Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 26, 2010, Pages 11835-11840

  Suen, Der Fen ^a   Narendra, Derek P ^a   Tanaka, Atsushi ^a   Manfredi, Giovanni ^b   Youle, Richard J ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Autophagy; Mitochondria; Neurodegeneration; Parkinson disease; PINK1

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; PARKIN;

ARTICLE; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; GENE OVEREXPRESSION; GENE TRANSLOCATION; HETEROPLASMY; HUMAN; HUMAN CELL; MITOCHONDRIAL GENOME; MITOCHONDRION; PRIORITY JOURNAL;

CELL LINE; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX IV; GENE EXPRESSION; HUMANS; HYBRID CELLS; MEMBRANE FUSION; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MODELS, BIOLOGICAL; MUTATION; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 77955398958     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0914569107     Document Type: Article

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