Altered Hematopoietic Cell Gene Expression Precedes Development of Therapy-Related Myelodysplasia/Acute Myeloid Leukemia and Identifies Patients at Risk

Cancer Cell

Volumn 20, Issue 5, 2011, Pages 591-605

  Li, Liang ^a   Li, Min ^a   Sun, Canlan ^a   Francisco, Liton ^a   Chakraborty, Sujata ^a   Sabado, Melanie ^a   McDonald, Tinisha ^a   Gyorffy, Janelle ^a   Chang, Karen ^a   Wang, Shirong ^a   Fan, Wenhong ^b   Li, Jiangning ^b   Zhao, Lue Ping ^b   Radich, Jerald ^b   Forman, Stephen ^a   Bhatia, Smita ^a   Bhatia, Ravi ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; CELL CYCLE REGULATION; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; LYMPHOMA; MYELODYSPLASTIC SYNDROME; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

EID: 81255162528     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccr.2011.09.011     Document Type: Article

References (41)

1. Abruzzese E., Radford J.E., Miller J.S., Vredenburgh J.J., Rao P.N., Pettenati M.J., Cruz J.M., Perry J.J., Amadori S., Hurd D.D. Detection of abnormal pretransplant clones in progenitor cells of patients who developed myelodysplasia after autologous transplantation. Blood 1999, 94:1814-1819.
2. Ben-Yehuda D., Krichevsky S., Caspi O., Rund D., Polliack A., Abeliovich D., Zelig O., Yahalom V., Paltiel O., Or R., et al. Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype. Blood 1996, 88:4296-4303.
3. Bhatia R., Van Heijzen K., Palmer A., Komiya A., Slovak M.L., Chang K.L., Fung H., Krishnan A., Molina A., Nademanee A., et al. Longitudinal assessment of hematopoietic abnormalities after autologous hematopoietic cell transplantation for lymphoma. J. Clin. Oncol. 2005, 23:6699-6711.
4. Bhatia S., Ramsay N.K., Steinbuch M., Dusenbery K.E., Shapiro R.S., Weisdorf D.J., Robison L.L., Miller J.S., Neglia J.P. Malignant neoplasms following bone marrow transplantation. Blood 1996, 87:3633-3639.
5. Chakraborty S., Sun C.L., Francisco L., Sabado M., Li L., Chang K.L., Forman S., Bhatia S., Bhatia R. Accelerated telomere shortening precedes development of therapy-related myelodysplasia or acute myelogenous leukemia after autologous transplantation for lymphoma. J. Clin. Oncol. 2009, 27:791-798.
6. Chen H.Z., Tsai S.Y., Leone G. Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat. Rev. Cancer 2009, 9:785-797.
7. Colburn N.H., Kensler T.W. Targeting transcription factors for cancer prevention-the case of Nrf2. Cancer Prev. Res. (Phila.) 2008, 1:153-155.
8. Ebert B.L., Pretz J., Bosco J., Chang C.Y., Tamayo P., Galili N., Raza A., Root D.E., Attar E., Ellis S.R., Golub T.R. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature 2008, 451:335-339.
9. Faber P., Fisch P., Waterhouse M., Schmitt-Gräff A., Bertz H., Finke J., Spyridonidis A. Frequent genomic alterations in epithelium measured by microsatellite instability following allogeneic hematopoietic cell transplantation in humans. Blood 2006, 107:3389-3396.
10. Feldser D.M., Greider C.W. Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell 2007, 11:461-469.
11. Fumagalli S., Di Cara A., Neb-Gulati A., Natt F., Schwemberger S., Hall J., Babcock G.F., Bernardi R., Pandolfi P.P., Thomas G. Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction. Nat. Cell Biol. 2009, 11:501-508.
12. Grivennikova V.G., Vinogradov A.D. Generation of superoxide by the mitochondrial Complex I. Biochim. Biophys. Acta 2006, 1757:553-561.
13. Gupta R., Soupir C.P., Johari V., Hasserjian R.P. Myelodysplastic syndrome with isolated deletion of chromosome 20q: an indolent disease with minimal morphological dysplasia and frequent thrombocytopenic presentation. Br. J. Haematol. 2007, 139:265-268.
14. Han J.Y., Theil K.S. Karyotypic identification of abnormal clones preceding morphological changes or occurring with no definite morphological features of myelodysplastic syndrome: a preliminary study. Lab. Hematol. 2007, 13:17-21.
15. Harper J.W., Elledge S.J. The DNA damage response: ten years after. Mol. Cell 2007, 28:739-745.
16. Ito K., Hirao A., Arai F., Matsuoka S., Takubo K., Hamaguchi I., Nomiyama K., Hosokawa K., Sakurada K., Nakagata N., et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 2004, 431:997-1002.
17. Kalaycio M., Rybicki L., Pohlman B., Sobecks R., Andresen S., Kuczkowski E., Bolwell B. Risk factors before autologous stem-cell transplantation for lymphoma predict for secondary myelodysplasia and acute myelogenous leukemia. J. Clin. Oncol. 2006, 24:3604-3610.
