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Volumn 114, Issue 19, 2009, Pages 4045-4053

Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction

Author keywords

[No Author keywords available]

Indexed keywords

PYRIMIDINE;

EID: 77950236668     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-08-169474     Document Type: Article
Times cited : (89)

References (49)
  • 1
    • 46749151451 scopus 로고    scopus 로고
    • Myelodysplastic syndromes
    • Nimer SD. Myelodysplastic syndromes. Blood. 2008;111(10):4841-4851.
    • (2008) Blood , vol.111 , Issue.10 , pp. 4841-4851
    • Nimer, S.D.1
  • 2
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281(5381):1309-1312.
    • (1998) Science , vol.281 , Issue.5381 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 3
    • 35448934364 scopus 로고    scopus 로고
    • Apoptosis and antiapoptotic mechanisms in the progression of myelodysplastic syndrome
    • Kerbauy DB, Deeg HJ. Apoptosis and antiapoptotic mechanisms in the progression of myelodysplastic syndrome. Exp Hematol. 2007;35(11):1739-1746.
    • (2007) Exp Hematol. , vol.35 , Issue.11 , pp. 1739-1746
    • Kerbauy, D.B.1    Deeg, H.J.2
  • 5
    • 0018712317 scopus 로고
    • A new syndrome of refractory sideroblastic anemia with vacuolization of marrow precursors and exocrine pancreatic dysfunction
    • Pearson HA, Lobel JS, Kocoshis SA, et al. A new syndrome of refractory sideroblastic anemia with vacuolization of marrow precursors and exocrine pancreatic dysfunction. J Pediatr. 1979;95(6):976-984.
    • (1979) J Pediatr. , vol.95 , Issue.6 , pp. 976-984
    • Pearson, H.A.1    Lobel, J.S.2    Kocoshis, S.A.3
  • 6
    • 0025133424 scopus 로고
    • Pearson's marrow-pancreas syndrome. a multisystem mitochondrial disorder in infancy
    • Rötig A, Cormier V, Blanche S, et al. Pearson's marrow-pancreas syndrome. A multisystem mitochondrial disorder in infancy. J Clin Invest. 1990;86(5):1601-1608.
    • (1990) J Clin Invest. , vol.86 , Issue.5 , pp. 1601-1608
    • Rötig, A.1    Cormier, V.2    Blanche, S.3
  • 7
    • 0014833832 scopus 로고
    • Reversible bone marrow suppression from chloramphenicol. a consequence of mitochondrial injury
    • Yunis AA, Smith US, Restrepo A. Reversible bone marrow suppression from chloramphenicol. A consequence of mitochondrial injury. Arch Intern Med. 1970;126(2):272-275.
    • (1970) Arch Intern Med. , vol.126 , Issue.2 , pp. 272-275
    • Yunis, A.A.1    Smith, U.S.2    Restrepo, A.3
  • 8
    • 27644538945 scopus 로고    scopus 로고
    • Linezolid-induced dyserythropoiesis: Chloramphenicol toxicity revisited
    • Dawson MA, Davis A, Elliott P, Cole-Sinclair M. Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited. Intern Med J. 2005;35(10):626-628.
    • (2005) Intern Med J. , vol.35 , Issue.10 , pp. 626-628
    • Dawson, M.A.1    Davis, A.2    Elliott, P.3    Cole-Sinclair, M.4
  • 9
    • 0030761388 scopus 로고    scopus 로고
    • Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides
    • Löffler M, Jockel J, Schuster G, Becker C. Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides. Mol Cell Biochem. 1997;174(1-2):125-129.
    • (1997) Mol Cell Biochem. , vol.174 , Issue.1-2 , pp. 125-129
    • Löffler, M.1    Jockel, J.2    Schuster, G.3    Becker, C.4
  • 10
    • 0033358580 scopus 로고    scopus 로고
    • Relaxed replication of mtDNA: A model with implications for the expression of disease
    • Chinnery PF, Samuels DC. Relaxed replication of mtDNA: a model with implications for the expression of disease. Am J Hum Genet. 1999;64(4):1158- 1165.
    • (1999) Am J Hum Genet. , vol.64 , Issue.4 , pp. 1158-1165
    • Chinnery, P.F.1    Samuels, D.C.2
  • 11
    • 0029587469 scopus 로고
    • Molecular genetic aspects of human mitochondrial disorders
    • Larsson NG, Clayton DA. Molecular genetic aspects of human mitochondrial disorders. Annu Rev Genet. 1995;29:151-178.
