메뉴 건너뛰기




Volumn 9, Issue 11, 2013, Pages 1737-1749

Mitophagy in hematopoietic stem cells: The case for exploration

Author keywords

Autophagy; Commitment; Differentiation; Hematopoiesis; Hematopoietic progenitor cells; Hematopoietic stem cells; Mitochondria; Mitophagy; Quiescence; Self renewal

Indexed keywords

ADENOSINE TRIPHOSPHATE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; RECEPTOR;

EID: 84887456727     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.26681     Document Type: Review
Times cited : (56)

References (159)
  • 1
    • 0031918742 scopus 로고    scopus 로고
    • The mitochondrial death/life regulator in apoptosis and necrosis
    • DOI 10.1146/annurev.physiol.60.1.619
    • Kroemer G, Dallaporta B, Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 1998; 60: 619-42; PMID: 9558479; h t t p://d x. d oi.or g/10.114 6/a n nu re v. physiol.60.1.619 (Pubitemid 28157889)
    • (1998) Annual Review of Physiology , vol.60 , pp. 619-642
    • Kroemer, G.1    Dallaporta, B.2    Resche-Rigon, M.3
  • 2
    • 0033971898 scopus 로고    scopus 로고
    • Mitochondria and neu-ronal survival
    • PMID: 10617771
    • Nicholls DG, Budd SL. Mitochondria and neu-ronal survival. Physiol Rev 2000; 80: 315-60; PMID: 10617771
    • (2000) Physiol Rev , vol.80 , pp. 315-360
    • Nicholls, D.G.1    Budd, S.L.2
  • 3
    • 67651119928 scopus 로고    scopus 로고
    • Mitochondria: Determinants of stem cell fate?
    • PMID 19563264
    • Parker GC, Acsadi G, Brenner CA. Mitochondria: determinants of stem cell fate? Stem Cells Dev 2009; 18: 803-6; PMID: 19563264; http://dx.doi.org/10.1089/ scd.2009.1806.edi
    • (2009) Stem Cells Dev , vol.18 , pp. 803-806
    • Parker, G.C.1    Acsadi, G.2    Brenner, C.A.3
  • 4
    • 27744491193 scopus 로고    scopus 로고
    • Emerging functions of mammalian mitochondrial fusion and fission
    • DOI 10.1093/hmg/ddi270
    • Chen H, Chan DC. Emerging functions of mammalian mitochondrial fusion and fission. Hum Mol Genet 2005; 14 Spec No. 2:R283-9; PMID: 16244327; http://dx.doi.org/10.1093/hmg/ddi270 (Pubitemid 41631897)
    • (2005) Human Molecular Genetics , vol.14 , Issue.SUPPL. 2
    • Chen, H.1    Chan, D.C.2
  • 5
    • 67651159365 scopus 로고    scopus 로고
    • Transcriptional control of mito-chondrial biogenesis and function
    • PMID: 19575678
    • Hock MB, Kralli A. Transcriptional control of mito-chondrial biogenesis and function. Annu Rev Physiol 2009; 71: 177-203; PMID: 19575678; http://dx.doi.org/10.114 6/annurev.physiol.010908.163119
    • (2009) Annu Rev Physiol , vol.71 , pp. 177-203
    • Hock, M.B.1    Kralli, A.2
  • 6
    • 84871005673 scopus 로고    scopus 로고
    • The pathways of mitophagy for quality control and clearance of mitochondria
    • PMID: 22743996
    • Ashrafi G, Schwarz TL. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ 2013; 20: 31-42; PMID: 22743996; http://dx.doi.org/10.1038/cdd.2012.81
    • (2013) Cell Death Differ , vol.20 , pp. 31-42
    • Ashrafi, G.1    Schwarz, T.L.2
  • 7
    • 41749114288 scopus 로고    scopus 로고
    • Autophagy: Basic principles and relevance to disease
    • DOI 10.1146/annurev.pathmechdis.2.010506.091842
    • Kundu M, Thompson CB. Autophagy: basic principles and relevance to disease. Annu Rev Pathol 2008; 3: 427-55; PMID: 18039129; http://dx.doi.org/10. 1146/annurev.pathmechdis.2.010506.091842 (Pubitemid 351488288)
    • (2008) Annual Review of Pathology: Mechanisms of Disease , vol.3 , pp. 427-455
    • Kundu, M.1    Thompson, C.B.2
  • 8
    • 35448981935 scopus 로고    scopus 로고
    • Autophagy: From phenomenology to molecular understanding in less than a decade
    • DOI 10.1038/nrm2245, PII NRM2245
    • Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007; 8: 931-7; PMID: 17712358; http://dx.doi.org/10.1038/nrm2245 (Pubitemid 47622558)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.11 , pp. 931-937
    • Klionsky, D.J.1
  • 9
    • 67649467294 scopus 로고    scopus 로고
    • Dynamics and diversity in autophagy mechanisms: Lessons from yeast
    • PMID: 19491929
    • Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y. Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol 2009; 10: 458-67; PMID: 19491929; http://dx.doi.org/10.1038/nrm2708
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 458-467
    • Nakatogawa, H.1    Suzuki, K.2    Kamada, Y.3    Ohsumi, Y.4
  • 10
    • 77956404377 scopus 로고    scopus 로고
    • Eaten alive: A history of macroautophagy
    • PMID: 20811353
    • Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nat Cell Biol 2010; 12: 814-22; PMID: 20811353; http://dx.doi.org/10.1038/ncb0910-814
    • (2010) Nat Cell Biol , vol.12 , pp. 814-822
    • Yang, Z.1    Klionsky, D.J.2
  • 11
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • PMID: 20965422
    • Kroemer G, Mariño G, Levine B. Autophagy and the integrated stress response. Mol Cell 2010; 40: 280-93; PMID: 20965422; http://dx.doi.org/10.1016/ j. molcel.2010.09.023
    • (2010) Mol Cell , vol.40 , pp. 280-293
    • Kroemer, G.1    Mariño, G.2    Levine, B.3
  • 12
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • PMID: 18191218
    • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132: 27-42; PMID: 18191218; http://dx.doi.org/10.1016/j.cell.2007.12.018
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 13
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • DOI 10.1038/nature06639, PII NATURE06639
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451: 1069-75; PMID: 18305538; http://dx.doi.org/10.1038/nature06639 (Pubitemid 351317450)
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 14
    • 76249127368 scopus 로고    scopus 로고
    • Loss of auto-phagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo
    • PMID: 20080761
    • Mortensen M, Ferguson DJ, Edelmann M, Kessler B, Morten KJ, Komatsu M, Simon AK. Loss of auto-phagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci U S A 2010; 107: 832-7; PMID: 20080761; http://dx.doi.org/10.1073/pnas.0913170107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 832-837
    • Mortensen, M.1    Ferguson, D.J.2    Edelmann, M.3    Kessler, B.4    Morten, K.J.5    Komatsu, M.6    Simon, A.K.7
  • 18
    • 77950236668 scopus 로고    scopus 로고
    • Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction
    • PMID: 19734452
    • Chen ML, Logan TD, Hochberg ML, Shelat SG, Yu X, Wilding GE, Ta n W, Kujoth GC, Prolla TA, Selak MA, et al. Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction. Blood 2009; 114: 4045-53; PMID: 19734 452; http://dx.doi.org/10.1182/blood-2008-08- 169474
    • (2009) Blood , vol.114 , pp. 4045-4053
    • Chen, M.L.1    Logan, T.D.2    Hochberg, M.L.3    Shelat, S.G.4    Yu, X.5    Wilding, G.E.6    Tan, W.7    Kujoth, G.C.8    Prolla, T.A.9    Selak, M.A.10
  • 19
    • 84868632060 scopus 로고    scopus 로고
    • A PML -PPAR- d pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
    • PMID: 22902876
    • Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, Schafer ZT, Evans RM, Suda T, Lee CH, et al. A PML -PPAR- d pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med 2012; 18: 1350-8; PMID: 22902876; http://dx.doi.org/10.1038/nm.2882
    • (2012) Nat Med , vol.18 , pp. 1350-1358
    • Ito, K.1    Carracedo, A.2    Weiss, D.3    Arai, F.4    Ala, U.5    Avigan, D.E.6    Schafer, Z.T.7    Evans, R.M.8    Suda, T.9    Lee, C.H.10
  • 21
    • 22544446192 scopus 로고    scopus 로고
