The Roles of SIRT1 in Cancer

Genes and Cancer

Volumn 4, Issue 3-4, 2013, Pages 97-104

  Lin, Zhenghong ^a   Fang, Deyu ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

cancer; deacetylase; SIRT1

Indexed keywords

AUTOPHAGY PROTEIN 5; BETA CATENIN; BREAST CANCER ASSOCIATED PROTEIN 3; CAMBINOL; ENZYME ACTIVATOR; ENZYME INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JGB 1741; ONCOPROTEIN; PROTEIN P53; RESVERATROL; SALERMIDE; SIRTINOL; SIRTUIN 1; SRT 1460; SRT 1720; SRT 2183; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WNT PROTEIN;

AUTOPHAGY; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CARCINOGENESIS; COLORECTAL CANCER; DEACETYLATION; DNA DAMAGE; DNA REPAIR; GENE OVEREXPRESSION; HUMAN; INTRACELLULAR SIGNALING; MALIGNANT NEOPLASTIC DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIRT1 GENE;

EID: 84887428122     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601912475079     Document Type: Review

References (114)

1. Zhang J,Lee SM,Shannon S,et al.The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice.J Clin Invest. 2009;119:3048-58.
2. Lin Z,Yang H,Kong Q,et al.USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development.Mol Cell. 2012;46:484-94.
3. Wu Y,Li X,Zhu JX,et al.Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson's disease.Neurosignals. 2011;19:163-74.
4. Guarente L,Picard F.Calorie restriction: the SIR2 connection.Cell. 2005;120:473-82.
5. Qiang L,Wang L,Kon N,et al.Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppargamma.Cell. 2012;150:620-32.
6. Wang RH,Sengupta K,Li C,et al.Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.Cancer Cell. 2008;14:312-23.
7. Vinciguerra M,Santini MP,Martinez C,et al.mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart.Aging Cell. 2012;11:139-49.
8. Inoue T,Hiratsuka M,Osaki M,Oshimura M.The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation.Cell Cycle. 2007;6:1011-8.
9. Blander G,Guarente L.The Sir2 family of protein deacetylases.Annu Rev Biochem. 2004;73:417-35.
10. Lavu S,Boss O,Elliott PJ,Lambert PD.Sirtuins: novel therapeutic targets to treat age-associated diseases.Nat Rev Drug Discov. 2008;7:841-53.
11. Imai S,Armstrong CM,Kaeberlein M,Guarente L.Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.Nature. 2000;403:795-800.
12. Vaquero A,Scher M,Lee D,Erdjument-Bromage H,Tempst P,Reinberg D.Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.Mol Cell. 2004;16:93-105.
13. Vaziri H,Dessain SK,Ng Eaton E,et al.hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.Cell. 2001;107:149-59.
14. Luo J,Nikolaev AY,Imai S,et al.Negative control of p53 by Sir2alpha promotes cell survival under stress.Cell. 2001;107:137-48.
15. Dai JM,Wang ZY,Sun DC,Lin RX,Wang SQ.SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity.J Cell Physiol. 2007;210:161-6.
16. Chen WY,Wang DH,Yen RC,Luo J,Gu W,Baylin SB.Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.Cell. 2005;123:437-48.
17. Kong S,Kim SJ,Sandal B,et al.The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation.J Biol Chem. 2011;286:16967-75.
18. Yeung F,Hoberg JE,Ramsey CS,et al.Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.EMBO J. 2004;23:2369-80.
19. Schug TT,Xu Q,Gao H,et al.Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress.Mol Cell Biol. 2010;30:4712-21.
20. Chen LF,Mu Y,Greene WC.Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.EMBO J. 2002;21:6539-48.
21. Kiernan R,Bres V,Ng RW,et al.Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65.J Biol Chem. 2003;278:2758-66.
22. Brunet A,Sweeney LB,Sturgill JF,et al.Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.Science. 2004;303:2011-5.
23. Motta MC,Divecha N,Lemieux M,et al.Mammalian SIRT1 represses forkhead transcription factors.Cell. 2004;116:551-63.
