shrikhande G, Salgia R, Griffin JD. Hematopoietic growth factors signal through the formation of reactive oxygen species. Blood 1999; 93: 2928-35; PMID: 10216087 (Pubitemid 29200783)
-
(1999)
Blood
, vol.93
, Issue.9
, pp. 2928-2935
-
-
Sattler, M.1
Winkler, T.2
Verma, S.3
Byrne, C.H.4
Shrikhande, G.5
Salgia, R.6
Griffin, J.D.7
-
38
-
-
77953283847
-
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species
-
PMID: 20354168
-
Juntilla MM, Patil VD, Calamito M, Joshi R P, Birnbaum MJ, Koretzky GA. AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Blood 2010; 115: 4030-8; PMID: 20354168; http://dx.doi.org/10. 1182/blood-2009-09-241000
-
(2010)
Blood
, vol.115
, pp. 4030-4038
-
-
Juntilla, M.M.1
Patil, V.D.2
Calamito, M.3
Joshi, R.P.4
Birnbaum, M.J.5
Koretzky, G.A.6
-
39
-
-
17644379936
-
FOXO transcription factors in cell-cycle regulation and the response to oxidative stress
-
DOI 10.1089/ars.2005.7.752
-
Furukawa-Hibi Y, Kobayashi Y, Chen C, Motoyama N. FOXO transcription factors in cell-cycle regulation and the response to oxidative stress. Antioxid Redox Signal 2005; 7: 752-60; PMID: 15890021; http://dx.doi.org/10.1089/ars. 2005.7.752 (Pubitemid 40563215)
-
(2005)
Antioxidants and Redox Signaling
, vol.7
, Issue.5-6
, pp. 752-760
-
-
Furukawa-Hibi, Y.1
Kobayashi, Y.2
Chen, C.3
Motoyama, N.4
-
40
-
-
41849150779
-
FOXOs, cancer and regulation of apoptosis
-
DOI 10.1038/onc.2008.24, PII ONC200824
-
Fu Z, Tindall DJ. FOXOs, cancer and regulation of apoptosis. Oncogene 2008; 27: 2312-9; PMID: 18391973; http://dx.doi.org/10.1038/onc.2008.24 (Pubitemid 351501782)
-
(2008)
Oncogene
, vol.27
, Issue.16
, pp. 2312-2319
-
-
Fu, Z.1
Tindall, D.J.2
-
41
-
-
33747370384
-
Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer
-
PMID: 16806782
-
Arden KC. Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer. Exp Gerontol 2006; 41: 709-17; PMID: 16806782; http://dx.doi.org/10.1016/j. exger.2006.05.015
-
(2006)
Exp Gerontol
, vol.41
, pp. 709-717
-
-
Arden, K.C.1
-
42
-
-
81255195809
-
FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function
-
PMID: 21915097
-
Jensen KS, Binderup T, Jensen K T, Therkelsen I, Borup R, Nilsson E, Multhaupt H, Bouchard C, Quistorff B, Kjaer A, et al. FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function. EMBO J 2011; 30: 4554-70; PMID: 21915097; http://dx.doi.org/10.1038/emboj.2011.323
-
(2011)
EMBO J
, vol.30
, pp. 4554-4570
-
-
Jensen, K.S.1
Binderup, T.2
Jensen, K.T.3
Therkelsen, I.4
Borup, R.5
Nilsson, E.6
Multhaupt, H.7
Bouchard, C.8
Quistorff, B.9
Kjaer, A.10
-
43
-
-
33846419112
-
FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress
-
DOI 10.1016/j.cell.2007.01.003, PII S0092867407000505
-
Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007; 128: 325-39; PMID: 17254970; http://dx.doi.org/10.1016/j.cell.2007. 01.003 (Pubitemid 46137992)
-
(2007)
Cell
, vol.128
, Issue.2
, pp. 325-339
-
-
Tothova, Z.1
Kollipara, R.2
Huntly, B.J.3
Lee, B.H.4
Castrillon, D.H.5
Cullen, D.E.6
McDowell, E.P.7
Lazo-Kallanian, S.8
Williams, I.R.9
Sears, C.10
Armstrong, S.A.11
Passegue, E.12
DePinho, R.A.13
Gilliland, D.G.14
-
44
-
-
34249882777
-
Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool
-
DOI 10.1016/j.stem.2007.02.001, PII S1934590907000021
-
Miyamoto K, Araki KY, Naka K, Arai F, Ta kubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 2007; 1: 101-12; PMID: 18371339; http://dx.doi.org/10.1016/j.stem.2007.02.001 (Pubitemid 46865800)
-
(2007)
Cell Stem Cell
, vol.1
, Issue.1
, pp. 101-112
-
-
Miyamoto, K.1
Araki, K.Y.2
Naka, K.3
Arai, F.4
Takubo, K.5
Yamazaki, S.6
Matsuoka, S.7
Miyamoto, T.8
Ito, K.9
Ohmura, M.10
Chen, C.11
Hosokawa, K.12
Nakauchi, H.13
Nakayama, K.14
Nakayama, K.I.15
Harada, M.16
Motoyama, N.17
Suda, T.18
Hirao, A.19
-
45
-
-
78650302424
-
ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice
-
PMID 21113129
-
Yalcin S, Marinkovic D, Mungamuri SK, Zhang X, To n g W, Sellers R, Ghaffari S. ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice. EMBO J 2010; 29: 4118-31; PMID: 21113129; http://dx.doi.org/10.1038/emboj.2010.292
-
(2010)
EMBO J
, vol.29
, pp. 4118-4131
-
-
Yalcin, S.1
Marinkovic, D.2
Mungamuri, S.K.3
Zhang, X.4
Tong, W.5
Sellers, R.6
Ghaffari, S.7
-
46
-
-
78650510609
-
MTOR: From growth signal integration to cancer diabetes and ageing
-
PMID: 21157483
-
Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12: 21-35; PMID: 2115 74 83; http://dx.doi.org/10.1038/nrm3025
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
47
-
-
36749081539
-
MTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
-
DOI 10.1038/nature06322, PII NATURE06322
-
Cunningham JT, Rodgers JT, Arlow DH, Vazque z F, Mootha VK, Puigserver P. mTOR controls mitochon-drial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 2007; 450: 736-40; PMID: 18046414; http://dx.doi.org/10.1038/nature06322 (Pubitemid 350207689)
-
(2007)
Nature
, vol.450
, Issue.7170
, pp. 736-740
-
-
Cunningham, J.T.1
Rodgers, J.T.2
Arlow, D.H.3
Vazquez, F.4
Mootha, V.K.5
Puigserver, P.6
-
48
-
-
11244297916
-
Dysregulation of the TSC-mTOR pathway in human disease
-
DOI 10.1038/ng1494
-
Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 2005; 37: 19-24; PMID: 15624019; http://dx.doi.org/10. 1038/ng1494 (Pubitemid 40070934)
-
(2005)
Nature Genetics
, vol.37
, Issue.1
, pp. 19-24
-
-
Inoki, K.1
Corradetti, M.N.2
Guan, K.-L.3
-
49
-
-
53349091768
-
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
-
PMID: 18809716
-
Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Liu Y, Zheng P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med 2008; 205: 2397-408; PMID: 18809716; http://dx.doi.org/10.1084/jem.20081297
-
(2008)
J Exp Med
, vol.205
, pp. 2397-2408
-
-
Chen, C.1
Liu, Y.2
Liu, R.3
Ikenoue, T.4
Guan, K.L.5
Liu, Y.6
Zheng, P.7
-
50
-
-
65949113818
-
The axis of mTOR-mitochondria-ROS and stemness of the hemato-poietic stem cells
-
PMID: 19270502
-
Chen C, Liu Y, Liu Y, Zheng P. The axis of mTOR-mitochondria-ROS and stemness of the hemato-poietic stem cells. Cell Cycle 2009; 8: 1158-60; PMID: 19270502; http://dx.doi.org/10.4161/cc.8.8.8139
-
(2009)
Cell Cycle
, vol.8
, pp. 1158-1160
-
-
Chen, C.1
Liu, Y.2
Liu, Y.3
Zheng, P.4
-
51
-
-
34848867521
-
Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction
-
DOI 10.1016/j.bbrc.2007.09.014, PII S0006291X07019559
-
Hosokawa K, Arai F, Yoshihara H, Nakamura Y, Gomei Y, Iwasaki H, Miyamoto K, Shima H, Ito K, Suda T. Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction. Biochem Biophys Res Commun 2007; 363: 578-83; PMID: 1789 762 9; http://dx.doi.org/10.1016/j. bbrc.2007.09.014 (Pubitemid 47513670)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.363
, Issue.3
, pp. 578-583
-
-
Hosokawa, K.1
Arai, F.2
Yoshihara, H.3
Nakamura, Y.4
Gomei, Y.5
Iwasaki, H.6
Miyamoto, K.7
Shima, H.8
Ito, K.9
Suda, T.10
-
52
-
-
78751565017
-
Enhanced c-Met activity promotes G-CSF-induced mobilization of hema-topoietic progenitor cells via ROS signaling
-
PMID: 20585044
-
Te s i o M, Golan K, Corso S, Giordano S, Schajnovitz A, Va g ima Y, Shivtiel S, Kalinkovich A, Caione L, Gammaitoni L, et al. Enhanced c-Met activity promotes G-CSF-induced mobilization of hema-topoietic progenitor cells via ROS signaling. Blood 2 011; 117: 419-28; PMID: 20585044; http://dx.doi.org/10.1182/blood-2009-06-230359
-
(2011)
Blood
, vol.117
, pp. 419-428
-
-
Tesio, M.1
Golan, K.2
Corso, S.3
Giordano, S.4
Schajnovitz, A.5
Vagima, Y.6
Shivtiel, S.7
Kalinkovich, A.8
Caione, L.9
Gammaitoni, L.10
-
53
-
-
35548936968
-
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
-
DOI 10.1182/blood-2007-05-087759
-
Jang YY, Sharkis SJ. A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood 2007; 110: 3056-63; PMID: 17595331; http://dx.doi.org/10.1182/blood-2007- 05-087759 (Pubitemid 350006961)
-
(2007)
Blood
, vol.110
, Issue.8
, pp. 3056-3063
-
-
Jang, Y.-Y.1
Sharkis, S.J.2
-
54
-
-
80052715446
-
The relationship between oxygen concentration, reactive oxygen species and the biological characteristics of human bone marrow hematopoietic stem cells
-
PMID: 21911158
-
