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Volumn 43, Issue 6, 2011, Pages 536-546

The epigenomics revolution in myelodysplasia: A clinico-pathological perspective

Author keywords

Azacitidine; Epigenetic; Hypomethylating; Methylation; Myelodysplastic syndrome

Indexed keywords


EID: 81555216957     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1097/PAT.0b013e32834a4061     Document Type: Article
Times cited : (10)

References (136)
  • 1
    • 47249150213 scopus 로고    scopus 로고
    • Epidemiology of myelodys-plastic syndromes and chronic myeloproliferative disorders in the United States 2001-2004 using data from the NAACCR and SEER programs
    • Rollison DE, Howlader N, Smith MT, et al. Epidemiology of myelodys-plastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs. Blood 2008; 112: 45-52.
    • (2008) Blood , vol.112 , pp. 45-52
    • Rollison, D.E.1    Howlader, N.2    Smith, M.T.3
  • 2
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 2009; 10: 223-32.
    • (2009) Lancet Oncol , vol.10 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3
  • 3
    • 0022540321 scopus 로고
    • CpG-rich islands and the function of DNA methylation
    • Bird AP. Cp G-rich islands and the function of DNA methylation. Nature 1986; 321: 209-13. (Pubitemid 16016411)
    • (1986) Nature , vol.321 , Issue.6067 , pp. 209-213
    • Bird, A.P.1
  • 5
    • 0345357773 scopus 로고    scopus 로고
    • Gene Silencing in Cancer in Association with Promoter Hypermethylation
    • DOI 10.1056/NEJMra023075
    • Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003; 349: 2042-54. (Pubitemid 37448928)
    • (2003) New England Journal of Medicine , vol.349 , Issue.21 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 6
    • 31344460650 scopus 로고    scopus 로고
    • Optimizing therapy with methylation inhibitors in myelodysplas-tic syndromes: Dose, duration, and patient selection
    • Issa JP. Optimizing therapy with methylation inhibitors in myelodysplas-tic syndromes: dose, duration, and patient selection. Nat Clin Pract Oncol 2005; 2 (Suppl 1): S24-9.
    • (2005) Nat Clin Pract Oncol , vol.2 , Issue.SUPPL. 1
    • Issa, J.P.1
  • 9
    • 0021011844 scopus 로고
    • In vivo demethylation of chicken embryonic beta-type globin genes with 5-azacytidine
    • Ginder GD, Whitters M, Kelley K, Chase RA. In vivo demethylation of chicken embryonic beta-type globin genes with 5-azacytidine. Prog Clin Biol Res 1983; 134: 501-10.
    • (1983) Prog Clin Biol Res , vol.134 , pp. 501-510
    • Ginder, G.D.1    Whitters, M.2    Kelley, K.3    Chase, R.A.4
  • 10
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • Jones PA, Taylor SM. Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980; 20: 85-93. (Pubitemid 10117303)
    • (1980) Cell , vol.20 , Issue.1 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 12
    • 0019375555 scopus 로고
    • The inhibition of DNA(cytosine-5)methylases by 5-azacytidine. The effect of azacytosine-containing DNA
    • Friedman S. The inhibition of DNA(cytosine-5)methylases by 5-azacy-tidine. The effect of azacytosine-containing DNA. Mol Pharmacol 1981; 19: 314-20. (Pubitemid 11004237)
    • (1981) Molecular Pharmacology , vol.19 , Issue.2 , pp. 314-320
    • Friedman, S.1
  • 14
    • 33748474416 scopus 로고    scopus 로고
    • Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: Studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B
    • DOI 10.1200/JCO.2005.05.4346
    • Silverman LR, Mc Kenzie DR, Peterson BL, et al. Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and9221 bythe Cancer and Leukemia Group B.J Clin Oncol 2006; 24: 3895-903. (Pubitemid 46630737)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.24 , pp. 3895-3903
    • Silverman, L.R.1    McKenzie, D.R.2    Peterson, B.L.3    Holland, J.F.4    Backstrom, J.T.5    Beach, C.L.6    Larson, R.A.7
  • 16
    • 68949145132 scopus 로고    scopus 로고
    • Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: The alternative dosing for outpatient treatment (ADOPT) trial
    • Steensma DP, Baer MR, Slack JL, et al. Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the alternative dosing for outpatient treatment (ADOPT) trial. J Clin Oncol 2009; 27: 3842-8.
    • (2009) J Clin Oncol , vol.27 , pp. 3842-3848
    • Steensma, D.P.1    Baer, M.R.2    Slack, J.L.3
  • 17
    • 33845505652 scopus 로고    scopus 로고
    • Low-dose decitabine and high-risk MDS
    • author reply 91-2
    • Raza A, Raza FZ, Galili N. Low-dose decitabine and high-risk MDS. Blood 2006; 108: 4291; author reply 91-2.
    • (2006) Blood , vol.108 , pp. 4291
    • Raza, A.1    Raza, F.Z.2    Galili, N.3
  • 19
    • 33646071894 scopus 로고    scopus 로고
    • Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study
    • Kantarjian H, Issa JP, Rosenfeld CS, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer2006; 106: 1794-803.
    • (2006) Cancer , vol.106 , pp. 1794-1803
    • Kantarjian, H.1    Issa, J.P.2    Rosenfeld, C.S.3
  • 20
    • 79956294708 scopus 로고    scopus 로고
    • Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk mye-lodysplastic syndrome (MDS) ineligible for intensive chemotherapy: Final results of the randomized Phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group
    • Lubbert M, Suciu S, Baila L, et al. Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk mye-lodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized Phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group. J Clin Oncol 2011; 29: 1987-96.
