-
1
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
-
10.1038/19077. 10206644
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. MS Wolfe W Xia BL Ostaszewski TS Diehl WT Kimberly DJ Selkoe, Nature 1999 398 513 7 10.1038/19077 10206644
-
(1999)
Nature
, vol.398
, pp. 513-7
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
2
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
DOI 10.1126/science.1072994
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. J Hardy DJ Selkoe, Science 2002 297 353 6 (2002) 10.1126/science.1072994 12130773 (Pubitemid 34790756)
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
3
-
-
0036548070
-
γ-secretase, Notch, Aβ and Alzheimer's disease: Where do the presenilins fit in?
-
DOI 10.1038/nrn785
-
gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? SS Sisodia PH St George-Hyslop, Nat Rev Neurosci 2002 3 281 90 10.1038/nrn785 11967558 (Pubitemid 135706607)
-
(2002)
Nature Reviews Neuroscience
, vol.3
, Issue.4
, pp. 281-290
-
-
Sisodia, S.S.1
St George-Hyslop, P.H.2
-
4
-
-
0041355557
-
Notch and Presenilin: Regulated intramembrane proteolysis links development and degeneration
-
DOI 10.1146/annurev.neuro.26.041002.131334
-
Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. DJ Selkoe R Kopan, Annu Rev Neurosci 2003 26 565 97 10.1146/annurev.neuro.26.041002.131334 12730322 (Pubitemid 37064944)
-
(2003)
Annual Review of Neuroscience
, vol.26
, pp. 565-597
-
-
Selkoe, D.1
Kopan, R.2
-
5
-
-
0037431082
-
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex
-
10.1016/S0896-6273(03)00205-8. 12691659
-
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. B De Strooper, Neuron 38 9 12 10.1016/S0896-6273(03) 00205-8 12691659
-
Neuron
, vol.38
, pp. 9-12
-
-
De Strooper, B.1
-
6
-
-
0027258525
-
The carboxy terminus of the β amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
-
DOI 10.1021/bi00069a001
-
The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. JT Jarrett EP Berger PT Lansbury Jr, Biochemistry 1993 32 4693 7 10.1021/bi00069a001 8490014 (Pubitemid 23162022)
-
(1993)
Biochemistry
, vol.32
, Issue.18
, pp. 4693-4697
-
-
Jarrett, J.T.1
Berger, E.P.2
Lansbury Jr., P.T.3
-
7
-
-
0028169925
-
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43)
-
10.1016/0896-6273(94)90458-8. 8043280
-
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). T Iwatsubo A Odaka N Suzuki H Mizusawa N Nukina Y Ihara, Neuron 1994 13 45 53 10.1016/0896-6273(94)90458-8 8043280
-
(1994)
Neuron
, vol.13
, pp. 45-53
-
-
Iwatsubo, T.1
Odaka, A.2
Suzuki, N.3
Mizusawa, H.4
Nukina, N.5
Ihara, Y.6
-
8
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. A Goate MC Chartier-Harlin M Mullan J Brown F Crawford L Fidani L Giuffra A Haynes N Irving L James,, et al. Nature 1991 349 704 6 10.1038/349704a0 1671712 (Pubitemid 21912142)
-
(1991)
Nature
, vol.349
, Issue.6311
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.-C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fldani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
Mant, R.11
Newton, P.12
Rooke, K.13
Roques, P.14
Talbot, C.15
Pericak-Vance, M.16
Roses, A.17
Williamson, R.18
Rossor, M.19
Owen, M.20
Hardy, J.21
more..