Hao Y, Cheng D, Ma Y, Zhou W, Wang Y. The relationship between oxygen concentration, reactive oxygen species and the biological characteristics of human bone marrow hematopoietic stem cells. Transplant Proc 2 011; 43: 2755-61; PMID: 21911158; http://dx.doi.org/10.1016/j.transproceed.2011.06.026
-
(2011)
Transplant Proc
, vol.43
, pp. 2755-2761
-
-
Hao, Y.1
Cheng, D.2
Ma, Y.3
Zhou, W.4
Wang, Y.5
-
55
-
-
80052930073
-
Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells
-
PMID: 21734240
-
Yahata T, Takanashi T, Muguruma Y, Ibrahim AA, Matsuzawa H, Uno T, Sheng Y, Onizuka M, Ito M, Kato S, et al. Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells. Blood 2011; 118: 2941-50; PMID: 21734240; http://dx.doi.org/10.1182/blood-2011-01- 330050
-
(2011)
Blood
, vol.118
, pp. 2941-2950
-
-
Yahata, T.1
Takanashi, T.2
Muguruma, Y.3
Ibrahim, A.A.4
Matsuzawa, H.5
Uno, T.6
Sheng, Y.7
Onizuka, M.8
Ito, M.9
Kato, S.10
-
56
-
-
11244280878
-
NF-κB family proteins participate in multiple steps of hematopoiesis through elimination of reactive oxygen species
-
DOI 10.1074/jbc.M408238200
-
Nakata S, Matsumura I, Tanaka H, Ezoe S, Satoh Y, Ishikawa J, Era T, Kanakura Y. NF-kappaB family proteins participate in multiple steps of hematopoi-esis through elimination of reactive oxygen species. J Biol Chem 2004; 279: 55578-86; PMID: 1548584 3; http://dx.doi.org/10.1074/jbc.M408238200 (Pubitemid 40066561)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.53
, pp. 55578-55586
-
-
Nakata, S.1
Matsumura, I.2
Tanaka, H.3
Ezoe, S.4
Satoh, Y.5
Ishikawa, J.6
Era, T.7
Kanakura, Y.8
-
57
-
-
70349446465
-
Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
-
PMID: 19727075
-
Owusu-Ansah E, Banerjee U. Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature 2009; 461: 537-41; PMID: 19727075; http://dx.doi.org/10.1038/nature08313
-
(2009)
Nature
, vol.461
, pp. 537-541
-
-
Owusu-Ansah, E.1
Banerjee, U.2
-
58
-
-
17744393686
-
Mitochondrial DNA mutations in human disease
-
DOI 10.1038/nrg1606
-
Taylor RW, Tu r n b u l l DM. Mitochondrial DNA mutations in human disease. Nat Rev Genet 2005; 6: 389-402; PMID: 15861210; http://dx.doi.org/10. 1038/nrg1606 (Pubitemid 40577182)
-
(2005)
Nature Reviews Genetics
, vol.6
, Issue.5
, pp. 389-402
-
-
Taylor, R.W.1
Turnbull, D.M.2
-
59
-
-
2942531063
-
Mitochondrial defects in cancer
-
PMID 12513701
-
Carew JS, Huang P. Mitochondrial defects in cancer. Mol Cancer 2002; 1: 9; PMID: 12513701; http://dx.doi.org/10.1186/1476-4598-1-9
-
(2002)
Mol Cancer
, vol.1
, pp. 9
-
-
Carew, J.S.1
Huang, P.2
-
60
-
-
77956416339
-
Autophagy in mammalian development and differentiation
-
PMID: 20811354
-
Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat Cell Biol 2010; 12: 823-30; PMID: 20811354; http://dx.doi.org/10.1038/ncb0910-823
-
(2010)
Nat Cell Biol
, vol.12
, pp. 823-830
-
-
Mizushima, N.1
Levine, B.2
-
61
-
-
51649124519
-
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation
-
PMID: 18539900
-
Kundu M, Lindsten T, Yang CY, Wu J, Zhao F, Zhang J, Selak MA, Ney PA, Thompson CB. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood 2008; 112: 1493-502; PMID: 18539900; http://dx.doi.org/10.1182/blood-2008-02-137398
-
(2008)
Blood
, vol.112
, pp. 1493-1502
-
-
Kundu, M.1
Lindsten, T.2
Yang, C.Y.3
Wu, J.4
Zhao, F.5
Zhang, J.6
Selak, M.A.7
Ney, P.A.8
Thompson, C.B.9
-
62
-
-
77449094358
-
Neural-specific deletion of FIP200 leads to cerebel-lar degeneration caused by increased neuronal death and axon degeneration
-
PMID: 19940130
-
Liang CC, Wa ng C, Peng X, Gan B, Guan JL. Neural-specific deletion of FIP200 leads to cerebel-lar degeneration caused by increased neuronal death and axon degeneration. J Biol Chem 2010; 285: 3499-509; PMID: 19940130; http://dx.doi.org/10.1074/jbc.M109.072389
-
(2010)
J Biol Chem
, vol.285
, pp. 3499-3509
-
-
Liang, C.C.1
Wang, C.2
Peng, X.3
Gan, B.4
Guan, J.L.5
-
63
-
-
78649689953
-
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells
-
PMID: 20716775
-
Liu F, Lee JY, Wei H, Tanabe O, Engel JD, Morrison SJ, Guan JL. FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood 2010; 116: 4806-14; PMID: 20716775; http://dx.doi.org/10.1182/blood-2010- 06-288589
-
(2010)
Blood
, vol.116
, pp. 4806-4814
-
-
Liu, F.1
Lee, J.Y.2
Wei, H.3
Tanabe, O.4
Engel, J.D.5
Morrison, S.J.6
Guan, J.L.7
-
64
-
-
34249714158
-
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
-
DOI 10.1038/nm1574, PII NM1574
-
Nakai A, Yamaguchi O, Ta keda T, Higuchi Y, Hikoso S, Ta nii ke M, Omiya S, Mizote I, Matsumura Y, Asahi M, et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 2007; 13: 619-24; PMID: 17450150; http://dx.doi.org/10.1038/nm1574 (Pubitemid 46828485)
-
(2007)
Nature Medicine
, vol.13
, Issue.5
, pp. 619-624
-
-
Nakai, A.1
Yamaguchi, O.2
Takeda, T.3
Higuchi, Y.4
Hikoso, S.5
Taniike, M.6
Omiya, S.7
Mizote, I.8
Matsumura, Y.9
Asahi, M.10
Nishida, K.11
Hori, M.12
Mizushima, N.13
Otsu, K.14
-
65
-
-
67650216238
-
Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes
-
PMID: 19276668
-
Stephenson LM, Miller BC, Ng A, Eisenberg J, Zhao Z, Cadwell K, Graham DB, Mizushima NN, Xavier R, Virgin HW, et al. Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Autophagy 2009; 5: 625-35; PMID: 19276668; http://dx.doi.org/10. 4161/auto.5.5.8133
-
(2009)
Autophagy
, vol.5
, pp. 625-635
-
-
Stephenson, L.M.1
Miller, B.C.2
Ng, A.3
Eisenberg, J.4
Zhao, Z.5
Cadwell, K.6
Graham, D.B.7
Mizushima, N.N.8
Xavier, R.9
Virgin, H.W.10
-
66
-
-
33846461678
-
A critical role for the autophagy gene Atg5 in T cell survival and proliferation
-
DOI 10.1084/jem.20061303
-
Pua HH, Dzhagalov I, Chuck M, Mizushima N, He Y W. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med 2007; 204: 25-31; PMID: 17190837; http://dx.doi.org/10.1084/jem.20061303 (Pubitemid 46148752)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.1
, pp. 25-31
-
-
Pua, H.H.1
Dzhagalov, I.2
Chuck, M.3
Mizushima, N.4
He, Y.-W.5
-
67
-
-
77951169411
-
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice
-
PMID: 20200449
-
Hartleben B, Gödel M, Meyer-Schwesinger C, Liu S, Ulrich T, Köbler S, Wiech T, Grahammer F, Arnold SJ, Lindenmeyer MT, et al. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest 2010; 120: 1084-96; PMID: 20200449; http://dx.doi.org/10.1172/JCI39492
-
(2010)
J Clin Invest
, vol.120
, pp. 1084-1096
-
-
Hartleben, B.1
Gödel, M.2
Meyer-Schwesinger, C.3
Liu, S.4
Ulrich, T.5
Köbler, S.6
Wiech, T.7
Grahammer, F.8
Arnold, S.J.9
Lindenmeyer, M.T.10
-
68
-
-
70449927247
-
Autophagy is required to maintain muscle mass
-
PMID: 19945408
-
Masiero E, Agatea L, Mammucari C, Blaauw B, Loro E, Komatsu M, Metzger D, Reggiani C, Schiaffino S, Sandri M. Autophagy is required to maintain muscle mass. Cell Metab 2009; 10: 507-15; PMID: 19945408; http://dx.doi.org/10.1016/j. cmet.2009.10.008
-
(2009)
Cell Metab
, vol.10
, pp. 507-515
-
-
Masiero, E.1
Agatea, L.2
Mammucari, C.3
Blaauw, B.4
Loro, E.5
Komatsu, M.6
Metzger, D.7
Reggiani, C.8
Schiaffino, S.9
Sandri, M.10
-
69
-
-
21044455137
-
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
-
DOI 10.1083/jcb.200412022
-
Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanid a I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005; 169: 425-34; PMID: 15 8 6 6 8 8 7; http://dx.doi.org/10.1083/jcb.200412022 (Pubitemid 40686693)
-
(2005)
Journal of Cell Biology
, vol.169
, Issue.3
, pp. 425-434
-
-
Komatsu, M.1
Waguri, S.2
Ueno, T.3
Iwata, J.4
Murata, S.5
Tanida, I.6
Ezaki, J.7
Mizushima, N.8
Ohsumi, Y.9
Uchiyama, Y.10
Kominami, E.11
Tanaka, K.12
Chiba, T.13
-
70
-
-
36849089101
-
Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice
-
DOI 10.1016/j.cell.2007.10.035, PII S0092867407013542
-
Komatsu M, Wa guri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007; 131: 1149-63; PMID: 18083104; http://dx.doi.org/10.1016/j.cell.2007.10.035 (Pubitemid 350235021)
-
(2007)
Cell
, vol.131
, Issue.6
, pp. 1149-1163
-
-
Komatsu, M.1
Waguri, S.2
Koike, M.3
Sou, Y.-s.4
Ueno, T.5
Hara, T.6
Mizushima, N.7
Iwata, J.-i.8
Ezaki, J.9
Murata, S.10
Hamazaki, J.11
Nishito, Y.12
Iemura, S.-i.13
Natsume, T.14
Yanagawa, T.15
Uwayama, J.16
Warabi, E.17
Yoshida, H.18
Ishii, T.19
Kobayashi, A.20
Yamamoto, M.21
Yue, Z.22
Uchiyama, Y.23
Kominami, E.24
Tanaka, K.25
more..