    • (2011) J Clin Oncol , vol.29 , pp. 1987-1996
    • Lubbert, M.1    Suciu, S.2    Baila, L.3
  • 21
    • 67349200930 scopus 로고    scopus 로고
    • The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells
    • Flotho C, Claus R, Batz C, et al. The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia 2009; 23: 1019-28.
    • (2009) Leukemia , vol.23 , pp. 1019-1028
    • Flotho, C.1    Claus, R.2    Batz, C.3
  • 22
    • 77749302093 scopus 로고    scopus 로고
    • A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines
    • Hollenbach PW, Nguyen AN, Brady H, et al. A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines. PLo S One 2010; 5: e9001.
    • (2010) PLo S One , vol.5
    • Hollenbach, P.W.1    Nguyen, A.N.2    Brady, H.3
  • 23
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin Modifications and Their Function
    • DOI 10.1016/j.cell.2007.02.005, PII S0092867407001845
    • Kouzarides T Chromatin modifications and their function. Cell 2007; 128: 693-705. (Pubitemid 46273577)
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 24
    • 38449100788 scopus 로고    scopus 로고
    • Expression profile of class i histone deacetylases in human cancer tissues
    • Nakagawa M, Oda Y, Eguchi T, et al. Expression profile of class I histone deacetylases in human cancer tissues. Oncol Rep 2007; 18: 769-74.
    • (2007) Oncol Rep , vol.18 , pp. 769-774
    • Nakagawa, M.1    Oda, Y.2    Eguchi, T.3
  • 25
    • 0032546017 scopus 로고    scopus 로고
    • Role of the histone deacetylase complex in acute promyelocytic leukaemia
    • DOI 10.1038/35895
    • Lin RJ, Nagy L, Inoue S, Shao W, Miller WH Jr, Evans RM. Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 1998; 391: 811-4. (Pubitemid 28099682)
    • (1998) Nature , vol.391 , Issue.6669 , pp. 811-814
    • Lin, R.J.1    Nagy, L.2    Inoue, S.3    Shao, W.4    Miller Jr., W.H.5    Evans, R.M.6
  • 26
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • DOI 10.1038/30764
    • Nan X, Ng HH, Johnson CA, et al. Transcriptional repression by the methyl-Cp G-binding protein Me CP2 involves a histone deacetylase com-plex. Nature 1998; 393: 386-9. (Pubitemid 28269714)
    • (1998) Nature , vol.393 , Issue.6683 , pp. 386-389
    • Nan, X.1    Ng, H.-H.2    Johnson, C.A.3    Laherty, C.D.4    Turner, B.M.5    Eisenman, R.N.6    Bird, A.7
  • 28
    • 0019952276 scopus 로고
    • Proposals for the classification of the myelodysplastic syndromes
    • Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982; 51: 189-99. (Pubitemid 12073508)
    • (1982) British Journal of Haematology , vol.51 , Issue.2 , pp. 189-199
    • Bennett, J.M.1    Catovsky, D.2    Daniel, M.T.3
  • 32
    • 54949128600 scopus 로고    scopus 로고
    • Effect of azacitidine (AZA) on overall survival in higher-risk myelodysplastic syndromes (MDS) without com-plete remission
    • List AF, Fenaux P, Mufti GJ, et al. Effect of azacitidine (AZA) on overall survival in higher-risk myelodysplastic syndromes (MDS) without com-plete remission. ASCO Meeting Abstracts 2008; 26: 7006.
    • (2008) ASCO Meeting Abstracts , vol.26 , pp. 7006
    • List, A.F.1    Fenaux, P.2    Mufti, G.J.3
  • 34
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
    • Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009; 114: 937-51.
    • (2009) Blood , vol.114 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3
  • 35
    • 41949135951 scopus 로고    scopus 로고
    • Time-dependent prognostic scoring system for myelodysplastic syndromes has significant limitations that may influence its reproducibility and practical application
    • author reply 81-2
    • Bowen DT, Fenaux P, Hellstrom-Lindberg E, de Witte T. Time-dependent prognostic scoring system for myelodysplastic syndromes has significant limitations that may influence its reproducibility and practical application. J Clin Oncol 2008; 26: 1180; author reply 81-2.
    • (2008) J Clin Oncol , vol.26 , pp. 1180
    • Bowen, D.T.1    Fenaux, P.2    Hellstrom-Lindberg, E.3    De Witte, T.4
  • 36
    • 83055173257 scopus 로고    scopus 로고
    • 14 Revised International Prognostic Scoring System (IPSS-R) developed by the International Prognostic Working Group for Prognosis in MDS (IWG-PM)
    • Greenberg P, Tuechler H, Schanz J, et al. 14 Revised International Prognostic Scoring System (IPSS-R), developed by the International Prognostic Working Group for Prognosis in MDS (IWG-PM). Leukemia Res 2011; 35: S6-16.
    • (2011) Leukemia Res , vol.35
    • Greenberg, P.1    Tuechler, H.2    Schanz, J.3
  • 37
    • 84855930296 scopus 로고    scopus 로고
    • Proposal of a new, comprehensive cytogenetic scoring system for primary MDS
    • Schanz J, Tüchler H, Sole F, et al. Proposal of a new, comprehensive cytogenetic scoring system for primary MDS. Haematologica 2010; 95: 219.
    • (2010) Haematologica , vol.95 , pp. 219
    • Schanz, J.1    Tüchler, H.2    Sole, F.3
  • 38
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • DOI 10.1146/annurev.biochem.74.010904.153721
    • Goll MG, Bestor TH. Eukaryotic cytosine methyltransferases. Annu Rev Biochem 2005; 74: 481-514. (Pubitemid 40995515)
    • (2005) Annual Review of Biochemistry , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 39
    • 2342557977 scopus 로고    scopus 로고
    • A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
    • Yang AS, Estecio MR, Doshi K, Kondo Y, Tajara EH, Issa JP. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res 2004; 32: e38.