    • Characterization of mitochondrial and extra-mitochondrial oxygen consuming reactions in human hematopoietic stem cells: Novel evidence of the occurrence of NAD(P)H oxidase activity
    • DOI 10.1074/jbc.M500047200
    • Piccoli C, Ria R, Scrima R, Cela O, D'Apr ile A, Boffoli D, Falzetti F, Tabilio A, Capitanio N. Characterization of mitochondrial and extra-mito-chondrial oxygen consuming reactions in human hematopoietic stem cells. Novel evidence of the occurrence of NAD(P)H oxidase activity. J Biol Chem 2005; 280: 26467-76; PMID: 15 8 8316 3; http://dx.doi.org/10.1074/jbc. M500047200 (Pubitemid 41022243)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.28 , pp. 26467-26476
    • Piccoli, C.1    Ria, R.2    Scrima, R.3    Cela, O.4    D'Aprile, A.5    Boffoli, D.6    Falzetti, F.7    Tabilio, A.8    Capitanio, N.9
  • 22
    • 77953632556 scopus 로고    scopus 로고
    • Upregulation of nascent mitochondrial biogenesis in mouse hematopoietic stem cells parallels upregulation of CD34 and loss of pluripotency: A potential strategy for reducing oxidative risk in stem cells
    • PMID: 20495374
    • Mantel C, Messina-Graham S, Broxmeyer HE. Upregulation of nascent mitochondrial biogenesis in mouse hematopoietic stem cells parallels upregulation of CD34 and loss of pluripotency: a potential strategy for reducing oxidative risk in stem cells. Cell Cycle 2010; 9: 2008-17; PMID: 20495374; http://dx.doi.org/10.4161/cc.9.10.11733
    • (2010) Cell Cycle , vol.9 , pp. 2008-2017
    • Mantel, C.1    Messina-Graham, S.2    Broxmeyer, H.E.3
  • 23
    • 79955698235 scopus 로고    scopus 로고
    • Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging
    • PMID: 215 49 326
    • Norddahl GL, Pronk CJ, Wahlestedt M, Sten G, Nygren JM, Ugale A, Sigvardsson M, Bryder D. Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging. Cell Stem Cell 2 011; 8: 499-510; PMID: 215 49 3 2 6; http://dx.doi.org/10.1016/j.stem.2011.03.009
    • (2011) Cell Stem Cell , vol.8 , pp. 499-510
    • Norddahl, G.L.1    Pronk, C.J.2    Wahlestedt, M.3    Sten, G.4    Nygren, J.M.5    Ugale, A.6    Sigvardsson, M.7    Bryder, D.8
  • 24
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeo-stasis
    • PMID: 22436748
    • Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeo-stasis. Nat Rev Mol Cell Biol 2012; 13: 251-62; PMID: 22436748; http://dx.doi.org/10.1038/nrm3311
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 26
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
    • PMID: 19629071
    • Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 2009; 9: 563-75; PMID: 19629071; http://dx.doi.org/10.1038/nrc2676
    • (2009) Nat Rev Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 27
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • PMID: 14511394
    • Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2003; 2: 28; PMID: 14511394; http://dx.doi.org/10.1186/ 1475-4924-2-28
    • (2003) J Biol , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Mäkelä, T.P.6    Alessi, D.R.7    Hardie, D.G.8
  • 29
    • 78649811793 scopus 로고    scopus 로고
    • Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    • PMID: 211 2 4 45 0
    • Nakada D, Saunders TL, Morrison SJ. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 2010; 468: 653-8; PMID: 211 2 4 45 0; http://dx.doi.org/10.1038/nature09571
    • (2010) Nature , vol.468 , pp. 653-658
    • Nakada, D.1    Saunders, T.L.2    Morrison, S.J.3
  • 30
  • 32
    • 77957608608 scopus 로고    scopus 로고
    • A general introduction to the biochemistry of mitochondrial fatty acid ß-oxidation
    • PMID: 20195903
    • Houten SM, Wa nders RJ. A general introduction to the biochemistry of mitochondrial fatty acid ß-oxidation. J Inherit Metab Dis 2010; 33: 469-77; PMID: 20195903; http://dx.doi.org/10.1007/s10545-010-9061-2
    • (2010) J Inherit Metab Dis , vol.33 , pp. 469-477
    • Houten, S.M.1    Wanders, R.J.2
  • 33
    • 34547136480 scopus 로고    scopus 로고
    • New therapeutic target for metabolic syndrome: PPARδ
    • DOI 10.1507/endocrj.KR-99
    • Takahashi S, Tanaka T, Sakai J. New therapeutic target for metabolic syndrome: PPARdelta. Endocr J 2007; 54: 347-57; PMID: 17409576; http://dx.doi.org/10.1507/endocrj.KR-99 (Pubitemid 47105421)
    • (2007) Endocrine Journal , vol.54 , Issue.3 , pp. 347-357
    • Takahashi, S.1    Tanaka, T.2    Sakai, J.3
  • 34
    • 76449100708 scopus 로고    scopus 로고
    • PPARs: Diverse regulators in energy metabolism and metabolic diseases
    • PMID: 20101262
    • Wa n g YX. PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Res 2010; 20: 124-37; PMID: 20101262; http://dx.doi.org/10.1038/ cr.2010.13
    • (2010) Cell Res , vol.20 , pp. 124-137
    • Wang, Y.X.1
  • 35
    • 84872037830 scopus 로고    scopus 로고
    • Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation
    • PMID: 23290137
    • Yu WM, Liu X, Shen J, Jovanovic O, Pohl EE, Gerson SL, Finkel T, Broxmeyer HE, Qu CK. Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell 2013; 12: 62-74; PMID: 23290137; http://dx.doi.org/10.1016/j.stem.2012.11.022
    • (2013) Cell Stem Cell , vol.12 , pp. 62-74
    • Yu, W.M.1    Liu, X.2    Shen, J.3    Jovanovic, O.4    Pohl, E.E.5    Gerson, S.L.6    Finkel, T.7    Broxmeyer, H.E.8    Qu, C.K.9
  • 36
    • 79958780643 scopus 로고    scopus 로고
    • Superoxide flashes reactive oxygen species and the mitochondrial permeability transition pore: Potential implications for hematopoietic stem cell function
    • PMID: 215 3 7169
    • Mantel C, Messina-Graham SV, Broxmeyer HE. Superoxide flashes, reactive oxygen species, and the mitochondrial permeability transition pore: potential implications for hematopoietic stem cell function. Curr Opin Hematol 2011; 18: 208-13; PMID: 215 3 7 16 9; http://dx.doi.org/10.1097/MOH.0b013e3283475ffe
    • (2011) Curr Opin Hematol , vol.18 , pp. 208-213
    • Mantel, C.1    Messina-Graham, S.V.2    Broxmeyer, H.E.3
  • 37
    • 0033135256 scopus 로고    scopus 로고
    • Hematopoietic growth factors signal through the formation of reactive oxygen species
    • Sattler M, Winkler T, Verma S, Byrne CH, Shrikhande G, Salgia R, Griffin JD. Hematopoietic growth factors signal through the formation of reactive oxygen species. Blood 1999; 93: 2928-35; PMID: 10216087 (Pubitemid 29200783)
    • (1999) Blood , vol.93 , Issue.9 , pp. 2928-2935
    • Sattler, M.1    Winkler, T.2    Verma, S.3    Byrne, C.H.4    Shrikhande, G.5    Salgia, R.6    Griffin, J.D.7
  • 38
    • 77953283847 scopus 로고    scopus 로고
    • AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species
    • PMID: 20354168
    • Juntilla MM, Patil VD, Calamito M, Joshi R P, Birnbaum MJ, Koretzky GA. AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Blood 2010; 115: 4030-8; PMID: 20354168; http://dx.doi.org/10. 1182/blood-2009-09-241000
    • (2010) Blood , vol.115 , pp. 4030-4038
    • Juntilla, M.M.1    Patil, V.D.2    Calamito, M.3    Joshi, R.P.4    Birnbaum, M.J.5    Koretzky, G.A.6
  • 39
    • 17644379936 scopus 로고    scopus 로고
    • FOXO transcription factors in cell-cycle regulation and the response to oxidative stress
    • DOI 10.1089/ars.2005.7.752
    • Furukawa-Hibi Y, Kobayashi Y, Chen C, Motoyama N. FOXO transcription factors in cell-cycle regulation and the response to oxidative stress. Antioxid Redox Signal 2005; 7: 752-60; PMID: 15890021; http://dx.doi.org/10.1089/ars. 2005.7.752 (Pubitemid 40563215)
