Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene

Journal of Neuroscience Research

Volumn 87, Issue 9, 2009, Pages 2105-2114

  Wang, Pi Lin ^a   Niidome, Tetsuhiro ^a   Akaike, Akinori ^a   Kihara, Takeshi ^a   Sugimoto, Hachiro ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Hippocampal neurons; Rac1; Transcription

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; LACTACYSTIN; MESSENGER RNA; RAC1 PROTEIN; SERUM AMYLOID A; SMALL INTERFERING RNA;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; EMBRYO; ENZYME ACTIVITY; HIPPOCAMPUS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; RNA INTERFERENCE; TRANSCRIPTION REGULATION;

ALZHEIMER DISEASE; AMINOQUINOLINES; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELL LINE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; MICE; MICE, INBRED ICR; NEURONS; PEPTIDE FRAGMENTS; PROMOTER REGIONS, GENETIC; PROTEASOME ENDOPEPTIDASE COMPLEX; PYRIMIDINES; RAC1 GTP-BINDING PROTEIN; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 65849255721     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22039     Document Type: Article

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