    • (2004) Nucleic Acids Res , vol.32
    • Yang, A.S.1    Estecio, M.R.2    Doshi, K.3    Kondo, Y.4    Tajara, E.H.5    Issa, J.P.6
  • 41
    • 0020489781 scopus 로고
    • Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells
    • Ehrlich M, Gama-Sosa MA, Huang LH, et al. Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res 1982; 10: 2709-21.
    • (1982) Nucleic Acids Res , vol.10 , pp. 2709-2721
    • Ehrlich, M.1    Gama-Sosa, M.A.2    Huang, L.H.3
  • 43
    • 70450217879 scopus 로고    scopus 로고
    • Human DNA methylomes at base resolution show widespread epigenomic differences
    • Lister R, Pelizzola M, Dowen RH, et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 2009; 462: 315-22.
    • (2009) Nature , vol.462 , pp. 315-322
    • Lister, R.1    Pelizzola, M.2    Dowen, R.H.3
  • 44
    • 0026546877 scopus 로고
    • A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
    • Frommer M, Mc Donald LE, Millar DS, et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci USA 1992; 89: 1827-31.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1827-1831
    • Frommer, M.1    Mc Donald, L.E.2    Millar, D.S.3
  • 45
    • 49649125042 scopus 로고    scopus 로고
    • Genome-scale DNA methylation maps of pluripotent and differentiated cells
    • Meissner A, Mikkelsen TS, Gu H, et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 2008; 454: 766-70.
    • (2008) Nature , vol.454 , pp. 766-770
    • Meissner, A.1    Mikkelsen, T.S.2    Gu, H.3
  • 46
    • 23044514626 scopus 로고    scopus 로고
    • Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
    • DOI 10.1038/ng1598
    • Weber M, Davies JJ, Wittig D, et al. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet 2005; 37: 853-62. (Pubitemid 41077111)
    • (2005) Nature Genetics , vol.37 , Issue.8 , pp. 853-862
    • Weber, M.1    Davies, J.J.2    Wittig, D.3    Oakeley, E.J.4    Haase, M.5    Lam, W.L.6    Schubeler, D.7
  • 47
    • 39149133183 scopus 로고    scopus 로고
    • Methyl-DNA immunoprecipitation (Me DIP): Hunting down the DNA methylome
    • 37, 39
    • Jacinto FV, Ballestar E, Esteller M. Methyl-DNA immunoprecipitation (Me DIP): hunting down the DNA methylome. Biotechniques 2008; 44: 35; 37, 39.
    • (2008) Biotechniques , vol.44 , pp. 35
    • Jacinto, F.V.1    Ballestar, E.2    Esteller, M.3
  • 48
    • 77449127799 scopus 로고    scopus 로고
    • MBD-isolated Genome Sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome
    • Serre D, Lee BH, Ting AH. MBD-isolated Genome Sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome. Nucleic Acids Res 2010; 38: 391-9.
    • (2010) Nucleic Acids Res , vol.38 , pp. 391-399
    • Serre, D.1    Lee, B.H.2    Ting, A.H.3
  • 49
    • 84856306090 scopus 로고    scopus 로고
    • Genome-wide DNA methylation profiling using Infinium assay
    • Bibikova M, Le J, Barnes B, et al. Genome-wide DNA methylation profiling using Infinium assay. Epigenomics 2009; 1: 177-200.
    • (2009) Epigenomics , vol.1 , pp. 177-200
    • Bibikova, M.1    Le Barnes, J.B.2
  • 55
    • 42449142344 scopus 로고    scopus 로고
    • Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): High-throughput and probe-free quantitative DNA methylation detection
    • Kristensen LS, Mikeska T, Krypuy M, Dobrovic A. Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection. Nucleic Acids Res 2008; 36: e42.
    • (2008) Nucleic Acids Res , vol.36
    • Kristensen, L.S.1    Mikeska, T.2    Krypuy, M.3    Dobrovic, A.4
  • 56
    • 0030825309 scopus 로고    scopus 로고
    • COBRA: A sensitive and quantitative DNA methylation assay
    • DOI 10.1093/nar/25.12.2532
    • Xiong Z, Laird PW. COBRA: a sensitive and quantitative DNA methyla-tion assay. Nucleic Acids Res 1997; 25: 2532-4. (Pubitemid 27303718)
    • (1997) Nucleic Acids Research , vol.25 , Issue.12 , pp. 2532-2534
    • Xiong, Z.1    Laird, P.W.2
  • 57
    • 0038678777 scopus 로고    scopus 로고
    • Sensitive and quantitative universal Pyrosequencing™ methylation analysis of CpG sites
    • Colella S, Shen L, Baggerly KA, Issa JP, Krahe R. Sensitive and quantitative universal Pyrosequencing methylation analysis of Cp G sites. Biotechniques 2003; 35: 146-50. (Pubitemid 36828724)
    • (2003) BioTechniques , vol.35 , Issue.1 , pp. 146-150
    • Colella, S.1    Shen, L.2    Baggerly, K.A.3    Issa, J.-P.J.4    Krahe, R.5
  • 59
    • 34247849498 scopus 로고    scopus 로고
    • Methylation-sensitive high resolution melting (MS-HRM): A new approach for sensitive and high-throughput assessment of methylation
    • Wojdacz TK, Dobrovic A. Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation. Nucleic Acids Res 2007; 35: e41.
