Transcription factor AP-2 regulates human apolipoprotein E gene expression in astrocytoma cells

Journal of Neuroscience

Volumn 16, Issue 23, 1996, Pages 7550-7556

  García, Miguel A ^a   Vázquez, Jesús ^a   Giménez, Cecilio ^a   Valdivieso, Fernando ^a   Zafra, Francisco ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

AP 2; apolipoprotein E; astrocytes; cAMP; promoter; retinoic acid

Indexed keywords

APOLIPOPROTEIN E; CYCLIC AMP; DEOXYRIBONUCLEASE I; RETINOIC ACID; TRANSCRIPTION FACTOR AP 2;

ARTICLE; ASTROCYTOMA CELL; BINDING SITE; CONSENSUS SEQUENCE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HEPATOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; SITE DIRECTED MUTAGENESIS;

EID: 0029969180     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-23-07550.1996     Document Type: Article

References (46)

1. Basu SK, Brown MS, Ho YK, Havel RJ, Goldstein JL (1981) Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E. Proc Natl Acad Sci USA 78:7545-7549.
2. Berg DT, Calnek DS, Grinnell BW (1995) The human apolipoprotein E gene is negatively regulated in human liver HepG2 cells by the transcription factor BEF-1. J Biol Chem 270:15447-15450.
3. Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM (1985) Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 76:1501-1513.
4. Boyles JK, Zoellner CD, Anderson LJ, Kosik LM, Pitas RE, Weisgraber KH, Hui DY, Mahley RW, Gebicke-Haerter PJ, Ignatius MJ, Shooter EM (1989) A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. J Clin Invest 83:1015-1031.
5. Corder EH, Saunders AM, Strittmatter WJ, Schmechel D, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of AD in late onset families. Science 261:921-923.
6. Courtois SJ, Lafontaine DA, Lemaigre FP, Durviaux SM, Rousseau GG (1990) Nuclear factor-I and activator protein-2 bind in a mutually exclusive way to overlapping promoter sequences and transactivate the human growth hormone gene. Nucleic Acids Res 18:57-64.
7. Donaldson LF, McQueen DS, Seckl JR (1995) Induction of transcription factor AP-2 mRNA expression in rat primary afferent neurons during acute inflammation. Neurosci Lett 196:181-184.
8. + exchanger gene by the transcription factor AP-2. J Biol Chem 270:1375-1381.
9. Ekström TJ, Klump WM, Getman D, Karin M, Taylor P (1993) Promoter elements and transcriptional regulation of the acetylcholinesterase gene. DNA Cell Biol 12:63-72.
10. Elshourbagy NA, Liao WS, Mahley RW, Taylor JM (1985) Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets. Proc Natl Acad Sci USA 82:203-207.
11. Fedoroff S, McAuley WAJ, Houle JD, Devon RM (1984) Astrocytic cell linage. V. Similarity of astrocytes that form in the presence of dBcAMP in culture to reactive glia. J Neurosci Res 30:359-371.
12. Handelmann GE, Boyles JK, Weisgraber KH, Mahley RW, Pitas RE (1992) Effects of apolipoprotein E, β-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro. J Lipid Res 33:1677-1688.
13. Higuchi R (1990) Recombinant PCR. In: PCR protocols (Innis MA, Gelfand DH, Sninsky JJ, White TJ, eds), pp 177-183. New York: Academic.
14. Hyman SE, Comb M, Pearlberg J, Goodman HM (1989) An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene. Mol Cell Biol 9:321-324.
15. Ignatius MJ, Gebicke-Haerter PJ, Skene JHP, Schilling JW, Weisgraber KH, Mahley RW, Shooter EM (1986) Expression of apolipoprotein E during nerve degeneration and regeneration. Proc Natl Acad Sci USA 83:1125-1129.
16. Imagawa M, Chiu R, Karin M (1987) Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell 51:251-260.
17. Kayden HJ, Maschio F, Traber MG (1985) The secretion of apolipoprotein E by human monocyte-derived macrophages. Arch Biochem Biophys 239:388-395.
18. Krummel B (1990) DNase I footprinting. In: PCR protocols (Innis MA, Gelfand DH, Sninsky JJ, White TJ, eds), pp 184-188. New York: Academic.
19. Lin-Lee YC, Tanaka Y, Lin CT, Chan L (1981) Effects of an atherogenic diet on apolipoprotein E biosynthesis in the rat. Biochemistry 20:6474-6480.
20. Lüscher B, Mitchell PJ, Williams T, Tjian R (1989) Regulation of transcription factor AP-2 by the morphogen retinoic acid and second messengers. Genes Dev 3:1507-1517.