    • (1995) Annu Rev Genet. , vol.29 , pp. 151-178
    • Larsson, N.G.1    Clayton, D.A.2
  • 12
    • 0031467871 scopus 로고    scopus 로고
    • Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia
    • Gattermann N, Retzlaff S, Wang YL, et al. Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia. Blood. 1997;90(12):4961-4972.
    • (1997) Blood , vol.90 , Issue.12 , pp. 4961-4972
    • Gattermann, N.1    Retzlaff, S.2    Wang, Y.L.3
  • 13
    • 0842285640 scopus 로고    scopus 로고
    • Ineffective hematopoiesis linked with a mitochondrial tRNA mutation (G3242A) in a patient with myelodysplastic syndrome
    • Gattermann N, Wulfert M, Junge B, Germing U, Haas R, Hofhaus G. Ineffective hematopoiesis linked with a mitochondrial tRNA mutation (G3242A) in a patient with myelodysplastic syndrome. Blood. 2004;103(4):1499-1502.
    • (2004) Blood , vol.103 , Issue.4 , pp. 1499-1502
    • Gattermann, N.1    Wulfert, M.2    Junge, B.3    Germing, U.4    Haas, R.5    Hofhaus, G.6
  • 14
    • 0036180269 scopus 로고    scopus 로고
    • Increased incidence of mitochondrial cytochrome c-oxidase gene mutations in patients with myelodysplastic syndromes
    • Reddy PL, Shetty V, Dutt D, et al. Increased incidence of mitochondrial cytochrome c-oxidase gene mutations in patients with myelodysplastic syndromes. Br J Haematol. 2002;116(3):564-575.
    • (2002) Br J Haematol. , vol.116 , Issue.3 , pp. 564-575
    • Reddy, P.L.1    Shetty, V.2    Dutt, D.3
  • 15
    • 0038281403 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in patients with myelodysplastic syndromes
    • Shin MG, Kajigaya S, Levin BC, Young NS. Mitochondrial DNA mutations in patients with myelodysplastic syndromes. Blood. 2003;101(8):3118-3125.
    • (2003) Blood , vol.101 , Issue.8 , pp. 3118-3125
    • Shin, M.G.1    Kajigaya, S.2    Levin, B.C.3    Young, N.S.4
  • 16
    • 42249112646 scopus 로고    scopus 로고
    • Analysis of mitochondrial DNA in 104 patients with myelodysplastic syndromes
    • Wulfert M, Küpper AC, Tapprich C, et al. Analysis of mitochondrial DNA in 104 patients with myelodysplastic syndromes. Exp Hematol. 2008;36(5):577-586.
    • (2008) Exp Hematol. , vol.36 , Issue.5 , pp. 577-586
    • Wulfert, M.1    Küpper, A.C.2    Tapprich, C.3
  • 17
    • 2642580016 scopus 로고    scopus 로고
    • Premature ageing in mice expressing defective mitochondrial DNA polymerase
    • Trifunovic A, Wredenberg A, Falkenberg M, et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. 2004;429(6990):417- 423.
    • (2004) Nature , vol.429 , Issue.6990 , pp. 417-423
    • Trifunovic, A.1    Wredenberg, A.2    Falkenberg, M.3
  • 18
    • 22344456832 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
    • Kujoth GC, Hiona A, Pugh TD, et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science. 2005;309(5733):481-484.
    • (2005) Science , vol.309 , Issue.5733 , pp. 481-484
    • Kujoth, G.C.1    Hiona, A.2    Pugh, T.D.3
  • 19
    • 85047690518 scopus 로고    scopus 로고
    • Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia
    • Kong Y, Zhou S, Kihm AJ, et al. Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia. J Clin Invest. 2004;114(10):1457-1466.
    • (2004) J Clin Invest. , vol.114 , Issue.10 , pp. 1457-1466
    • Kong, Y.1    Zhou, S.2    Kihm, A.J.3
  • 20
    • 0028908916 scopus 로고
    • Longterm repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: In vivo expansion of stem cell phenotype but not function
    • Spangrude GJ, Brooks DM, Tumas DB. Longterm repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function. Blood. 1995;85(4):1006-1016.