    • (2005) Antioxidants and Redox Signaling , vol.7 , Issue.5-6 , pp. 752-760
    • Furukawa-Hibi, Y.1    Kobayashi, Y.2    Chen, C.3    Motoyama, N.4
  • 40
    • 41849150779 scopus 로고    scopus 로고
    • FOXOs, cancer and regulation of apoptosis
    • DOI 10.1038/onc.2008.24, PII ONC200824
    • Fu Z, Tindall DJ. FOXOs, cancer and regulation of apoptosis. Oncogene 2008; 27: 2312-9; PMID: 18391973; http://dx.doi.org/10.1038/onc.2008.24 (Pubitemid 351501782)
    • (2008) Oncogene , vol.27 , Issue.16 , pp. 2312-2319
    • Fu, Z.1    Tindall, D.J.2
  • 41
    • 33747370384 scopus 로고    scopus 로고
    • Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer
    • PMID: 16806782
    • Arden KC. Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer. Exp Gerontol 2006; 41: 709-17; PMID: 16806782; http://dx.doi.org/10.1016/j. exger.2006.05.015
    • (2006) Exp Gerontol , vol.41 , pp. 709-717
    • Arden, K.C.1
  • 45
    • 78650302424 scopus 로고    scopus 로고
    • ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice
    • PMID 21113129
    • Yalcin S, Marinkovic D, Mungamuri SK, Zhang X, To n g W, Sellers R, Ghaffari S. ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice. EMBO J 2010; 29: 4118-31; PMID: 21113129; http://dx.doi.org/10.1038/emboj.2010.292
    • (2010) EMBO J , vol.29 , pp. 4118-4131
    • Yalcin, S.1    Marinkovic, D.2    Mungamuri, S.K.3    Zhang, X.4    Tong, W.5    Sellers, R.6    Ghaffari, S.7
  • 46
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer diabetes and ageing
    • PMID: 21157483
    • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12: 21-35; PMID: 2115 74 83; http://dx.doi.org/10.1038/nrm3025
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 47
    • 36749081539 scopus 로고    scopus 로고
    • MTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
    • DOI 10.1038/nature06322, PII NATURE06322
    • Cunningham JT, Rodgers JT, Arlow DH, Vazque z F, Mootha VK, Puigserver P. mTOR controls mitochon-drial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 2007; 450: 736-40; PMID: 18046414; http://dx.doi.org/10.1038/nature06322 (Pubitemid 350207689)
    • (2007) Nature , vol.450 , Issue.7170 , pp. 736-740
    • Cunningham, J.T.1    Rodgers, J.T.2    Arlow, D.H.3    Vazquez, F.4    Mootha, V.K.5    Puigserver, P.6
  • 48
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the TSC-mTOR pathway in human disease
    • DOI 10.1038/ng1494
    • Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 2005; 37: 19-24; PMID: 15624019; http://dx.doi.org/10. 1038/ng1494 (Pubitemid 40070934)
    • (2005) Nature Genetics , vol.37 , Issue.1 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.-L.3
  • 49
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • PMID: 18809716
    • Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Liu Y, Zheng P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med 2008; 205: 2397-408; PMID: 18809716; http://dx.doi.org/10.1084/jem.20081297
    • (2008) J Exp Med , vol.205 , pp. 2397-2408
    • Chen, C.1    Liu, Y.2    Liu, R.3    Ikenoue, T.4    Guan, K.L.5    Liu, Y.6    Zheng, P.7
  • 50
    • 65949113818 scopus 로고    scopus 로고
    • The axis of mTOR-mitochondria-ROS and stemness of the hemato-poietic stem cells
    • PMID: 19270502
    • Chen C, Liu Y, Liu Y, Zheng P. The axis of mTOR-mitochondria-ROS and stemness of the hemato-poietic stem cells. Cell Cycle 2009; 8: 1158-60; PMID: 19270502; http://dx.doi.org/10.4161/cc.8.8.8139
    • (2009) Cell Cycle , vol.8 , pp. 1158-1160
    • Chen, C.1    Liu, Y.2    Liu, Y.3    Zheng, P.4
  • 52
    • 78751565017 scopus 로고    scopus 로고
    • Enhanced c-Met activity promotes G-CSF-induced mobilization of hema-topoietic progenitor cells via ROS signaling
    • PMID: 20585044
    • Te s i o M, Golan K, Corso S, Giordano S, Schajnovitz A, Va g ima Y, Shivtiel S, Kalinkovich A, Caione L, Gammaitoni L, et al. Enhanced c-Met activity promotes G-CSF-induced mobilization of hema-topoietic progenitor cells via ROS signaling. Blood 2 011; 117: 419-28; PMID: 20585044; http://dx.doi.org/10.1182/blood-2009-06-230359
    • (2011) Blood , vol.117 , pp. 419-428
    • Tesio, M.1    Golan, K.2    Corso, S.3    Giordano, S.4    Schajnovitz, A.5    Vagima, Y.6    Shivtiel, S.7    Kalinkovich, A.8    Caione, L.9    Gammaitoni, L.10
  • 53
    • 35548936968 scopus 로고    scopus 로고
    • A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
    • DOI 10.1182/blood-2007-05-087759
    • Jang YY, Sharkis SJ. A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood 2007; 110: 3056-63; PMID: 17595331; http://dx.doi.org/10.1182/blood-2007- 05-087759 (Pubitemid 350006961)
    • (2007) Blood , vol.110 , Issue.8 , pp. 3056-3063
    • Jang, Y.-Y.1    Sharkis, S.J.2
  • 54
    • 80052715446 scopus 로고    scopus 로고
    • The relationship between oxygen concentration, reactive oxygen species and the biological characteristics of human bone marrow hematopoietic stem cells
    • PMID: 21911158
    • Hao Y, Cheng D, Ma Y, Zhou W, Wang Y. The relationship between oxygen concentration, reactive oxygen species and the biological characteristics of human bone marrow hematopoietic stem cells. Transplant Proc 2 011; 43: 2755-61; PMID: 21911158; http://dx.doi.org/10.1016/j.transproceed.2011.06.026
    • (2011) Transplant Proc , vol.43 , pp. 2755-2761
    • Hao, Y.1    Cheng, D.2    Ma, Y.3    Zhou, W.4    Wang, Y.5
  • 55
    • 80052930073 scopus 로고    scopus 로고
    • Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells
    • PMID: 21734240
    • Yahata T, Takanashi T, Muguruma Y, Ibrahim AA, Matsuzawa H, Uno T, Sheng Y, Onizuka M, Ito M, Kato S, et al. Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells. Blood 2011; 118: 2941-50; PMID: 21734240; http://dx.doi.org/10.1182/blood-2011-01- 330050
    • (2011) Blood , vol.118 , pp. 2941-2950
    • Yahata, T.1    Takanashi, T.2    Muguruma, Y.3    Ibrahim, A.A.4    Matsuzawa, H.5    Uno, T.6    Sheng, Y.7    Onizuka, M.8    Ito, M.9    Kato, S.10
  • 56
    • 11244280878 scopus 로고    scopus 로고
    • NF-κB family proteins participate in multiple steps of hematopoiesis through elimination of reactive oxygen species
    • DOI 10.1074/jbc.M408238200
    • Nakata S, Matsumura I, Tanaka H, Ezoe S, Satoh Y, Ishikawa J, Era T, Kanakura Y. NF-kappaB family proteins participate in multiple steps of hematopoi-esis through elimination of reactive oxygen species. J Biol Chem 2004; 279: 55578-86; PMID: 1548584 3; http://dx.doi.org/10.1074/jbc.M408238200 (Pubitemid 40066561)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.53 , pp. 55578-55586
    • Nakata, S.1    Matsumura, I.2    Tanaka, H.3    Ezoe, S.4    Satoh, Y.5    Ishikawa, J.6    Era, T.7    Kanakura, Y.8
  • 57
    • 70349446465 scopus 로고    scopus 로고
    • Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
    • PMID: 19727075
    • Owusu-Ansah E, Banerjee U. Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature 2009; 461: 537-41; PMID: 19727075; http://dx.doi.org/10.1038/nature08313
    • (2009) Nature , vol.461 , pp. 537-541
    • Owusu-Ansah, E.1    Banerjee, U.2
  • 58
    • 17744393686 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in human disease
    • DOI 10.1038/nrg1606
    • Taylor RW, Tu r n b u l l DM. Mitochondrial DNA mutations in human disease. Nat Rev Genet 2005; 6: 389-402; PMID: 15861210; http://dx.doi.org/10. 1038/nrg1606 (Pubitemid 40577182)
