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Volumn 6, Issue 1, 2013, Pages

Transcriptional regulation and its misregulation in Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid ; Polymorphism; Transcription factors; Transcriptional regulatory element

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; BETA SECRETASE 1; PRESENILIN 1; PRESENILIN 2;

EID: 84886133344     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/1756-6606-6-44     Document Type: Review
Times cited : (54)

References (136)
  • 1
    • 33746310315 scopus 로고    scopus 로고
    • Alzheimer's disease
    • 10.1016/S0140-6736(06)69113-7 16876668
    • Alzheimer's disease. Blennow K, de Leon MJ, Zetterberg H, Lancet 2006 368 387 403 10.1016/S0140-6736(06)69113-7 16876668
    • (2006) Lancet , vol.368 , pp. 387-403
    • Blennow, K.1    De Leon, M.J.2    Zetterberg, H.3
  • 2
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • 10.1126/science.1072994 12130773
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Hardy J, Selkoe DJ, Science 2002 297 353 356 10.1126/science.1072994 12130773
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 3
    • 84862667837 scopus 로고    scopus 로고
    • Abeta toxicity in Alzheimer's disease
    • 10.1007/s12035-012-8251-3 22415442
    • Abeta toxicity in Alzheimer's disease. Cavallucci V, D'Amelio M, Cecconi F, Mol Neurobiol 2012 45 366 378 10.1007/s12035-012-8251-3 22415442
    • (2012) Mol Neurobiol , vol.45 , pp. 366-378
    • Cavallucci, V.1    D'Amelio, M.2    Cecconi, F.3
  • 4
    • 80052027401 scopus 로고    scopus 로고
    • Alzheimer's disease: Synapses gone cold
    • 10.1186/1750-1326-6-63 21871088
    • Alzheimer's disease: synapses gone cold. Koffie RM, Hyman BT, Spires-Jones TL, Mol Neurodegener 2011 6 63 10.1186/1750-1326-6-63 21871088
    • (2011) Mol Neurodegener , vol.6 , pp. 63
    • Koffie, R.M.1    Hyman, B.T.2    Spires-Jones, T.L.3
  • 5
    • 79959820844 scopus 로고    scopus 로고
    • Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons
    • 10.1186/1750-1326-6-47 21729327
    • Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons. Jung CG, Uhm KO, Miura Y, Hosono T, Horike H, Khanna KK, Kim MJ, Michikawa M, Mol Neurodegener 2011 6 47 10.1186/1750-1326-6-47 21729327
    • (2011) Mol Neurodegener , vol.6 , pp. 47
    • Jung, C.G.1    Uhm, K.O.2    Miura, Y.3    Hosono, T.4    Horike, H.5    Khanna, K.K.6    Kim, M.J.7    Michikawa, M.8
  • 6
    • 79955128215 scopus 로고    scopus 로고
    • Biology and pathophysiology of the amyloid precursor protein
    • 10.1186/1750-1326-6-27 21527012
    • Biology and pathophysiology of the amyloid precursor protein. Zheng H, Koo EH, Mol Neurodegener 2011 6 27 10.1186/1750-1326-6-27 21527012
    • (2011) Mol Neurodegener , vol.6 , pp. 27
    • Zheng, H.1    Koo, E.H.2
  • 7
    • 79955827892 scopus 로고    scopus 로고
    • Gene expression endophenotypes: A novel approach for gene discovery in Alzheimer's disease
    • 10.1186/1750-1326-6-31 21569597
    • Gene expression endophenotypes: a novel approach for gene discovery in Alzheimer's disease. Ertekin-Taner N, Mol Neurodegener 2011 6 31 10.1186/1750-1326-6-31 21569597
    • (2011) Mol Neurodegener , vol.6 , pp. 31
    • Ertekin-Taner, N.1
  • 8
    • 0033753842 scopus 로고    scopus 로고
    • Transcriptional regulation of Alzheimer's disease genes: Implications for susceptibility
    • 10.1093/hmg/9.16.2383 11005793
    • Transcriptional regulation of Alzheimer's disease genes: implications for susceptibility. Theuns J, Van Broeckhoven C, Hum Mol Genet 2000 9 2383 2394 10.1093/hmg/9.16.2383 11005793
    • (2000) Hum Mol Genet , vol.9 , pp. 2383-2394
    • Theuns, J.1    Van Broeckhoven, C.2
  • 9
    • 84655160766 scopus 로고    scopus 로고
    • Proteolytic processing of Alzheimer's beta-amyloid precursor protein
    • 22122372
    • Proteolytic processing of Alzheimer's beta-amyloid precursor protein. Zhang H, Ma Q, Zhang YW, Xu H, J Neurochem 2012 120 Suppl 1 9 21 22122372
    • (2012) J Neurochem , vol.120 , Issue.SUPPL. 1 , pp. 9-21
    • Zhang, H.1    Ma, Q.2    Zhang, Y.W.3    Xu, H.4
  • 10
    • 84876210341 scopus 로고    scopus 로고
    • BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and beta-amyloid production in Alzheimer's disease
    • 10.1186/1750-1326-7-52 23039869
    • BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and beta-amyloid production in Alzheimer's disease. Chami L, Checler F, Mol Neurodegener 2012 7 52 10.1186/1750-1326-7-52 23039869
    • (2012) Mol Neurodegener , vol.7 , pp. 52
    • Chami, L.1    Checler, F.2
  • 11
    • 38349107593 scopus 로고    scopus 로고
    • The Alzheimer's disease beta-secretase enzyme, BACE1
    • 10.1186/1750-1326-2-22 18005427
    • The Alzheimer's disease beta-secretase enzyme, BACE1. Cole SL, Vassar R, Mol Neurodegener 2007 2 22 10.1186/1750-1326-2-22 18005427
    • (2007) Mol Neurodegener , vol.2 , pp. 22
    • Cole, S.L.1    Vassar, R.2
  • 12
    • 0036260892 scopus 로고    scopus 로고
    • Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease
    • 10.1002/ana.10208 12112088
    • Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease. Holsinger RM, McLean CA, Beyreuther K, Masters CL, Evin G, Ann Neurol 2002 51 783 786 10.1002/ana.10208 12112088
    • (2002) Ann Neurol , vol.51 , pp. 783-786
    • Holsinger, R.M.1    McLean, C.A.2    Beyreuther, K.3    Masters, C.L.4    Evin, G.5
  • 13
    • 0037236622 scopus 로고    scopus 로고
    • Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
    • 10.1038/nm0103-3 12514700
    • Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Yang LB, Lindholm K, Yan R, Citron M, Xia W, Yang XL, Beach T, Sue L, Wong P, Price D, et al. Nat Med 2003 9 3 4 10.1038/nm0103-3 12514700
    • (2003) Nat Med , vol.9 , pp. 3-4
    • Yang, L.B.1    Lindholm, K.2    Yan, R.3    Citron, M.4    Xia, W.5    Yang, X.L.6    Beach, T.7    Sue, L.8    Wong, P.9    Price, D.10
  • 14
    • 33747347875 scopus 로고    scopus 로고
    • Transcriptional and translational regulation of BACE1 expression-implications for Alzheimer's disease
    • 10.1016/j.pneurobio.2006.06.001 16904810
    • Transcriptional and translational regulation of BACE1 expression-implications for Alzheimer's disease. Rossner S, Sastre M, Bourne K, Lichtenthaler SF, Prog Neurobiol 2006 79 95 111 10.1016/j.pneurobio.2006.06.001 16904810
    • (2006) Prog Neurobiol , vol.79 , pp. 95-111
    • Rossner, S.1    Sastre, M.2    Bourne, K.3    Lichtenthaler, S.F.4
  • 15
    • 0033595706 scopus 로고    scopus 로고
    • Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
    • 10.1126/science.286.5440.735 10531052
    • Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, et al. Science 1999 286 735 741 10.1126/science.286.5440.735 10531052