    • (1995) Blood , vol.85 , Issue.4 , pp. 1006-1016
    • Spangrude, G.J.1    Brooks, D.M.2    Tumas, D.B.3
  • 21
    • 33745634866 scopus 로고    scopus 로고
    • Suppression of fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo
    • Liu Y, Pop R, Sadegh C, Brugnara C, Haase VH, Socolovsky M. Suppression of fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood. 2006;108(1):123-133.
    • (2006) Blood , vol.108 , Issue.1 , pp. 123-133
    • Liu, Y.1    Pop, R.2    Sadegh, C.3    Brugnara, C.4    Haase, V.H.5    Socolovsky, M.6
  • 23
    • 34247129126 scopus 로고    scopus 로고
    • Molecular insights into stress erythropoiesis
    • Socolovsky M. Molecular insights into stress erythropoiesis. Curr Opin Hematol. 2007;14(3):215-224.
    • (2007) Curr Opin Hematol. , vol.14 , Issue.3 , pp. 215-224
    • Socolovsky, M.1
  • 24
    • 0035760889 scopus 로고    scopus 로고
    • Ineffective erythropoiesis in Stat5a-/-5b-/- Mice due to decreased survival of early erythroblasts
    • Socolovsky M, Nam H, Fleming M, Haase V, Brugnara C, Lodish H. Ineffective erythropoiesis in Stat5a-/-5b-/- mice due to decreased survival of early erythroblasts. Blood. 2001;98(12):3261-3273.
    • (2001) Blood , vol.98 , Issue.12 , pp. 3261-3273
    • Socolovsky, M.1    Nam, H.2    Fleming, M.3    Haase, V.4    Brugnara, C.5    Lodish, H.6
  • 25
    • 4944261763 scopus 로고    scopus 로고
    • Prevalence of anemia in persons 65 years and older in the United States: Evidence for a high rate of unexplained anemia
    • Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104(8):2263-2268.
    • (2004) Blood , vol.104 , Issue.8 , pp. 2263-2268
    • Guralnik, J.M.1    Eisenstaedt, R.S.2    Ferrucci, L.3    Klein, H.G.4    Woodman, R.C.5
  • 26
    • 0026688084 scopus 로고
    • Age-related incidence and other epidemiological aspects of myelodysplastic syndromes
    • Aul C, Gattermann N, Schneider W. Age-related incidence and other epidemiological aspects of myelodysplastic syndromes. Br J Haematol. 1992;82(2):358-367.
    • (1992) Br J Haematol. , vol.82 , Issue.2 , pp. 358-367
    • Aul, C.1    Gattermann, N.2    Schneider, W.3
  • 28
    • 47249150213 scopus 로고    scopus 로고
    • Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs
    • Rollison DE, Howlader N, Smith MT, et al. Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs. Blood. 2008;112(1):45-52.
    • (2008) Blood , vol.112 , Issue.1 , pp. 45-52
    • Rollison, D.E.1    Howlader, N.2    Smith, M.T.3
  • 29
    • 77950435862 scopus 로고    scopus 로고
    • Accessed July 2
    • NIEHS - Mitochondrial DNA Replication Group. Human DNA polymerase gamma mutation database. http://tools.niehs.nih.gov/polg/. Accessed July 2, 2008.
    • (2008) Human DNA Polymerase Gamma Mutation Database
  • 30
    • 57849140614 scopus 로고    scopus 로고
    • Molecular and clinical genetics of mitochondrial diseases due to POLG mutations
    • Wong LC, Naviaux RK, Brunetti-Pierri N, et al. Molecular and clinical genetics of mitochondrial diseases due to POLG mutations. Hum Mutat. 2008;29(9):E150-E172.
    • (2008) Hum Mutat. , vol.29 , Issue.9
    • Wong, L.C.1    Naviaux, R.K.2    Brunetti-Pierri, N.3
  • 32
    • 33947407724 scopus 로고    scopus 로고
    • A new disease categorization of low-grade myelodysplastic syndromes based on the expression of cytopenia and dysplasia in one versus more than one lineage improves on the WHO classification
    • Verburgh E, Achten R, Louw VJ, et al. A new disease categorization of low-grade myelodysplastic syndromes based on the expression of cytopenia and dysplasia in one versus more than one lineage improves on the WHO classification. Leukemia. 2007;21(4):668-677.