-
71
-
-
33645221489
-
Excess peroxisomes are degraded by autophagic machinery in mammals
-
DOI 10.1074/jbc.M512283200
-
Iwata J, Ezaki J, Komatsu M, Yokota S, Ueno T, Tan ida I, Chiba T, Tanaka K, Kominami E. Excess peroxisomes are degraded by autophagic machinery in mammals. J Biol Chem 2006; 281: 4035-41; PMID: 16332691; http://dx.doi.org/10. 1074/jbc. M512283200 (Pubitemid 43847828)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.7
, pp. 4035-4041
-
-
Iwata, J.-I.1
Ezaki, J.2
Komatsu, M.3
Yokota, S.4
Ueno, T.5
Tanida, I.6
Chiba, T.7
Tanaka, K.8
Kominami, E.9
-
72
-
-
64249123646
-
Autophagy is essential for mitochondrial clearance in mature T lymphocytes
-
PMID: 19299702
-
Pua HH, Guo J, Komatsu M, He YW. Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol 2009; 182: 4046-55; PMID: 19299702; http://dx.doi.org/10.4049/jimmunol.0801143
-
(2009)
J Immunol
, vol.182
, pp. 4046-4055
-
-
Pua, H.H.1
Guo, J.2
Komatsu, M.3
He, Y.W.4
-
73
-
-
70449448312
-
Autophagy regulates adipose mass and differentiation in mice
-
PMID: 19855132
-
Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, Ta ng Y, Pessin JE, Schwartz GJ, Czaja MJ. Autophagy regulates adipose mass and differentiation in mice. J Clin Invest 2009; 119: 3329-39; PMID: 19855132
-
(2009)
J Clin Invest
, vol.119
, pp. 3329-3339
-
-
Singh, R.1
Xiang, Y.2
Wang, Y.3
Baikati, K.4
Cuervo, A.M.5
Luu, Y.K.6
Tang, Y.7
Pessin, J.E.8
Schwartz, G.J.9
Czaja, M.J.10
-
74
-
-
73949124173
-
Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogen-esis
-
PMID: 19910529
-
Zhang Y, Goldman S, Baerga R, Zhao Y, Komatsu M, Jin S. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogen-esis. Proc Natl Acad Sci U S A 2009; 106: 19860-5; PMID: 19910529
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 19860-19865
-
-
Zhang, Y.1
Goldman, S.2
Baerga, R.3
Zhao, Y.4
Komatsu, M.5
Jin, S.6
-
75
-
-
52749094770
-
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglyce-mia
-
PMID: 18840362
-
Jung HS, Chung KW, Won Kim J, Kim J, Komatsu M, Tanaka K, Nguyen YH, Kang TM, Yoon KH, Kim JW, et al. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglyce-mia. Cell Metab 2008; 8: 318-24; PMID: 18840362; http://dx.doi.org/10.1016/j.cmet.2008.08.013
-
(2008)
Cell Metab
, vol.8
, pp. 318-324
-
-
Jung, H.S.1
Chung, K.W.2
Won Kim, J.3
Kim, J.4
Komatsu, M.5
Tanaka, K.6
Nguyen, Y.H.7
Kang, T.M.8
Yoon, K.H.9
Kim, J.W.10
-
76
-
-
52749093177
-
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet
-
PMID: 18840363
-
Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, Komiya K, Azuma K, Hirose T, Tanaka K, Kominami E, et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab 2008; 8: 325-32; PMID: 18840363; http://dx.doi.org/10.1016/j. cmet.2008.08.009
-
(2008)
Cell Metab
, vol.8
, pp. 325-332
-
-
Ebato, C.1
Uchida, T.2
Arakawa, M.3
Komatsu, M.4
Ueno, T.5
Komiya, K.6
Azuma, K.7
Hirose, T.8
Tanaka, K.9
Kominami, E.10
-
77
-
-
57749121573
-
Mitophagy in yeast occurs through a selective mechanism
-
PMID: 18818209
-
Kanki T, Klionsky DJ. Mitophagy in yeast occurs through a selective mechanism. J Biol Chem 2008; 283: 32386-93; PMID: 18818209; http://dx.doi.org/ 10.1074/jbc.M802403200
-
(2008)
J Biol Chem
, vol.283
, pp. 32386-32393
-
-
Kanki, T.1
Klionsky, D.J.2
-
78
-
-
77953515698
-
A genomic screen for yeast mutants defective in mitophagy
-
PMID: 20364111
-
Kanki T, Wang K, Klionsky DJ. A genomic screen for yeast mutants defective in mitophagy. Autophagy 2010; 6: 278-80; PMID: 203 64111; http://dx.doi.org/10.4161/auto.6.2.10901
-
(2010)
Autophagy
, vol.6
, pp. 278-280
-
-
Kanki, T.1
Wang, K.2
Klionsky, D.J.3
-
79
-
-
74049153002
-
Nix is a selective autophagy receptor for mitochondrial clearance
-
PMID: 20010802
-
Novak I, Kirkin V, McEwan DG, Zhang J, Wild P, Rozenknop A, Rogov V, Löhr F, Popovic D, Occhipinti A, et al. Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep 2010; 11: 45-51; PMID: 20010802; http://dx.doi.org/10.1038/embor.2009.256
-
(2010)
EMBO Rep
, vol.11
, pp. 45-51
-
-
Novak, I.1
Kirkin, V.2
McEwan, D.G.3
Zhang, J.4
Wild, P.5
Rozenknop, A.6
Rogov, V.7
Löhr, F.8
Popovic, D.9
Occhipinti, A.10
-
80
-
-
67650219052
-
Nix directly binds to GABARAP: A possible crosstalk between apop-tosis and autophagy
-
PMID: 19363302
-
Schwarten M, Mohrlüder J, Ma P, Stoldt M, Thielmann Y, Stangler T, Hersch N, Hoffmann B, Merkel R, Willbold D. Nix directly binds to GABARAP: a possible crosstalk between apop-tosis and autophagy. Autophagy 2009; 5: 690-8; PMID: 19363302; http://dx.doi.org/10.4161/auto.5.5.8494
-
(2009)
Autophagy
, vol.5
, pp. 690-698
-
-
Schwarten, M.1
Mohrlüder, J.2
Ma, P.3
Stoldt, M.4
Thielmann, Y.5
Stangler, T.6
Hersch, N.7
Hoffmann, B.8
Merkel, R.9
Willbold, D.10
-
81
-
-
84872291490
-
Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis
-
PMID: 23209295
-
Zhu Y, Massen S, Te r e n z i o M, Lang V, Chen-Lindner S, Eils R, Novak I, Dikic I, Hamacher-Brady A, Brady NR. Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem 2013; 288: 1099-113; PMID: 23209295; http://dx.doi.org/ 10.1074/jbc.M112.399345
-
(2013)
J Biol Chem
, vol.288
, pp. 1099-1113
-
-
Zhu, Y.1
Massen, S.2
Terenzio, M.3
Lang, V.4
Chen-Lindner, S.5
Eils, R.6
Novak, I.7
Dikic, I.8
Hamacher-Brady, A.9
Brady, N.R.10
-
82
-
-
84870302121
-
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
-
PMID: 22922758
-
Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, et al. Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nat Chem Biol 2012; 8: 831-8; PMID: 22922758; http://dx.doi.org/10.1038/nchembio.1059
-
(2012)
Nat Chem Biol
, vol.8
, pp. 831-838
-
-
Sentelle, R.D.1
Senkal, C.E.2
Jiang, W.3
Ponnusamy, S.4
Gencer, S.5
Selvam, S.P.6
Ramshesh, V.K.7
Peterson, Y.K.8
Lemasters, J.J.9
Szulc, Z.M.10
-
83
-
-
84885176082
-
Cardiolipin external-ization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
-
PMID: 24036476
-
Chu CT, Ji J, Dagda RK, Jiang JF, Ty u r i n a Y Y, Kapralov AA, Ty u r i n VA , Yanamala N, Shrivastava IH, Mohammadyani D, et al. Cardiolipin external-ization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nat Cell Biol 2013; 15: 1197-205; PMID: 24036476; http://dx.doi.org/10.1038/ncb2837
-
(2013)
Nat Cell Biol
, vol.15
, pp. 1197-1205
-
-
Chu, C.T.1
Ji, J.2
Dagda, R.K.3
Jiang, J.F.4
Tyurina, Y.Y.5
Kapralov, A.A.6
Tyurin, V.A.7
Yanamala, N.8
Shrivastava, I.H.9
Mohammadyani, D.10
-
84
-
-
37649017266
-
NIX is required for programmed mitochondrial clearance during reticulocyte maturation
-
PMID: 18048346
-
Schweers RL, Zhang J, Randall MS, Loyd MR, Li W, Dorsey FC, Kundu M, Opferman JT, Cleveland JL, Miller JL, et al. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A 2007; 104: 19500-5; PMID: 18048346; http://dx.doi.org/10.1073/pnas.0708818104
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19500-19505
-
-
Schweers, R.L.1
Zhang, J.2
Randall, M.S.3
Loyd, M.R.4
Li, W.5
Dorsey, F.C.6
Kundu, M.7
Opferman, J.T.8
Cleveland, J.L.9
Miller, J.L.10
-
85
-
-
47049100413
-
Essential role for Nix in autophagic maturation of erythroid cells