    • (1999) Science , vol.286 , pp. 735-741
    • Vassar, R.1    Bennett, B.D.2    Babu-Khan, S.3    Kahn, S.4    Mendiaz, E.A.5    Denis, P.6    Teplow, D.B.7    Ross, S.8    Amarante, P.9    Loeloff, R.10
  • 16
    • 0035116273 scopus 로고    scopus 로고
    • Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
    • 10.1038/85059 11224535
    • Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Luo Y, Bolon B, Kahn S, Bennett BD, Babu-Khan S, Denis P, Fan W, Kha H, Zhang J, Gong Y, et al. Nat Neurosci 2001 4 231 232 10.1038/85059 11224535
    • (2001) Nat Neurosci , vol.4 , pp. 231-232
    • Luo, Y.1    Bolon, B.2    Kahn, S.3    Bennett, B.D.4    Babu-Khan, S.5    Denis, P.6    Fan, W.7    Kha, H.8    Zhang, J.9    Gong, Y.10
  • 17
    • 17344388652 scopus 로고    scopus 로고
    • BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: Implications for Alzheimer's disease therapeutics
    • 10.1093/hmg/10.12.1317 11406613
    • BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, et al. Hum Mol Genet 2001 10 1317 1324 10.1093/hmg/10.12.1317 11406613
    • (2001) Hum Mol Genet , vol.10 , pp. 1317-1324
    • Roberds, S.L.1    Anderson, J.2    Basi, G.3    Bienkowski, M.J.4    Branstetter, D.G.5    Chen, K.S.6    Freedman, S.B.7    Frigon, N.L.8    Games, D.9    Hu, K.10
  • 19
    • 30444440132 scopus 로고    scopus 로고
    • BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions
    • 10.1523/JNEUROSCI.2766-05.2005 16354928
    • BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, et al. J Neurosci 2005 25 11693 11709 10.1523/JNEUROSCI.2766-05.2005 16354928
    • (2005) J Neurosci , vol.25 , pp. 11693-11709
    • Laird, F.M.1    Cai, H.2    Savonenko, A.V.3    Farah, M.H.4    He, K.5    Melnikova, T.6    Wen, H.7    Chiang, H.C.8    Xu, G.9    Koliatsos, V.E.10
  • 20
    • 84455162426 scopus 로고    scopus 로고
    • The Alzheimer's beta-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
    • 10.1186/1750-1326-6-88 22204380
    • The Alzheimer's beta-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb. Rajapaksha TW, Eimer WA, Bozza TC, Vassar R, Mol Neurodegener 2011 6 88 10.1186/1750-1326-6-88 22204380
    • (2011) Mol Neurodegener , vol.6 , pp. 88
    • Rajapaksha, T.W.1    Eimer, W.A.2    Bozza, T.C.3    Vassar, R.4
  • 22
    • 79952106055 scopus 로고    scopus 로고
    • Differential regulation of BACE1 expression by oxidative and nitrosative signals
    • 10.1186/1750-1326-6-17 21371311
    • Differential regulation of BACE1 expression by oxidative and nitrosative signals. Kwak YD, Wang R, Li JJ, Zhang YW, Xu H, Liao FF, Mol Neurodegener 2011 6 17 10.1186/1750-1326-6-17 21371311
    • (2011) Mol Neurodegener , vol.6 , pp. 17
    • Kwak, Y.D.1    Wang, R.2    Li, J.J.3    Zhang, Y.W.4    Xu, H.5    Liao, F.F.6
  • 23
    • 49749153496 scopus 로고    scopus 로고
    • Post-translational control of sp-family transcription factors
    • 10.2174/138920208785133244 19471608
    • Post-translational control of sp-family transcription factors. Waby JS, Bingle CD, Corfe BM, Curr Genomics 2008 9 301 311 10.2174/138920208785133244 19471608
    • (2008) Curr Genomics , vol.9 , pp. 301-311
    • Waby, J.S.1    Bingle, C.D.2    Corfe, B.M.3
  • 24
    • 0347356360 scopus 로고    scopus 로고
    • Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1
    • 10.1128/MCB.24.2.865-874.2004 14701757
    • Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1. Christensen MA, Zhou W, Qing H, Lehman A, Philipsen S, Song W, Mol Cell Biol 2004 24 865 874 10.1128/MCB.24.2.865-874.2004 14701757
    • (2004) Mol Cell Biol , vol.24 , pp. 865-874
    • Christensen, M.A.1    Zhou, W.2    Qing, H.3    Lehman, A.4    Philipsen, S.5    Song, W.6
  • 25
    • 0024604148 scopus 로고
    • Measurement of the binding of transcription factor Sp1 to a single GC box recognition sequence
    • 10.1093/nar/17.7.2639 2717405
    • Measurement of the binding of transcription factor Sp1 to a single GC box recognition sequence. Letovsky J, Dynan WS, Nucleic Acids Res 1989 17 2639 2653 10.1093/nar/17.7.2639 2717405
    • (1989) Nucleic Acids Res , vol.17 , pp. 2639-2653
    • Letovsky, J.1    Dynan, W.S.2
  • 26
    • 84856146554 scopus 로고    scopus 로고
    • Transcriptional regulation of beta-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments
    • 10.1002/ana.22625 22275252
    • Transcriptional regulation of beta-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments. Chu J, Zhuo JM, Pratico D, Ann Neurol 2012 71 57 67 10.1002/ana.22625 22275252
    • (2012) Ann Neurol , vol.71 , pp. 57-67
    • Chu, J.1    Zhuo, J.M.2    Pratico, D.3
  • 27
    • 0027209915 scopus 로고
    • A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation
    • 8253080
    • A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation. Perkins ND, Edwards NL, Duckett CS, Agranoff AB, Schmid RM, Nabel GJ, EMBO J 1993 12 3551 3558 8253080
    • (1993) EMBO J , vol.12 , pp. 3551-3558
    • Perkins, N.D.1    Edwards, N.L.2    Duckett, C.S.3    Agranoff, A.B.4    Schmid, R.M.5    Nabel, G.J.6
  • 29
    • 34248178463 scopus 로고    scopus 로고
    • Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides
    • 10.1002/jnr.21252 17385716
    • Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides. Bourne KZ, Ferrari DC, Lange-Dohna C, Rossner S, Wood TG, Perez-Polo JR, J Neurosci Res 2007 85 1194 1204 10.1002/jnr.21252 17385716
    • (2007) J Neurosci Res , vol.85 , pp. 1194-1204
    • Bourne, K.Z.1    Ferrari, D.C.2    Lange-Dohna, C.3    Rossner, S.4    Wood, T.G.5    Perez-Polo, J.R.6
  • 30
    • 84863798868 scopus 로고    scopus 로고
    • Nuclear factor-kappaB regulates betaAPP and beta- and gamma-secretases differently at physiological and supraphysiological Abeta concentrations
    • 10.1074/jbc.M111.333054 22654105
    • Nuclear factor-kappaB regulates betaAPP and beta- and gamma-secretases differently at physiological and supraphysiological Abeta concentrations. Chami L, Buggia-Prevot V, Duplan E, Delprete D, Chami M, Peyron JF, Checler F, J Biol Chem 2012 287 24573 24584 10.1074/jbc.M111.333054 22654105
    • (2012) J Biol Chem , vol.287 , pp. 24573-24584
    • Chami, L.1    Buggia-Prevot, V.2    Duplan, E.3    Delprete, D.4    Chami, M.5    Peyron, J.F.6    Checler, F.7
  • 31
    • 3142523739 scopus 로고    scopus 로고
    • HIF-1: An oxygen and metal responsive transcription factor
    • 10.4161/cbt.3.1.547 14726713
    • HIF-1: an oxygen and metal responsive transcription factor. Maxwell P, Salnikow K, Cancer Biol Ther 2004 3 29 35 10.4161/cbt.3.1.547 14726713
    • (2004) Cancer Biol Ther , vol.3 , pp. 29-35
    • Maxwell, P.1    Salnikow, K.2
  • 32