    • (2005) Nature Reviews Genetics , vol.6 , Issue.5 , pp. 389-402
    • Taylor, R.W.1    Turnbull, D.M.2
  • 59
    • 2942531063 scopus 로고    scopus 로고
    • Mitochondrial defects in cancer
    • PMID 12513701
    • Carew JS, Huang P. Mitochondrial defects in cancer. Mol Cancer 2002; 1: 9; PMID: 12513701; http://dx.doi.org/10.1186/1476-4598-1-9
    • (2002) Mol Cancer , vol.1 , pp. 9
    • Carew, J.S.1    Huang, P.2
  • 60
    • 77956416339 scopus 로고    scopus 로고
    • Autophagy in mammalian development and differentiation
    • PMID: 20811354
    • Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat Cell Biol 2010; 12: 823-30; PMID: 20811354; http://dx.doi.org/10.1038/ncb0910-823
    • (2010) Nat Cell Biol , vol.12 , pp. 823-830
    • Mizushima, N.1    Levine, B.2
  • 61
    • 51649124519 scopus 로고    scopus 로고
    • Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation
    • PMID: 18539900
    • Kundu M, Lindsten T, Yang CY, Wu J, Zhao F, Zhang J, Selak MA, Ney PA, Thompson CB. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood 2008; 112: 1493-502; PMID: 18539900; http://dx.doi.org/10.1182/blood-2008-02-137398
    • (2008) Blood , vol.112 , pp. 1493-1502
    • Kundu, M.1    Lindsten, T.2    Yang, C.Y.3    Wu, J.4    Zhao, F.5    Zhang, J.6    Selak, M.A.7    Ney, P.A.8    Thompson, C.B.9
  • 62
    • 77449094358 scopus 로고    scopus 로고
    • Neural-specific deletion of FIP200 leads to cerebel-lar degeneration caused by increased neuronal death and axon degeneration
    • PMID: 19940130
    • Liang CC, Wa ng C, Peng X, Gan B, Guan JL. Neural-specific deletion of FIP200 leads to cerebel-lar degeneration caused by increased neuronal death and axon degeneration. J Biol Chem 2010; 285: 3499-509; PMID: 19940130; http://dx.doi.org/10.1074/jbc.M109.072389
    • (2010) J Biol Chem , vol.285 , pp. 3499-3509
    • Liang, C.C.1    Wang, C.2    Peng, X.3    Gan, B.4    Guan, J.L.5
  • 63
    • 78649689953 scopus 로고    scopus 로고
    • FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells
    • PMID: 20716775
    • Liu F, Lee JY, Wei H, Tanabe O, Engel JD, Morrison SJ, Guan JL. FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood 2010; 116: 4806-14; PMID: 20716775; http://dx.doi.org/10.1182/blood-2010- 06-288589
    • (2010) Blood , vol.116 , pp. 4806-4814
    • Liu, F.1    Lee, J.Y.2    Wei, H.3    Tanabe, O.4    Engel, J.D.5    Morrison, S.J.6    Guan, J.L.7
  • 65
    • 67650216238 scopus 로고    scopus 로고
    • Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes
    • PMID: 19276668
    • Stephenson LM, Miller BC, Ng A, Eisenberg J, Zhao Z, Cadwell K, Graham DB, Mizushima NN, Xavier R, Virgin HW, et al. Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Autophagy 2009; 5: 625-35; PMID: 19276668; http://dx.doi.org/10. 4161/auto.5.5.8133
    • (2009) Autophagy , vol.5 , pp. 625-635
    • Stephenson, L.M.1    Miller, B.C.2    Ng, A.3    Eisenberg, J.4    Zhao, Z.5    Cadwell, K.6    Graham, D.B.7    Mizushima, N.N.8    Xavier, R.9    Virgin, H.W.10
  • 66
    • 33846461678 scopus 로고    scopus 로고
    • A critical role for the autophagy gene Atg5 in T cell survival and proliferation
    • DOI 10.1084/jem.20061303
    • Pua HH, Dzhagalov I, Chuck M, Mizushima N, He Y W. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med 2007; 204: 25-31; PMID: 17190837; http://dx.doi.org/10.1084/jem.20061303 (Pubitemid 46148752)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.1 , pp. 25-31
    • Pua, H.H.1    Dzhagalov, I.2    Chuck, M.3    Mizushima, N.4    He, Y.-W.5
  • 72
    • 64249123646 scopus 로고    scopus 로고
    • Autophagy is essential for mitochondrial clearance in mature T lymphocytes
    • PMID: 19299702
    • Pua HH, Guo J, Komatsu M, He YW. Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol 2009; 182: 4046-55; PMID: 19299702; http://dx.doi.org/10.4049/jimmunol.0801143
    • (2009) J Immunol , vol.182 , pp. 4046-4055
    • Pua, H.H.1    Guo, J.2    Komatsu, M.3    He, Y.W.4
  • 74
    • 73949124173 scopus 로고    scopus 로고
    • Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogen-esis
    • PMID: 19910529
    • Zhang Y, Goldman S, Baerga R, Zhao Y, Komatsu M, Jin S. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogen-esis. Proc Natl Acad Sci U S A 2009; 106: 19860-5; PMID: 19910529
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 19860-19865
    • Zhang, Y.1    Goldman, S.2    Baerga, R.3    Zhao, Y.4    Komatsu, M.5    Jin, S.6
  • 75
    • 52749094770 scopus 로고    scopus 로고
    • Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglyce-mia
    • PMID: 18840362
    • Jung HS, Chung KW, Won Kim J, Kim J, Komatsu M, Tanaka K, Nguyen YH, Kang TM, Yoon KH, Kim JW, et al. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglyce-mia. Cell Metab 2008; 8: 318-24; PMID: 18840362; http://dx.doi.org/10.1016/j.cmet.2008.08.013
    • (2008) Cell Metab , vol.8 , pp. 318-324
    • Jung, H.S.1    Chung, K.W.2    Won Kim, J.3    Kim, J.4    Komatsu, M.5    Tanaka, K.6    Nguyen, Y.H.7    Kang, T.M.8    Yoon, K.H.9    Kim, J.W.10
  • 76
    • 52749093177 scopus 로고    scopus 로고
    • Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet
    • PMID: 18840363
    • Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, Komiya K, Azuma K, Hirose T, Tanaka K, Kominami E, et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab 2008; 8: 325-32; PMID: 18840363; http://dx.doi.org/10.1016/j. cmet.2008.08.009
    • (2008) Cell Metab , vol.8 , pp. 325-332
    • Ebato, C.1    Uchida, T.2    Arakawa, M.3    Komatsu, M.4    Ueno, T.5    Komiya, K.6    Azuma, K.7    Hirose, T.8    Tanaka, K.9    Kominami, E.10
  • 77
    • 57749121573 scopus 로고    scopus 로고
    • Mitophagy in yeast occurs through a selective mechanism
    • PMID: 18818209
    • Kanki T, Klionsky DJ. Mitophagy in yeast occurs through a selective mechanism. J Biol Chem 2008; 283: 32386-93; PMID: 18818209; http://dx.doi.org/ 10.1074/jbc.M802403200
    • (2008) J Biol Chem , vol.283 , pp. 32386-32393
    • Kanki, T.1    Klionsky, D.J.2
  • 78
    • 77953515698 scopus 로고    scopus 로고
    • A genomic screen for yeast mutants defective in mitophagy
    • PMID: 20364111
    • Kanki T, Wang K, Klionsky DJ. A genomic screen for yeast mutants defective in mitophagy. Autophagy 2010; 6: 278-80; PMID: 203 64111; http://dx.doi.org/10.4161/auto.6.2.10901
    • (2010) Autophagy , vol.6 , pp. 278-280
    • Kanki, T.1    Wang, K.2    Klionsky, D.J.3
  • 81
    • 84872291490 scopus 로고    scopus 로고
    • Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis
    • PMID: 23209295
    • Zhu Y, Massen S, Te r e n z i o M, Lang V, Chen-Lindner S, Eils R, Novak I, Dikic I, Hamacher-Brady A, Brady NR. Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem 2013; 288: 1099-113; PMID: 23209295; http://dx.doi.org/ 10.1074/jbc.M112.399345
    • (2013) J Biol Chem , vol.288 , pp. 1099-1113
    • Zhu, Y.1    Massen, S.2    Terenzio, M.3    Lang, V.4    Chen-Lindner, S.5    Eils, R.6    Novak, I.7    Dikic, I.8    Hamacher-Brady, A.9    Brady, N.R.10
  • 83
    • 84885176082 scopus 로고    scopus 로고
    • Cardiolipin external-ization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
    • PMID: 24036476
    • Chu CT, Ji J, Dagda RK, Jiang JF, Ty u r i n a Y Y, Kapralov AA, Ty u r i n VA , Yanamala N, Shrivastava IH, Mohammadyani D, et al. Cardiolipin external-ization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nat Cell Biol 2013; 15: 1197-205; PMID: 24036476; http://dx.doi.org/10.1038/ncb2837