-
DOI 10.1038/nature07006, PII NATURE07006
-
Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J. Essential role for Nix in autophagic maturation of erythroid cells. Nature 2008; 454: 232-5; PMID: 18454133; http://dx.doi.org/10.1038/nature07006 (Pubitemid 351969889)
-
(2008)
Nature
, vol.454
, Issue.7201
, pp. 232-235
-
-
Sandoval, H.1
Thiagarajan, P.2
Dasgupta, S.K.3
Schumacher, A.4
Prchal, J.T.5
Chen, M.6
Wang, J.7
-
86
-
-
84861733247
-
Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy
-
PMID: 22505714
-
Hanna RA, Quinsay MN, Orogo AM, Giang K, Rikka S, Gustafsson AB. Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy. J Biol Chem 2012; 287: 19094-104; PMID: 22505714; http://dx.doi.org/10.1074/jbc.M111.322933
-
(2012)
J Biol Chem
, vol.287
, pp. 19094-19104
-
-
Hanna, R.A.1
Quinsay, M.N.2
Orogo, A.M.3
Giang, K.4
Rikka, S.5
Gustafsson, A.B.6
-
87
-
-
33845511362
-
Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy
-
DOI 10.1038/sj.cdd.4401936, PII 4401936
-
Hamacher-Brady A, Brady NR, Logue SE, Sayen MR, Jinno M, Kirshenbaum LA, Gottlieb RA, Gustafsson AB. Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Cell Death Differ 2007; 14: 146-57; PMID: 16645637; http://dx.doi.org/10.1038/sj.cdd.4401936 (Pubitemid 44911902)
-
(2007)
Cell Death and Differentiation
, vol.14
, Issue.1
, pp. 146-157
-
-
Hamacher-Brady, A.1
Brady, N.R.2
Logue, S.E.3
Sayen, M.R.4
Jinno, M.5
Kirshenbaum, L.A.6
Gottlieb, R.A.7
Gustafsson, A.B.8
-
88
-
-
80052589570
-
Autophagy regulates hypoxia-induced osteoclastogenesis through the HIF-1a/BNIP3 signaling pathway
-
PMID: 21465467
-
Zhao Y, Chen G, Zhang W, Xu N, Zhu JY, Jia J, Sun ZJ, Wa ng YN, Zhao YF. Autophagy regulates hypoxia-induced osteoclastogenesis through the HIF-1a/BNIP3 signaling pathway. J Cell Physiol 2012; 227: 639-48; PMID: 21465467; http://dx.doi.org/10.1002/jcp.22768
-
(2012)
J Cell Physiol
, vol.227
, pp. 639-648
-
-
Zhao, Y.1
Chen, G.2
Zhang, W.3
Xu, N.4
Zhu, J.Y.5
Jia, J.6
Sun, Z.J.7
Wang, Y.N.8
Zhao, Y.F.9
-
89
-
-
66349121718
-
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
-
PMID 19 2 73585
-
Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouysségur J, Mazure NM. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol 2009; 29: 2570-81; PMID: 19 2 735 85; http://dx.doi.org/10.1128/MCB.00166-09
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2570-2581
-
-
Bellot, G.1
Garcia-Medina, R.2
Gounon, P.3
Chiche, J.4
Roux, D.5
Pouysségur, J.6
Mazure, N.M.7
-
90
-
-
43649104579
-
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
-
PMID: 18281291
-
Zhang H, Bosch-Marce M, Shimoda LA, Ta n YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 2008; 283: 10892-903; PMID: 18281291; http://dx.doi.org/10.1074/jbc.M800102200
-
(2008)
J Biol Chem
, vol.283
, pp. 10892-10903
-
-
Zhang, H.1
Bosch-Marce, M.2
Shimoda, L.A.3
Tan, Y.S.4
Baek, J.H.5
Wesley, J.B.6
Gonzalez, F.J.7
Semenza, G.L.8
-
91
-
-
84862789618
-
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
-
PMID: 22267086
-
Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, Ma Q, Zhu C, Wang R, Qi W, et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol 2012; 14: 177-85; PMID: 22267086; http://dx.doi.org/10.1038/ncb2422
-
(2012)
Nat Cell Biol
, vol.14
, pp. 177-185
-
-
Liu, L.1
Feng, D.2
Chen, G.3
Chen, M.4
Zheng, Q.5
Song, P.6
Ma, Q.7
Zhu, C.8
Wang, R.9
Qi, W.10
-
92
-
-
27944482199
-
Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast
-
DOI 10.1038/sj.cdd.4401697, PII 4401697
-
Priault M, Salin B, Schaeffer J, Vallet te FM, di Rago JP, Martinou JC. Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitoph-agy in yeast. Cell Death Differ 2005; 12: 1613-21; PMID: 15947785; http://dx.doi.org/10.1038/sj.cdd.4401697 (Pubitemid 41679166)
-
(2005)
Cell Death and Differentiation
, vol.12
, Issue.12
, pp. 1613-1621
-
-
Priault, M.1
Salin, B.2
Schaeffer, J.3
Vallette, F.M.4
Di Rago, J.-P.5
Martinou, J.-C.6
-
93
-
-
34250898919
-
+ exchange activity, osmotic swelling and mitophagy
-
DOI 10.1038/sj.cdd.4402167, PII 4402167
-
Nowikovsky K, Reipert S, Devenish RJ, Schweyen RJ. Mdm38 protein depletion causes loss of mito-chondrial K+/H+ exchange activity, osmotic swelling and mitophagy. Cell Death Differ 2007; 14: 1647-56; PMID: 17541427; http://dx.doi.org/10.1038/sj.cdd.4402167 (Pubitemid 47278850)
-
(2007)
Cell Death and Differentiation
, vol.14
, Issue.9
, pp. 1647-1656
-
-
Nowikovsky, K.1
Reipert, S.2
Devenish, R.J.3
Schweyen, R.J.4
-
94
-
-
58149314211
-
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
-
PMID: 19029340
-
Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008; 183: 795-803; PMID: 19029340; http://dx.doi.org/10.1083/jcb.200809125
-
(2008)
J Cell Biol
, vol.183
, pp. 795-803
-
-
Narendra, D.1
Tanaka, A.2
Suen, D.F.3
Youle, R.J.4
-
95
-
-
79954622220
-
Mitophagy selectively degrades individual damaged mitochondria after photoir-radiation
-
PMID: 21126216
-
Kim I, Lemasters JJ. Mitophagy selectively degrades individual damaged mitochondria after photoir-radiation. Antioxid Redox Signal 2011; 14: 1919-28; PMID: 21126216; http://dx.doi.org/10.1089/ars.2010.3768
-
(2011)
Antioxid Redox Signal
, vol.14
, pp. 1919-1928
-
-
Kim, I.1
Lemasters, J.J.2
-
96
-
-
77955398958
-
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells
-
PMID: 20547844
-
Suen DF, Narendra DP, Tanaka A, Manfredi G, Youle RJ. Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Proc Natl Acad Sci U S A 2010; 107: 11835-40; PMID: 20547844; http://dx.doi.org/10.1073/pnas.0914569107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 11835-11840
-
-
Suen, D.F.1
Narendra, D.P.2
Tanaka, A.3
Manfredi, G.4
Youle, R.J.5
-
97
-
-
82255192465
-
Degradation of paternal mitochondria by fertilization-triggered autophagy in C elegans embryos
-
PMID 21998252
-
Sato M, Sato K. Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos. Science 2011; 334: 1141-4; PMID: 21998252; http://dx.doi.org/10.1126/science.1210333
-
(2011)
Science
, vol.334
, pp. 1141-1144
-
-
Sato, M.1
Sato, K.2
-
98
-
-
82255183165
-
Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission
-
PMID: 22033522
-
Al Rawi S, Louvet-Vallée S, Djeddi A, Sachse M, Culetto E, Hajjar C, Boyd L, Legouis R, Galy V. Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission. Science 2011; 334: 1144-7; PMID: 22033522; http://dx.doi.org/10.1126/scienc e.1211878
-
(2011)
Science
, vol.334
, pp. 1144-1147
-
-
Al Rawi, S.1
Louvet-Vallée, S.2
Djeddi, A.3
Sachse, M.4
Culetto, E.5
Hajjar, C.6
Boyd, L.7
Legouis, R.8
Galy, V.9
-
99
-
-
84859124525
-
Maternal inheritance of mitochon-drial DNA: Degradation of paternal mitochondria by allogeneic organelle autophagy, allophagy
-
PMID: 22302002
-
Sato M, Sato K. Maternal inheritance of mitochon-drial DNA: degradation of paternal mitochondria by allogeneic organelle autophagy, allophagy. Autophagy 2012; 8: 424-5; PMID: 22302002; http://dx.doi.org/10.4161/auto.19243
-
(2012)
Autophagy
, vol.8
, pp. 424-425
-
-
Sato, M.1
Sato, K.2
-
100
-
-