    • 0036469038 scopus 로고    scopus 로고
    • Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    • 10.1126/science.1068592 11823643
    • Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML, Science 2002 295 858 861 10.1126/science.1068592 11823643
    • (2002) Science , vol.295 , pp. 858-861
    • Lando, D.1    Peet, D.J.2    Whelan, D.A.3    Gorman, J.J.4    Whitelaw, M.L.5
  • 33
    • 33845505233 scopus 로고    scopus 로고
    • Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression
    • 10.1073/pnas.0606298103 17121991
    • Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression. Sun X, He G, Qing H, Zhou W, Dobie F, Cai F, Staufenbiel M, Huang LE, Song W, Proc Natl Acad Sci USA 2006 103 18727 18732 10.1073/pnas.0606298103 17121991
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 18727-18732
    • Sun, X.1    He, G.2    Qing, H.3    Zhou, W.4    Dobie, F.5    Cai, F.6    Staufenbiel, M.7    Huang, L.E.8    Song, W.9
  • 34
    • 34249727115 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation
    • 10.1074/jbc.M608856200 17303576
    • Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H, Zhang YW, J Biol Chem 2007 282 10873 10880 10.1074/jbc.M608856200 17303576
    • (2007) J Biol Chem , vol.282 , pp. 10873-10880
    • Zhang, X.1    Zhou, K.2    Wang, R.3    Cui, J.4    Lipton, S.A.5    Liao, F.F.6    Xu, H.7    Zhang, Y.W.8
  • 35
    • 58549119790 scopus 로고    scopus 로고
    • The up-regulation of BACE1 mediated by hypoxia and ischemic injury: Role of oxidative stress and HIF1alpha
    • 10.1111/j.1471-4159.2008.05858.x 19196431
    • The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha. Guglielmotto M, Aragno M, Autelli R, Giliberto L, Novo E, Colombatto S, Danni O, Parola M, Smith MA, Perry G, et al. J Neurochem 2009 108 1045 1056 10.1111/j.1471-4159.2008.05858.x 19196431
    • (2009) J Neurochem , vol.108 , pp. 1045-1056
    • Guglielmotto, M.1    Aragno, M.2    Autelli, R.3    Giliberto, L.4    Novo, E.5    Colombatto, S.6    Danni, O.7    Parola, M.8    Smith, M.A.9    Perry, G.10
  • 36
    • 77955331953 scopus 로고    scopus 로고
    • Salidroside attenuates hypoxia-induced abnormal processing of amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells
    • 10.1016/j.neulet.2010.06.076 20599477
    • Salidroside attenuates hypoxia-induced abnormal processing of amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells. Li QY, Wang HM, Wang ZQ, Ma JF, Ding JQ, Chen SD, Neurosci Lett 2010 481 154 158 10.1016/j.neulet.2010.06.076 20599477
    • (2010) Neurosci Lett , vol.481 , pp. 154-158
    • Li, Q.Y.1    Wang, H.M.2    Wang, Z.Q.3    Ma, J.F.4    Ding, J.Q.5    Chen, S.D.6
  • 38
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    • 10.1016/0092-8674(94)90006-X 8001151
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Tontonoz P, Hu E, Spiegelman BM, Cell 1994 79 1147 1156 10.1016/0092-8674(94)90006-X 8001151
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 39
    • 80051774038 scopus 로고    scopus 로고
    • Nuclear receptors as therapeutic targets for Alzheimer's disease
    • 10.1517/14728222.2011.594043 21718217
    • Nuclear receptors as therapeutic targets for Alzheimer's disease. Mandrekar-Colucci S, Landreth GE, Expert Opin Ther Targets 2011 15 1085 1097 10.1517/14728222.2011.594043 21718217
    • (2011) Expert Opin Ther Targets , vol.15 , pp. 1085-1097
    • Mandrekar-Colucci, S.1    Landreth, G.E.2
  • 41
    • 0035693924 scopus 로고    scopus 로고
    • Inflammation, autotoxicity and Alzheimer disease
    • 10.1016/S0197-4580(01)00289-5 11754986
    • Inflammation, autotoxicity and Alzheimer disease. McGeer PL, McGeer EG, Neurobiol Aging 2001 22 799 809 10.1016/S0197-4580(01)00289-5 11754986
    • (2001) Neurobiol Aging , vol.22 , pp. 799-809
    • McGeer, P.L.1    McGeer, E.G.2
  • 42
    • 0024299370 scopus 로고
    • Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
    • 10.1126/science.3283935 3283935
    • Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Mahley RW, Science 1988 240 622 630 10.1126/science.3283935 3283935
    • (1988) Science , vol.240 , pp. 622-630
    • Mahley, R.W.1
  • 43
    • 84873722367 scopus 로고    scopus 로고
    • Apolipoprotein e and Alzheimer disease: Risk, mechanisms and therapy
    • 10.1038/nrneurol.2012.263 23296339
    • Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Liu CC, Kanekiyo T, Xu H, Bu G, Nat Rev Neurol 2013 9 106 118 10.1038/nrneurol. 2012.263 23296339
    • (2013) Nat Rev Neurol , vol.9 , pp. 106-118
    • Liu, C.C.1    Kanekiyo, T.2    Xu, H.3    Bu, G.4
  • 44
    • 33750333569 scopus 로고    scopus 로고
    • Reelin, lipoprotein receptors and synaptic plasticity
    • 10.1038/nrn2009 17053810
    • Reelin, lipoprotein receptors and synaptic plasticity. Herz J, Chen Y, Nat Rev Neurosci 2006 7 850 859 10.1038/nrn2009 17053810
    • (2006) Nat Rev Neurosci , vol.7 , pp. 850-859
    • Herz, J.1    Chen, Y.2
  • 45
    • 80052604940 scopus 로고    scopus 로고
    • Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions
    • 10.1073/pnas.1106420108 21873229
    • Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions. Chen J, Li Q, Wang J, Proc Natl Acad Sci USA 2011 108 14813 14818 10.1073/pnas.1106420108 21873229
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 14813-14818
    • Chen, J.1    Li, Q.2    Wang, J.3
  • 46
    • 84861903643 scopus 로고    scopus 로고
    • Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease
    • 10.1073/pnas.1207022109 22615372
    • Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease. Frieden C, Garai K, Proc Natl Acad Sci U S A 2012 109 8913 8918 10.1073/pnas.1207022109 22615372
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 8913-8918
    • Frieden, C.1    Garai, K.2
  • 47
    • 65249158083 scopus 로고    scopus 로고
    • Understanding the association of apolipoprotein E4 with Alzheimer disease: Clues from its structure
    • 18948255
    • Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure. Zhong N, Weisgraber KH, J Biol Chem 2009 284 6027 6031 18948255
    • (2009) J Biol Chem , vol.284 , pp. 6027-6031
    • Zhong, N.1    Weisgraber, K.H.2
  • 48
    • 67349270965 scopus 로고    scopus 로고
    • Apolipoprotein e and its receptors in Alzheimer's disease: Pathways, pathogenesis and therapy
    • 10.1038/nrn2620 19339974
    • Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Bu G, Nat Rev Neurosci 2009 10 333 344 10.1038/nrn2620 19339974
    • (2009) Nat Rev Neurosci , vol.10 , pp. 333-344
    • Bu, G.1
  • 50
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex, and ethnicity on the association between apolipoprotein e genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer disease meta analysis consortium