-
9
-
-
74049112323
-
Clinical, neuropathologic, and biochemical profile of the amyloid precursor protein I716F mutation
-
10.1097/NEN.0b013e3181c6b84d. 20010303
-
Clinical, neuropathologic, and biochemical profile of the amyloid precursor protein I716F mutation. C Guardia-Laguarta M Pera J Clarimán JL Molinuevo R Snchez-Valle A Lladá M Coma T Gámez-Isla R Blesa I Ferrer A Lleá J Neuropathol Exp Neurol 2010 69 53 9 10.1097/NEN. 0b013e3181c6b84d 20010303
-
(2010)
J Neuropathol Exp Neurol
, vol.69
, pp. 53-9
-
-
Guardia-Laguarta, C.1
Pera, M.2
Clarimán, J.3
Molinuevo, J.L.4
Snchez-Valle, R.5
Lladá, A.6
Coma, M.7
Gámez-Isla, T.8
Blesa, R.9
Ferrer, I.10
Lleá, A.11
-
10
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
10.1038/375754a0. 7596406
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. R Sherrington EI Rogaev Y Liang EA Rogaeva G Levesque M Ikeda H Chi C Lin G Li K Holman,, et al. Nature 1995 375 754 60 10.1038/375754a0 7596406
-
(1995)
Nature
, vol.375
, pp. 754-60
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
-
11
-
-
0028861041
-
Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3
-
10.1093/hmg/4.12.2363. 8634711
-
Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3. M Cruts H Backhovens SY Wang G Van Gassen J Theuns CD De Jonghe A Wehnert J De Voecht G De Winter P Cras,, et al. Hum Mol Genet 1995 4 2363 71 10.1093/hmg/4.12.2363 8634711
-
(1995)
Hum Mol Genet
, vol.4
, pp. 2363-71
-
-
Cruts, M.1
Backhovens, H.2
Wang, S.Y.3
Van Gassen, G.4
Theuns, J.5
De Jonghe, C.D.6
Wehnert, A.7
De Voecht, J.8
De Winter, G.9
Cras, P.10
-
12
-
-
0029554875
-
A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene
-
A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. J Perez-Tur S Froelich G Prihar R Crook M Baker K Duff M Wragg F Busfield C Lendon RF Clark,, et al. Neuroreport 1995 7 297 301 8742474 (Pubitemid 26077246)
-
(1995)
NeuroReport
, vol.7
, Issue.1
, pp. 297-301
-
-
Perez-Tur, J.1
Froelich, S.2
Prihar, G.3
Crook, R.4
Baker, M.5
Duff, K.6
Wragg, M.7
Busfield, F.8
Lendon, C.9
Clark, R.F.10
Roques, P.11
Fuldner, R.A.12
Johnston, J.13
Cowburn, R.14
Forsell, C.15
Axelman, K.16
Lilius, L.17
Houlden, H.18
Karran, E.19
-
13
-
-
34250336128
-
Aβ42 overproduction associated with structural changes in the catalytic pore of γ-secretase: Common effects of Pen-2 N-terminal elongation and fenofibrate
-
DOI 10.1074/jbc.M611549200
-
Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate. N Isoo C Sato H Miyashita M Shinohara N Takasugi Y Morohashi S Tsuji T Tomita T Iwatsubo, J Biol Chem 2007 282 12388 96 10.1074/jbc.M611549200 17329245 (Pubitemid 47100594)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.17
, pp. 12388-12396
-
-
Isoo, N.1
Sato, C.2
Miyashita, H.3
Shinohara, M.4
Takasugi, N.5
Morohashi, Y.6
Tsuji, S.7
Tomita, T.8
Iwatsubo, T.9
-
14
-
-
65549140727
-
Gamma-Secretase heterogeneity in the Aph1 subunit: Relevance for Alzheimer's disease
-
10.1126/science.1171176. 19299585
-
gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. L Serneels J Van Biervliet K Craessaerts T Dejaegere K Horré T Van Houtvin H Esselmann S Paul MK Schäfer O Berezovska BT Hyman B Sprangers R Sciot L Moons M Jucker Z Yang PC May E Karran J Wiltfang R D'Hooge B De Strooper, Science 2009 324 639 42 10.1126/science.1171176 19299585
-
(2009)
Science
, vol.324
, pp. 639-42
-
-
Serneels, L.1
Van Biervliet, J.2
Craessaerts, K.3
Dejaegere, T.4
Horré, K.5
Van Houtvin, T.6
Esselmann, H.7
Paul, S.8
Schäfer, M.K.9
Berezovska, O.10
Hyman, B.T.11
Sprangers, B.12
Sciot, R.13
Moons, L.14
Jucker, M.15
Yang, Z.16
May, P.C.17
Karran, E.18
Wiltfang, J.19
D'Hooge, R.20
De Strooper, B.21
more..