    • (2007) Nucleic Acids Res , vol.35
    • Wojdacz, T.K.1    Dobrovic, A.2
  • 60
    • 68149157845 scopus 로고    scopus 로고
    • Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: Application to the CDKN2B (p15) gene
    • Candiloro IL, Mikeska T, Hokland P, Dobrovic A. Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: application to the CDKN2B (p15) gene. Epigenetics Chromatin 2008; 1: 7.
    • (2008) Epigenetics Chromatin , vol.1 , pp. 7
    • Candiloro, I.L.1    Mikeska, T.2    Hokland, P.3    Dobrovic, A.4
  • 64
    • 0035134705 scopus 로고    scopus 로고
    • INK4B gene in myelodysplastic syndrome: It can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation
    • DOI 10.1046/j.1365-2141.2001.02496.x
    • Tien HF, Tang JL, Tsay W, et al. Methylation of the p15INK4B gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transforma-tion. Br J Haem 2001; 112: 148-54. (Pubitemid 32151162)
    • (2001) British Journal of Haematology , vol.112 , Issue.1 , pp. 148-154
    • Tien, H.-F.1    Tang, J.-L.2    Tsay, W.3    Liu, M.-C.4    Lee, F.-Y.5    Wang, C.-H.6    Chen, Y.-C.7    Shen, M.-C.8
  • 65
    • 34548131144 scopus 로고    scopus 로고
    • CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine
    • DOI 10.1038/sj.leu.2404796, PII 2404796
    • Raj K, John A, Ho A, et al. CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine. Leukemia 2007; 21: 1937-44. (Pubitemid 47299967)
    • (2007) Leukemia , vol.21 , Issue.9 , pp. 1937-1944
    • Raj, K.1    John, A.2    Ho, A.3    Chronis, C.4    Khan, S.5    Samuel, J.6    Pomplun, S.7    Thomas, N.S.B.8    Mufti, G.J.9
  • 66
    • 33644878393 scopus 로고    scopus 로고
    • Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients
    • Aggerholm A, Holm MS, Guldberg P, Olesen LH, Hokland P. Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients. Eur J Haematol 2006; 76: 23-32.
    • (2006) Eur J Haematol , vol.76 , pp. 23-32
    • Aggerholm, A.1    Holm, M.S.2    Guldberg, P.3    Olesen, L.H.4    Hokland, P.5
  • 67
    • 77449149371 scopus 로고    scopus 로고
    • DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes
    • Shen L, Kantarjian H, Guo Y, et al. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol 2010; 28: 605-13.
    • (2010) J Clin Oncol , vol.28 , pp. 605-613
    • Shen, L.1    Kantarjian, H.2    Guo, Y.3
  • 68
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • DOI 10.1038/nrg2005, PII NRG2005
    • Esteller M. Cancer epigenomics: DNA methylomes and histone-modifi-cation maps. Nat Rev Genet 2007; 8: 286-98. (Pubitemid 46439286)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.4 , pp. 286-298
    • Esteller, M.1
  • 69
    • 60849089645 scopus 로고    scopus 로고
    • Aberrant DNA methylation is a dominant mechanism in MDS progression to AML
    • Jiang Y, Dunbar A, Gondek LP, et al. Aberrant DNA methylation is a dominant mechanism in MDS progression to AML. Blood 2009; 113: 1315-25.
    • (2009) Blood , vol.113 , pp. 1315-1325
    • Jiang, Y.1    Dunbar, A.2    Gondek, L.P.3
  • 70
    • 70350720044 scopus 로고    scopus 로고
    • MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
    • Figueroa ME, Skrabanek L, Li Y, et al. MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. Blood 2009; 114: 3448-58.
    • (2009) Blood , vol.114 , pp. 3448-3458
    • Figueroa, M.E.1    Skrabanek, L.2    Li, Y.3
  • 72
    • 0035862199 scopus 로고    scopus 로고
    • The human histone deacetylase family
    • DOI 10.1006/excr.2000.5080
    • Gray SG, Ekstrom TJ. The human histone deacetylase family. Exp Cell Res 2001; 262: 75-83. (Pubitemid 32980246)
    • (2001) Experimental Cell Research , vol.262 , Issue.2 , pp. 75-83
    • Gray, S.G.1    Ekstrom, T.J.2
  • 74
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5m C to 5hm C conversion ES-cell self-renewal and inner cell mass specification
    • Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y Role of Tet proteins in 5m C to 5hm C conversion, ES-cell self-renewal and inner cell mass specification. Nature 2010; 466: 1129-33.
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1    D'Alessio, A.C.2    Taranova, O.V.3    Hong, K.4    Sowers, L.C.5    Zhang, Y.6
  • 75
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani M, Koh KP, Shen Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009; 324: 930-5.
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3
  • 76
    • 69849110150 scopus 로고    scopus 로고
    • Novel TET2 mutations associated with UPD4q24 in myelodysplastic syndrome
    • Mohamedali AM, Smith AE, Gaken J, et al. Novel TET2 mutations associated with UPD4q24 in myelodysplastic syndrome. J Clin Oncol 2009; 27: 4002-6.
    • (2009) J Clin Oncol , vol.27 , pp. 4002-4006
    • Mohamedali, A.M.1    Smith, A.E.2    Gaken, J.3
  • 77
    • 67649876132 scopus 로고    scopus 로고
    • Acquired mutations in TET2 are common in myelodysplastic syndromes
    • Langemeijer SM, Kuiper RP, Berends M, et al. Acquired mutations in TET2 are common in myelodysplastic syndromes. Nat Genet 2009; 41: 838-42.
    • (2009) Nat Genet , vol.41 , pp. 838-842
    • Langemeijer, S.M.1    Kuiper, R.P.2    Berends, M.3
  • 78
    • 78149454504 scopus 로고    scopus 로고
    • Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value
    • Smith AE, Mohamedali AM, Kulasekararaj A, et al. Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value. Blood 2010; 116: 3923-32.