    • (2013) Nat Cell Biol , vol.15 , pp. 1197-1205
    • Chu, C.T.1    Ji, J.2    Dagda, R.K.3    Jiang, J.F.4    Tyurina, Y.Y.5    Kapralov, A.A.6    Tyurin, V.A.7    Yanamala, N.8    Shrivastava, I.H.9    Mohammadyani, D.10
  • 85
    • 47049100413 scopus 로고    scopus 로고
    • Essential role for Nix in autophagic maturation of erythroid cells
    • DOI 10.1038/nature07006, PII NATURE07006
    • Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J. Essential role for Nix in autophagic maturation of erythroid cells. Nature 2008; 454: 232-5; PMID: 18454133; http://dx.doi.org/10.1038/nature07006 (Pubitemid 351969889)
    • (2008) Nature , vol.454 , Issue.7201 , pp. 232-235
    • Sandoval, H.1    Thiagarajan, P.2    Dasgupta, S.K.3    Schumacher, A.4    Prchal, J.T.5    Chen, M.6    Wang, J.7
  • 86
    • 84861733247 scopus 로고    scopus 로고
    • Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy
    • PMID: 22505714
    • Hanna RA, Quinsay MN, Orogo AM, Giang K, Rikka S, Gustafsson AB. Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy. J Biol Chem 2012; 287: 19094-104; PMID: 22505714; http://dx.doi.org/10.1074/jbc.M111.322933
    • (2012) J Biol Chem , vol.287 , pp. 19094-19104
    • Hanna, R.A.1    Quinsay, M.N.2    Orogo, A.M.3    Giang, K.4    Rikka, S.5    Gustafsson, A.B.6
  • 88
    • 80052589570 scopus 로고    scopus 로고
    • Autophagy regulates hypoxia-induced osteoclastogenesis through the HIF-1a/BNIP3 signaling pathway
    • PMID: 21465467
    • Zhao Y, Chen G, Zhang W, Xu N, Zhu JY, Jia J, Sun ZJ, Wa ng YN, Zhao YF. Autophagy regulates hypoxia-induced osteoclastogenesis through the HIF-1a/BNIP3 signaling pathway. J Cell Physiol 2012; 227: 639-48; PMID: 21465467; http://dx.doi.org/10.1002/jcp.22768
    • (2012) J Cell Physiol , vol.227 , pp. 639-648
    • Zhao, Y.1    Chen, G.2    Zhang, W.3    Xu, N.4    Zhu, J.Y.5    Jia, J.6    Sun, Z.J.7    Wang, Y.N.8    Zhao, Y.F.9
  • 89
    • 66349121718 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
    • PMID 19 2 73585
    • Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouysségur J, Mazure NM. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol 2009; 29: 2570-81; PMID: 19 2 735 85; http://dx.doi.org/10.1128/MCB.00166-09
    • (2009) Mol Cell Biol , vol.29 , pp. 2570-2581
    • Bellot, G.1    Garcia-Medina, R.2    Gounon, P.3    Chiche, J.4    Roux, D.5    Pouysségur, J.6    Mazure, N.M.7
  • 90
  • 91
    • 84862789618 scopus 로고    scopus 로고
    • Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
    • PMID: 22267086
    • Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, Ma Q, Zhu C, Wang R, Qi W, et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol 2012; 14: 177-85; PMID: 22267086; http://dx.doi.org/10.1038/ncb2422
    • (2012) Nat Cell Biol , vol.14 , pp. 177-185
    • Liu, L.1    Feng, D.2    Chen, G.3    Chen, M.4    Zheng, Q.5    Song, P.6    Ma, Q.7    Zhu, C.8    Wang, R.9    Qi, W.10
  • 92
    • 27944482199 scopus 로고    scopus 로고
    • Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast
    • DOI 10.1038/sj.cdd.4401697, PII 4401697
    • Priault M, Salin B, Schaeffer J, Vallet te FM, di Rago JP, Martinou JC. Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitoph-agy in yeast. Cell Death Differ 2005; 12: 1613-21; PMID: 15947785; http://dx.doi.org/10.1038/sj.cdd.4401697 (Pubitemid 41679166)
    • (2005) Cell Death and Differentiation , vol.12 , Issue.12 , pp. 1613-1621
    • Priault, M.1    Salin, B.2    Schaeffer, J.3    Vallette, F.M.4    Di Rago, J.-P.5    Martinou, J.-C.6
  • 93
    • 34250898919 scopus 로고    scopus 로고
    • + exchange activity, osmotic swelling and mitophagy
    • DOI 10.1038/sj.cdd.4402167, PII 4402167
    • Nowikovsky K, Reipert S, Devenish RJ, Schweyen RJ. Mdm38 protein depletion causes loss of mito-chondrial K+/H+ exchange activity, osmotic swelling and mitophagy. Cell Death Differ 2007; 14: 1647-56; PMID: 17541427; http://dx.doi.org/10.1038/sj.cdd.4402167 (Pubitemid 47278850)
    • (2007) Cell Death and Differentiation , vol.14 , Issue.9 , pp. 1647-1656
    • Nowikovsky, K.1    Reipert, S.2    Devenish, R.J.3    Schweyen, R.J.4
  • 94
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • PMID: 19029340
    • Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008; 183: 795-803; PMID: 19029340; http://dx.doi.org/10.1083/jcb.200809125
    • (2008) J Cell Biol , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 95
    • 79954622220 scopus 로고    scopus 로고
    • Mitophagy selectively degrades individual damaged mitochondria after photoir-radiation
    • PMID: 21126216
    • Kim I, Lemasters JJ. Mitophagy selectively degrades individual damaged mitochondria after photoir-radiation. Antioxid Redox Signal 2011; 14: 1919-28; PMID: 21126216; http://dx.doi.org/10.1089/ars.2010.3768
    • (2011) Antioxid Redox Signal , vol.14 , pp. 1919-1928
    • Kim, I.1    Lemasters, J.J.2
  • 96
    • 77955398958 scopus 로고    scopus 로고
    • Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells
    • PMID: 20547844
    • Suen DF, Narendra DP, Tanaka A, Manfredi G, Youle RJ. Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Proc Natl Acad Sci U S A 2010; 107: 11835-40; PMID: 20547844; http://dx.doi.org/10.1073/pnas.0914569107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 11835-11840
    • Suen, D.F.1    Narendra, D.P.2    Tanaka, A.3    Manfredi, G.4    Youle, R.J.5
  • 97
    • 82255192465 scopus 로고    scopus 로고
    • Degradation of paternal mitochondria by fertilization-triggered autophagy in C elegans embryos
    • PMID 21998252
    • Sato M, Sato K. Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos. Science 2011; 334: 1141-4; PMID: 21998252; http://dx.doi.org/10.1126/science.1210333
    • (2011) Science , vol.334 , pp. 1141-1144
    • Sato, M.1    Sato, K.2
  • 98
    • 82255183165 scopus 로고    scopus 로고
    • Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission
    • PMID: 22033522
    • Al Rawi S, Louvet-Vallée S, Djeddi A, Sachse M, Culetto E, Hajjar C, Boyd L, Legouis R, Galy V. Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission. Science 2011; 334: 1144-7; PMID: 22033522; http://dx.doi.org/10.1126/scienc e.1211878
    • (2011) Science , vol.334 , pp. 1144-1147
    • Al Rawi, S.1    Louvet-Vallée, S.2    Djeddi, A.3    Sachse, M.4    Culetto, E.5    Hajjar, C.6    Boyd, L.7    Legouis, R.8    Galy, V.9
  • 99
    • 84859124525 scopus 로고    scopus 로고
    • Maternal inheritance of mitochon-drial DNA: Degradation of paternal mitochondria by allogeneic organelle autophagy, allophagy
    • PMID: 22302002
    • Sato M, Sato K. Maternal inheritance of mitochon-drial DNA: degradation of paternal mitochondria by allogeneic organelle autophagy, allophagy. Autophagy 2012; 8: 424-5; PMID: 22302002; http://dx.doi.org/10.4161/auto.19243
    • (2012) Autophagy , vol.8 , pp. 424-425
    • Sato, M.1    Sato, K.2
  • 100
    • 78650467974 scopus 로고    scopus 로고
    • Mechanisms of mitophagy
    • PMID: 21179058
    • Youle RJ, Narendra DP. Mechanisms of mitoph-agy. Nat Rev Mol Cell Biol 2011; 12: 9-14; PMID: 21179058; http://dx.doi.org/10.1038/nrm3028
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 9-14
    • Youle, R.J.1    Narendra, D.P.2
  • 102
    • 84857032953 scopus 로고    scopus 로고
    • Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin
    • PMID: 22280891
