Radiobiologic response of medulloblastoma cell lines: Involvement of β-catenin?

Journal of Neuro-Oncology

Volumn 90, Issue 3, 2008, Pages 243-251

  Salaroli, Roberta ^a   Di Tomaso, Tiziano ^a,b   Ronchi, Alice ^a   Ceccarelli, Claudio ^a   Cammelli, Silvia ^a   Cappellini, Alessandra ^a   Martinelli, Giuseppe Nicola ^a   Barbieri, Enza ^a   Giangaspero, Felice ^c,d   Cenacchi, Giovanna ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF TERAMO   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d IRCCS NEUROMED   (Italy)

Author keywords

catenin; Celllines; Ionizing radiation; Medulloblastoma; p53; Wingless(WNT) signalling

Indexed keywords

BETA CATENIN; PROTEIN P53; WNT PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL MUTANT; CONTROLLED STUDY; GAMMA RADIATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION; MEDULLOBLASTOMA; MOLECULAR DYNAMICS; PROGNOSIS; RADIATION RESPONSE; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; WILD TYPE;

APOPTOSIS; BETA CATENIN; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MEDULLOBLASTOMA; RADIATION, IONIZING; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53; WNT PROTEINS;

EID: 56249131423     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-008-9659-5     Document Type: Article

References (53)