    • (2010) Blood , vol.116 , pp. 3923-3932
    • Smith, A.E.1    Mohamedali, A.M.2    Kulasekararaj, A.3
  • 80
    • 78650175023 scopus 로고    scopus 로고
    • Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    • Ko M, Huang Y, Jankowska AM, et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 2010; 468: 839-43.
    • (2010) Nature , vol.468 , pp. 839-843
    • Ko, M.1    Huang, Y.2    Jankowska, A.M.3
  • 81
    • 70350438115 scopus 로고    scopus 로고
    • TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)
    • Kosmider O, Gelsi-Boyer V, Cheok M, et al. TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs). Blood 2009; 114: 3285-91.
    • (2009) Blood , vol.114 , pp. 3285-3291
    • Kosmider, O.1    Gelsi-Boyer, V.2    Cheok, M.3
  • 82
    • 66849124925 scopus 로고    scopus 로고
    • Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia
    • Gelsi-Boyer V, Trouplin V, Adelaide J, et al. Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia. Br J Haematol 2009; 145: 788-800.
    • (2009) Br J Haematol , vol.145 , pp. 788-800
    • Gelsi-Boyer, V.1    Trouplin, V.2    Adelaide, J.3
  • 83
    • 79959317767 scopus 로고    scopus 로고
    • Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes
    • Thol F, Friesen I, Damm F, et al. Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes. J Clin Oncol 2011; 29: 2499-506.
    • (2011) J Clin Oncol , vol.29 , pp. 2499-2506
    • Thol, F.1    Friesen, I.2    Damm, F.3
  • 84
    • 79960406959 scopus 로고    scopus 로고
    • Polycomb complex group gene mutations and their prognostic relevance in 5-azacitidine treated myelodysplastic syndrome patients
    • Kulasekararaj AG, Mohamedali AM, Smith AE, et al. Polycomb complex group gene mutations and their prognostic relevance in 5-azacitidine treated myelodysplastic syndrome patients. Blood (ASHAnnual Meeting Abstracts) 2010; 116: 125.
    • (2010) Blood (ASHAnnual Meeting Abstracts) , vol.116 , pp. 125
    • Kulasekararaj, A.G.1    Mohamedali, A.M.2    Smith, A.E.3
  • 85
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • Paschka P, Schlenk RF, Gaidzik VI, et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol 2010; 28: 3636.
    • (2010) J Clin Oncol , vol.28 , pp. 3636
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3
  • 86
    • 77952426827 scopus 로고    scopus 로고
    • Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms
    • Kosmider O, Gelsi-Boyer V, Slama L, et al. Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms. Leukemia 2010; 24: 1094-6.
    • (2010) Leukemia , vol.24 , pp. 1094-1096
    • Kosmider, O.1    Gelsi-Boyer, V.2    Slama, L.3
  • 87
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 func-tion, and impair hematopoietic differentiation
    • Figueroa ME, Abdel-Wahab O, Lu C, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 func-tion, and impair hematopoietic differentiation. Cancer Cell 2010; 18: 553-67.
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3
  • 88
    • 78650306174 scopus 로고    scopus 로고
    • IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia
    • Caramazza D, Lasho TL, Finke CM, et al. IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia. Leukemia 2010; 24: 2120-2.
    • (2010) Leukemia , vol.24 , pp. 2120-2122
    • Caramazza, D.1    Lasho, T.L.2    Finke, C.M.3
  • 89
    • 77957806536 scopus 로고    scopus 로고
    • IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis
    • Thol F, Weissinger EM, Krauter J, et al. IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis. Haematologica 2010; 95: 1668-74.
    • (2010) Haematologica , vol.95 , pp. 1668-1674
    • Thol, F.1    Weissinger, E.M.2    Krauter, J.3
  • 90
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med 2010; 363: 2424-33.
    • (2010) N Engl J Med , vol.363 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 91
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan XJ, Xu J, Gu ZH, et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet 2011; 43: 309-15.
    • (2011) Nat Genet , vol.43 , pp. 309-315
    • Yan, X.J.1    Xu, J.2    Zh, G.3
  • 92
    • 79960255863 scopus 로고    scopus 로고
    • Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
    • Mar 18: Epub ahead of print
    • Walter MJ, Ding L, Shen D, et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia 2011; Mar 18: Epub ahead of print.
    • (2011) Leukemia
    • Walter, M.J.1    Ding, L.2    Shen, D.3
  • 94
    • 77955087290 scopus 로고    scopus 로고
    • Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
    • Nikoloski G, Langemeijer SM, Kuiper RP, et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat Genet 2010; 42: 665-7.
    • (2010) Nat Genet , vol.42 , pp. 665-667
    • Nikoloski, G.1    Langemeijer, S.M.2    Kuiper, R.P.3
  • 95
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst T, Chase AJ, Score J, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 2010; 42: 722-6.
    • (2010) Nat Genet , vol.42 , pp. 722-726
    • Ernst, T.1    Chase, A.J.2    Score, J.3
  • 96
    • 55949136562 scopus 로고    scopus 로고
    • Roles of the EZH2 histone methyltransferase in cancer epigenetics
    • Simon JA, Lange CA. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res 2008; 647: 21-9.
    • (2008) Mutat Res , vol.647 , pp. 21-29
    • Simon, J.A.1    Lange, C.A.2
  • 97
    • 70350494322 scopus 로고    scopus 로고
    • Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
    • Fiskus W, Wang Y, Sreekumar A, et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood 2009; 114: 2733-43.