21. Mahley RW (1988) Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240:622-630.
22. Maxam AM, Gilbert W (1980) Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol 65:499-560.
23. Mitchell PJ, Wang C, Tjian R (1987) Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV-40 T antigen. Cell 50:847-861.
24. Mitchell PJ, Timmons PM, Hebert JM, Rigby PW, Tjian R (1991) Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Genes Dev 5:105-119.
25. Muchardt C, Seeler JS, Nirula A, Gong S, Gaynor R (1992) Interleukin-1β regulates proenkephalin gene expression in astrocytes cultured from rat cortex. Glia 6:206-212.
26. Müller HW, Gebicke-Härter PJ, Hangen DH, Shooter EM (1985) A specific 37,000-dalton protein that accumulates in regenerating but not in nonregenerating mammalian nerves. Science 228:499-501.
27. Nathan BP, Bellosta S, Sanan DA, Weisgraber KH, Mahley RW, Pitas RE (1994) Differential effects of apolipoprotein E3 and E4 on neuronal growth in vitro. Science 264:850-852.
28. Nordeen SK (1988) Luciferase reporter gene vector for analysis of promoters and enhancers. Biotechniques 6:454-457.
29. Olivares L, Aragón C, Giménez C, Zafra F (1995) The role of N-glycosylation in the targeting and activity of the GLYT1 glycine transporter. J Biol Chem 270:9437-9442.
30. Paik YK, Chang DJ, Reardon CA, Walker MD, Taxman E, Taylor JM (1988) Identification and characterization of transcriptional regulatory regions associated with expression of the human apolipoprotein E gene. J Biol Chem 263:13340-13349.
31. Philipp J, Mitchell PJ, Malipiero U, Fontana A (1994) Cell type-specific regulation of expression of transcription factor AP-2 in neuroectodermal cells. Dev Biol 165:602-614.
32. Pitas RE, Boyles JK, Lee SH, Foss D, Mahley RW (1987) Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim Biophys Acta 917:148-161.
33. Poirier J, Hess M, May PC, Finch CE (1991) Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning. Mol Brain Res 11:97-106.
34. Rall Jr SC, Weisgraber KH, Mahley RW (1982) Human apolipoprotein E. The complete amino acid sequence. J Biol Chem 257:4171-4178.
35. Reue KL, Quon DH, O'Donnell KA, Dizikes GJ, Fareed GC, Lusis AJ (1984) Cloning and regulation of messenger RNA for mouse apolipoprotein E. J Biol Chem 259:2100-2107.
36. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual, 2nd Ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
37. Schorle H, Meier P, Buchert M, Jaenisch R, Mitchell PJ (1996) Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature 381:235-238.
38. Sharma SK, Raj AB (1987) Transient increase in intracellular concentrations of adenosine 3′:5′-cyclic monophosphate results in morphological and biochemical differentiation of C6 glioma cells in culture. J Neurosci Res 17:137-141.
39. Simonet WS, Bucay N, Lauer SJ, Wirak DO, Stevens ME, Weisgraber KH, Pitas RE, Taylor JM (1990) In the absence of downstream element, the apolipoprotein E gene is expressed at high level in kidneys of transgenic mice. J Biol Chem 265:10809-10812.
40. Simonet WS, Bucay N, Lauer SJ, Taylor JM (1993) A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-1 genes in transgenic mice. J Biol Chem 268:8221-8229.
41. Smith JD, Melián A, Leff T, Breslow JL (1988) Expression of the human apolipoprotein E gene is regulated by multiple positive and negative elements. J Biol Chem 263:8300-8308.
42. Snipes GJ, McGuire CB, Norden JJ, Freeman JA (1986) Nerve injury stimulates the secretion of apolipoprotein E by non-neuronal cells. Proc Natl Acad Sci USA 83:1130-1134.
43. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD (1993) Apolipoprotein E: high avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 90:1977-1981.
44. Williams T, Tjian R (1991) Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev 5:670-682.
45. Williams T, Admon A, Lüscher B, Tjian R (1988) Cloning and expression of AP-2, a cell type-specific transcription factor that activates inducible enhancer elements. Genes Dev 2:1557-1569.
46. Zhang J, Hagopian-Donaldson S, Serbedzija G, Elsemore J, Plehn-Dujowich D, McMahon AP, Flavell RA, Williams T (1996) Neural tube, skeletal, and body wall defects in mice lacking transcription factor AP-2. Nature 381:238-241.