78650467974
-
Mechanisms of mitophagy
-
PMID: 21179058
-
Youle RJ, Narendra DP. Mechanisms of mitoph-agy. Nat Rev Mol Cell Biol 2011; 12: 9-14; PMID: 21179058; http://dx.doi.org/10.1038/nrm3028
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 9-14
-
-
Youle, R.J.1
Narendra, D.P.2
-
101
-
-
75749156257
-
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
-
PMID: 20126261
-
Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 2010; 8:e1000298; PMID: 20126261; http://dx.doi.org/10.1371/ journal. pbio.1000298
-
(2010)
PLoS Biol
, vol.8
-
-
Narendra, D.P.1
Jin, S.M.2
Tanaka, A.3
Suen, D.F.4
Gautier, C.A.5
Shen, J.6
Cookson, M.R.7
Youle, R.J.8
-
102
-
-
84857032953
-
Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin
-
PMID: 22280891
-
Lazarou M, Jin SM, Kane LA, Youle RJ. Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell 2012; 22: 320-33; PMID: 22280891; http://dx.doi.org/10.1016/j. devcel.2011.12.014
-
(2012)
Dev Cell
, vol.22
, pp. 320-333
-
-
Lazarou, M.1
Jin, S.M.2
Kane, L.A.3
Youle, R.J.4
-
103
-
-
84876531457
-
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria
-
PMID: 23620 051
-
Chen Y, Dorn GW 2nd. PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science 2013; 340: 471-5; PMID: 23620 051; http://dx.doi.org/10.1126/s c i e nc e.12 31031
-
(2013)
Science
, vol.340
, pp. 471-475
-
-
Chen, Y.1
Dorn, I.I.G.W.2
-
104
-
-
84879885169
-
Parkin mitochondrial trans-location is achieved through a novel catalytic activity coupled mechanism
-
PMID: 23670163
-
Zheng X, Hunter T. Parkin mitochondrial trans-location is achieved through a novel catalytic activity coupled mechanism. Cell Res 2013; 23: 886-97; PMID: 23670163; http://dx.doi.org/10.1038/cr.2013.66
-
(2013)
Cell Res
, vol.23
, pp. 886-897
-
-
Zheng, X.1
Hunter, T.2
-
105
-
-
79954520907
-
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy
-
PMID: 21296869
-
Chan NC, Salazar AM, Pham AH, Sweredoski MJ, Kolawa NJ, Graham RL, Hess S, Chan DC. Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet 2011; 20: 1726-37; PMID: 21296869; http://dx.doi.org/10.1093/hmg/ddr048
-
(2011)
Hum Mol Genet
, vol.20
, pp. 1726-1737
-
-
Chan, N.C.1
Salazar, A.M.2
Pham, A.H.3
Sweredoski, M.J.4
Kolawa, N.J.5
Graham, R.L.6
Hess, S.7
Chan, D.C.8
-
106
-
-
77950384477
-
Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin
-
PMID: 20194754
-
Ziviani E, Ta o RN, Whitworth AJ. Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc Natl Acad Sci U S A 2010; 107: 5018-23; PMID: 20194754; http://dx.doi.org/10.1073/pnas.0913485107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 5018-5023
-
-
Ziviani, E.1
Tao, R.N.2
Whitworth, A.J.3
-
107
-
-
78649463381
-
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
-
PMID: 20871098
-
Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AH, Taanman JW. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet 2010; 19: 4861-70; PMID: 20871098; http://dx.doi.org/10.1093/hmg/ddq419
-
(2010)
Hum Mol Genet
, vol.19
, pp. 4861-4870
-
-
Gegg, M.E.1
Cooper, J.M.2
Chau, K.Y.3
Rojo, M.4
Schapira, A.H.5
Taanman, J.W.6
-
108
-
-
75949130828
-
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
-
PMID: 20098416
-
Geisler S, Holmström KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, Springer W. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 2010; 12: 119-31; PMID: 20098416; http://dx.doi.org/ 10.1038/ncb2012
-
(2010)
Nat Cell Biol
, vol.12
, pp. 119-131
-
-
Geisler, S.1
Holmström, K.M.2
Skujat, D.3
Fiesel, F.C.4
Rothfuss, O.C.5
Kahle, P.J.6
Springer, W.7
-
109
-
-
84876070458
-
VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations
-
PMID: 23 49 8974
-
Kim NC, Tresse E, Kolaitis RM, Molliex A, Thomas RE, Alami NH, Wang B, Joshi A, Smith RB, Ritson GP, et al. VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron 2013; 78: 65-80; PMID: 23 49 8 9 74; http://dx.doi.org/10.1016/j. neuron.2013.02.029
-
(2013)
Neuron
, vol.78
, pp. 65-80
-
-
Kim, N.C.1
Tresse, E.2
Kolaitis, R.M.3
Molliex, A.4
Thomas, R.E.5
Alami, N.H.6
Wang, B.7
Joshi, A.8
Smith, R.B.9
Ritson, G.P.10
-
110
-
-
77952326081
-
Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy
-
PMID: 20457763
-
Lee JY, Nagano Y, Tay lor JP, Lim KL, Yao TP. Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol 2010; 189: 671-9; PMID: 20457763; http://dx.doi.org/10. 1083/jcb.201001039
-
(2010)
J Cell Biol
, vol.189
, pp. 671-679
-
-
Lee, J.Y.1
Nagano, Y.2
Taylor, J.P.3
Lim, K.L.4
Yao, T.P.5
-
111
-
-
78649300971
-
P62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitoph-agy; VDAC1 is dispensable for both
-
PMID: 20890124
-
Narendra D, Kane LA, Hauser DN, Fearnley IM, Youle RJ. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitoph-agy; VDAC1 is dispensable for both. Autophagy 2010; 6: 1090-106; PMID: 20890124; http://dx.doi.org/10.4161/auto.6.8.13426
-
(2010)
Autophagy
, vol.6
, pp. 1090-1106
-
-
Narendra, D.1
Kane, L.A.2
Hauser, D.N.3
Fearnley, I.M.4
Youle, R.J.5
-
112
-
-
77954695260
-
P62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
-
PMID: 20604804
-
Okatsu K, Saisho K, Shimanuki M, Nakada K, Shitara H, Sou YS, Kimura M, Sato S, Hattori N, Komatsu M, et al. p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells 2010; 15: 887-900; PMID: 20604804
-
(2010)
Genes Cells
, vol.15
, pp. 887-900
-
-
Okatsu, K.1
Saisho, K.2
Shimanuki, M.3
Nakada, K.4
Shitara, H.5
Sou, Y.S.6
Kimura, M.7
Sato, S.8
Hattori, N.9
Komatsu, M.10
-
113
-
-
77952242572
-
The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy
-
PMID: 20057503
-
Michiorri S, Gelmetti V, Giarda E, Lombardi F, Romano F, Marongiu R, Nerini-Molteni S, Sale P, Vago R, Arena G, et al. The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy. Cell Death Differ 2010; 17: 962-74; PMID: 20057503; http://dx.doi.org/10.1038/cdd.2009.200
-
(2010)
Cell Death Differ
, vol.17
, pp. 962-974
-
-
Michiorri, S.1
Gelmetti, V.2
Giarda, E.3
Lombardi, F.4
Romano, F.5
Marongiu, R.6
Nerini-Molteni, S.7
Sale, P.8
Vago, R.9
Arena, G.10
-
114
-
-
79960407069
-
Parkin interacts with Ambra1 to induce mitophagy
-
PMID: 217530 02
-
Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, Vandenberghe W. Parkin interacts with Ambra1 to induce mitophagy. J Neurosci 2 011; 31: 10249-61; PMID: 217530 02; http://dx.doi.org/10.1523/JN EU ROSCI.1917-11. 2011
-
(2011)
J Neurosci
, vol.31
, pp. 10249-10261
-
-
Van Humbeeck, C.1
Cornelissen, T.2
Hofkens, H.3
Mandemakers, W.4
Gevaert, K.5
De Strooper, B.6
Vandenberghe, W.7
-
115
-
-
82555187810
-
Image-based genome-wide siRNA screen identifies selective autophagy factors
-
PMID: 22020285
-
Orvedahl A, Sumpter R Jr., Xiao G, Ng A, Zou Z, Ta n g Y, Narimatsu M, Gilpin C, Sun Q, Roth M, et al. Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature 2011; 480: 113-7; PMID: 22020285; http://dx.doi.org/10.1038/nature10546
-
(2011)
Nature
, vol.480
, pp. 113-117
-
-
Orvedahl, A.1
Sumpter Jr., R.2
Xiao, G.3
Ng, A.4
Zou, Z.5
Tang, Y.6
Narimatsu, M.7
Gilpin, C.8
Sun, Q.9
Roth, M.10
-
116
-
-
84871426886
-