    • 10.1001/jama.1997.03550160069041 9343467
    • Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer disease meta analysis consortium. Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM, JAMA 1997 278 1349 1356 10.1001/jama.1997.03550160069041 9343467
    • (1997) JAMA , vol.278 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3    Hyman, B.4    Kukull, W.A.5    Mayeux, R.6    Myers, R.H.7    Pericak-Vance, M.A.8    Risch, N.9    Van Duijn, C.M.10
  • 51
    • 0037345672 scopus 로고    scopus 로고
    • Expanding the association between the APOE gene and the risk of Alzheimer's disease: Possible roles for APOE promoter polymorphisms and alterations in APOE transcription
    • 10.1046/j.1471-4159.2003.01615.x 12614323
    • Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. Laws SM, Hone E, Gandy S, Martins RN, J Neurochem 2003 84 1215 1236 10.1046/j.1471-4159.2003.01615.x 12614323
    • (2003) J Neurochem , vol.84 , pp. 1215-1236
    • Laws, S.M.1    Hone, E.2    Gandy, S.3    Martins, R.N.4
  • 52
    • 0031043673 scopus 로고    scopus 로고
    • Increased plasma apolipoprotein e (apoE) levels in Alzheimer's disease
    • 10.1016/S0304-3940(97)13394-8 9058415
    • Increased plasma apolipoprotein E (apoE) levels in Alzheimer's disease. Taddei K, Clarnette R, Gandy SE, Martins RN, Neurosci Lett 1997 223 29 32 10.1016/S0304-3940(97)13394-8 9058415
    • (1997) Neurosci Lett , vol.223 , pp. 29-32
    • Taddei, K.1    Clarnette, R.2    Gandy, S.E.3    Martins, R.N.4
  • 53
    • 0030801045 scopus 로고    scopus 로고
    • Cerebrospinal fluid apolipoprotein e (apoE) levels in Alzheimer's disease patients are increased at follow up and show a correlation with levels of tau protein
    • 10.1016/S0304-3940(97)00429-1 9223597
    • Cerebrospinal fluid apolipoprotein E (apoE) levels in Alzheimer's disease patients are increased at follow up and show a correlation with levels of tau protein. Lindh M, Blomberg M, Jensen M, Basun H, Lannfelt L, Engvall B, Scharnagel H, Marz W, Wahlund LO, Cowburn RF, Neurosci Lett 1997 229 85 88 10.1016/S0304-3940(97)00429-1 9223597
    • (1997) Neurosci Lett , vol.229 , pp. 85-88
    • Lindh, M.1    Blomberg, M.2    Jensen, M.3    Basun, H.4    Lannfelt, L.5    Engvall, B.6    Scharnagel, H.7    Marz, W.8    Wahlund, L.O.9    Cowburn, R.F.10
  • 56
    • 0030001328 scopus 로고    scopus 로고
    • Brain expression of apolipoproteins E, J, and A-I in Alzheimer's disease
    • 8632166
    • Brain expression of apolipoproteins E, J, and A-I in Alzheimer's disease. Harr SD, Uint L, Hollister R, Hyman BT, Mendez AJ, J Neurochem 1996 66 2429 2435 8632166
    • (1996) J Neurochem , vol.66 , pp. 2429-2435
    • Harr, S.D.1    Uint, L.2    Hollister, R.3    Hyman, B.T.4    Mendez, A.J.5
  • 57
    • 0032829336 scopus 로고    scopus 로고
    • Apolipoprotein e and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein e genotype dependent
    • 10.1016/S0006-8993(99)01894-6 10528114
    • Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent. Beffert U, Cohn JS, Petit-Turcotte C, Tremblay M, Aumont N, Ramassamy C, Davignon J, Poirier J, Brain Res 1999 843 87 94 10.1016/S0006-8993(99)01894-6 10528114
    • (1999) Brain Res , vol.843 , pp. 87-94
    • Beffert, U.1    Cohn, J.S.2    Petit-Turcotte, C.3    Tremblay, M.4    Aumont, N.5    Ramassamy, C.6    Davignon, J.7    Poirier, J.8
  • 59
    • 84858423000 scopus 로고    scopus 로고
    • Reducing human apolipoprotein e levels attenuates age-dependent Abeta accumulation in mutant human amyloid precursor protein transgenic mice
    • 10.1523/JNEUROSCI.0033-12.2012 22492035
    • Reducing human apolipoprotein E levels attenuates age-dependent Abeta accumulation in mutant human amyloid precursor protein transgenic mice. Bien-Ly N, Gillespie AK, Walker D, Yoon SY, Huang Y, J Neurosci 2012 32 4803 4811 10.1523/JNEUROSCI.0033-12.2012 22492035
    • (2012) J Neurosci , vol.32 , pp. 4803-4811
    • Bien-Ly, N.1    Gillespie, A.K.2    Walker, D.3    Yoon, S.Y.4    Huang, Y.5
  • 60
    • 83055160869 scopus 로고    scopus 로고
    • Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-beta amyloidosis
    • 10.1523/JNEUROSCI.3773-11.2011 22159114
    • Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-beta amyloidosis. Kim J, Jiang H, Park S, Eltorai AE, Stewart FR, Yoon H, Basak JM, Finn MB, Holtzman DM, J Neurosci 2011 31 18007 18012 10.1523/JNEUROSCI.3773-11.2011 22159114
    • (2011) J Neurosci , vol.31 , pp. 18007-18012
    • Kim, J.1    Jiang, H.2    Park, S.3    Eltorai, A.E.4    Stewart, F.R.5    Yoon, H.6    Basak, J.M.7    Finn, M.B.8    Holtzman, D.M.9
  • 61
    • 0019834202 scopus 로고
    • Effects of an atherogenic diet on apolipoprotein e biosynthesis in the rat
    • 10.1021/bi00525a028 6171300
    • Effects of an atherogenic diet on apolipoprotein E biosynthesis in the rat. Lin-Lee YC, Tanaka Y, Lin CT, Chan L, Biochemistry 1981 20 6474 6480 10.1021/bi00525a028 6171300
    • (1981) Biochemistry , vol.20 , pp. 6474-6480
    • Lin-Lee, Y.C.1    Tanaka, Y.2    Lin, C.T.3    Chan, L.4
  • 62
    • 0023899914 scopus 로고
    • Expression of the human apolipoprotein e gene is regulated by multiple positive and negative elements
    • 3372525
    • Expression of the human apolipoprotein E gene is regulated by multiple positive and negative elements. Smith JD, Melian A, Leff T, Breslow JL, J Biol Chem 1988 263 8300 8308 3372525
    • (1988) J Biol Chem , vol.263 , pp. 8300-8308
    • Smith, J.D.1    Melian, A.2    Leff, T.3    Breslow, J.L.4
  • 63
    • 0025405872 scopus 로고
    • The apolipoprotein gene family: Organization of upstream elements and regulation of gene expression
    • 2133052
    • The apolipoprotein gene family: organization of upstream elements and regulation of gene expression. Surguchov AP, Biomed Sci 1990 1 344 353 2133052
    • (1990) Biomed Sci , vol.1 , pp. 344-353
    • Surguchov, A.P.1
  • 65
    • 0029969180 scopus 로고    scopus 로고
    • Transcription factor AP-2 regulates human apolipoprotein e gene expression in astrocytoma cells
    • 8922411
    • Transcription factor AP-2 regulates human apolipoprotein E gene expression in astrocytoma cells. Garcia MA, Vazquez J, Gimenez C, Valdivieso F, Zafra F, J Neurosci 1996 16 7550 7556 8922411
    • (1996) J Neurosci , vol.16 , pp. 7550-7556
    • Garcia, M.A.1    Vazquez, J.2    Gimenez, C.3    Valdivieso, F.4    Zafra, F.5
  • 67
    • 79956311751 scopus 로고    scopus 로고
    • Critical role of astroglial apolipoprotein e and liver X receptor-alpha expression for microglial Abeta phagocytosis
    • 10.1523/JNEUROSCI.6546-10.2011 21562267