-
15
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
-
DOI 10.1038/35102591
-
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. S Weggen JL Eriksen P Das SA Sagi R Wang CU Pietrzik KA Findlay TE Smith MP Murphy T Bulter DE Kang N Marquez-Sterling TE Golde EH Koo, Nature 2001 414 212 6 10.1038/35102591 11700559 (Pubitemid 33051236)
-
(2001)
Nature
, vol.414
, Issue.6860
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
Sagi, S.A.4
Wang, R.5
Pietrzik, C.U.6
Findlay, K.A.7
Smith, T.E.8
Murphy, M.P.9
Bulter, T.10
Kang, D.E.11
Marquez-Sterling, N.12
Golde, T.E.13
Koo, E.H.14
-
16
-
-
85047691727
-
NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo
-
DOI 10.1172/JCI200318162
-
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. JL Eriksen SA Sagi TE Smith S Weggen P Das DC McLendon VV Ozols KW Jessing KH Zavitz EH Koo TE Golde, J Clin Invest 2003 112 440 9 12897211 (Pubitemid 38063773)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.3
, pp. 440-449
-
-
Eriksen, J.L.1
Sagi, S.A.2
Smith, T.E.3
Weggen, S.4
Das, P.5
McLendon, D.C.6
Ozols, V.V.7
Jessing, K.W.8
Zavitz, K.H.9
Koo, E.H.10
Golde, T.E.11
-
17
-
-
21044458540
-
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Aβ42 production
-
DOI 10.1038/nm1235
-
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. T Kukar MP Murphy JL Eriksen SA Sagi S Weggen TE Smith T Ladd MA Khan R Kache J Beard M Dodson S Merit VV Ozols PZ Anastasiadis P Das A Fauq EH Koo TE Golde, Nat Med 2005 11 545 50 10.1038/nm1235 15834426 (Pubitemid 40685978)
-
(2005)
Nature Medicine
, vol.11
, Issue.5
, pp. 545-550
-
-
Kukar, T.1
Murphy, M.P.2
Eriksen, J.L.3
Sagi, S.A.4
Weggen, S.5
Smith, T.E.6
Ladd, T.7
Khan, M.A.8
Kache, R.9
Beard, J.10
Dodson, M.11
Merit, S.12
Ozols, V.V.13
Anastasiadis, P.Z.14
Das, P.15
Fauq, A.16
Koo, E.H.17
Golde, T.E.18
-
18
-
-
45149105232
-
Substrate-targeting gamma-secretase modulators
-
10.1038/nature07055. 18548070
-
Substrate-targeting gamma-secretase modulators. TL Kukar TB Ladd MA Bann PC Fraering R Narlawar GM Maharvi B Healy R Chapman AT Welzel RW Price B Moore V Rangachari B Cusack J Eriksen K Jansen-West C Verbeeck D Yager C Eckman W Ye S Sagi BA Cottrell J Torpey TL Rosenberry A Fauq MS Wolfe B Schmidt DM Walsh EH Koo TE Golde, Nature 2008 453 925 9 10.1038/nature07055 18548070
-
(2008)
Nature
, vol.453
, pp. 925-9
-
-
Kukar, T.L.1
Ladd, T.B.2
Bann, M.A.3
Fraering, P.C.4
Narlawar, R.5
Maharvi, G.M.6
Healy, B.7
Chapman, R.8
Welzel, A.T.9
Price, R.W.10
Moore, B.11
Rangachari, V.12
Cusack, B.13
Eriksen, J.14
Jansen-West, K.15
Verbeeck, C.16
Yager, D.17
Eckman, C.18
Ye, W.19
Sagi, S.20
Cottrell, B.A.21
Torpey, J.22
Rosenberry, T.L.23
Fauq, A.24
Wolfe, M.S.25
Schmidt, B.26
Walsh, D.M.27
Koo, E.H.28
Golde, T.E.29
more..