1. Eberhart CG, Kepner JL, Goldthwaite PT et al (2002) Histopatologic grading of medulloblastomas: A pediatric oncology group study. Cancer 94:552-560. doi: 10.1002/cncr.10189
2. Kleihues P, Luis DN, Scheithauer BW et al (2002) The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61:215-225
3. Ellison D (2002) Classifying the medulloblastoma: Insights from morphology and molecular genetics. Neuropathol Appl Neurobiol 28:257-280. doi: 10.1046/j.1365-2990.2002.00419.x
4. Gilbertson RJ (2004) Medulloblastoma: Signaling a change in treatment. Lancet Oncol 5:209-218. doi: 10.1016/S1470-2045(04)01424-X
5. Giangaspero F, Wellek S, Masuoka J et al (2006) Stratification of medulloblastoma on the basis of histopathological grading. Acta Neuropathol 112:5-12. doi: 10.1007/s00401-006-0064-x
6. Koch A, Hrychyk A, Hartmann W et al (2007) Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas. Int J Cancer 121:284-291. doi: 10.1002/ijc.22675
7. Eberhart CG, Tuhan T, Burger PC (2000) Nuclear localization and mutation of β-catenin in medulloblastomas. J Neuropathol Exp Neurol 59:333-337
8. Clifford SC, Lusher ME, Lindsey JC et al (2006) WNT/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis. Cell Cycle 5:2666-2670
9. Ellison DW, Clifford SC, Gajjar A et al (2003) What's new in neuro-oncology? Recent advances in medulloblastoma. Eur J Paediatr Neurol 7:53-66. doi: 10.1016/S1090-3798(03)00014-X
10. Cadigan KM, Liu YI (2006) Wnt signaling: Complexity at the surface. J Cell Sci 119:395-402. doi: 10.1242/jcs.02826
11. Marino S (2005) Medulloblastoma: Developmental mechanisms out of control. Trends Mol Med 11:17-22. doi: 10.1016/j.molmed.2004.11.008
12. Ellison DW, Onilude OE, Lindsey JC, United Kingdom Children's Cancer Study Group Brain Tumour Committe et al (2005) β-Catenin status predicts a favorable outcome in childhood medulloblastoma: The United Kingdom Children's Cancer Study Group Brain Tumour Committee. J Clin Oncol 23:7951-7957. doi: 10.1200/JCO.2005.01.5479
13. Woodward WA, Chen M, Behbod F et al (2007) WNT/β-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci USA 104:618-623. doi: 10.1073/pnas.0606599104
14. Rodningen OK, Borresen-Dale AL, Alsner J et al (2008) Radiation-induced gene expression in human subcutaneous fibroblasts is predictive of radiation-induced fibrosis. Radiother Oncol 86:314-320. doi: 10.1016/ j.radonc.2007.09.013
15. Siu IM, Lal A, Blakenship JR et al (2003) c-Myc promoter activation in medulloblastoma. Cancer Res 63:4773-4776
16. Gassler N, Herr I, Keith M et al (2004) Wnt-signaling and apoptosis after neoadjuvant short-term radiotherapy for rectal cancer. Int J Oncol 25:1543-1549
17. Chen MS, Woodward WA, Behbod F et al (2007) Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line. J Cell Sci 120:468-477. doi: 10.1242/jcs.03348
18. Dihlmann S, Siermann A, von Knebel Doeberitz M (2001) The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate β-catenin/TCF-4 signaling. Oncogene 20:645-653. doi: 10.1038/ sj.onc.1204123
19. Ricciardiello L, Baglioni M, Giovannini C et al (2003) Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus. Cancer Res 63:7256-7262
20. Nusse M, Beisker W, Hoffmann C et al (1990) Flow cytometric analysis of G1- and G2/M-phase subpopulations in mammalian cell nuclei using side scatter and DNA content measurements. Cytometry 11:813-821. doi: 10.1002/ cyto.990110707
21. Salaroli R, Russo A, Ceccarelli C et al (2007) Intracellular distribution of beta-catenin in human medulloblastoma cell lines with different degree of neuronal differentiation. Ultrastruct Pathol 31:33-44. doi: 10.1080/01913120601169501
22. Jozwiak J, Grajkowska W, Wlodarski P (2007) Pathogenesis of medulloblastoma and current treatment outlook. Med Res Rev 27:869-890. doi: 10.1002/med.20088
23. Kumar KS, Sonnemann J, Hong le TT et al (2007) Histone deacetylase inhibitors, but not vincristine, cooperate with radiotherapy to induce cell death in medulloblastoma. Anticancer Res 27:465-470
24. Whelan HT, Krouwer HG, Schmidt MH et al (1998) Current therapy and perspectives in the treatment of Medulloblastoma. Pediatr Neurol 18:103-115. doi: 10.1016/S0887-8994(97)00221-X
25. Cervoni L, Cantore G (1995) Medulloblastoma in pediatric age: A single institution review of prognostic factors. Childs Nerv Syst 11:80-85. doi: 10.1007/BF00303809
26. Hoppe-Hirsch E, Brunet L, Laroussinie F et al (1995) Intellectual outcome in children whit malignant tumors of the posterior fossa: influence of the field of irradiation and quality of surgery. Childs Nerv Syst 11:340-346. doi: 10.1007/BF00301666
27. Dennis M, Spiegler BJ, Htherington CR et al (1996) Neuropsychological sequela of the treatment of children with medulloblastoma in infants. J Neurooncol 29:91-101. doi: 10.1007/BF00165522
28. Criswell T, Leskov K, Miyamoto S et al (2003) Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation. Oncogene 22:5813-5827. doi: 10.1038/sj.onc.1206680
29. Belka C (2006) The fate of irradiated tumor cells. Oncogene 25:969-970. doi: 10.1038/sj.onc.1209175
30. Gudkov AV, Komarova EA (2003) The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer 3:117-129. doi: 10.1038/nrc992
31. Willers H, Dahm-Daphi J, Powell SN (2004) Repair of radiation damage to DNA. Br J Cancer 90:1297-1301. doi: 10.1038/sj.bjc.6601729
32. Zhou BB, Elledge SJ (2000) The DNA damage response: Putting checkpoints in perspective. Nature 408:433-439. doi: 10.1038/35044005
33. Niida H, Nakanishi M (2006) DNA damage checkpoints in mammals. Mutagenesis 21:3-9. doi: 10.1093/mutage/gei063
34. Perry ME (2004) MDM2 in response to radiation. Mol Cancer Res 2:9-19
35. Chang BD, Broude EV, Dokmanovic M et al (1999) A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res 59:3761-3767
36. Kemp CJ, Sun S, Gurley KE (2001) p53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent. Cancer Res 61:327-332
37. Roninson IB, Broude EV, Chang BD (2001) If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Update 4:303-313. doi: 10.1054/drup. 2001.0213
38. Gottardo NG, Gajjar A (2006) Current therapy for medulloblastoma. Curr Treat Options Neurol 8:319-334. doi: 10.1007/s11940-006-0022-x
39. Oren M (2003) Decision making by p53: Life, death and cancer. Cell Death Differ 10:431-442. doi: 10.1038/sj.cdd.4401183
40. Appella E, Anderson CW (2001) Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 268:2764-2772. doi: 10.1046/j.1432-1327.2001.02225.x
41. Maya R, Balass M, Kim ST et al (2001) ATM-dependent phosphorylation of Mdm2 on serine 395: Role in p53 activation by DNA damage. Genes Dev 15:1067-1077. doi: 10.1101/gad.886901
42. Offer H, Erez N, Zurer I et al (2002) The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA. Carcinogenesis 23:1025-1032. doi: 10.1093/carcin/23.6.1025
43. Frank AJ, Hernan R, Hollander A et al (2004) The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma. Brain Res Mol Brain Res 121:137-140. doi: 10.1016/ j.molbrainres.2003.11.016
44. Li Y, He L, Bruce A et al (2006) p14ARF inhibits the growth of p53 deficient cells in a cell-specific manner. Biochim Biophys Acta 1763:787-796. doi: 10.1016/j.bbamcr.2006.04.011
45. Iwai A, Marusawa H, Matsuzawa S et al (2004) Siah-1L, a novel transcript variant belonging to the human S family of proteins, regulates beta catenin activity in a p53-dependent manner. Oncogene 23:7593-7560. doi: 10.1038/sj.onc.1208016
46. Sadot E, Geiger B, Oren M et al (2001) Down-regulation of beta-catenin by activated p53. Mol Cell Biol 21:6768-6781. doi: 10.1128/ MCB.21.20.6768-6781.2001
47. Jüllig M, Zhang WV, Ferreira A et al (2006) MG132 induced apoptosis is associated with p53-independent induction of pro-apoptotic Noxa and transcriptional activity of beta-catenin. Apoptosis 11:627-641. doi: 10.1007/s10495-006-4990-9
48. van Gijn ME, Snel F, Cleutjens JP et al (2001) Overexpression of components of the Frizzled-Dishevelled cascade results in apoptotic cell death, mediated by beta-catenin. Exp Cell Res 265:46-53. doi: 10.1006/ excr.2001.5174
49. Tell S, Yi H, Jockovich ME et al (2006) The Wnt signaling pathway has tumor suppressor properties in retinoblastoma. Biochem Biophys Res Commun 349:261-269. doi: 10.1016/j.bbrc.2006.08.044
50. Kim K, Pang KM, Evans M et al (2000) Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol Biol Cell 11:3509-3523
51. Olmeda D, Castel S, Vilaro S et al (2003) β-catenin regulation during the cell cycle: Implications in G2/M and apoptosis. Mol Biol Cell 14:2844-2860. doi: 10.1091/mbc.E03-01-0865
52. Abramova MV, Pospelova TV, Nikulenkov FP et al (2006) G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin. J Biol Chem 281:21040-21051. doi: 10.1074/jbc.M511059200
53. Damalas A, Kahan S, Shtutman M et al (2001) Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in trasformation. EMBO J 20:4912-4922. doi: 10.1093/emboj/20.17.4912