SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β-catenin

Biochemical and Biophysical Research Communications

Volumn 423, Issue 2, 2012, Pages 270-275

  Cho, Il Rae ^a   Koh, Sang Seok ^b,c   Malilas, Waraporn ^a   Srisuttee, Ratakorn ^a   Moon, Jeong ^a   Choi, Young Whan ^a   Horio, Yoshiyuki ^d   Oh, Sangtaek ^e   Chung, Young Hwa ^a  

^a Pusan National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c University of Science and Technology (UST)   (South Korea)

^d SAPPORO MEDICAL UNIVERSITY   (Japan)

^e Kookmin University   (South Korea)

Author keywords

Catenin; Pancreatic cancer; PAUF; SIRT1

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA CATENIN; CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3BETA; RESVERATROL; SIRTUIN 1; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL; CANCER MODEL; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; ENZYME REPRESSION; GENE MUTATION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; ONCOGENE; PANCREAS ADENOCARCINOMA; PANCREAS CELL; PANCREATIC ADENOCARCINOMA UP-REGULATED FACTOR GENE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; UPREGULATION;

BETA CATENIN; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; CYCLIN D1; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; LECTINS; LEUPEPTINS; ONCOGENES; PANCREATIC NEOPLASMS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; SIRTUIN 1;

EID: 84862852344     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.05.107     Document Type: Article

References (32)