    • Critical role of astroglial apolipoprotein E and liver X receptor-alpha expression for microglial Abeta phagocytosis. Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson JA, Holtzman DM, Heneka MT, J Neurosci 2011 31 7049 7059 10.1523/JNEUROSCI.6546-10.2011 21562267
    • (2011) J Neurosci , vol.31 , pp. 7049-7059
    • Terwel, D.1    Steffensen, K.R.2    Verghese, P.B.3    Kummer, M.P.4    Gustafsson, J.A.5    Holtzman, D.M.6    Heneka, M.T.7
  • 68
    • 9144242586 scopus 로고    scopus 로고
    • Divergent effects of peroxisome proliferator-activated receptor gamma agonists and tumor necrosis factor alpha on adipocyte ApoE expression
    • 10.1074/jbc.M408461200 15339912
    • Divergent effects of peroxisome proliferator-activated receptor gamma agonists and tumor necrosis factor alpha on adipocyte ApoE expression. Yue L, Rasouli N, Ranganathan G, Kern PA, Mazzone T, J Biol Chem 2004 279 47626 47632 10.1074/jbc.M408461200 15339912
    • (2004) J Biol Chem , vol.279 , pp. 47626-47632
    • Yue, L.1    Rasouli, N.2    Ranganathan, G.3    Kern, P.A.4    Mazzone, T.5
  • 69
    • 0028130370 scopus 로고
    • Cell type-specific regulation of expression of transcription factor AP-2 in neuroectodermal cells
    • 10.1006/dbio.1994.1279 7958425
    • Cell type-specific regulation of expression of transcription factor AP-2 in neuroectodermal cells. Philipp J, Mitchell PJ, Malipiero U, Fontana A, Dev Biol 1994 165 602 614 10.1006/dbio.1994.1279 7958425
    • (1994) Dev Biol , vol.165 , pp. 602-614
    • Philipp, J.1    Mitchell, P.J.2    Malipiero, U.3    Fontana, A.4
  • 70
    • 0024740707 scopus 로고
    • Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers
    • 10.1101/gad.3.10.1507 2482225
    • Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers. Luscher B, Mitchell PJ, Williams T, Tjian R, Genes Dev 1989 3 1507 1517 10.1101/gad.3.10.1507 2482225
    • (1989) Genes Dev , vol.3 , pp. 1507-1517
    • Luscher, B.1    Mitchell, P.J.2    Williams, T.3    Tjian, R.4
  • 71
    • 33746234890 scopus 로고    scopus 로고
    • The AP-2 family of transcription factors
    • 10.1186/gb-2005-6-13-246 16420676
    • The AP-2 family of transcription factors. Eckert D, Buhl S, Weber S, Jager R, Schorle H, Genome Biol 2005 6 246 10.1186/gb-2005-6-13-246 16420676
    • (2005) Genome Biol , vol.6 , pp. 246
    • Eckert, D.1    Buhl, S.2    Weber, S.3    Jager, R.4    Schorle, H.5
  • 72
    • 25444528682 scopus 로고    scopus 로고
    • Transcription factor AP-2 and monoaminergic functions in the central nervous system
    • 10.1007/s00702-005-0325-1 15959839
    • Transcription factor AP-2 and monoaminergic functions in the central nervous system. Damberg M, J Neural Transm 2005 112 1281 1296 10.1007/s00702-005-0325-1 15959839
    • (2005) J Neural Transm , vol.112 , pp. 1281-1296
    • Damberg, M.1
  • 73
    • 84857782207 scopus 로고    scopus 로고
    • AP-2beta regulates amyloid beta-protein stimulation of apolipoprotein e transcription in astrocytes
    • 22325097
    • AP-2beta regulates amyloid beta-protein stimulation of apolipoprotein E transcription in astrocytes. Rossello XS, Igbavboa U, Weisman GA, Sun GY, Wood WG, Brain Res 2012 1444 87 95 22325097
    • (2012) Brain Res , vol.1444 , pp. 87-95
    • Rossello, X.S.1    Igbavboa, U.2    Weisman, G.A.3    Sun, G.Y.4    Wood, W.G.5
  • 75
    • 9144229429 scopus 로고    scopus 로고
    • A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein e expression, secretion and cholesterol homeostasis in astrocytes
    • 10.1111/j.1471-4159.2004.02183.x 14720212
    • A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes. Liang Y, Lin S, Beyer TP, Zhang Y, Wu X, Bales KR, DeMattos RB, May PC, Li SD, Jiang XC, et al. J Neurochem 2004 88 623 634 10.1111/j.1471-4159. 2004.02183.x 14720212
    • (2004) J Neurochem , vol.88 , pp. 623-634
    • Liang, Y.1    Lin, S.2    Beyer, T.P.3    Zhang, Y.4    Wu, X.5    Bales, K.R.6    Demattos, R.B.7    May, P.C.8    Li, S.D.9    Jiang, X.C.10
  • 76
    • 0034663172 scopus 로고    scopus 로고
    • Apolipoprotein e gene promoter polymorphisms in Alzheimer's disease
    • 10.1002/1097-0029(20000815)50:4<261: AID-JEMT2>3.0.CO;2-B 10936877
    • Apolipoprotein E gene promoter polymorphisms in Alzheimer's disease. Bullido MJ, Valdivieso F, Microsc Res Tech 2000 50 261 267 10.1002/1097- 0029(20000815)50:4<261::AID-JEMT2>3.0.CO;2-B 10936877
    • (2000) Microsc Res Tech , vol.50 , pp. 261-267
    • Bullido, M.J.1    Valdivieso, F.2
  • 79
    • 0031911596 scopus 로고    scopus 로고
    • A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease
    • 10.1093/hmg/7.3.533 9467014
    • A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease. Lambert JC, Pasquier F, Cottel D, Frigard B, Amouyel P, Chartier-Harlin MC, Hum Mol Genet 1998 7 533 540 10.1093/hmg/7.3.533 9467014
    • (1998) Hum Mol Genet , vol.7 , pp. 533-540
    • Lambert, J.C.1    Pasquier, F.2    Cottel, D.3    Frigard, B.4    Amouyel, P.5    Chartier-Harlin, M.C.6
  • 80
    • 0030054380 scopus 로고    scopus 로고
    • A newly identified polymorphism in the apolipoprotein e enhancer gene region is associated with Alzheimer's disease and strongly with the epsilon 4 allele
    • 10.1212/WNL.47.1.196 8710077
    • A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the epsilon 4 allele. Mui S, Briggs M, Chung H, Wallace RB, Gomez-Isla T, Rebeck GW, Hyman BT, Neurology 1996 47 196 201 10.1212/WNL.47.1.196 8710077
    • (1996) Neurology , vol.47 , pp. 196-201
    • Mui, S.1    Briggs, M.2    Chung, H.3    Wallace, R.B.4    Gomez-Isla, T.5    Rebeck, G.W.6    Hyman, B.T.7
  • 81
    • 0032498118 scopus 로고    scopus 로고
    • Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein e gene
    • 10.1016/S0014-5793(97)01543-3 9468288
    • Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene. Artiga MJ, Bullido MJ, Sastre I, Recuero M, Garcia MA, Aldudo J, Vazquez J, Valdivieso F, FEBS Lett 1998 421 105 108 10.1016/S0014-5793(97)01543-3 9468288
    • (1998) FEBS Lett , vol.421 , pp. 105-108
    • Artiga, M.J.1    Bullido, M.J.2    Sastre, I.3    Recuero, M.4    Garcia, M.A.5    Aldudo, J.6    Vazquez, J.7    Valdivieso, F.8
  • 82
    • 7344221464 scopus 로고    scopus 로고
    • Pronounced impact of Th1/E47cs mutation compared with -491 at mutation on neural APOE gene expression and risk of developing Alzheimer's disease
    • 10.1093/hmg/7.9.1511 9700208
    • Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease. Lambert JC, Berr C, Pasquier F, Delacourte A, Frigard B, Cottel D, Perez-Tur J, Mouroux V, Mohr M, Cecyre D, et al. Hum Mol Genet 1998 7 1511 1516 10.1093/hmg/7.9.1511 9700208
    • (1998) Hum Mol Genet , vol.7 , pp. 1511-1516