    • (2009) Blood , vol.114 , pp. 2733-2743
    • Fiskus, W.1    Wang, Y.2    Sreekumar, A.3
  • 98
    • 78650172030 scopus 로고    scopus 로고
    • Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syn-dromes treated with azacitidine
    • Itzykson R, Thepot S, Quesnel B, et al. Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syn-dromes treated with azacitidine. Blood 2011; 117: 403-11.
    • (2011) Blood , vol.117 , pp. 403-411
    • Itzykson, R.1    Thepot, S.2    Quesnel, B.3
  • 99
    • 0037108309 scopus 로고    scopus 로고
    • Demethylation of a hyper-methylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment
    • Daskalakis M, Nguyen TT, Nguyen C, et al. Demethylation of a hyper-methylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment. Blood 2002; 100: 2957-64.
    • (2002) Blood , vol.100 , pp. 2957-2964
    • Daskalakis, M.1    Nguyen, T.T.2    Nguyen, C.3
  • 100
    • 33745714230 scopus 로고    scopus 로고
    • Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
    • Gore SD, Baylin S, Sugar E, et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res 2006; 66: 6361-9.
    • (2006) Cancer Res , vol.66 , pp. 6361-6369
    • Gore, S.D.1    Baylin, S.2    Sugar, E.3
  • 101
    • 70350506791 scopus 로고    scopus 로고
    • Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
    • Fandy TE, Herman JG, Kerns P, et al. Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. Blood 2009; 114: 2764-73.
    • (2009) Blood , vol.114 , pp. 2764-2773
    • Fandy, T.E.1    Herman, J.G.2    Kerns, P.3
  • 105
    • 33750530675 scopus 로고    scopus 로고
    • Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia
    • Garcia-Manero G, Kantarjian HM, Sanchez-Gonzalez B, et al. Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia. Blood 2006; 108: 3271-9.
    • (2006) Blood , vol.108 , pp. 3271-3279
    • Garcia-Manero, G.1    Kantarjian, H.M.2    Sanchez-Gonzalez, B.3
  • 106
    • 50849098153 scopus 로고    scopus 로고
    • Aberrant hypomethylation of the cancer-testis antigen PRAME correlates with PRAME expression in acute myeloid leukemia
    • Ortmann CA, Eisele L, Nuckel H, et al. Aberrant hypomethylation of the cancer-testis antigen PRAME correlates with PRAME expression in acute myeloid leukemia. Ann Hematol 2008; 87: 809-18.
    • (2008) Ann Hematol , vol.87 , pp. 809-818
    • Ortmann, C.A.1    Eisele, L.2    Nuckel, H.3
  • 108
    • 66149168684 scopus 로고    scopus 로고
    • Treatment of chronic lymphocytic leukemia with a hypomethy-lating agent induces expression of NXF2, an immunogenic cancer testis antigen
    • Dubovsky JA, Mc Neel DG, Powers JJ, Gordon J, Sotomayor EM, Pinilla-Ibarz JA. Treatment of chronic lymphocytic leukemia with a hypomethy-lating agent induces expression of NXF2, an immunogenic cancer testis antigen. Clin Cancer Res 2009; 15: 3406-15.
    • (2009) Clin Cancer Res , vol.15 , pp. 3406-3415
    • Dubovsky, J.A.1    Mc Neel, D.G.2    Powers, J.J.3    Gordon, J.4    Sotomayor, E.M.5    Pinilla-Ibarz, J.A.6
  • 109
    • 77956924038 scopus 로고    scopus 로고
    • Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia
    • Goodyear O, Agathanggelou A, Novitzky-Basso I, et al. Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia. Blood 2010; 116: 1908-18.
    • (2010) Blood , vol.116 , pp. 1908-1918
    • Goodyear, O.1    Agathanggelou, A.2    Novitzky-Basso, I.3
  • 110
    • 77957018936 scopus 로고    scopus 로고
    • Practical use of azacitidine in higher-risk myelodysplastic syndromes: An expertpanel opinion
    • Fenaux P, Bowen D, Gattermann N, et al. Practical use of azacitidine in higher-risk myelodysplastic syndromes: an expertpanel opinion. Leuk Res 2010; 34: 1410-6.
    • (2010) Leuk Res , vol.34 , pp. 1410-1416
    • Fenaux, P.1    Bowen, D.2    Gattermann, N.3
  • 112
    • 79960229916 scopus 로고    scopus 로고
    • Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias
    • Apr 15: Epub ahead of print
    • Itzykson R, Kosmider O, Cluzeau T, et al. Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias. Leukemia 2011; Apr 15: Epub ahead of print..
    • (2011) Leukemia
    • Itzykson, R.1    Kosmider, O.2    Cluzeau, T.3
  • 113
    • 79959318635 scopus 로고    scopus 로고
    • Phase i study of oral azacitidine in myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia
    • Garcia-Manero G, Gore SD, Cogle C, et al. Phase I study of oral azacitidine in myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia. J Clin Oncol 2011; 29: 2521-7.
    • (2011) J Clin Oncol , vol.29 , pp. 2521-2527
    • Garcia-Manero, G.1    Gore, S.D.2    Cogle, C.3
  • 114
    • 33846122993 scopus 로고    scopus 로고
    • Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug
    • DOI 10.1038/nbt1272, PII NBT1272
    • Marks PA, Breslow R. Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat Biotechnol 2007; 25: 84-90. (Pubitemid 46087907)
    • (2007) Nature Biotechnology , vol.25 , Issue.1 , pp. 84-90
    • Marks, P.A.1    Breslow, R.2
  • 115
    • 73949149251 scopus 로고    scopus 로고
    • Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
    • Piekarz RL, Frye R, Turner M, et al. Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. J Clin Oncol 2009; 27: 5410-7.