1. Ghaneh P., Tudur-Smith C., Neoptolemos J.P. Comment on " adjuvant therapy in pancreatic cancer: a critical appraisal" Drugs 2007, 67:2487-2490. [Discussion 2491-2483].
2. Maitra A., Hruban R.H. Pancreatic cancer. Annu. Rev. Pathol. 2008, 3:157-188.
3. Hawes R.H., Xiong Q., Waxman I., Chang K.J., Evans D.B., Abbruzzese J.L. A multispecialty approach to the diagnosis and management of pancreatic cancer. Am. J. Gastroenterol. 2000, 95:17-31.
4. Kim S.A., Lee Y., Jung D.E., Park K.H., Park J.Y., Gang J., Jeon S.B., Park E.C., Kim Y.G., Lee B., Liu Q., Zeng W., Yeramilli S., Lee S., Koh S.S., Song S.Y. Pancreatic adenocarcinoma up-regulated factor (PAUF), a novel up-regulated secretory protein in pancreatic ductal adenocarcinoma. Cancer Sci. 2009, 100:828-836.
5. Lee Y., Kim S.J., Park H.D., Park E.H., Huang S.M., Jeon S.B., Kim J.M., Lim D.S., Koh S.S. PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression. Oncogene 2010, 29:56-67.
6. Cho I.R., Koh S.S., Min H.J., Kim S.J., Lee Y., Park E.H., Ratakorn S., Jhun B.H., Oh S., Johnston R.N., Chung Y.H. Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the expression of beta-catenin, leading to a rapid proliferation of pancreatic cells. Exp. Mol. Med. 2011, 43:82-90.
7. Polakis P. Wnt signaling and cancer. Genes Dev. 2000, 14:1837-1851.
8. Giles R.H., van Es J.H., Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim. Biophys. Acta 2003, 1653:1-24.
9. Tetsu O., McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999, 398:422-426.
10. He T.C., Sparks A.B., Rago C., Hermeking H., Zawel L., da Costa L.T., Morin P.J., Vogelstein B., Kinzler K.W. Identification of c-MYC as a target of the APC pathway. Science 1998, 281:1509-1512.
11. He T.C., Chan T.A., Vogelstein B., Kinzler K.W. PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 1999, 99:335-345.
12. Saadeddin A., Babaei-Jadidi R., Spencer-Dene B., Nateri A.S. The links between transcription, beta-catenin/JNK signaling, and carcinogenesis. Mol. Cancer Res. 2009, 7:1189-1196.
13. Rubinfeld B., Albert I., Porfiri E., Fiol C., Munemitsu S., Polakis P. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 1996, 272:1023-1026.
14. Aberle H., Bauer A., Stappert J., Kispert A., Kemler R. Beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 1997, 16:3797-3804.
15. Liu J., Stevens J., Rote C.A., Yost H.J., Hu Y., Neufeld K.L., White R.L., Matsunami N. Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol. Cell 2001, 7:927-936.
16. Brooks C.L., Gu W. How does SIRT1 affect metabolism, senescence and cancer?. Nat. Rev. Cancer 2009, 9:123-128.
17. Lin S.J., Defossez P.A., Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 2000, 289:2126-2128.
18. Burnett C., Valentini S., Cabreiro F., Goss M., Somogyvari M., Piper M.D., Hoddinott M., Sutphin G.L., Leko V., McElwee J.J., Vazquez-Manrique R.P., Orfila A.M., Ackerman D., Au C., Vinti G., Riesen M., Howard K., Neri C., Bedalov A., Kaeberlein M., Soti C., Partridge L., Gems D. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 2011, 477:482-485.
19. Vaquero A., Scher M., Lee D., Erdjument-Bromage H., Tempst P., Reinberg D. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol. Cell 2004, 16:93-105.
20. Yeung F., Hoberg J.E., Ramsey C.S., Keller M.D., Jones D.R., Frye R.A., Mayo M.W. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. Embo J. 2004, 23:2369-2380.
21. Luo J., Nikolaev A.Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 2001, 107:137-148.
22. Cohen H.Y., Miller C., Bitterman K.J., Wall N.R., Hekking B., Kessler B., Howitz K.T., Gorospe M., de Cabo R., Sinclair D.A. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004, 305:390-392.
23. Brunet A., Sweeney L.B., Sturgill J.F., Chua K.F., Greer P.L., Lin Y., Tran H., Ross S.E., Mostoslavsky R., Cohen H.Y., Hu L.S., Cheng H.L., Jedrychowski M.P., Gygi S.P., Sinclair D.A., Alt F.W., Greenberg M.E. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004, 303:2011-2015.
24. Chu F., Chou P.M., Zheng X., Mirkin B.L., Rebbaa A. Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1. Cancer Res. 2005, 65:10183-10187.
25. Yang Y., Fu W., Chen J., Olashaw N., Zhang X., Nicosia S.V., Bhalla K., Bai W. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat. Cell Biol. 2007, 9:1253-1262.
26. Firestein R., Blander G., Michan S., Oberdoerffer P., Ogino S., Campbell J., Bhimavarapu A., Luikenhuis S., de Cabo R., Fuchs C., Hahn W.C., Guarente L.P., Sinclair D.A. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 2008, 3:e2020.
27. Wang R.H., Sengupta K., Li C., Kim H.S., Cao L., Xiao C., Kim S., Xu X., Zheng Y., Chilton B., Jia R., Zheng Z.M., Appella E., Wang X.W., Ried T., Deng C.X. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 2008, 14:312-323.
28. Tanno M., Sakamoto J., Miura T., Shimamoto K., Horio Y. Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J. Biol. Chem. 2007, 282:6823-6832.
29. Choi H., Gwak J., Cho M., Ryu M.J., Lee J.H., Kim S.K., Kim Y.H., Lee G.W., Yun M.Y., Cuong N.M., Shin J.G., Song G.Y., Oh S. Murrayafoline A attenuates the Wnt/beta-catenin pathway by promoting the degradation of intracellular beta-catenin proteins. Biochem. Biophys. Res. Commun. 2010, 391:915-920.
30. Park S., Gwak J., Cho M., Song T., Won J., Kim D.E., Shin J.G., Oh S. Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation. Mol. Pharmacol. 2006, 70:960-966.
31. Chua K.F., Mostoslavsky R., Lombard D.B., Pang W.W., Saito S., Franco S., Kaushal D., Cheng H.L., Fischer M.R., Stokes N., Murphy M.M., Appella E., Alt F.W. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab. 2005, 2:67-76.
32. Fu M., Liu M., Sauve A.A., Jiao X., Zhang X., Wu X., Powell M.J., Yang T., Gu W., Avantaggiati M.L., Pattabiraman N., Pestell T.G., Wang F., Quong A.A., Wang C., Pestell R.G. Hormonal control of androgen receptor function through SIRT1. Mol. Cell Biol. 2006, 26:8122-8135.