    • Lambert, J.C.1    Berr, C.2    Pasquier, F.3    Delacourte, A.4    Frigard, B.5    Cottel, D.6    Perez-Tur, J.7    Mouroux, V.8    Mohr, M.9    Cecyre, D.10
  • 83
    • 0025219026 scopus 로고
    • Genomic organization of the human amyloid beta-protein precursor gene
    • 10.1016/0378-1119(90)90310-N 2110105
    • Genomic organization of the human amyloid beta-protein precursor gene. Yoshikai S, Sasaki H, Doh-ura K, Furuya H, Sakaki Y, Gene 1990 87 257 263 10.1016/0378-1119(90)90310-N 2110105
    • (1990) Gene , vol.87 , pp. 257-263
    • Yoshikai, S.1    Sasaki, H.2    Doh-Ura, K.3    Furuya, H.4    Sakaki, Y.5
  • 84
    • 0023495384 scopus 로고
    • Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease
    • 3322812
    • Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease. Goedert M, EMBO J 1987 6 3627 3632 3322812
    • (1987) EMBO J , vol.6 , pp. 3627-3632
    • Goedert, M.1
  • 85
    • 0027380288 scopus 로고
    • Structural features of the 5' upstream regulatory region of the gene encoding rat amyloid precursor protein
    • 10.1016/0378-1119(93)90648-M 8224912
    • Structural features of the 5' upstream regulatory region of the gene encoding rat amyloid precursor protein. Chernak JM, Gene 1993 133 255 260 10.1016/0378-1119(93)90648-M 8224912
    • (1993) Gene , vol.133 , pp. 255-260
    • Chernak, J.M.1
  • 86
    • 0026611932 scopus 로고
    • Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse
    • 10.1016/0378-1119(92)90375-Y 1555768
    • Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse. Izumi R, Yamada T, Yoshikai S, Sasaki H, Hattori M, Sakaki Y, Gene 1992 112 189 195 10.1016/0378-1119(92)90375-Y 1555768
    • (1992) Gene , vol.112 , pp. 189-195
    • Izumi, R.1    Yamada, T.2    Yoshikai, S.3    Sasaki, H.4    Hattori, M.5    Sakaki, Y.6
  • 88
    • 0024542108 scopus 로고
    • Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene
    • 10.1016/0006-291X(89)92437-6 2538123
    • Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene. La Fauci G, Lahiri DK, Salton SR, Robakis NK, Biochem Biophys Res Commun 1989 159 297 304 10.1016/0006-291X(89)92437-6 2538123
    • (1989) Biochem Biophys Res Commun , vol.159 , pp. 297-304
    • La Fauci, G.1    Lahiri, D.K.2    Salton, S.R.3    Robakis, N.K.4
  • 89
    • 0029838173 scopus 로고    scopus 로고
    • The initiator element and proximal upstream sequences affect transcriptional activity and start site selection in the amyloid beta-protein precursor promoter
    • 10.1074/jbc.271.36.22231 8703038
    • The initiator element and proximal upstream sequences affect transcriptional activity and start site selection in the amyloid beta-protein precursor promoter. Quitschke WW, Matthews JP, Kraus RJ, Vostrov AA, J Biol Chem 1996 271 22231 22239 10.1074/jbc.271.36.22231 8703038
    • (1996) J Biol Chem , vol.271 , pp. 22231-22239
    • Quitschke, W.W.1    Matthews, J.P.2    Kraus, R.J.3    Vostrov, A.A.4
  • 90
    • 0026806977 scopus 로고
    • The amyloid beta-protein precursor promoter. A region essential for transcriptional activity contains a nuclear factor binding domain
    • 1380960
    • The amyloid beta-protein precursor promoter. A region essential for transcriptional activity contains a nuclear factor binding domain. Quitschke WW, Goldgaber D, J Biol Chem 1992 267 17362 17368 1380960
    • (1992) J Biol Chem , vol.267 , pp. 17362-17368
    • Quitschke, W.W.1    Goldgaber, D.2
  • 91
    • 0032517094 scopus 로고    scopus 로고
    • Functional identification of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein
    • 10.1016/S0378-1119(98)00340-0 9795200
    • Functional identification of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein. Song W, Lahiri DK, Gene 1998 217 165 176 10.1016/S0378-1119(98)00340-0 9795200
    • (1998) Gene , vol.217 , pp. 165-176
    • Song, W.1    Lahiri, D.K.2
  • 92
    • 0026507460 scopus 로고
    • The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter
    • 10.1093/nar/20.1.63 1738605
    • The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter. Pollwein P, Masters CL, Beyreuther K, Nucleic Acids Res 1992 20 63 68 10.1093/nar/20.1.63 1738605
    • (1992) Nucleic Acids Res , vol.20 , pp. 63-68
    • Pollwein, P.1    Masters, C.L.2    Beyreuther, K.3
  • 93
    • 0028023541 scopus 로고
    • Two nuclear factor binding domains activate expression from the human amyloid beta-protein precursor promoter
    • 8063744
    • Two nuclear factor binding domains activate expression from the human amyloid beta-protein precursor promoter. Quitschke WW, J Biol Chem 1994 269 21229 21233 8063744
    • (1994) J Biol Chem , vol.269 , pp. 21229-21233
    • Quitschke, W.W.1
  • 94
    • 0031468080 scopus 로고    scopus 로고
    • The zinc finger protein CTCF binds to the APBbeta domain of the amyloid beta-protein precursor promoter. Evidence for a role in transcriptional activation
    • 10.1074/jbc.272.52.33353 9407128
    • The zinc finger protein CTCF binds to the APBbeta domain of the amyloid beta-protein precursor promoter. Evidence for a role in transcriptional activation. Vostrov AA, Quitschke WW, J Biol Chem 1997 272 33353 33359 10.1074/jbc.272.52.33353 9407128
    • (1997) J Biol Chem , vol.272 , pp. 33353-33359
    • Vostrov, A.A.1    Quitschke, W.W.2
  • 95
    • 0028981078 scopus 로고
    • USF binds to the APB alpha sequence in the promoter of the amyloid beta-protein precursor gene
    • 10.1093/nar/23.14.2734 7651835
    • USF binds to the APB alpha sequence in the promoter of the amyloid beta-protein precursor gene. Vostrov AA, Quitschke WW, Vidal F, Schwarzman AL, Goldgaber D, Nucleic Acids Res 1995 23 2734 2741 10.1093/nar/23.14.2734 7651835
    • (1995) Nucleic Acids Res , vol.23 , pp. 2734-2741
    • Vostrov, A.A.1    Quitschke, W.W.2    Vidal, F.3    Schwarzman, A.L.4    Goldgaber, D.5
  • 96
    • 0027198067 scopus 로고
    • Overlapping binding sites of two different transcription factors in the promoter of the human gene for the Alzheimer amyloid precursor protein
    • 10.1006/bbrc.1993.1096 8427604
    • Overlapping binding sites of two different transcription factors in the promoter of the human gene for the Alzheimer amyloid precursor protein. Pollwein P, Biochem Biophys Res Commun 1993 190 637 647 10.1006/bbrc.1993.1096 8427604
    • (1993) Biochem Biophys Res Commun , vol.190 , pp. 637-647
    • Pollwein, P.1
  • 97
    • 0030058190 scopus 로고    scopus 로고
    • Heat shock factor-1 mediates the transcriptional activation of Alzheimer's beta-amyloid precursor protein gene in response to stress
    • 10.1016/0169-328X(95)00214-D 8717371
    • Heat shock factor-1 mediates the transcriptional activation of Alzheimer's beta-amyloid precursor protein gene in response to stress. Dewji NN, Do C, Brain Res Mol Brain Res 1996 35 325 328 10.1016/0169-328X(95)00214-D 8717371