24. van der Horst A,Tertoolen LG,de Vries-Smits LM,Frye RA,Medema RH,Burgering BM.FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).J Biol Chem. 2004;279:28873-9.
25. Xiong S,Salazar G,Patrushev N,Alexander RW.FoxO1 mediates an autofeedback loop regulating SIRT1 expression.J Biol Chem. 2011;286:5289-99.
26. Rodgers JT,Lerin C,Haas W,Gygi SP,Spiegelman BM,Puigserver P.Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.Nature. 2005;434:113-8.
27. Han L,Zhou R,Niu J,McNutt MA,Wang P,Tong T.SIRT1 is regulated by a PPAR{gamma}-SIRT1 negative feedback loop associated with senescence.Nucleic Acids Res. 2010;38:7458-71.
28. Hallows WC,Lee S,Denu JM.Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.Proc Natl Acad Sci U S A. 2006;103:10230-5.
29. Dioum EM,Chen R,Alexander MS,et al.Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1.Science. 2009;324:1289-93.
30. Lim JH,Lee YM,Chun YS,Chen J,Kim JE,Park JW.Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha.Mol Cell. 2010;38:864-78.
31. Leiser SF,Kaeberlein M.A role for SIRT1 in the hypoxic response.Mol Cell. 2010;38:779-80.
32. Ikenoue T,Inoki K,Zhao B,Guan KL.PTEN acetylation modulates its interaction with PDZ domain.Cancer Res. 2008;68:6908-12.
33. Kume S,Haneda M,Kanasaki K,et al.SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation.J Biol Chem. 2007;282:151-8.
34. Li J,Qu X,Ricardo SD,Bertram JF,Nikolic-Paterson DJ.Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3.Am J Pathol. 2010;177:1065-71.
35. Firestein R,Blander G,Michan S,et al.The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.PloS One. 2008;3:e2020.
36. Holloway KR,Calhoun TN,Saxena M,et al.SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.Proc Natl Acad Sci U S A. 2010;107:9216-21.
37. Jeong J,Juhn K,Lee H,et al.SIRT1 promotes DNA repair activity and deacetylation of Ku70.Exp Mol Med. 2007;39:8-13.
38. Fan W,Luo J.SIRT1 regulates UV-induced DNA repair through deacetylating XPA.Mol Cell. 2010;39:247-58.
39. Ming M,Shea CR,Guo X,et al.Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C.Proc Natl Acad Sci U S A. 2010;107:22623-8.
40. Yuan Z,Zhang X,Sengupta N,Lane WS,Seto E.SIRT1 regulates the function of the Nijmegen breakage syndrome protein.Mol Cell. 2007;27:149-62.
41. Lane DP.Cancer: p53, guardian of the genome.Nature. 1992;358:15-6.
42. Lain S,Lane D.Improving cancer therapy by non-genotoxic activation of p53.Eur J Cancer. 2003;39:1053-60.
43. Bouras T,Fu M,Sauve AA,et al.SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.J Biol Chem. 2005;280:10264-76.
44. Stiehl DP,Fath DM,Liang D,Jiang Y,Sang N.Histone deacetylase inhibitors synergize p300 autoacetylation that regulates its transactivation activity and complex formation.Cancer Res. 2007;67:2256-64.
45. Langley E,Pearson M,Faretta M,et al.Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.EMBO J. 2002;21:2383-96.
46. van Leeuwen I,Lain S.Sirtuins and p53.Adv Cancer Res. 2009;102:171-95.
47. Wales MM,Biel MA,el Deiry W,et al.p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.Nat Med. 1995;1:570-7.
48. Tissenbaum HA,Guarente L.Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.Nature. 2001;410:227-30.
49. Nemoto S,Fergusson MM,Finkel T.SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}.J Biol Chem. 2005;280:16456-60.
50. Yang Y,Hou H,Haller EM,Nicosia SV,Bai W.Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation.EMBO J. 2005;24:1021-32.
51. Wang F,Chan CH,Chen K,Guan X,Lin HK,Tong Q.Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation.Oncogene. 2012;31:1546-57.
52. Nemoto S,Fergusson MM,Finkel T.Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.Science. 2004;306:2105-8.
53. Gao B,Kong Q,Kemp K,Zhao YS,Fang D.Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2-mediated reversal of T-cell tolerance.Proc Natl Acad Sci U S A. 2012;109:899-904.
54. Clague MJ,Urbe S.Ubiquitin: same molecule, different degradation pathways.Cell. 2010;143:682-5.