    • (2009) J Clin Oncol , vol.27 , pp. 5410-5417
    • Piekarz, R.L.1    Frye, R.2    Turner, M.3
  • 116
    • 79952977561 scopus 로고    scopus 로고
    • Phase II trial of romidepsin in patients with peripheral T-cell lymphoma
    • Piekarz RL, Frye R, Prince HM, et al. Phase II trial of romidepsin in patients with peripheral T-cell lymphoma. Blood 2011; 117: 5827-34.
    • (2011) Blood , vol.117 , pp. 5827-5834
    • Piekarz, R.L.1    Frye, R.2    Prince, H.M.3
  • 117
    • 79751528245 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia
    • Quintas-Cardama A, Santos FP, Garcia-Manero G. Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia. Leukemia 2011; 25: 226-35.
    • (2011) Leukemia , vol.25 , pp. 226-235
    • Quintas-Cardama, A.1    Santos, F.P.2    Garcia-Manero, G.3
  • 118
    • 4444309863 scopus 로고    scopus 로고
    • Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid
    • DOI 10.1182/blood-2003-12-4333
    • Kuendgen A, Strupp C, Aivado M, et al. Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid. Blood 2004; 104: 1266-9. (Pubitemid 39166498)
    • (2004) Blood , vol.104 , Issue.5 , pp. 1266-1269
    • Kuendgen, A.1    Strupp, C.2    Aivado, M.3    Bernhardt, A.4    Hildebrandt, B.5    Haas, R.6    Germing, U.7    Gattermann, N.8
  • 119
    • 51649110503 scopus 로고    scopus 로고
    • Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia
    • Garcia-Manero G, Assouline S, Cortes J, et al. Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia. Blood 2008; 112: 981-9.
    • (2008) Blood , vol.112 , pp. 981-989
    • Garcia-Manero, G.1    Assouline, S.2    Cortes, J.3
  • 121
    • 67449109154 scopus 로고    scopus 로고
    • Phase IA/II study of oral panobinostat (LBH589) a novel pan-deacetylase inhibitor (DACi) de-monstrating efficacy in patients with advanced hematologic malignancies
    • Ottmann OG, Spencer A, Prince HM, et al. Phase IA/II study of oral panobinostat (LBH589), a novel pan-deacetylase inhibitor (DACi) de-monstrating efficacy in patients with advanced hematologic malignancies. Blood (ASHAnnual Meeting Abstracts) 2008; 112: 958.
    • (2008) Blood (ASHAnnual Meeting Abstracts) , vol.112 , pp. 958
    • Ottmann, O.G.1    Spencer, A.2    Prince, H.M.3
  • 123
    • 33645083241 scopus 로고    scopus 로고
    • Six (or more) drugs in search of a mechanism: DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes
    • Gore SD. Six (or more) drugs in search of a mechanism: DNA methyl-transferase and histone deacetylase inhibitors in the treatment of myelo-dysplastic syndromes. J Natl Compr Canc Netw 2006; 4: 83-90. (Pubitemid 44265383)
    • (2006) JNCCN Journal of the National Comprehensive Cancer Network , vol.4 , Issue.1 , pp. 83-90
    • Gore, S.D.1
  • 124
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re- expression of genes silenced in cancer
    • DOI 10.1038/5047
    • Cameron EE, Bachman KE, Myohanen S, Herman JG, Baylin SB. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 1999; 21: 103-7. (Pubitemid 29036293)
    • (1999) Nature Genetics , vol.21 , Issue.1 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 125
    • 83055168502 scopus 로고    scopus 로고
    • Phase Ib study of oral panobinostat in combination with 5-azacitidine (5-aza) in patients with myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML), or acute myeloid leukemia (AML)
    • Fenaux P, De Angelo DJ, Garcia-Manero G, et al. Phase Ib study of oral panobinostat in combination with 5-azacitidine (5-aza) in patients with myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML), or acute myeloid leukemia (AML). Blood (ASH Annual Meet-ing Abstracts) 2010; 116: 4957.
    • (2010) Blood (ASH Annual Meet-ing Abstracts) , vol.116 , pp. 4957
    • Fenaux, P.1    De Angelo, D.J.2    Garcia-Manero, G.3
  • 126
    • 79959636015 scopus 로고    scopus 로고
    • Phase i study of panobinostat plus decitabine in elderly patients with advanced MDS or AML
    • Uy GL, Abboud CN, Cashen AF, et al. Phase I study of panobinostat plus decitabine in elderly patients with advanced MDS or AML. Blood (ASH Annual Meeting Abstracts)2010; 116: 1060.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 1060
    • Uy, G.L.1    Abboud, C.N.2    Cashen, A.F.3
  • 127
    • 66749108988 scopus 로고    scopus 로고
    • Randomized phase II study of combined epigenetic therapy: Decitabine vs. decitabine and valproic acid in MDS and AML
    • Issa J-P, Castoro R, Ravandi-Kashani F, et al. Randomized phase II study of combined epigenetic therapy: decitabine vs. decitabine and valproic acid in MDS and AML. Blood (ASH Annual Meeting Abstracts) 2008; 112: 228.