    • (1996) Brain Res Mol Brain Res , vol.35 , pp. 325-328
    • Dewji, N.N.1    Do, C.2
  • 98
    • 0029666276 scopus 로고    scopus 로고
    • Interleukin-1beta and glutamate activate the NF-kappaB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures
    • 10.1074/jbc.271.25.15002 8663145
    • Interleukin-1beta and glutamate activate the NF-kappaB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures. Grilli M, Goffi F, Memo M, Spano P, J Biol Chem 1996 271 15002 15007 10.1074/jbc.271.25.15002 8663145
    • (1996) J Biol Chem , vol.271 , pp. 15002-15007
    • Grilli, M.1    Goffi, F.2    Memo, M.3    Spano, P.4
  • 99
    • 0028972237 scopus 로고
    • Identification and characterization of a kappa B/Rel binding site in the regulatory region of the amyloid precursor protein gene
    • 10.1074/jbc.270.45.26774 7592914
    • Identification and characterization of a kappa B/Rel binding site in the regulatory region of the amyloid precursor protein gene. Grilli M, Ribola M, Alberici A, Valerio A, Memo M, Spano P, J Biol Chem 1995 270 26774 26777 10.1074/jbc.270.45.26774 7592914
    • (1995) J Biol Chem , vol.270 , pp. 26774-26777
    • Grilli, M.1    Ribola, M.2    Alberici, A.3    Valerio, A.4    Memo, M.5    Spano, P.6
  • 100
    • 65849255721 scopus 로고    scopus 로고
    • Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene
    • 10.1002/jnr.22039 19267423
    • Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene. Wang PL, Niidome T, Akaike A, Kihara T, Sugimoto H, J Neurosci Res 2009 87 2105 2114 10.1002/jnr.22039 19267423
    • (2009) J Neurosci Res , vol.87 , pp. 2105-2114
    • Wang, P.L.1    Niidome, T.2    Akaike, A.3    Kihara, T.4    Sugimoto, H.5
  • 101
    • 4544288083 scopus 로고    scopus 로고
    • Mechanism of promoter activity of the beta-amyloid precursor protein gene in different cell lines: Identification of a specific 30 bp fragment in the proximal promoter region
    • 10.1111/j.1471-4159.2004.02608.x 15341527
    • Mechanism of promoter activity of the beta-amyloid precursor protein gene in different cell lines: identification of a specific 30 bp fragment in the proximal promoter region. Ge YW, Ghosh C, Song W, Maloney B, Lahiri DK, J Neurochem 2004 90 1432 1444 10.1111/j.1471-4159.2004.02608.x 15341527
    • (2004) J Neurochem , vol.90 , pp. 1432-1444
    • Ge, Y.W.1    Ghosh, C.2    Song, W.3    Maloney, B.4    Lahiri, D.K.5
  • 102
    • 2442586535 scopus 로고    scopus 로고
    • Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene
    • 10.1074/jbc.M400805200 14985339
    • Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene. Bellingham SA, Lahiri DK, Maloney B, La Fontaine S, Multhaup G, Camakaris J, J Biol Chem 2004 279 20378 20386 10.1074/jbc.M400805200 14985339
    • (2004) J Biol Chem , vol.279 , pp. 20378-20386
    • Bellingham, S.A.1    Lahiri, D.K.2    Maloney, B.3    La Fontaine, S.4    Multhaup, G.5    Camakaris, J.6
  • 103
    • 37549040895 scopus 로고    scopus 로고
    • Promoter polymorphisms which modulate APP expression may increase susceptibility to Alzheimer's disease
    • 10.1016/j.neurobiolaging.2006.10.001 17112637
    • Promoter polymorphisms which modulate APP expression may increase susceptibility to Alzheimer's disease. Lv H, Jia L, Jia J, Neurobiol Aging 2008 29 194 202 10.1016/j.neurobiolaging.2006.10.001 17112637
    • (2008) Neurobiol Aging , vol.29 , pp. 194-202
    • Lv, H.1    Jia, L.2    Jia, J.3
  • 104
    • 66349133387 scopus 로고    scopus 로고
    • Secretase inhibitors and modulators for Alzheimer's disease treatment
    • 10.1586/ern.09.24 19402777
    • Secretase inhibitors and modulators for Alzheimer's disease treatment. Tomita T, Expert Rev Neurother 2009 9 661 679 10.1586/ern.09.24 19402777
    • (2009) Expert Rev Neurother , vol.9 , pp. 661-679
    • Tomita, T.1
  • 109
    • 79751538598 scopus 로고    scopus 로고
    • Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation
    • 10.1186/1750-1326-6-15 21310068
    • Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation. Uemura K, Farner KC, Nasser-Ghodsi N, Jones P, Berezovska O, Mol Neurodegener 2011 6 15 10.1186/1750-1326-6-15 21310068
    • (2011) Mol Neurodegener , vol.6 , pp. 15
    • Uemura, K.1    Farner, K.C.2    Nasser-Ghodsi, N.3    Jones, P.4    Berezovska, O.5
  • 112
    • 0030816386 scopus 로고    scopus 로고
    • Transcriptional regulation of the mouse presenilin-1 gene
    • 10.1074/jbc.272.38.23489 9295283
    • Transcriptional regulation of the mouse presenilin-1 gene. Mitsuda N, Roses AD, Vitek MP, J Biol Chem 1997 272 23489 23497 10.1074/jbc.272.38.23489 9295283
    • (1997) J Biol Chem , vol.272 , pp. 23489-23497
    • Mitsuda, N.1    Roses, A.D.2    Vitek, M.P.3
  • 114
    • 0033588382 scopus 로고    scopus 로고
    • An upstream element containing an ETS binding site is crucial for transcription of the human presenilin-1 gene
    • 10.1074/jbc.274.34.24297 10446206
    • An upstream element containing an ETS binding site is crucial for transcription of the human presenilin-1 gene. Pastorcic M, Das HK, J Biol Chem 1999 274 24297 24307 10.1074/jbc.274.34.24297 10446206
    • (1999) J Biol Chem , vol.274 , pp. 24297-24307
    • Pastorcic, M.1    Das, H.K.2
  • 115
    • 0034634467 scopus 로고    scopus 로고
    • Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene
    • 10.1074/jbc.M005411200 10942770
    • Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene. Pastorcic M, Das HK, J Biol Chem 2000 275 34938 34945 10.1074/jbc.M005411200 10942770
    • (2000) J Biol Chem , vol.275 , pp. 34938-34945
    • Pastorcic, M.1    Das, H.K.2
  • 116
    • 33845979451 scopus 로고    scopus 로고
    • Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM
    • 17126306
    • Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM. Pastorcic M, Das HK, Brain Res 2007 1128 21 32 17126306
    • (2007) Brain Res , vol.1128 , pp. 21-32
    • Pastorcic, M.1    Das, H.K.2
  • 117
    • 33847387163 scopus 로고    scopus 로고
    • The C-terminal region of CHD3/ZFH interacts with the CIDD region of the Ets transcription factor ERM and represses transcription of the human presenilin 1 gene
    • 10.1111/j.1742-4658.2007.05684.x 17489097
    • The C-terminal region of CHD3/ZFH interacts with the CIDD region of the Ets transcription factor ERM and represses transcription of the human presenilin 1 gene. Pastorcic M, Das HK, FEBS J 2007 274 1434 1448 10.1111/j.1742-4658. 2007.05684.x 17489097
    • (2007) FEBS J , vol.274 , pp. 1434-1448
    • Pastorcic, M.1    Das, H.K.2
  • 118
    • 38449113274 scopus 로고    scopus 로고
    • Transcriptional regulation of the presenilin-1 gene: Implication in Alzheimer's disease