-
19
-
-
77957096840
-
Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization
-
10.1073/pnas.1003026107. 20679249
-
Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. L Richter LM Munter J Ness PW Hildebrand M Dasari S Unterreitmeier B Bulic M Beyermann R Gust B Reif S Weggen D Langosch G Multhaup, Proc Natl Acad Sci USA 2010 107 14597 602 10.1073/pnas.1003026107 20679249
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 14597-602
-
-
Richter, L.1
Munter, L.M.2
Ness, J.3
Hildebrand, P.W.4
Dasari, M.5
Unterreitmeier, S.6
Bulic, B.7
Beyermann, M.8
Gust, R.9
Reif, B.10
Weggen, S.11
Langosch, D.12
Multhaup, G.13
-
20
-
-
79952079871
-
The APP C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds gamma-secretase modulators
-
10.1021/bi1014002
-
The APP C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds gamma-secretase modulators. A Botev LM Münter R Wenzel L Richter V Althoff J Ismer U Gerling C Weise B Koksch PW Hildebrand R Bittl G Multhaup, Biochemistry 2010 50 5 828 35 10.1021/bi1014002
-
(2010)
Biochemistry
, vol.50
, Issue.5
, pp. 828-35
-
-
Botev, A.1
Münter, L.M.2
Wenzel, R.3
Richter, L.4
Althoff, V.5
Ismer, J.6
Gerling, U.7
Weise, C.8
Koksch, B.9
Hildebrand, P.W.10
Bittl, R.11
Multhaup, G.12
-
21
-
-
0041876229
-
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid β42 production by direct modulation of γ-secretase activity
-
DOI 10.1074/jbc.M303592200
-
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. S Weggen JL Eriksen SA Sagi CU Pietrzik V Ozols A Fauq TE Golde EH Koo, J Biol Chem 2003 278 31831 7 Epub 2003 10.1074/jbc.M303592200 12805356 (Pubitemid 37048365)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.34
, pp. 31831-31837
-
-
Weggen, S.1
Eriksen, J.L.2
Sagi, S.A.3
Pietrzik, C.U.4
Ozols, V.5
Fauq, A.6
Golde, T.E.7
Koo, E.H.8
-
22
-
-
6344233805
-
Selected non-steroidal anti-inflammatory drugs and their derivatives target γ-secretase at a novel site: Evidence for an allosteric mechanism
-
DOI 10.1074/jbc.M404937200
-
Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism. D Beher EE Clarke JD Wrigley AC Martin A Nadin I Churcher MS Shearman, J Biol Chem 2004 279 43419 26 10.1074/jbc.M404937200 15304503 (Pubitemid 39390641)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.42
, pp. 43419-43426
-
-
Beher, D.1
Clarke, E.E.2
Wrigley, J.D.J.3
Martin, A.C.L.4
Nadin, A.5
Churcher, I.6
Shearman, M.S.7
-
23
-
-
73949087262
-
Modulation of gamma-secretase specificity using small molecule allosteric inhibitors
-
10.1073/pnas.0910757106. 19906985
-
Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. CC Shelton L Zhu D Chau L Yang R Wang H Djaballah H Zheng YM Li, Proc Natl Acad Sci USA 2009 106 20228 33 10.1073/pnas.0910757106 19906985
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 20228-33
-
-
Shelton, C.C.1
Zhu, L.2
Chau, D.3
Yang, L.4
Wang, R.5
Djaballah, H.6
Zheng, H.7
Li, Y.M.8
-
24
-
-
78650047391
