Mitochondrial disruption and limited apoptosis of erythroblasts are associated with high risk myelodysplasia. An ultrastructural analysis

Leukemia Research

Volumn 25, Issue 5, 2001, Pages 385-393

  Van De Loosdrecht, Arjan A ^a,c   Brada, Simo J L ^a   Blom, Nel R ^a   Hendriks, Dick W ^a   Smit, Jan W ^a   Van Den Berg, Eva ^b   De Wolf, Joost Th M ^a   Vellenga, Edo ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apoptosis; Erythroblasts; Mitochondria; Myelodysplasia; Ultrastructure

Indexed keywords

ADULT; AGED; APOPTOSIS; ARTICLE; CHRONIC MYELOMONOCYTIC LEUKEMIA; CLASSIFICATION; CLINICAL ARTICLE; CYTOGENETICS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON MICROSCOPY; ERYTHROBLAST; ERYTHROPOIESIS; FEMALE; HUMAN; HUMAN CELL; KARYOTYPE; MALE; MYELODYSPLASIA; PATHOGENESIS; PRIORITY JOURNAL; REFRACTORY ANEMIA;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; ERYTHROBLASTS; FEMALE; HUMANS; KARYOTYPING; MALE; MIDDLE AGED; MITOCHONDRIA; MYELODYSPLASTIC SYNDROMES; PROGNOSIS;

EID: 0035075298     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(00)00151-X     Document Type: Article

References (38)

1. Ineffective haemopoiesis and apoptosis in myelodysplastic syndromes
2. Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes
3. Apoptosis in bone marrow of myelodysplastic syndrome patients
4. Is apoptosis a massive process in myelodysplastic syndromes?
5. Cell cycle kinetic studies in 68 patients with myelodysplastic syndromes following intravenous iodo-bromodeoxyuridine
6. - sorted bone marrow cells of myelodysplasia patients
7. - cells from myelodysplasia patients have a limited capacity to proliferate but can differentiate in response to Epo and MGF stimulation
8. Ultrastructural observations on bone marrow cells of 26 patients with myelodysplastic syndromes
9. Incidence and role of apoptosis in myelodysplastic syndrome: morphological and ultrastructural assessment
10. Ultrastructural abnormalities of bone marrow erythroblasts in refractory anemia
11. Proposals for the classification of the myelodysplastic syndromes
12. International scoring system for evaluating prognosis in myelodysplastic syndromes
13. Apoptosis in TNF-α dependent monocyte mediated leukemic cell death. A functional, morphologic and flow-cytometric analysis
14. Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells
15. Low-risk myelodysplastic syndrome is associated with excessive apoptosis and an increased ratio of pro- versus anti-apoptotic bcl-2-related proteins
16. - cells to undergo apoptosis in myelodysplastic marrows
17. Simultaneous assessment of cell kinetics and programmed cell death in bone marrow biposies of myelodysplastics reveals extensive apoptosis as the probable basis for ineffective hematopoiesis
18. Biological characteristics of myelodysplastic syndrome patient who demonstrated high versus no intramedullary apoptosis
19. Biologic characteristics of 164 patients with myelodysplastic syndromes
20. Evidence for involvement of tumor necrosis factor-alpha in apoptotic death of bone marrow cells in myelodysplastic syndromes
21. Fas/APO-1 (CD95) expression in myelodysplastic syndromes
22. Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia
23. A role for tumour necrosis factor-α, Fas and Fas-ligand in marrow failure associated with myelodysplastic syndrome
24. Apoptotic role of Fas/Fas-L ligand system in the regulation of erythropoiesis
25. Mitochondria and apoptosis
26. Mitochondrial control of apoptosis
27. Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition
28. MtDNA mutations associated with sideroblastic anaemia cause a defect of mitochondrial cytochrome c oxidase
29. Hetroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia
30. Mitochondria harbouring mutant mtDNA-a cuckoo in the nest?
31. Death receptors: signaling and modulation
32. Caspases: Enemies within
33. Actin cleavage by CPP-32/apopain during the development of apoptosis
34. Actin polymerization in neutrophils from patients affected by myelodysplastic syndromes-a flow cytometric study
35. Abnormalities of cytoskeletal proteins of red blood cells in myelodysplastic syndromes
36. Abnormal erythrocyte band 4.1 protein in myelodysplastic syndrome with elliptocytosis