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112 , pp. 228
    • Issa, J.-P.1    Castoro, R.2    Ravandi-Kashani, F.3
  • 128
    • 80052592899 scopus 로고    scopus 로고
    • Phase II study of 5-azacitidine and vorinostat in patients (pts) with newly diagnosed myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML) not eligible for clinical trials because poor performance or presence of othercomorbidities
    • Garcia-Manero G, Estey EH, Jabbour E, et al. Phase II study of 5-azacitidine and vorinostat in patients (pts) with newly diagnosed myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML) not eligible for clinical trials because poor performance or presence of othercomorbidities. Blood (ASH Annual Meeting Abstracts) 2010; 116: 604.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 604
    • Garcia-Manero, G.1    Estey, E.H.2    Jabbour, E.3
  • 129
    • 71149090513 scopus 로고    scopus 로고
    • Phase i study of vorinostat in combination with decitabine in patients with relapsed or newly diagnosed acute myelogenous leukemia or myelodysplastic syndrome
    • Kirschbaum M, Gojo I, Goldberg SL, et al. Phase I study of vorinostat in combination with decitabine in patients with relapsed or newly diagnosed acute myelogenous leukemia or myelodysplastic syndrome. Blood (ASH Annual Meeting Abstracts) 2008; 112: 3651.
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112 , pp. 3651
    • Kirschbaum, M.1    Gojo, I.2    Goldberg, S.L.3
  • 130
    • 80052592644 scopus 로고    scopus 로고
    • Prolonged administration of azacitidine with or without entinostat increases rate of hematologic normalization for myelodysplastic syndrome and acute myeloid leukemia with myelodys-plasia-related changes: Results of the US Leukemia Intergroup Trial E1905
    • Prebet T, Gore SD, Sun Z, et al. Prolonged administration of azacitidine with or without entinostat increases rate of hematologic normalization for myelodysplastic syndrome and acute myeloid leukemia with myelodys-plasia-related changes: results of the US Leukemia Intergroup Trial E1905. Blood (ASH Annual Meeting Abstracts) 2010; 116: 601.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 601
    • Prebet, T.1    Gore, S.D.2    Sun, Z.3
  • 131
    • 45949112533 scopus 로고    scopus 로고
    • Phase I/II study of MGCD0103, an oral isotype-selective histone deacetylase (HDAC) in-hibitor, in combination with 5-azacitidine in higher-risk myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML)
    • Garcia-Manero G, Yang AS, Klimek V, et al. Phase I/II study of MGCD0103, an oral isotype-selective histone deacetylase (HDAC) in-hibitor, in combination with 5-azacitidine in higher-risk myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML). Blood (ASH Annual Meeting Abstracts) 2007; 110: 444.
    • (2007) Blood (ASH Annual Meeting Abstracts) , vol.110 , pp. 444
    • Garcia-Manero, G.1    Yang, A.S.2    Klimek, V.3
  • 132
    • 83055168501 scopus 로고    scopus 로고
    • Addition of 5-azacitidine to standard induction therapy is feasible in older patients with acute myeloid leukemia: The AML-AZA trial of the SAL Study Group
    • Krug UO, Koschmieder A, Gerss J, et al. Addition of 5-azacitidine to standard induction therapy is feasible in older patients with acute myeloid leukemia: the AML-AZA trial of the SAL Study Group. Blood (ASH Annual Meeting Abstracts) 2010; 116: 2180.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 2180
    • Krug, U.O.1    Koschmieder, A.2    Gerss, J.3
  • 133
    • 83055182166 scopus 로고    scopus 로고
    • Induction therapy with idarubicin and etoposide combined with sequential or concurrent azaci-tidine in patients with high-risk acute myeloid leukemia: Pilot-phase of the AMLSG 12-09 study
    • Rucker FG, Stilgenbauer S, Bommer M, et al. Induction therapy with idarubicin and etoposide combined with sequential or concurrent azaci-tidine in patients with high-risk acute myeloid leukemia: pilot-phase of the AMLSG 12-09 study. Blood (ASH Annual Meeting Abstracts) 2010; 116: 2184.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 2184
    • Rucker, F.G.1    Stilgenbauer, S.2    Bommer, M.3
  • 134
    • 77953272954 scopus 로고    scopus 로고
    • Clofarabine plus low-dose cytarabine induction followed by consolidation with clofarabine plus low-dose cytarabine alternating with decitabine as frontline therapy for patients with acute myeloid leukemia (AML) < = 60 years
    • Parikh SA, Kantarjian H, Garcia-Manero G, et al. Clofarabine plus low-dose cytarabine induction followed by consolidation with clofarabine plus low-dose cytarabine alternating with decitabine as frontline therapy for patients with acute myeloid leukemia (AML) < = 60 years. Blood (ASH Annual Meeting Abstracts) 2009; 114: 2058.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 2058
    • Parikh, S.A.1    Kantarjian, H.2    Garcia-Manero, G.3
  • 135
    • 83055163837 scopus 로고    scopus 로고
    • A phase Ib dose-finding study of oral panobinostat in combination with cytarabine (ara-C) and mitoxan-trone as salvage therapy for refractory or relapsed acute myeloid leukemia (AML)
    • Krauter J, Schlenk RF, Schaich M, et al. A phase Ib dose-finding study of oral panobinostat in combination with cytarabine (ara-C) and mitoxan-trone as salvage therapy for refractory or relapsed acute myeloid leukemia (AML). Blood (ASH Annual Meeting Abstracts) 2010; 116: 3310.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 3310
    • Krauter, J.1    Schlenk, R.F.2    Schaich, M.3
  • 136
    • 79960034446 scopus 로고    scopus 로고
    • Final report of a phase II trial of vorinostat idarubicin and cytarabine in previously untreated acute myelogenous leukemia (AML) or high risk myelodysplastic syndrome (MDS)
    • Garcia-Manero G, Tambaro FP, Bekele N, et al. Final report of a phase II trial of vorinostat, idarubicin and cytarabine in previously untreated acute myelogenous leukemia (AML) or high risk myelodysplastic syndrome (MDS). Blood (ASH Annual Meeting Abstracts) 2010; 116: 2189.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 2189
    • Garcia-Manero, G.1    Tambaro, F.P.2    Bekele, N.3


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