    • (2007) Leukemia , vol.21 , Issue.4 , pp. 668-677
    • Verburgh, E.1    Achten, R.2    Louw, V.J.3
  • 33
    • 27644572272 scopus 로고    scopus 로고
    • Evidence for reduced B-cell progenitors in early (lowrisk) myelodysplastic syndrome
    • Sternberg A, Killick S, Littlewood T, et al. Evidence for reduced B-cell progenitors in early (lowrisk) myelodysplastic syndrome. Blood. 2005;106(9):2982-2991.
    • (2005) Blood , vol.106 , Issue.9 , pp. 2982-2991
    • Sternberg, A.1    Killick, S.2    Littlewood, T.3
  • 35
    • 38949196414 scopus 로고    scopus 로고
    • Identification of distinct prognostic subgroups in low- And intermediate-1-risk myelodysplastic syndromes by flow cytometry
    • van de Loosdrecht AA, Westers TM, Westra AH, Drager AM, van der Velden VHJ, Ossenkoppele GJ. Identification of distinct prognostic subgroups in low- and intermediate-1-risk myelodysplastic syndromes by flow cytometry. Blood. 2008;111(3):1067-1077.
    • (2008) Blood , vol.111 , Issue.3 , pp. 1067-1077
    • Van De Loosdrecht, A.A.1    Westers, T.M.2    Westra, A.H.3    Drager, A.M.4    Van Der Velden, V.H.J.5    Ossenkoppele, G.J.6
  • 36
    • 0041940300 scopus 로고    scopus 로고
    • Increased apoptosis in bone marrow B lymphocytes but not T lymphocytes in myelodysplastic syndrome
    • Amin HM, Jilani I, Estey EH, et al. Increased apoptosis in bone marrow B lymphocytes but not T lymphocytes in myelodysplastic syndrome. Blood. 2003;102(5):1866-1868.
    • (2003) Blood , vol.102 , Issue.5 , pp. 1866-1868
    • Amin, H.M.1    Jilani, I.2    Estey, E.H.3
  • 37
    • 0036400123 scopus 로고    scopus 로고
    • Molecular and flow cytometric characterization of the CD4 and CD8 T-cell repertoire in patients with myelodysplastic syndrome
    • Melenhorst JJ, Eniafe R, Follmann D, Nakamura R, Kirby M, Barrett AJ. Molecular and flow cytometric characterization of the CD4 and CD8 T-cell repertoire in patients with myelodysplastic syndrome. Br J Haematol. 2002;119(1):97-105.
    • (2002) Br J Haematol. , vol.119 , Issue.1 , pp. 97-105
    • Melenhorst, J.J.1    Eniafe, R.2    Follmann, D.3    Nakamura, R.4    Kirby, M.5    Barrett, A.J.6
  • 38
    • 0036660179 scopus 로고    scopus 로고
    • Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice
    • Kogan SC, Ward JM, Anver MR, et al. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood. 2002;100(1):238-245.
    • (2002) Blood , vol.100 , Issue.1 , pp. 238-245
    • Kogan, S.C.1    Ward, J.M.2    Anver, M.R.3
  • 39
    • 10644281151 scopus 로고    scopus 로고
    • On the pathogenesis of erythroleukaemia (H0493)
    • Parry TE. On the pathogenesis of erythroleukaemia (H0493). Leuk Res. 2005;29(2):119-121.
    • (2005) Leuk Res. , vol.29 , Issue.2 , pp. 119-121
    • Parry, T.E.1
  • 40
    • 0016759430 scopus 로고
    • Characterization of ineffective erythropoiesis in erythroleukaemia
    • Queisser W, Pepperl U, Kempgens U, Muller U. Characterization of ineffective erythropoiesis in erythroleukaemia. Acta Haematol. 1975;54(2):65-74.
    • (1975) Acta Haematol. , vol.54 , Issue.2 , pp. 65-74
    • Queisser, W.1    Pepperl, U.2    Kempgens, U.3    Muller, U.4
  • 41
    • 0014324904 scopus 로고
    • Coexistence of pernicious anaemia and acute erythraemic myelosis
    • Riddell EM, Davidson RJL. Coexistence of pernicious anaemia and acute erythraemic myelosis. J Clin Pathol. 1968;21(5):590-594.