18. Kang J., Shakya A., Tantin D. Stem cells, stress, metabolism and cancer: a drama in two Octs. Trends Biochem. Sci. 2009, 34:491-499.
19. Kastan M.B., Bartek J. Cell-cycle checkpoints and cancer. Nature 2004, 432:316-323.
20. Kinner A., Wu W., Staudt C., Iliakis G. Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res. 2008, 36:5678-5694.
21. Kowaltowski A.J., de Souza-Pinto N.C., Castilho R.F., Vercesi A.E. Mitochondria and reactive oxygen species. Free Radic. Biol. Med. 2009, 47:333-343.
22. Krishnan A., Bhatia S., Slovak M.L., Arber D.A., Niland J.C., Nademanee A., Fung H., Bhatia R., Kashyap A., Molina A., et al. Predictors of therapy-related leukemia and myelodysplasia following autologous transplantation for lymphoma: an assessment of risk factors. Blood 2000, 95:1588-1593.
23. Lenka N., Vijayasarathy C., Mullick J., Avadhani N.G. Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex. Prog. Nucleic Acid Res. Mol. Biol. 1998, 61:309-344.
24. Litzow M.R., Tarima S., Pérez W.S., Bolwell B.J., Cairo M.S., Camitta B.M., Cutler C.S., de Lima M., Dipersio J.F., Gale R.P., et al. Allogeneic transplantation for therapy-related myelodysplastic syndrome and acute myeloid leukemia. Blood 2010, 115:1850-1857.
25. Mason P.J. Stem cells, telomerase and dyskeratosis congenita. Bioessays 2003, 25:126-133.
26. Miller J.S., Arthur D.C., Litz C.E., Neglia J.P., Miller W.J., Weisdorf D.J. Myelodysplastic syndrome after autologous bone marrow transplantation: an additional late complication of curative cancer therapy. Blood 1994, 83:3780-3786.
27. Nugent S.M., Mothersill C.E., Seymour C., McClean B., Lyng F.M., Murphy J.E. Increased mitochondrial mass in cells with functionally compromised mitochondria after exposure to both direct gamma radiation and bystander factors. Radiat. Res. 2007, 168:134-142.
28. Oehler V.G., Yeung K.Y., Choi Y.E., Bumgarner R.E., Raftery A.E., Radich J.P. The derivation of diagnostic markers of chronic myeloid leukemia progression from microarray data. Blood 2009, 114:3292-3298.
29. Osburn W.O., Kensler T.W. Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat. Res. 2008, 659:31-39.
30. Pedersen-Bjergaard J. Insights into leukemogenesis from therapy-related leukemia. N. Engl. J. Med. 2005, 352:1591-1594.
31. Pedersen-Bjergaard J., Andersen M.K., Christiansen D.H. Therapy-related acute myeloid leukemia and myelodysplasia after high-dose chemotherapy and autologous stem cell transplantation. Blood 2000, 95:3273-3279.
32. Pedersen-Bjergaard J., Andersen M.T., Andersen M.K. Genetic pathways in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia. Hematology (Am. Soc. Hematol. Educ. Program) 2007, 392-397.
33. Qian Z., Fernald A.A., Godley L.A., Larson R.A., Le Beau M.M. Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia. Proc. Natl. Acad. Sci. USA 2002, 99:14925-14930.
34. Raponi M., Dossey L., Jatkoe T., Wu X., Chen G., Fan H., Beer D.G. MicroRNA classifiers for predicting prognosis of squamous cell lung cancer. Cancer Res. 2009, 69:5776-5783.
35. Rassool F.V., Gaymes T.J., Omidvar N., Brady N., Beurlet S., Pla M., Reboul M., Lea N., Chomienne C., Thomas N.S., et al. Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia?. Cancer Res. 2007, 67:8762-8771.
36. Stone R.M., Neuberg D., Soiffer R., Takvorian T., Whelan M., Rabinowe S.N., Aster J.C., Leavitt P., Mauch P., Freedman A.S., et al. Myelodysplastic syndrome as a late complication following autologous bone marrow transplantation for non-Hodgkin's lymphoma. J. Clin. Oncol. 1994, 12:2535-2542.
37. Subramanian A., Tamayo P., Mootha V.K., Mukherjee S., Ebert B.L., Gillette M.A., Paulovich A., Pomeroy S.L., Golub T.R., Lander E.S., Mesirov J.P. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 2005, 102:15545-15550.
38. Tolkovsky A.M. Mitophagy. Biochim. Biophys. Acta 2009, 1793:1508-1515.
39. Tothova Z., Kollipara R., Huntly B.J., Lee B.H., Castrillon D.H., Cullen D.E., McDowell E.P., Lazo-Kallanian S., Williams I.R., Sears C., et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007, 128:325-339.
40. Wagner P.D., Verma M., Srivastava S. Challenges for biomarkers in cancer detection. Ann. N Y Acad. Sci. 2004, 1022:9-16.
41. Wallace D.C. Mitochondria and cancer: Warburg addressed. Cold Spring Harb. Symp. Quant. Biol. 2005, 70:363-374.