Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 303, Issue 2, 2012, Pages

  Xu, Bing ^a   Chen, Hui ^a   Xu, Wei ^a   Zhang, Wenming ^a   Buckley, Sue ^a   Zheng, Song Guo ^b   Warburton, David ^a   Kolb, Martin ^c   Gauldie, Jack ^c   Shi, Wei ^a  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

Matrix metalloproteinase 9; NF B; Pea3; Sirtuin 1

Indexed keywords

GELATINASE B; HISTONE H3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN C JUN; SIRTUIN 1; SMAD3 PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR PEA3; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HISTONE ACETYLATION; LUNG DEVELOPMENT; LUNG EMPHYSEMA; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; UPREGULATION;

ACETYLATION; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; GENE EXPRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HISTONES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PULMONARY EMPHYSEMA; SIGNAL TRANSDUCTION; SIRTUIN 1; SMAD3 PROTEIN; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84863898701     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00060.2012     Document Type: Article

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