    • (1968) J Clin Pathol. , vol.21 , Issue.5 , pp. 590-594
    • Riddell, E.M.1    Davidson, R.J.L.2
  • 42
    • 0035003371 scopus 로고    scopus 로고
    • Concurrent pernicious anemia and myelodysplastic syndrome
    • Drabick JJ, Davis BJ, Byrd JC. Concurrent pernicious anemia and myelodysplastic syndrome. Ann Hematol. 2001;80(4):243-245.
    • (2001) Ann Hematol. , vol.80 , Issue.4 , pp. 243-245
    • Drabick, J.J.1    Davis, B.J.2    Byrd, J.C.3
  • 43
    • 0022389993 scopus 로고
    • Cobalamin inactivation decreases purine and methionine synthesis in cultured lymphoblasts
    • Boss GR. Cobalamin inactivation decreases purine and methionine synthesis in cultured lymphoblasts. J Clin Invest. 1985;76(1):213-218.
    • (1985) J Clin Invest. , vol.76 , Issue.1 , pp. 213-218
    • Boss, G.R.1
  • 44
    • 0025834082 scopus 로고
    • Folate-deficient human lymphoblasts: Changes in deoxynucleotide metabolism and thymidylate cycle activities
    • van der Weyden MB, Hayman RJ, Rose IS, Brumley J. Folate-deficient human lymphoblasts: changes in deoxynucleotide metabolism and thymidylate cycle activities. Eur J Haematol. 1991;47:109.
    • (1991) Eur J Haematol. , vol.47 , pp. 109
    • Van Der Weyden, M.B.1    Hayman, R.J.2    Rose, I.S.3    Brumley, J.4
  • 45
    • 0034329261 scopus 로고    scopus 로고
    • Apoptosis in megaloblastic anemia occurs during DNA synthesis by a p53-independent, nucleoside-reversible mechanism
    • Koury MJ, Price JO, Hicks GG. Apoptosis in megaloblastic anemia occurs during DNA synthesis by a p53-independent, nucleoside-reversible mechanism. Blood. 2000;96(9):3249-3255.
    • (2000) Blood , vol.96 , Issue.9 , pp. 3249-3255
    • Koury, M.J.1    Price, J.O.2    Hicks, G.G.3
  • 46
    • 0742282012 scopus 로고    scopus 로고
    • Severe impairment of nucleotide synthesis through inhibition of mitochondrial respiration
    • Gattermann N, Dadak M, Hofhaus G, et al. Severe impairment of nucleotide synthesis through inhibition of mitochondrial respiration. Nucleosides Nucleotides Nucleic Acids. 2004;23(8-9):1275-1279.
    • (2004) Nucleosides Nucleotides Nucleic Acids , vol.23 , Issue.8-9 , pp. 1275-1279
    • Gattermann, N.1    Dadak, M.2    Hofhaus, G.3
  • 47
    • 35348827253 scopus 로고    scopus 로고
    • Pancytopenia, including macrocytic anemia, associated with leflunomide in a rheumatoid arthritis patient
    • Toyokawa Y, Kingetsu I, Yasuda C, et al. Pancytopenia, including macrocytic anemia, associated with leflunomide in a rheumatoid arthritis patient. Mod Rheumatol. 2007;17(5):436-440.
    • (2007) Mod Rheumatol. , vol.17 , Issue.5 , pp. 436-440
    • Toyokawa, Y.1    Kingetsu, I.2    Yasuda, C.3
  • 48
    • 0032804664 scopus 로고    scopus 로고
    • Mechanism of action for leflunomide in rheumatoid arthritis
    • Fox RI, Herrmann ML, Frangou CG, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999;93(3):198-208.
    • (1999) Clin Immunol. , vol.93 , Issue.3 , pp. 198-208
    • Fox, R.I.1    Herrmann, M.L.2    Frangou, C.G.3
  • 49
    • 0022804866 scopus 로고
    • Myelodysplastic syndromes: Natural history and features of prognostic importance
    • Mufti GJ, Galton DA. Myelodysplastic syndromes: natural history and features of prognostic importance. Clin Haematol. 1986;15(4):953-971.
    • (1986) Clin Haematol. , vol.15 , Issue.4 , pp. 953-971
    • Mufti, G.J.1    Galton, D.A.2


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