    • Lazarou M, Jin SM, Kane LA, Youle RJ. Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell 2012; 22: 320-33; PMID: 22280891; http://dx.doi.org/10.1016/j. devcel.2011.12.014
    • (2012) Dev Cell , vol.22 , pp. 320-333
    • Lazarou, M.1    Jin, S.M.2    Kane, L.A.3    Youle, R.J.4
  • 103
    • 84876531457 scopus 로고    scopus 로고
    • PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria
    • PMID: 23620 051
    • Chen Y, Dorn GW 2nd. PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science 2013; 340: 471-5; PMID: 23620 051; http://dx.doi.org/10.1126/s c i e nc e.12 31031
    • (2013) Science , vol.340 , pp. 471-475
    • Chen, Y.1    Dorn, I.I.G.W.2
  • 104
    • 84879885169 scopus 로고    scopus 로고
    • Parkin mitochondrial trans-location is achieved through a novel catalytic activity coupled mechanism
    • PMID: 23670163
    • Zheng X, Hunter T. Parkin mitochondrial trans-location is achieved through a novel catalytic activity coupled mechanism. Cell Res 2013; 23: 886-97; PMID: 23670163; http://dx.doi.org/10.1038/cr.2013.66
    • (2013) Cell Res , vol.23 , pp. 886-897
    • Zheng, X.1    Hunter, T.2
  • 105
  • 106
    • 77950384477 scopus 로고    scopus 로고
    • Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin
    • PMID: 20194754
    • Ziviani E, Ta o RN, Whitworth AJ. Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc Natl Acad Sci U S A 2010; 107: 5018-23; PMID: 20194754; http://dx.doi.org/10.1073/pnas.0913485107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 5018-5023
    • Ziviani, E.1    Tao, R.N.2    Whitworth, A.J.3
  • 107
    • 78649463381 scopus 로고    scopus 로고
    • Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
    • PMID: 20871098
    • Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AH, Taanman JW. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet 2010; 19: 4861-70; PMID: 20871098; http://dx.doi.org/10.1093/hmg/ddq419
    • (2010) Hum Mol Genet , vol.19 , pp. 4861-4870
    • Gegg, M.E.1    Cooper, J.M.2    Chau, K.Y.3    Rojo, M.4    Schapira, A.H.5    Taanman, J.W.6
  • 109
    • 84876070458 scopus 로고    scopus 로고
    • VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations
    • PMID: 23 49 8974
    • Kim NC, Tresse E, Kolaitis RM, Molliex A, Thomas RE, Alami NH, Wang B, Joshi A, Smith RB, Ritson GP, et al. VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron 2013; 78: 65-80; PMID: 23 49 8 9 74; http://dx.doi.org/10.1016/j. neuron.2013.02.029
    • (2013) Neuron , vol.78 , pp. 65-80
    • Kim, N.C.1    Tresse, E.2    Kolaitis, R.M.3    Molliex, A.4    Thomas, R.E.5    Alami, N.H.6    Wang, B.7    Joshi, A.8    Smith, R.B.9    Ritson, G.P.10
  • 110
    • 77952326081 scopus 로고    scopus 로고
    • Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy
    • PMID: 20457763
    • Lee JY, Nagano Y, Tay lor JP, Lim KL, Yao TP. Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol 2010; 189: 671-9; PMID: 20457763; http://dx.doi.org/10. 1083/jcb.201001039
    • (2010) J Cell Biol , vol.189 , pp. 671-679
    • Lee, J.Y.1    Nagano, Y.2    Taylor, J.P.3    Lim, K.L.4    Yao, T.P.5
  • 111
    • 78649300971 scopus 로고    scopus 로고
    • P62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitoph-agy; VDAC1 is dispensable for both
    • PMID: 20890124
    • Narendra D, Kane LA, Hauser DN, Fearnley IM, Youle RJ. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitoph-agy; VDAC1 is dispensable for both. Autophagy 2010; 6: 1090-106; PMID: 20890124; http://dx.doi.org/10.4161/auto.6.8.13426
    • (2010) Autophagy , vol.6 , pp. 1090-1106
    • Narendra, D.1    Kane, L.A.2    Hauser, D.N.3    Fearnley, I.M.4    Youle, R.J.5
  • 115
    • 82555187810 scopus 로고    scopus 로고
    • Image-based genome-wide siRNA screen identifies selective autophagy factors
    • PMID: 22020285
    • Orvedahl A, Sumpter R Jr., Xiao G, Ng A, Zou Z, Ta n g Y, Narimatsu M, Gilpin C, Sun Q, Roth M, et al. Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature 2011; 480: 113-7; PMID: 22020285; http://dx.doi.org/10.1038/nature10546
    • (2011) Nature , vol.480 , pp. 113-117
    • Orvedahl, A.1    Sumpter Jr., R.2    Xiao, G.3    Ng, A.4    Zou, Z.5    Tang, Y.6    Narimatsu, M.7    Gilpin, C.8    Sun, Q.9    Roth, M.10
  • 116
    • 84871426886 scopus 로고    scopus 로고
    • The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuli
    • PMID: 23140641
    • Lokireddy S, Wijesoma I W, Te n g S, Bonala S, Gluckman PD, McFarlane C, Sharma M, Kambadur R. The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuli. Cell Metab 2012; 16: 613-24; PMID: 23140641; http://dx.doi.org/10.1016/j.cmet.2012.10.005
    • (2012) Cell Metab , vol.16 , pp. 613-624
    • Lokireddy, S.1    Wijesoma, I.W.2    Teng, S.3    Bonala, S.4    Gluckman, P.D.5    McFarlane, C.6    Sharma, M.7    Kambadur, R.8
  • 118
    • 34548482499 scopus 로고    scopus 로고
    • SIRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy
    • DOI 10.1074/jbc.M703663200
    • Chan EY, Kir S, Tooze SA. siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem 2007; 282: 25464-74; PMID: 17595159; http://dx.doi.org/10.1074/jbc. M703663200 (Pubitemid 47372826)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.35 , pp. 25464-25474
    • Chan, E.Y.W.1    Kir, S.2    Tooze, S.A.3
  • 119
    • 58149473473 scopus 로고    scopus 로고
    • Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism
    • PMID: 1 8 9 3 615 7
    • Chan EY, Longatti A, McKnight NC, Tooze SA. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol 2009; 29: 15 7-71; PMID: 1 8 9 3 615 7; http://dx.doi.org/10.1128/MCB.01082-08
    • (2009) Mol Cell Biol , vol.29 , pp. 157-171
    • Chan, E.Y.1    Longatti, A.2    McKnight, N.C.3    Tooze, S.A.4
  • 122
    • 28444455308 scopus 로고    scopus 로고
    • Organelle degradation during the lens and erythroid differentiation is independent of autophagy
    • DOI 10.1016/j.bbrc.2005.11.044, PII S0006291X05025441
    • Matsui M, Yamamoto A, Kuma A, Ohsumi Y, Mizushima N. Organelle degradation during the lens and erythroid differentiation is independent of autophagy. Biochem Biophys Res Commun 2006; 339: 485-9; PMID: 16300732; http://dx.doi.org/10.1016/j.bbrc.2005.11.044 (Pubitemid 41739693)
    • (2006) Biochemical and Biophysical Research Communications , vol.339 , Issue.2 , pp. 485-489
    • Matsui, M.1    Yamamoto, A.2    Kuma, A.3    Ohsumi, Y.4    Mizushima, N.5
  • 123
    • 39749119904 scopus 로고    scopus 로고
    • FIP200, a key signaling node to coordinately regulate various cellular processes
    • DOI 10.1016/j.cellsig.2007.10.021, PII S0898656807003245
    • Gan B, Guan JL. FIP200, a key signaling node to coordinately regulate various cellular processes. Cell Signal 2008; 20: 787-94; PMID: 18036779; http://dx.doi.org/10.1016/j.cellsig.2007.10.021 (Pubitemid 351312869)
    • (2008) Cellular Signalling , vol.20 , Issue.5 , pp. 787-794
    • Gan, B.1    Guan, J.-L.2
  • 124
    • 43149090064 scopus 로고    scopus 로고
    • FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
    • DOI 10.1083/jcb.200712064
    • Hara T, Tak a mur a A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol 2008; 181: 497-510; PMID: 18443221; http://dx.doi.org/10.1083/jcb.200712064 (Pubitemid 351645039)
    • (2008) Journal of Cell Biology , vol.181 , Issue.3 , pp. 497-510
    • Hara, T.1    Takamura, A.2    Kishi, C.3    Iemura, S.-I.4    Natsume, T.5    Guan, J.-L.6    Mizushima, N.7
  • 125
    • 84874192375 scopus 로고    scopus 로고