55. Salminen A,Kaarniranta K.Regulation of the aging process by autophagy.Trends Mol Med. 2009;15:217-24.
56. Salminen A,Kaarniranta K.SIRT1: regulation of longevity via autophagy.Cell Signal. 2009;21:1356-60.
57. Powell MJ,Casimiro MC,Cordon-Cardo C,et al.Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation.Cancer Res. 2011;71:964-75.
58. Lee IH,Cao L,Mostoslavsky R,et al.A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.Proc Natl Acad Sci U S A. 2008;105:3374-9.
59. Geng J,Klionsky DJ.The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series.EMBO Rep. 2008;9:859-64.
60. Massague J.TGF-beta signal transduction.Annu Rev Biochem. 1998;67:753-91.
61. Massague J,Blain SW,Lo RS.TGFbeta signaling in growth control, cancer, and heritable disorders.Cell. 2000;103:295-309.
62. Yan X,Lin Z,Chen F,et al.Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.J Biol Chem. 2009;284:30097-104.
63. Nakao A,Afrakhte M,Moren A,et al.Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.Nature. 1997;389:631-5.
64. Xu B,Chen H,Xu W,et al.Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice.Am J Physiol Lung Cell Mol Physiol. 2012;303:L89-96.
65. Nelson WJ,Nusse R.Convergence of Wnt, beta-catenin, and cadherin pathways.Science. 2004;303:1483-7.
66. Lin Z,Gao C,Ning Y,He X,Wu W,Chen YG.The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.J Biol Chem. 2008;283:33053-8.
67. Morin PJ,Sparks AB,Korinek V,et al.Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.Science. 1997;275:1787-90.
68. Korinek V,Barker N,Morin PJ,et al.Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.Science. 1997;275:1784-7.
69. Wolf D,Rodova M,Miska EA,Calvet JP,Kouzarides T.Acetylation of beta-catenin by CREB-binding protein (CBP).J Biol Chem. 2002;277:25562-7.
70. Levy L,Wei Y,Labalette C,et al.Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction.Mol Cell Biol. 2004;24:3404-14.
71. Salaroli R,Di Tomaso T,Ronchi A,et al.Radiobiologic response of medulloblastoma cell lines: involvement of beta-catenin?.J Neurooncol. 2008;90:243-51.
72. Cho IR,Koh SS,Malilas W,et al.SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of beta-catenin.Biochem Biophys Res Commun. 2012;423:270-5.
73. Sirakov M,Skah S,Lone IN,Nadjar J,Angelov D,Plateroti M.Multi-level interactions between the nuclear receptor TRalpha1 and the WNT effectors beta-catenin/Tcf4 in the intestinal epithelium.PloS One. 2012;7:e34162.
74. Hussain M,Rao M,Humphries AE,et al.Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer cells.Cancer Res. 2009;69:3570-8.
75. Wei W,Li M,Wang J,Nie F,Li L.The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.Mol Cell Biol. 2012;32:3903-12.
76. Chen L,Fischle W,Verdin E,Greene WC.Duration of nuclear NF-kappaB action regulated by reversible acetylation.Science. 2001;293:1653-7.
77. Yang L,Zhang J,Yan C,et al.SIRT1 regulates CD40 expression induced by TNF-alpha via NF-kB pathway in endothelial cells.Cell Physiol Biochem. 2012;30:1287-98.
78. Yang XD,Tajkhorshid E,Chen LF.Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB.Mol Cell Biol. 2010;30:2170-80.
79. Yang SR,Wright J,Bauter M,Seweryniak K,Kode A,Rahman I.Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.Am J Physiol Lung Cell Mol Physiol. 2007;292:L567-76.
80. Zhu X,Liu Q,Wang M,et al.Activation of Sirt1 by resveratrol inhibits TNF-alpha induced inflammation in fibroblasts.PloS One. 2011;6:e27081.
81. An Y,Kiang A,Lopez JP,et al.Cigarette smoke promotes drug resistance and expansion of cancer stem cell-like side population.PloS One. 2012;7:e47919.
82. Gao F,Cheng J,Shi T,Yeh ET.Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription.Nat Cell Biol. 2006;8:1171-7.
83. Ghosh HS,Spencer JV,Ng B,McBurney MW,Robbins PD.Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription.Biochem J. 2007;408:105-11.
