FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function

EMBO Journal

Volumn 30, Issue 22, 2011, Pages 4554-4570

  Jensen, Kim Steen ^a   Binderup, Tina ^b,c   Jensen, Klaus Thorleif ^a   Therkelsen, Ib ^c   Borup, Rehannah ^d   Nilsson, Elise ^e   Multhaupt, Hinke ^a   Bouchard, Caroline ^f   Quistorff, Bjørn ^c   Kjr, Andreas ^b,c   Landberg, Göran ^e,g   Staller, Peter ^a,h  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e LUND UNIVERSITY   (Sweden)

^f PHILIPPS UNIVERSITY MARBURG   (Germany)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

^h EpiTherapeutics   (Denmark)

Author keywords

FoxO3A; hypoxia; metabolism; mitochondrion; Myc

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; MYC PROTEIN; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR FKHRL1;

ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; GENE REPRESSION; GLYCOLYSIS; HUMAN; HUMAN TISSUE; HYPOXIA; METABOLISM; MITOCHONDRIAL GENE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN BINDING; STRESS; XENOGRAFT;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; FORKHEAD TRANSCRIPTION FACTORS; GENES, MITOCHONDRIAL; GLYCOLYSIS; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, NUDE; MITOCHONDRIA; NEOPLASM TRANSPLANTATION; OXYGEN; OXYGEN CONSUMPTION; PROTO-ONCOGENE PROTEINS C-MYC; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; STRESS, PHYSIOLOGICAL; TRANSPLANTATION, HETEROLOGOUS;

METAZOA;

EID: 81255195809     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.323     Document Type: Article

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