    • FOXO3A directs a protective autophagy program in haematopoietic stem cells
    • PMID: 23389440
    • Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegué E. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature 2013; 494: 323-7; PMID: 23389440; http://dx.doi.org/10.1038/nature11895
    • (2013) Nature , vol.494 , pp. 323-327
    • Warr, M.R.1    Binnewies, M.2    Flach, J.3    Reynaud, D.4    Garg, T.5    Malhotra, R.6    Debnath, J.7    Passegué, E.8
  • 126
    • 84856800302 scopus 로고    scopus 로고
    • Role of AMPK-mTOR-Ulk1/2 in the regulation of auto-phagy: Cross talk shortcuts and feedbacks
    • PMID: 22025673
    • Alers S, Löffler AS, Wesselborg S, Stork B. Role of AMPK-mTOR-Ulk1/2 in the regulation of auto-phagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol 2012; 32: 2-11; PMID: 22025673; http://dx.doi. o r g/10.112 8/MC B. 0 6159-11
    • (2012) Mol Cell Biol , vol.32 , pp. 2-11
    • Alers, S.1    Löffler, A.S.2    Wesselborg, S.3    Stork, B.4
  • 127
    • 65249176304 scopus 로고    scopus 로고
    • ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy mach inery
    • PMID: 19225151
    • Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy mach inery. Mol Biol Cell 2009; 20: 1992-2003; PMID: 19225151; http://dx.doi.org/10.1091/ mbc. E08-12-1249
    • (2009) Mol Biol Cell , vol.20 , pp. 1992-2003
    • Jung, C.H.1    Jun, C.B.2    Ro, S.H.3    Kim, Y.M.4    Otto, N.M.5    Cao, J.6    Kundu, M.7    Kim, D.H.8
  • 128
    • 0032512636 scopus 로고    scopus 로고
    • Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
    • DOI 10.1074/jbc.273.7.3963
    • Noda T, Ohsumi Y. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem 19 9 8; 273: 3963-6; PMID: 9 4 615 8 3; http://dx.doi.org/10.1074/jbc.273.7.3963 (Pubitemid 28103257)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.7 , pp. 3963-3966
    • Noda, T.1    Ohsumi, Y.2
  • 129
    • 4344563878 scopus 로고    scopus 로고
    • Role and regulation of starvation-induced autophagy in the Drosophila fat body
    • DOI 10.1016/j.devcel.2004.07.009, PII S153458070400245X
    • Scott RC, Schuldiner O, Neufeld TP. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell 2004; 7: 167-78; PMID: 152 9 67 14; http://dx.doi.org/10.1016/j. devcel.2004.07.009 (Pubitemid 39145023)
    • (2004) Developmental Cell , vol.7 , Issue.2 , pp. 167-178
    • Scott, R.C.1    Schuldiner, O.2    Neufeld, T.P.3
  • 130
    • 84860840558 scopus 로고    scopus 로고
    • Mitochondrial diseases
    • PMID: 22482939
    • Schapira AH. Mitochondrial diseases. Lancet 2012; 379: 1825-34; PMID: 22482939; http://dx.doi.org/10.1016/S0140-6736(11)61305-6
    • (2012) Lancet , vol.379 , pp. 1825-1834
    • Schapira, A.H.1
  • 131
    • 34548686839 scopus 로고    scopus 로고
    • Hematological manifestations of primary mitochondrial disorders
    • DOI 10.1159/000105676
    • Finsterer J. Hematological manifestations of primary mitochondrial disorders. Acta Haematol 2007; 118: 88-98; PMID: 17637511; http://dx.doi.org/10. 1159/000105676 (Pubitemid 47413792)
    • (2007) Acta Haematologica , vol.118 , Issue.2 , pp. 88-98
    • Finsterer, J.1
  • 132
    • 0032533927 scopus 로고    scopus 로고
    • MtDNA mutations associated with sideroblastic anaemia cause a defect of mitochondrial cytochrome c oxidase
    • DOI 10.1046/j.1432-1327.1998.2580132.x
    • Bröker S, Meunier B, Rich P, Gattermann N, Hofhaus G. MtDNA mutations associated with sideroblastic anaemia cause a defect of mito-chondrial cytochrome c oxidase. Eur J Biochem 19 98; 258: 132-8; PMID: 9 851701; http://dx.doi.org/10.1046/j.1432-1327.1998.2580132.x (Pubitemid 28538317)
    • (1998) European Journal of Biochemistry , vol.258 , Issue.1 , pp. 132-138
    • Broker, S.1    Meunier, B.2    Rich, P.3    Gattermann, N.4    Hofhaus, G.5
  • 133
    • 84858153637 scopus 로고    scopus 로고
    • Congenital sideroblastic anemias: Iron and heme lost in mitochondrial translation
    • PMID: 22160084
    • Fleming MD. Congenital sideroblastic anemias: iron and heme lost in mitochondrial translation. Hematology Am Soc Hematol Educ Program 2011; 2011: 525-31; PMID: 22160084; http://dx.doi.org/10.1182/a sheduc at ion-2011.1.525
    • (2011) Hematology Am Soc Hematol Educ Program , vol.2011 , pp. 525-531
    • Fleming, M.D.1
  • 134
    • 79953211019 scopus 로고
    • Mitochondrial DNA deletion syndromes
    • Pagon RA, Adam MP, Bird TD, Dolan CR, Fong CT, Stephens K, eds. Seattle (WA)
    • DiMauro S, Hirano M. Mitochondrial DNA Deletion Syndromes. In: Pagon RA, Adam MP, Bird TD, Dolan CR, Fong CT, Stephens K, eds. GeneReviews. Seattle (WA), 1993
    • (1993) GeneReviews
    • Dimauro, S.1    Hirano, M.2
  • 135
    • 84880702851 scopus 로고    scopus 로고
    • Barth syndrome
    • PMID: 23843353
    • Jefferies JL. Barth syndrome. Am J Med Genet C Semin Med Genet 2013; 163C: 198-205; PMID: 23843353; http://dx.doi.org/10.1002/a jm g.c.31372
    • (2013) Am J Med Genet C Semin Med Genet , vol.163 C , pp. 198-205
    • Jefferies, J.L.1
  • 136
    • 84856951239 scopus 로고    scopus 로고
    • Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition
    • PMID: 22080835
    • Gilkerson RW, De Vries RL, Lebot P, Wikstrom JD, Torgyekes E, Shirihai OS, Przedborski S, Schon EA. Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition. Hum Mol Genet 2012; 21: 978-90; PMID: 22080835; http://dx.doi.org/ 10.1093/hmg/ddr529
    • (2012) Hum Mol Genet , vol.21 , pp. 978-990
    • Gilkerson, R.W.1    De Vries, R.L.2    Lebot, P.3    Wikstrom, J.D.4    Torgyekes, E.5    Shirihai, O.S.6    Przedborski, S.7    Schon, E.A.8
  • 137
    • 33845807882 scopus 로고    scopus 로고
    • Enhanced growth of myelodysplastic colonies in hypoxic conditions
    • DOI 10.1016/j.exphem.2006.08.017, PII S0301472X06005509
    • Thompson JE, Conlon JP, Yang X, Sanchez PV, Carroll M. Enhanced growth of myelodysplas-tic colonies in hypoxic conditions. Exp Hematol 2007; 35: 21-31; PMID: 17198870; http://dx.doi.org/10.1016/j.exphem.2006.08.017 (Pubitemid 46014366)
    • (2007) Experimental Hematology , vol.35 , Issue.1 , pp. 21-31
    • Thompson, J.E.1    Conlon, J.P.2    Yang, X.3    Sanchez, P.V.4    Carroll, M.5
  • 138
    • 79956266039 scopus 로고    scopus 로고
    • Impaired mitochondrial gene transcription in myelodysplas-tic syndromes and acute myeloid leukemia with myelodysplasia-related changes
    • e1; PMID: 21447369
    • Schildgen V, Wulfert M, Gattermann N. Impaired mitochondrial gene transcription in myelodysplas-tic syndromes and acute myeloid leukemia with myelodysplasia-related changes. Exp Hematol 2 011; 39: 666-75, e1; PMID: 21447369; http://dx.doi.org/10.1016/j.exphem.2011.03.007
    • (2011) Exp Hematol , vol.39 , pp. 666-675
    • Schildgen, V.1    Wulfert, M.2    Gattermann, N.3
  • 139
    • 81555216957 scopus 로고    scopus 로고
    • The epigenomics revolution in myelodysplasia: A clinico-pathological perspective
    • PMID 21881538
    • Tan PT, Wei AH. The epigenomics revolution in myelodysplasia: a clinico-pathological perspective. Pathology 2011; 43: 536-46; PMID: 218 81538
    • (2011) Pathology , vol.43 , pp. 536-546
    • Tan, P.T.1    Wei, A.H.2
  • 140
    • 42249112646 scopus 로고    scopus 로고
    • Analysis of mitochondrial DNA in 104 patients with myelodysplastic syndromes
    • DOI 10.1016/j.exphem.2008.01.004, PII S0301472X08000209