The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuli
-
PMID: 23140641
-
Lokireddy S, Wijesoma I W, Te n g S, Bonala S, Gluckman PD, McFarlane C, Sharma M, Kambadur R. The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuli. Cell Metab 2012; 16: 613-24; PMID: 23140641; http://dx.doi.org/10.1016/j.cmet.2012.10.005
-
(2012)
Cell Metab
, vol.16
, pp. 613-624
-
-
Lokireddy, S.1
Wijesoma, I.W.2
Teng, S.3
Bonala, S.4
Gluckman, P.D.5
McFarlane, C.6
Sharma, M.7
Kambadur, R.8
-
117
-
-
0032495976
-
Identification of mouse ULK1, a novel protein kinase structurally related to C elegans UNC-51
-
DOI 10.1006/bbrc.1998.8546
-
Yan J, Kuroyanagi H, Kuroiwa A, Matsuda Y, To k u m i t s u H, To m o d a T, Shirasawa T, Muramatsu M. Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Biochem Biophys Res Commun 1998; 246: 222-7; PMID: 9600096; http://dx.doi.org/10.1006/bbrc.1998.8546 (Pubitemid 28413955)
-
(1998)
Biochemical and Biophysical Research Communications
, vol.246
, Issue.1
, pp. 222-227
-
-
Yan, J.1
Kuroyanagi, H.2
Kuroiwa, A.3
Matsuda, Y.-I.4
Tokumitsu, H.5
Tomoda, T.6
Shirasawa, T.7
Muramatsu, M.-A.8
-
118
-
-
34548482499
-
SIRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy
-
DOI 10.1074/jbc.M703663200
-
Chan EY, Kir S, Tooze SA. siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem 2007; 282: 25464-74; PMID: 17595159; http://dx.doi.org/10.1074/jbc. M703663200 (Pubitemid 47372826)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.35
, pp. 25464-25474
-
-
Chan, E.Y.W.1
Kir, S.2
Tooze, S.A.3
-
119
-
-
58149473473
-
Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism
-
PMID: 1 8 9 3 615 7
-
Chan EY, Longatti A, McKnight NC, Tooze SA. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol 2009; 29: 15 7-71; PMID: 1 8 9 3 615 7; http://dx.doi.org/10.1128/MCB.01082-08
-
(2009)
Mol Cell Biol
, vol.29
, pp. 157-171
-
-
Chan, E.Y.1
Longatti, A.2
McKnight, N.C.3
Tooze, S.A.4
-
120
-
-
80051729441
-
Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy
-
PMID: 21855797
-
Joo JH, Dorsey FC, Joshi A, Hennessy-Walters KM, Rose KL, McCastlain K, Zhang J, Iyengar R, Jung CH, Suen DF, et al. Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell 2 011; 43: 572-85; PMID: 21855797; http://dx.doi.org/10.1016/j.molcel.2011.06.018
-
(2011)
Mol Cell
, vol.43
, pp. 572-585
-
-
Joo, J.H.1
Dorsey, F.C.2
Joshi, A.3
Hennessy-Walters, K.M.4
Rose, K.L.5
McCastlain, K.6
Zhang, J.7
Iyengar, R.8
Jung, C.H.9
Suen, D.F.10
-
121
-
-
70349687405
-
Discovery of Atg5/Atg7-independent alternative macroautophagy
-
PMID: 19794493
-
Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, Komatsu M, Otsu K, Tsujimoto Y, Shimizu S. Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature 2009; 461: 654-8; PMID: 19794493; http://dx.doi.org/10.1038/nature08455
-
(2009)
Nature
, vol.461
, pp. 654-658
-
-
Nishida, Y.1
Arakawa, S.2
Fujitani, K.3
Yamaguchi, H.4
Mizuta, T.5
Kanaseki, T.6
Komatsu, M.7
Otsu, K.8
Tsujimoto, Y.9
Shimizu, S.10
-
122
-
-
28444455308
-
Organelle degradation during the lens and erythroid differentiation is independent of autophagy
-
DOI 10.1016/j.bbrc.2005.11.044, PII S0006291X05025441
-
Matsui M, Yamamoto A, Kuma A, Ohsumi Y, Mizushima N. Organelle degradation during the lens and erythroid differentiation is independent of autophagy. Biochem Biophys Res Commun 2006; 339: 485-9; PMID: 16300732; http://dx.doi.org/10.1016/j.bbrc.2005.11.044 (Pubitemid 41739693)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.339
, Issue.2
, pp. 485-489
-
-
Matsui, M.1
Yamamoto, A.2
Kuma, A.3
Ohsumi, Y.4
Mizushima, N.5
-
123
-
-
39749119904
-
FIP200, a key signaling node to coordinately regulate various cellular processes
-
DOI 10.1016/j.cellsig.2007.10.021, PII S0898656807003245
-
Gan B, Guan JL. FIP200, a key signaling node to coordinately regulate various cellular processes. Cell Signal 2008; 20: 787-94; PMID: 18036779; http://dx.doi.org/10.1016/j.cellsig.2007.10.021 (Pubitemid 351312869)
-
(2008)
Cellular Signalling
, vol.20
, Issue.5
, pp. 787-794
-
-
Gan, B.1
Guan, J.-L.2
-
124
-
-
43149090064
-
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
-
DOI 10.1083/jcb.200712064
-
Hara T, Tak a mur a A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol 2008; 181: 497-510; PMID: 18443221; http://dx.doi.org/10.1083/jcb.200712064 (Pubitemid 351645039)
-
(2008)
Journal of Cell Biology
, vol.181
, Issue.3
, pp. 497-510
-
-
Hara, T.1
Takamura, A.2
Kishi, C.3
Iemura, S.-I.4
Natsume, T.5
Guan, J.-L.6
Mizushima, N.7
-
125
-
-
84874192375
-
FOXO3A directs a protective autophagy program in haematopoietic stem cells
-
PMID: 23389440
-
Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegué E. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature 2013; 494: 323-7; PMID: 23389440; http://dx.doi.org/10.1038/nature11895
-
(2013)
Nature
, vol.494
, pp. 323-327
-
-
Warr, M.R.1
Binnewies, M.2
Flach, J.3
Reynaud, D.4
Garg, T.5
Malhotra, R.6
Debnath, J.7
Passegué, E.8
-
126
-
-
84856800302
-
Role of AMPK-mTOR-Ulk1/2 in the regulation of auto-phagy: Cross talk shortcuts and feedbacks
-
PMID: 22025673
-
Alers S, Löffler AS, Wesselborg S, Stork B. Role of AMPK-mTOR-Ulk1/2 in the regulation of auto-phagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol 2012; 32: 2-11; PMID: 22025673; http://dx.doi. o r g/10.112 8/MC B. 0 6159-11
-
(2012)
Mol Cell Biol
, vol.32
, pp. 2-11
-
-
Alers, S.1
Löffler, A.S.2
Wesselborg, S.3
Stork, B.4
-
127
-
-
65249176304
-
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy mach inery
-
PMID: 19225151
-
Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy mach inery. Mol Biol Cell 2009; 20: 1992-2003; PMID: 19225151; http://dx.doi.org/10.1091/ mbc. E08-12-1249
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1992-2003
-
-
Jung, C.H.1
Jun, C.B.2
Ro, S.H.3
Kim, Y.M.4
Otto, N.M.5
Cao, J.6
Kundu, M.7
Kim, D.H.8
-
128
-
-
0032512636
-
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
-
DOI 10.1074/jbc.273.7.3963
-
Noda T, Ohsumi Y. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem 19 9 8; 273: 3963-6; PMID: 9 4 615 8 3; http://dx.doi.org/10.1074/jbc.273.7.3963 (Pubitemid 28103257)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.7
, pp. 3963-3966
-
-
Noda, T.1
Ohsumi, Y.2
-
129
-
-
4344563878
-
Role and regulation of starvation-induced autophagy in the Drosophila fat body
-
DOI 10.1016/j.devcel.2004.07.009, PII S153458070400245X
-
Scott RC, Schuldiner O, Neufeld TP. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell 2004; 7: 167-78; PMID: 152 9 67 14; http://dx.doi.org/10.1016/j. devcel.2004.07.009 (Pubitemid 39145023)
-
(2004)
Developmental Cell
, vol.7
, Issue.2
, pp. 167-178
-
-
Scott, R.C.1
Schuldiner, O.2
Neufeld, T.P.3
-
130
-
-
84860840558
-
Mitochondrial diseases
-
PMID: 22482939
-
Schapira AH. Mitochondrial diseases. Lancet 2012; 379: 1825-34; PMID: 22482939; http://dx.doi.org/10.1016/S0140-6736(11)61305-6
-
(2012)
Lancet
, vol.379
, pp. 1825-1834
-
-
Schapira, A.H.1
-
131
-
-
34548686839
-
Hematological manifestations of primary mitochondrial disorders