84. Gao Z,Ye J.Inhibition of transcriptional activity of c-JUN by SIRT1.Biochem Biophys Res Commun. 2008;376:793-6.
85. Dey S,Bakthavatchalu V,Tseng MT,et al.Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells.Carcinogenesis. 2008;29:1920-9.
86. Vries RG,Prudenziati M,Zwartjes C,Verlaan M,Kalkhoven E,Zantema A.A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300.EMBO J. 2001;20:6095-103.
87. Hoeijmakers JH.Genome maintenance mechanisms for preventing cancer.Nature. 2001;411:366-74.
88. Mostoslavsky R,Chua KF,Lombard DB,et al.Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.Cell. 2006;124:315-29.
89. Oberdoerffer P,Michan S,McVay M,et al.SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.Cell. 2008;135:907-18.
90. Solomon JM,Pasupuleti R,Xu L,et al.Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage.Mol Cell Biol. 2006;26:28-38.
91. Bakkenist CJ,Kastan MB.DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.Nature. 2003;421:499-506.
92. Lim DS,Kim ST,Xu B,et al.ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway.Nature. 2000;404:613-7.
93. Wu X,Ranganathan V,Weisman DS,et al.ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response.Nature. 2000;405:477-82.
94. Yuan J,Luo K,Liu T,Lou Z.Regulation of SIRT1 activity by genotoxic stress.Genes Dev. 2012;26:791-6.
95. Abdelmohsen K,Pullmann R,Lal A,et al.Phosphorylation of HuR by Chk2 regulates SIRT1 expression.Mol Cell. 2007;25:543-57.
96. Yang Y,Fu W,Chen J,et al.SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress.Nat Cell Biol. 2007;9:1253-62.
97. Herranz D,Munoz-Martin M,Canamero M,et al.Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.Nat Commun. 2010;1:3.
98. Pervaiz S,Holme AL.Resveratrol: its biologic targets and functional activity.Antioxid Redox Signal. 2009;11:2851-97.
99. Baur JA,Sinclair DA.Therapeutic potential of resveratrol: the in vivo evidence.Nat Rev Drug Discov. 2006;5:493-506.
100. Milne JC,Lambert PD,Schenk S,et al.Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.Nature. 2007;450:712-6.
101. Pacholec M,Bleasdale JE,Chrunyk B,et al.SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.J Biol Chem. 2010;285:8340-51.
102. Huber JL,McBurney MW,Distefano PS,McDonagh T.SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183.Future Med Chem. 2010;2:1751-9.
103. Cohen HY,Lavu S,Bitterman KJ,et al.Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.Mol Cell. 2004;13:627-38.
104. Zhao W,Kruse JP,Tang Y,Jung SY,Qin J,Gu W.Negative regulation of the deacetylase SIRT1 by DBC1.Nature. 2008;451:587-90.
105. Ford J,Jiang M,Milner J.Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.Cancer Res. 2005;65:10457-63.
106. Brooks CL,Gu W.p53 activation: a case against Sir.Cancer Cell. 2008;13:377-8.
107. Lara E,Mai A,Calvanese V,et al.Salermide, a sirtuin inhibitor with a strong cancer-specific proapoptotic effect.Oncogene. 2009;28:781-91.
108. Haigis MC,Sinclair DA.Mammalian sirtuins: biological insights and disease relevance.Annu Rev Pathol. 2010;5:253-95.
109. Heltweg B,Gatbonton T,Schuler AD,et al.Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.Cancer Res. 2006;66:4368-77.
110. Ota H,Tokunaga E,Chang K,et al.Sirt1 inhibitor, sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.Oncogene. 2006;25:176-85.
111. Kalle AM,Mallika A,Badiger J,Alinakhi,Talukdar P,Sachchidanand.Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells.Biochem Biophys Res Commun. 2010;401:13-9.
112. Trapp J,Meier R,Hongwiset D,Kassack MU,Sippl W,Jung M.Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins).Chem Med Chem. 2007;2:1419-31.
113. Lain S,Hollick JJ,Campbell J,et al.Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.Cancer Cell. 2008;13:454-63.
114. Peck B,Chen CY,Ho KK,et al.SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.Mol Cancer Ther. 2010;9:844-55.