-
Substrate docking to -secretase allows access of -secretase modulators to an allosteric site
-
10.1038/ncomms1129
-
Substrate docking to -secretase allows access of -secretase modulators to an allosteric site. K Uemura KC Farner T Hashimoto N Nasser-Ghodsi MS Wolfe EH Koo BT Hyman O Berezovska, Nat Commun 2010 8 130 10.1038/ncomms1129
-
(2010)
Nat Commun
, vol.8
, pp. 130
-
-
Uemura, K.1
Farner, K.C.2
Hashimoto, T.3
Nasser-Ghodsi, N.4
Wolfe, M.S.5
Koo, E.H.6
Hyman, B.T.7
Berezovska, O.8
-
25
-
-
77956311201
-
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease
-
10.1016/j.neuron.2010.08.018. 20826309
-
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. MZ Kounnas AM Danks S Cheng C Tyree E Ackerman X Zhang K Ahn P Nguyen D Comer L Mao C Yu D Pleynet PJ Digregorio G Velicelebi KA Stauderman WT Comer WC Mobley YM Li SS Sisodia RE Tanzi SL Wagner, Neuron 2010 67 769 80 10.1016/j.neuron.2010.08.018 20826309
-
(2010)
Neuron
, vol.67
, pp. 769-80
-
-
Kounnas, M.Z.1
Danks, A.M.2
Cheng, S.3
Tyree, C.4
Ackerman, E.5
Zhang, X.6
Ahn, K.7
Nguyen, P.8
Comer, D.9
Mao, L.10
Yu, C.11
Pleynet, D.12
Digregorio, P.J.13
Velicelebi, G.14
Stauderman, K.A.15
Comer, W.T.16
Mobley, W.C.17
Li, Y.M.18
Sisodia, S.S.19
Tanzi, R.E.20
Wagner, S.L.21
more..
-
26
-
-
7044254509
-
42 and change presenilin 1 conformation
-
DOI 10.1038/nm1112
-
Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation. A Lleá O Berezovska L Herl S Raju A Deng BJ Bacskai MP Frosch M Irizarry BT Hyman, Nat Med 2004 10 1065 6 15448688 (Pubitemid 39424866)
-
(2004)
Nature Medicine
, vol.10
, Issue.10
, pp. 1065-1066
-
-
Lleo, A.1
Berezovska, O.2
Herl, L.3
Raju, S.4
Deng, A.5
Bacskai, B.J.6
Frosch, M.P.7
Irizarry, M.8
Hyman, B.T.9
-
27
-
-
15244341378
-
Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein
-
DOI 10.1523/JNEUROSCI.0364-05.2005
-
Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. O Berezovska A Lleo LD Herl MP Frosch EA Stern BJ Bacskai BT Hyman, J Neurosci 2005 25 3009 17 10.1523/JNEUROSCI.0364-05.2005 15772361 (Pubitemid 40389259)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.11
, pp. 3009-3017
-
-
Berezovska, O.1
Lleo, A.2
Herl, L.D.3
Frosch, M.P.4
Stern, E.A.5
Bacskai, B.J.6
Hyman, B.T.7
-
28
-
-
70849116652
-
Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio
-
10.1371/journal.pone.0007893. 19924286
-
Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. K Uemura CM Lill X Li JA Peters A Ivanov Z Fan B DeStrooper BJ Bacskai BT Hyman O Berezovska, PLoS One 2009 4 7893 10.1371/journal.pone.0007893 19924286
-
(2009)
PLoS One
, vol.4
, pp. 57893
-
-
Uemura, K.1
Lill, C.M.2
Li, X.3
Peters, J.A.4
Ivanov, A.5
Fan, Z.6
Destrooper, B.7
Bacskai, B.J.8
Hyman, B.T.9
Berezovska, O.10
-
29
-
-
67349212228
-
Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase
-
10.1016/j.mcn.2009.02.008. 19281847
-
Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase. L Herl AV Thomas CM Lill M Banks A Deng PB Jones R Spoelgen BT Hyman O Berezovska, Mol Cell Neurosci 2009 41 166 74 10.1016/j.mcn.2009.02.008 19281847
-
(2009)
Mol Cell Neurosci
, vol.41
, pp. 166-74
-
-
Herl, L.1
Thomas, A.V.2
Lill, C.M.3
Banks, M.4
Deng, A.5
Jones, P.B.6
Spoelgen, R.7
Hyman, B.T.8
Berezovska, O.9
-
30
-
-
26844552573
-
APP substitutions V715F and L720P alter PS1 conformation and differentially affect Aβ and AICD generation
-
DOI 10.1111/j.1471-4159.2005.03381.x
-
APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation. G Tesco A Ginestroni M Hiltunen M Kim G Dolios BT Hyman R Wang O Berezovska RE Tanzi, J Neurochem 2005 95 446 56 10.1111/j.1471-4159.2005.03381.x 16086682 (Pubitemid 41457513)
-
(2005)
Journal of Neurochemistry
, vol.95
, Issue.2
, pp. 446-456
-
-
Tesco, G.1
Ginestroni, A.2
Hiltunen, M.3
Kim, M.4
Dolios, G.5
Hyman, B.T.6
Wang, R.7
Berezovska, O.8
Tanzi, R.E.9
-
31
-
-
51549106517
-
Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): Does APP function as a cholesterol sensor?
-
10.1021/bi800993c. 18702528
-
Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor? AJ Beel CK Mobley HJ Kim F Tian A Hadziselimovic B Jap JH Prestegard CR Sanders, Biochemistry 2008 47 9428 46 10.1021/bi800993c 18702528
-
(2008)
Biochemistry
, vol.47
, pp. 9428-46
-
-
Beel, A.J.1
Mobley, C.K.2
Kim, H.J.3
Tian, F.4
Hadziselimovic, A.5
Jap, B.6
Prestegard, J.H.7
Sanders, C.R.8
-
32
-
-
0030599284
-
717 of amyloid precursor protein are specific for the increased secretion of Aβ42(43)
-
DOI 10.1006/bbrc.1996.1577
-
Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43). K Maruyama T Tomita K Shinozaki H Kume H Asada TC Saido S Ishiura T Iwatsubo K Obata, Biochem Biophys Res Commun 1996 227 730 5 10.1006/bbrc.1996.1577 8886002 (Pubitemid 26387796)
-
(1996)
Biochemical and Biophysical Research Communications
, vol.227
, Issue.3
, pp. 730-735
-
-
Maruyama, K.1
Tomita, T.2
Shinozaki, K.3
Kume, H.4
Asada, H.5
Saido, T.C.6
Ishiura, S.7
Iwatsubo, T.8
Obata, K.9
-
33
-
-
70349847477
-
A reporter of local dendritic translocation shows plaque-related loss of neural system function in APP-transgenic mice
-
10.1523/JNEUROSCI.1948-09.2009. 19812338
-
A reporter of local dendritic translocation shows plaque-related loss of neural system function in APP-transgenic mice. M Meyer-Luehmann M Mielke TL Spires-Jones W Stoothoff P Jones BJ Bacskai BT Hyman, J Neurosci 2009 29 12636 40 10.1523/JNEUROSCI.1948-09.2009 19812338
-
(2009)
J Neurosci
, vol.29
, pp. 12636-40
-
-
Meyer-Luehmann, M.1
Mielke, M.2
Spires-Jones, T.L.3
Stoothoff, W.4
Jones, P.5
Bacskai, B.J.6
Hyman, B.T.7
-
34
-
-
0141509025
-
Designed helical peptides inhibit an intramembrane protease
-
DOI 10.1021/ja037131v
-
Designed helical peptides inhibit an intramembrane protease. C Das O Berezovska TS Diehl C Genet I Buldyrev JY Tsai BT Hyman MS Wolfe, J Am Chem Soc 2003 125 11794 5 10.1021/ja037131v 14505382 (Pubitemid 37175395)