-
DOI 10.1159/000105676
-
Finsterer J. Hematological manifestations of primary mitochondrial disorders. Acta Haematol 2007; 118: 88-98; PMID: 17637511; http://dx.doi.org/10. 1159/000105676 (Pubitemid 47413792)
-
(2007)
Acta Haematologica
, vol.118
, Issue.2
, pp. 88-98
-
-
Finsterer, J.1
-
132
-
-
0032533927
-
MtDNA mutations associated with sideroblastic anaemia cause a defect of mitochondrial cytochrome c oxidase
-
DOI 10.1046/j.1432-1327.1998.2580132.x
-
Bröker S, Meunier B, Rich P, Gattermann N, Hofhaus G. MtDNA mutations associated with sideroblastic anaemia cause a defect of mito-chondrial cytochrome c oxidase. Eur J Biochem 19 98; 258: 132-8; PMID: 9 851701; http://dx.doi.org/10.1046/j.1432-1327.1998.2580132.x (Pubitemid 28538317)
-
(1998)
European Journal of Biochemistry
, vol.258
, Issue.1
, pp. 132-138
-
-
Broker, S.1
Meunier, B.2
Rich, P.3
Gattermann, N.4
Hofhaus, G.5
-
133
-
-
84858153637
-
Congenital sideroblastic anemias: Iron and heme lost in mitochondrial translation
-
PMID: 22160084
-
Fleming MD. Congenital sideroblastic anemias: iron and heme lost in mitochondrial translation. Hematology Am Soc Hematol Educ Program 2011; 2011: 525-31; PMID: 22160084; http://dx.doi.org/10.1182/a sheduc at ion-2011.1.525
-
(2011)
Hematology Am Soc Hematol Educ Program
, vol.2011
, pp. 525-531
-
-
Fleming, M.D.1
-
134
-
-
79953211019
-
Mitochondrial DNA deletion syndromes
-
Pagon RA, Adam MP, Bird TD, Dolan CR, Fong CT, Stephens K, eds. Seattle (WA)
-
DiMauro S, Hirano M. Mitochondrial DNA Deletion Syndromes. In: Pagon RA, Adam MP, Bird TD, Dolan CR, Fong CT, Stephens K, eds. GeneReviews. Seattle (WA), 1993
-
(1993)
GeneReviews
-
-
Dimauro, S.1
Hirano, M.2
-
135
-
-
84880702851
-
Barth syndrome
-
PMID: 23843353
-
Jefferies JL. Barth syndrome. Am J Med Genet C Semin Med Genet 2013; 163C: 198-205; PMID: 23843353; http://dx.doi.org/10.1002/a jm g.c.31372
-
(2013)
Am J Med Genet C Semin Med Genet
, vol.163 C
, pp. 198-205
-
-
Jefferies, J.L.1
-
136
-
-
84856951239
-
Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition
-
PMID: 22080835
-
Gilkerson RW, De Vries RL, Lebot P, Wikstrom JD, Torgyekes E, Shirihai OS, Przedborski S, Schon EA. Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition. Hum Mol Genet 2012; 21: 978-90; PMID: 22080835; http://dx.doi.org/ 10.1093/hmg/ddr529
-
(2012)
Hum Mol Genet
, vol.21
, pp. 978-990
-
-
Gilkerson, R.W.1
De Vries, R.L.2
Lebot, P.3
Wikstrom, J.D.4
Torgyekes, E.5
Shirihai, O.S.6
Przedborski, S.7
Schon, E.A.8
-
137
-
-
33845807882
-
Enhanced growth of myelodysplastic colonies in hypoxic conditions
-
DOI 10.1016/j.exphem.2006.08.017, PII S0301472X06005509
-
Thompson JE, Conlon JP, Yang X, Sanchez PV, Carroll M. Enhanced growth of myelodysplas-tic colonies in hypoxic conditions. Exp Hematol 2007; 35: 21-31; PMID: 17198870; http://dx.doi.org/10.1016/j.exphem.2006.08.017 (Pubitemid 46014366)
-
(2007)
Experimental Hematology
, vol.35
, Issue.1
, pp. 21-31
-
-
Thompson, J.E.1
Conlon, J.P.2
Yang, X.3
Sanchez, P.V.4
Carroll, M.5
-
138
-
-
79956266039
-
Impaired mitochondrial gene transcription in myelodysplas-tic syndromes and acute myeloid leukemia with myelodysplasia-related changes
-
e1; PMID: 21447369
-
Schildgen V, Wulfert M, Gattermann N. Impaired mitochondrial gene transcription in myelodysplas-tic syndromes and acute myeloid leukemia with myelodysplasia-related changes. Exp Hematol 2 011; 39: 666-75, e1; PMID: 21447369; http://dx.doi.org/10.1016/j.exphem.2011.03.007
-
(2011)
Exp Hematol
, vol.39
, pp. 666-675
-
-
Schildgen, V.1
Wulfert, M.2
Gattermann, N.3
-
139
-
-
81555216957
-
The epigenomics revolution in myelodysplasia: A clinico-pathological perspective
-
PMID 21881538
-
Tan PT, Wei AH. The epigenomics revolution in myelodysplasia: a clinico-pathological perspective. Pathology 2011; 43: 536-46; PMID: 218 81538
-
(2011)
Pathology
, vol.43
, pp. 536-546
-
-
Tan, P.T.1
Wei, A.H.2
-
140
-
-
42249112646
-
Analysis of mitochondrial DNA in 104 patients with myelodysplastic syndromes
-
DOI 10.1016/j.exphem.2008.01.004, PII S0301472X08000209
-
Wulfert M, Küpper AC, Tapprich C, Bottomley SS, Bowen D, Germing U, Haas R, Gattermann N. Analysis of mitochondrial DNA in 104 patients with myelodysplastic syndromes. Exp Hematol 2008; 36: 577-86; PMID: 18439489; http://dx.doi.org/10.1016/j.exphem.2008.01.004 (Pubitemid 351551472)
-
(2008)
Experimental Hematology
, vol.36
, Issue.5
, pp. 577-586
-
-
Wulfert, M.1
Kupper, A.C.2
Tapprich, C.3
Bottomley, S.S.4
Bowen, D.5
Germing, U.6
Haas, R.7
Gattermann, N.8
-
141
-
-
1542615082
-
Comprehensive Scanning of Somatic Mitochondrial DNA Alterations in Acute Leukemia Developing from Myelodysplastic Syndromes
-
DOI 10.1158/0008-5472.CAN-03-2956
-
Linnartz B, Anglmayer R, Zanssen S. Comprehensive scanning of somatic mitochondrial DNA alterations in acute leukemia developing from myelodys-plastic syndromes. Cancer Res 2004; 64: 1966-71; PMID: 15026331; http://dx.doi.org/10. 1158/0008-5472.CAN-03-2956 (Pubitemid 38339441)
-
(2004)
Cancer Research
, vol.64
, Issue.6
, pp. 1966-1971
-
-
Linnartz, B.1
Anglmayer, R.2
Zanssen, S.3
-
142
-
-
0034142678
-
From sideroblastic anemia to the role of mitochondrial DNA mutations in myelo-dysplastic syndromes
-
PMID: 10654450
-
Gattermann N. From sideroblastic anemia to the role of mitochondrial DNA mutations in myelo-dysplastic syndromes. Leuk Res 2000; 24: 141-51; PMID: 10654450; http://dx.doi.org/10.1016/S0145-2126(99)00160-5
-
(2000)
Leuk Res
, vol.24
, pp. 141-151
-
-
Gattermann, N.1
-
143
-
-
84875391007
-
Inosine Triphosphate Pyrophosphohydrolase (ITPA) polymorphic sequence variants in adult hematological malignancy patients and possible association with mitochondrial DNA defects
-
PMID: 23547827
-
Zamzami MA, Duley JA, Price GR, Venter DJ, Yarham JW, Taylor RW, Catley LP, Florin TH, Marinaki AM, Bowling F. Inosine Triphosphate Pyrophosphohydrolase (ITPA) polymorphic sequence variants in adult hematological malignancy patients and possible association with mitochondrial DNA defects. J Hematol Oncol 2013; 6: 24; PMID: 23547827; http://dx.doi.org/10.1186/1756-8722-6-24
-
(2013)
J Hematol Oncol
, vol.6
, pp. 24
-
-
Zamzami, M.A.1
Duley, J.A.2
Price, G.R.3
Venter, D.J.4
Yarham, J.W.5
Taylor, R.W.6
Catley, L.P.7
Florin, T.H.8
Marinaki, A.M.9
Bowling, F.10
-
144
-
-
79958241183
-
NMR-based metabolomic analysis of the molecular pathogenesis of therapy-related myelodysplasia/acute myeloid leukemia
-
PMID: 21510650
-
Cano KE, Li L, Bhatia S, Bhatia R, Forman SJ, Chen Y. NMR-based metabolomic analysis of the molecular pathogenesis of therapy-related myelodysplasia/acute myeloid leukemia. J Proteome Res 2011; 10: 2873-81; PMID: 21510650; http://dx.doi.org/10.1021/pr200200y
-
(2011)
J Proteome Res
, vol.10
, pp. 2873-2881
-
-
Cano, K.E.1
Li, L.2
Bhatia, S.3
Bhatia, R.4
Forman, S.J.5
Chen, Y.6
-
145
-
-
81255162528
-
A ltered hematopoietic cell gene expression precedes development of therapy-related myelodysplasia/acute myeloid leukemia and identifies patients at risk