    • Wulfert M, Küpper AC, Tapprich C, Bottomley SS, Bowen D, Germing U, Haas R, Gattermann N. Analysis of mitochondrial DNA in 104 patients with myelodysplastic syndromes. Exp Hematol 2008; 36: 577-86; PMID: 18439489; http://dx.doi.org/10.1016/j.exphem.2008.01.004 (Pubitemid 351551472)
    • (2008) Experimental Hematology , vol.36 , Issue.5 , pp. 577-586
    • Wulfert, M.1    Kupper, A.C.2    Tapprich, C.3    Bottomley, S.S.4    Bowen, D.5    Germing, U.6    Haas, R.7    Gattermann, N.8
  • 141
    • 1542615082 scopus 로고    scopus 로고
    • Comprehensive Scanning of Somatic Mitochondrial DNA Alterations in Acute Leukemia Developing from Myelodysplastic Syndromes
    • DOI 10.1158/0008-5472.CAN-03-2956
    • Linnartz B, Anglmayer R, Zanssen S. Comprehensive scanning of somatic mitochondrial DNA alterations in acute leukemia developing from myelodys-plastic syndromes. Cancer Res 2004; 64: 1966-71; PMID: 15026331; http://dx.doi.org/10. 1158/0008-5472.CAN-03-2956 (Pubitemid 38339441)
    • (2004) Cancer Research , vol.64 , Issue.6 , pp. 1966-1971
    • Linnartz, B.1    Anglmayer, R.2    Zanssen, S.3
  • 142
    • 0034142678 scopus 로고    scopus 로고
    • From sideroblastic anemia to the role of mitochondrial DNA mutations in myelo-dysplastic syndromes
    • PMID: 10654450
    • Gattermann N. From sideroblastic anemia to the role of mitochondrial DNA mutations in myelo-dysplastic syndromes. Leuk Res 2000; 24: 141-51; PMID: 10654450; http://dx.doi.org/10.1016/S0145-2126(99)00160-5
    • (2000) Leuk Res , vol.24 , pp. 141-151
    • Gattermann, N.1
  • 143
    • 84875391007 scopus 로고    scopus 로고
    • Inosine Triphosphate Pyrophosphohydrolase (ITPA) polymorphic sequence variants in adult hematological malignancy patients and possible association with mitochondrial DNA defects
    • PMID: 23547827
    • Zamzami MA, Duley JA, Price GR, Venter DJ, Yarham JW, Taylor RW, Catley LP, Florin TH, Marinaki AM, Bowling F. Inosine Triphosphate Pyrophosphohydrolase (ITPA) polymorphic sequence variants in adult hematological malignancy patients and possible association with mitochondrial DNA defects. J Hematol Oncol 2013; 6: 24; PMID: 23547827; http://dx.doi.org/10.1186/1756-8722-6-24
    • (2013) J Hematol Oncol , vol.6 , pp. 24
    • Zamzami, M.A.1    Duley, J.A.2    Price, G.R.3    Venter, D.J.4    Yarham, J.W.5    Taylor, R.W.6    Catley, L.P.7    Florin, T.H.8    Marinaki, A.M.9    Bowling, F.10
  • 144
    • 79958241183 scopus 로고    scopus 로고
    • NMR-based metabolomic analysis of the molecular pathogenesis of therapy-related myelodysplasia/acute myeloid leukemia
    • PMID: 21510650
    • Cano KE, Li L, Bhatia S, Bhatia R, Forman SJ, Chen Y. NMR-based metabolomic analysis of the molecular pathogenesis of therapy-related myelodysplasia/acute myeloid leukemia. J Proteome Res 2011; 10: 2873-81; PMID: 21510650; http://dx.doi.org/10.1021/pr200200y
    • (2011) J Proteome Res , vol.10 , pp. 2873-2881
    • Cano, K.E.1    Li, L.2    Bhatia, S.3    Bhatia, R.4    Forman, S.J.5    Chen, Y.6
  • 145
    • 81255162528 scopus 로고    scopus 로고
    • A ltered hematopoietic cell gene expression precedes development of therapy-related myelodysplasia/acute myeloid leukemia and identifies patients at risk
    • PMID: 22094254
    • Li L, Li M, Sun C, Francisco L, Chakraborty S, Sabado M, McDonald T, Gyorffy J, Chang K, Wang S, et al. A ltered hematopoietic cell gene expression precedes development of therapy-related myelodysplasia/acute myeloid leukemia and identifies patients at risk. Cancer Cell 2011; 20: 591-605; PMID: 22094254; http://dx.doi.org/10.1016/j.ccr.2011.09.011
    • (2011) Cancer Cell , vol.20 , pp. 591-605
    • Li, L.1    Li, M.2    Sun, C.3    Francisco, L.4    Chakraborty, S.5    Sabado, M.6    McDonald, T.7    Gyorffy, J.8    Chang, K.9    Wang, S.10
  • 146
    • 67349201057 scopus 로고    scopus 로고
    • Erythroid precursors from patients with low-risk myelodysplasia demonstrate ultrastructural features of enhanced auto-phagy of mitochondria
    • PMID: 19148135
    • Houwerzijl EJ, Pol H W, Blom NR, van der Want JJ, de Wolf JT, Velleng a E. Erythroid precursors from patients with low-risk myelodysplasia demonstrate ultrastructural features of enhanced auto-phagy of mitochondria. Leukemia 2009; 23: 886-91; PMID: 19148135; http://dx.doi.org/10.1038/leu.2008.389
    • (2009) Leukemia , vol.23 , pp. 886-891
    • Houwerzijl, E.J.1    Pol, H.W.2    Blom, N.R.3    Van Der Want, J.J.4    De Wolf, J.T.5    Vellenga, E.6
  • 147
    • 0035075298 scopus 로고    scopus 로고
    • Mitochondrial disruption and limited apoptosis of erythroblasts are associated with high risk myelodysplasia. An ultrastructural analysis
    • DOI 10.1016/S0145-2126(00)00151-X, PII S014521260000151X
    • van de Loosdrecht AA, Brada SJ, Blom NR, Hendriks DW, Smit JW, van den Berg E, de Wolf JT, Vel leng a E. Mitochondrial disruption and limited apoptosis of erythroblasts are associated with high risk myelo-dysplasia. An ultrastructural analysis. Leuk Res 2001; 25: 385-93; PMID: 1130110 6; http://dx.doi.org/10.1016/S0145-2126(00)00151-X (Pubitemid 32294283)
    • (2001) Leukemia Research , vol.25 , Issue.5 , pp. 385-393
    • Van De Loosdrecht, A.A.1    Brada, S.J.L.2    Blom, N.R.3    Hendriks, D.W.4    Smit, J.W.5    Van Den Berg, E.6    De Wolf, J.Th.M.7    Vellenga, E.8
  • 149
    • 79955469664 scopus 로고    scopus 로고
    • Autophagy: Limiting factors
    • PMID: 21508966
    • McCarthy N. Autophagy: limiting factors. Nat Rev Cancer 2 011; 11: 313; PMID: 215 0 8 9 6 6; http://dx.doi.org/10.1038/nrc3054
    • (2011) Nat Rev Cancer , vol.11 , pp. 313
    • McCarthy, N.1
  • 152
    • 33750284176 scopus 로고    scopus 로고
    • Autophagy in cancer: Good, bad, or both?
    • PMID: 17018585
    • Hippert MM, O ' To o l e PS, Thorburn A. Autophagy in cancer: good, bad, or both? Cancer Res 2006; 66: 9349-51; PMID: 17018585; http://dx.doi.org/10. 1158/0008-5472.CAN-06-1597
    • (2006) Cancer Res , vol.66 , pp. 9349-9351
    • Hippert, M.M.1    O'Toole, P.S.2    Thorburn, A.3
  • 153
    • 79957883170 scopus 로고    scopus 로고
    • The multiple roles of auto-phagy in cancer
    • PMID 21317301
    • Rosenfeldt MT, Ryan KM. The multiple roles of auto-phagy in cancer. Carcinogenesis 2011; 32: 955-63; PMID: 213173 01; http://dx.doi.org/10.1093/ carcin/bgr031
    • (2011) Carcinogenesis , vol.32 , pp. 955-963
    • Rosenfeldt, M.T.1    Ryan, K.M.2
  • 154
    • 34347404887 scopus 로고    scopus 로고
    • Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
    • DOI 10.1101/gad.1565707
    • Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S, White E. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 2007; 21: 1621-35; PMID: 17606641; http://dx.doi.org/ 10.1101/g ad.1565707 (Pubitemid 47026367)
    • (2007) Genes and Development , vol.21 , Issue.13 , pp. 1621-1635
    • Karantza-Wadsworth, V.1    Patel, S.2    Kravchuk, O.3    Chen, G.4    Mathew, R.5    Jin, S.6    White, E.7
  • 159
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigen-esis
    • PMID: 16843265
    • Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gélinas C, Fan Y, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigen-esis. Cancer Cell 2006; 10: 51-64; PMID: 16843265; http://dx.doi.org/10.1016/j.ccr.2006.06.001
    • (2006) Cancer Cell , vol.10 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3    Bray, K.4    Anderson, D.5    Chen, G.6    Mukherjee, C.7    Shi, Y.8    Gélinas, C.9    Fan, Y.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.