    • 10.2741/2723
    • Transcriptional regulation of the presenilin-1 gene: implication in Alzheimer's disease. Das HK, Front Biosci 2008 13 822 832 10.2741/2723
    • (2008) Front Biosci , vol.13 , pp. 822-832
    • Das, H.K.1
  • 120
    • 0242515917 scopus 로고    scopus 로고
    • Alzheimer-associated C allele of the promoter polymorphism -22C > T causes a critical neuron-specific decrease of presenilin 1 expression
    • 10.1093/hmg/ddg098 12668610
    • Alzheimer-associated C allele of the promoter polymorphism -22C > T causes a critical neuron-specific decrease of presenilin 1 expression. Theuns J, Remacle J, Killick R, Corsmit E, Vennekens K, Huylebroeck D, Cruts M, Van Broeckhoven C, Hum Mol Genet 2003 12 869 877 10.1093/hmg/ddg098 12668610
    • (2003) Hum Mol Genet , vol.12 , pp. 869-877
    • Theuns, J.1    Remacle, J.2    Killick, R.3    Corsmit, E.4    Vennekens, K.5    Huylebroeck, D.6    Cruts, M.7    Van Broeckhoven, C.8
  • 121
    • 0034984156 scopus 로고    scopus 로고
    • The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain
    • 10.1136/jmg.38.6.353 11389157
    • The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain. Lambert JC, Mann DM, Harris JM, Chartier-Harlin MC, Cumming A, Coates J, Lemmon H, StClair D, Iwatsubo T, Lendon C, J Med Genet 2001 38 353 355 10.1136/jmg.38.6.353 11389157
    • (2001) J Med Genet , vol.38 , pp. 353-355
    • Lambert, J.C.1    Mann, D.M.2    Harris, J.M.3    Chartier-Harlin, M.C.4    Cumming, A.5    Coates, J.6    Lemmon, H.7    Stclair, D.8    Iwatsubo, T.9    Lendon, C.10
  • 123
    • 0242317327 scopus 로고    scopus 로고
    • Egr-1 upregulates the Alzheimer's disease presenilin-2 gene in neuronal cells
    • 14585504
    • Egr-1 upregulates the Alzheimer's disease presenilin-2 gene in neuronal cells. Renbaum P, Beeri R, Gabai E, Amiel M, Gal M, Ehrengruber MU, Levy-Lahad E, Gene 2003 318 113 124 14585504
    • (2003) Gene , vol.318 , pp. 113-124
    • Renbaum, P.1    Beeri, R.2    Gabai, E.3    Amiel, M.4    Gal, M.5    Ehrengruber, M.U.6    Levy-Lahad, E.7
  • 126
    • 33846316333 scopus 로고    scopus 로고
    • The TREM receptor family and signal integration
    • 10.1038/ni1411 17110943
    • The TREM receptor family and signal integration. Klesney-Tait J, Turnbull IR, Colonna M, Nat Immunol 2006 7 1266 1273 10.1038/ni1411 17110943
    • (2006) Nat Immunol , vol.7 , pp. 1266-1273
    • Klesney-Tait, J.1    Turnbull, I.R.2    Colonna, M.3
  • 127
    • 14244268775 scopus 로고    scopus 로고
    • Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
    • 10.1084/jem.20041611 15728241
    • Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. Takahashi K, Rochford CD, Neumann H, J Exp Med 2005 201 647 657 10.1084/jem.20041611 15728241
    • (2005) J Exp Med , vol.201 , pp. 647-657
    • Takahashi, K.1    Rochford, C.D.2    Neumann, H.3
  • 129
    • 33646089457 scopus 로고    scopus 로고
    • Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes
    • 16365156
    • Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes. Walker DG, Link J, Lue LF, Dalsing-Hernandez JE, Boyes BE, J Leukoc Biol 2006 79 596 610 16365156
    • (2006) J Leukoc Biol , vol.79 , pp. 596-610
    • Walker, D.G.1    Link, J.2    Lue, L.F.3    Dalsing-Hernandez, J.E.4    Boyes, B.E.5
  • 130
    • 84864917736 scopus 로고    scopus 로고
    • Transient pharmacologic lowering of Abeta production prior to deposition results in sustained reduction of amyloid plaque pathology
    • 10.1186/1750-1326-7-39 22892055
    • Transient pharmacologic lowering of Abeta production prior to deposition results in sustained reduction of amyloid plaque pathology. Das P, Verbeeck C, Minter L, Chakrabarty P, Felsenstein K, Kukar T, Maharvi G, Fauq A, Osborne BA, Golde TE, Mol Neurodegener 2012 7 39 10.1186/1750-1326-7-39 22892055
    • (2012) Mol Neurodegener , vol.7 , pp. 39
    • Das, P.1    Verbeeck, C.2    Minter, L.3    Chakrabarty, P.4    Felsenstein, K.5    Kukar, T.6    Maharvi, G.7    Fauq, A.8    Osborne, B.A.9    Golde, T.E.10
  • 132
    • 79959636033 scopus 로고    scopus 로고
    • The many substrates of presenilin/gamma-secretase
    • 21335653
    • The many substrates of presenilin/gamma-secretase. Haapasalo A, Kovacs DM, J Alzheimers Dis 2011 25 3 28 21335653
    • (2011) J Alzheimers Dis , vol.25 , pp. 3-28
    • Haapasalo, A.1    Kovacs, D.M.2
  • 133
    • 8444247084 scopus 로고    scopus 로고
    • Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation
    • 10.1093/toxsci/kfh254 15319485
    • Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation. Milano J, McKay J, Dagenais C, Foster-Brown L, Pognan F, Gadient R, Jacobs RT, Zacco A, Greenberg B, Ciaccio PJ, Toxicol Sci 2004 82 341 358 10.1093/toxsci/kfh254 15319485
    • (2004) Toxicol Sci , vol.82 , pp. 341-358
    • Milano, J.1    McKay, J.2    Dagenais, C.3    Foster-Brown, L.4    Pognan, F.5    Gadient, R.6    Jacobs, R.T.7    Zacco, A.8    Greenberg, B.9    Ciaccio, P.J.10
  • 134
    • 84862161020 scopus 로고    scopus 로고
    • Inhibition of gamma-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia
    • 10.1186/1750-1326-7-19 22537414
    • Inhibition of gamma-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia. Tamayev R, D'Adamio L, Mol Neurodegener 2012 7 19 10.1186/1750-1326-7-19 22537414
    • (2012) Mol Neurodegener , vol.7 , pp. 19
    • Tamayev, R.1    D'Adamio, L.2
  • 135
    • 84870203105 scopus 로고    scopus 로고
    • Alzheimer's disease: Presenilin 2-sparing gamma-secretase inhibition is a tolerable Abeta peptide-lowering strategy
    • 10.1523/JNEUROSCI.1451-12.2012 23197721
    • Alzheimer's disease: presenilin 2-sparing gamma-secretase inhibition is a tolerable Abeta peptide-lowering strategy. Borgegard T, Gustavsson S, Nilsson C, Parpal S, Klintenberg R, Berg AL, Rosqvist S, Serneels L, Svensson S, Olsson F, et al. J Neurosci 2012 32 17297 17305 10.1523/JNEUROSCI.1451-12.2012 23197721
    • (2012) J Neurosci , vol.32 , pp. 17297-17305
    • Borgegard, T.1    Gustavsson, S.2    Nilsson, C.3    Parpal, S.4    Klintenberg, R.5    Berg, A.L.6    Rosqvist, S.7    Serneels, L.8    Svensson, S.9    Olsson, F.10
  • 136
    • 78049385467 scopus 로고    scopus 로고
    • Transcriptome profiling in neurodegenerative disease
    • 10.1016/j.jneumeth.2010.08.018 20800617
    • Transcriptome profiling in neurodegenerative disease. Courtney E, Kornfeld S, Janitz K, Janitz M, J Neurosci Methods 2010 193 189 202 10.1016/j.jneumeth.2010.08.018 20800617
    • (2010) J Neurosci Methods , vol.193 , pp. 189-202
    • Courtney, E.1    Kornfeld, S.2    Janitz, K.3    Janitz, M.4


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