-
PMID: 22094254
-
Li L, Li M, Sun C, Francisco L, Chakraborty S, Sabado M, McDonald T, Gyorffy J, Chang K, Wang S, et al. A ltered hematopoietic cell gene expression precedes development of therapy-related myelodysplasia/acute myeloid leukemia and identifies patients at risk. Cancer Cell 2011; 20: 591-605; PMID: 22094254; http://dx.doi.org/10.1016/j.ccr.2011.09.011
-
(2011)
Cancer Cell
, vol.20
, pp. 591-605
-
-
Li, L.1
Li, M.2
Sun, C.3
Francisco, L.4
Chakraborty, S.5
Sabado, M.6
McDonald, T.7
Gyorffy, J.8
Chang, K.9
Wang, S.10
-
146
-
-
67349201057
-
Erythroid precursors from patients with low-risk myelodysplasia demonstrate ultrastructural features of enhanced auto-phagy of mitochondria
-
PMID: 19148135
-
Houwerzijl EJ, Pol H W, Blom NR, van der Want JJ, de Wolf JT, Velleng a E. Erythroid precursors from patients with low-risk myelodysplasia demonstrate ultrastructural features of enhanced auto-phagy of mitochondria. Leukemia 2009; 23: 886-91; PMID: 19148135; http://dx.doi.org/10.1038/leu.2008.389
-
(2009)
Leukemia
, vol.23
, pp. 886-891
-
-
Houwerzijl, E.J.1
Pol, H.W.2
Blom, N.R.3
Van Der Want, J.J.4
De Wolf, J.T.5
Vellenga, E.6
-
147
-
-
0035075298
-
Mitochondrial disruption and limited apoptosis of erythroblasts are associated with high risk myelodysplasia. An ultrastructural analysis
-
DOI 10.1016/S0145-2126(00)00151-X, PII S014521260000151X
-
van de Loosdrecht AA, Brada SJ, Blom NR, Hendriks DW, Smit JW, van den Berg E, de Wolf JT, Vel leng a E. Mitochondrial disruption and limited apoptosis of erythroblasts are associated with high risk myelo-dysplasia. An ultrastructural analysis. Leuk Res 2001; 25: 385-93; PMID: 1130110 6; http://dx.doi.org/10.1016/S0145-2126(00)00151-X (Pubitemid 32294283)
-
(2001)
Leukemia Research
, vol.25
, Issue.5
, pp. 385-393
-
-
Van De Loosdrecht, A.A.1
Brada, S.J.L.2
Blom, N.R.3
Hendriks, D.W.4
Smit, J.W.5
Van Den Berg, E.6
De Wolf, J.Th.M.7
Vellenga, E.8
-
148
-
-
53249123632
-
-
Fourth Edition
-
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, Fourth Edition. 2008.
-
(2008)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
-
-
Swerdlow, S.H.1
Campo, E.2
Harris, N.L.3
Jaffe, E.S.4
Pileri, S.A.5
Stein, H.6
Thiele, J.7
Vardiman, J.W.8
-
149
-
-
79955469664
-
Autophagy: Limiting factors
-
PMID: 21508966
-
McCarthy N. Autophagy: limiting factors. Nat Rev Cancer 2 011; 11: 313; PMID: 215 0 8 9 6 6; http://dx.doi.org/10.1038/nrc3054
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 313
-
-
McCarthy, N.1
-
150
-
-
79952228407
-
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
-
PMID: 21317241
-
Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V, et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev 2011; 25: 460-70; PMID: 21317241; http://dx.doi.org/10.1101/gad.2016311
-
(2011)
Genes Dev
, vol.25
, pp. 460-470
-
-
Guo, J.Y.1
Chen, H.Y.2
Mathew, R.3
Fan, J.4
Strohecker, A.M.5
Karsli-Uzunbas, G.6
Kamphorst, J.J.7
Chen, G.8
Lemons, J.M.9
Karantza, V.10
-
151
-
-
79952229430
-
Pancreatic cancers require autophagy for tumor growth
-
PMID: 21406549
-
Yang S, Wa ng X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev 2011; 25: 717-29; PMID: 21406549; http://dx.doi.org/10. 1101/g a d. 2 016111
-
(2011)
Genes Dev
, vol.25
, pp. 717-729
-
-
Yang, S.1
Wang, X.2
Contino, G.3
Liesa, M.4
Sahin, E.5
Ying, H.6
Bause, A.7
Li, Y.8
Stommel, J.M.9
Dell'Antonio, G.10
-
152
-
-
33750284176
-
Autophagy in cancer: Good, bad, or both?
-
PMID: 17018585
-
Hippert MM, O ' To o l e PS, Thorburn A. Autophagy in cancer: good, bad, or both? Cancer Res 2006; 66: 9349-51; PMID: 17018585; http://dx.doi.org/10. 1158/0008-5472.CAN-06-1597
-
(2006)
Cancer Res
, vol.66
, pp. 9349-9351
-
-
Hippert, M.M.1
O'Toole, P.S.2
Thorburn, A.3
-
153
-
-
79957883170
-
The multiple roles of auto-phagy in cancer
-
PMID 21317301
-
Rosenfeldt MT, Ryan KM. The multiple roles of auto-phagy in cancer. Carcinogenesis 2011; 32: 955-63; PMID: 213173 01; http://dx.doi.org/10.1093/ carcin/bgr031
-
(2011)
Carcinogenesis
, vol.32
, pp. 955-963
-
-
Rosenfeldt, M.T.1
Ryan, K.M.2
-
154
-
-
34347404887
-
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
-
DOI 10.1101/gad.1565707
-
Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S, White E. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 2007; 21: 1621-35; PMID: 17606641; http://dx.doi.org/ 10.1101/g ad.1565707 (Pubitemid 47026367)
-
(2007)
Genes and Development
, vol.21
, Issue.13
, pp. 1621-1635
-
-
Karantza-Wadsworth, V.1
Patel, S.2
Kravchuk, O.3
Chen, G.4
Mathew, R.5
Jin, S.6
White, E.7
-
155
-
-
66449099090
-
Autophagy suppresses tumorigenesis through elimination of p62
-
PMID 19 5245 0 9
-
Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, Bray K, Reddy A, Bhanot G, Gelinas C, et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009; 137: 1062-75; PMID: 19 5245 0 9; http://dx.doi.org/10.1016/j. cell.2009.03.048
-
(2009)
Cell
, vol.137
, pp. 1062-1075
-
-
Mathew, R.1
Karp, C.M.2
Beaudoin, B.3
Vuong, N.4
Chen, G.5
Chen, H.Y.6
Bray, K.7
Reddy, A.8
Bhanot, G.9
Gelinas, C.10
-
156
-
-
34249863298
-
Autophagy suppresses tumor progression by limiting chromosomal instability
-
DOI 10.1101/gad.1545107
-
Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, Chen G, Jin S, White E. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 2007; 21: 1367-81; PMID: 17510285; http://dx.doi.org/10. 1101/gad.1545107 (Pubitemid 46871040)
-
(2007)
Genes and Development
, vol.21
, Issue.11
, pp. 1367-1381
-
-
Mathew, R.1
Kongara, S.2
Beaudoin, B.3
Karp, C.M.4
Bray, K.5
Degenhardt, K.6
Chen, G.7
Jin, S.8
White, E.9
-
157
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
DOI 10.1073/pnas.2436255100
-
Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 2003; 100: 15 0 7 7-82; PMID: 14657337; http://dx.doi.org/10.1073/pna s.2436255100 (Pubitemid 37518019)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.25
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
158
-
-
33846794896
-
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
-
DOI 10.1172/JCI28833
-
Amaravadi RK, Yu D, Lum JJ, Bui T, Christophorou MA, Evan GI, Thomas-Tikhonenko A, Thompson CB. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 2007; 117: 326-36; PMID: 17235397; http://dx.doi.org/10.1172/JCI28833 (Pubitemid 46203961)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.2
, pp. 326-336
-
-
Amaravadi, R.K.1
Yu, D.2
Lum, J.J.3
Bui, T.4
Christophorou, M.A.5
Evan, G.I.6
Thomas-Tikhonenko, A.7
Thompson, C.B.8
-
159
-
-
33745713171
-
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigen-esis
-
PMID: 16843265
-
Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gélinas C, Fan Y, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigen-esis. Cancer Cell 2006; 10: 51-64; PMID: 16843265; http://dx.doi.org/10.1016/j.ccr.2006.06.001
-
(2006)
Cancer Cell
, vol.10
, pp. 51-64
-
-
Degenhardt, K.1
Mathew, R.2
Beaudoin, B.3
Bray, K.4
Anderson, D.5
Chen, G.6
Mukherjee, C.7
Shi, Y.8
Gélinas, C.9
Fan, Y.10
|