-
(2003)
Journal of the American Chemical Society
, vol.125
, Issue.39
, pp. 11794-11795
-
-
Das, C.1
Berezovska, O.2
Diehl, T.S.3
Genet, C.4
Buldyrev, I.5
Tsai, J.-Y.6
Hyman, B.T.7
Wolfe, M.S.8
-
35
-
-
28644437291
-
The amyloid-β precursor protein: Integrating structure with biological function
-
DOI 10.1038/sj.emboj.7600860
-
The amyloid-beta precursor protein: integrating structure with biological function. C Reinhard SS Hébert B De Strooper, EMBO J 2005 24 3996 4006 10.1038/sj.emboj.7600860 16252002 (Pubitemid 41752869)
-
(2005)
EMBO Journal
, vol.24
, Issue.23
, pp. 3996-4006
-
-
Reinhard, C.1
Hebert, S.S.2
De Strooper, B.3
-
36
-
-
0035818998
-
Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP
-
DOI 10.1038/414643a
-
Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. A Kamal A Almenar-Queralt JF LeBlanc EA Roberts LS Goldstein, Nature 2001 414 643 8 10.1038/414643a 11740561 (Pubitemid 33151260)
-
(2001)
Nature
, vol.414
, Issue.6864
, pp. 643-648
-
-
Kamal, A.1
Almenar-Queralt, A.2
LeBlanc, J.F.3
Roberts, E.A.4
Goldstein, L.S.B.5
-
37
-
-
28644449284
-
Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain
-
DOI 10.1038/sj.emboj.7600757, PII 7600757
-
Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. M Leyssen D Ayaz SS Hébert S Reeve B De Strooper BA Hassan, EMBO J 2005 24 2944 55 10.1038/sj.emboj.7600757 16052209 (Pubitemid 43079897)
-
(2005)
EMBO Journal
, vol.24
, Issue.16
, pp. 2944-2955
-
-
Leyssen, M.1
Ayaz, D.2
Hebert, S.S.3
Reeve, S.4
De Strooper, B.5
Hassan, B.A.6
-
38
-
-
2642582435
-
Dissection of amyloid-β precursor protein-dependent transcriptional transactivation
-
DOI 10.1074/jbc.M402248200
-
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. X Cao TC Südhof, J Biol Chem 2004 279 24601 11 10.1074/jbc.M402248200 15044485 (Pubitemid 38725327)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.23
, pp. 24601-24611
-
-
Cao, X.1
Sudhof, T.C.2
-
39
-
-
27744587358
-
A γ-secretase-independent mechanism of signal transduction by the amyloid precursor protein
-
DOI 10.1074/jbc.M502861200
-
A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. MR Hass BA Yankner, J Biol Chem 2005 280 36895 904 10.1074/jbc.M502861200 16103124 (Pubitemid 41587771)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.44
, pp. 36895-36904
-
-
Hass, M.R.1
Yankner, B.A.2
-
40
-
-
0034646447
-
Transient structure of the amyloid precursor protein cytoplasmic tail indicates preordering of structure for binding to cytosolic factors
-
DOI 10.1021/bi992580m
-
Transient structure of the amyloid precursor protein cytoplasmic tail indicates preordering of structure for binding to cytosolic factors. TA Ramelot LN Gentile LK Nicholson, Biochemistry 2000 39 2714 25 10.1021/bi992580m 10704223 (Pubitemid 30148926)
-
(2000)
Biochemistry
, vol.39
, Issue.10
, pp. 2714-2725
-
-
Ramelot, T.A.1
Gentile, L.N.2
Nicholson, L.K.3
-
41
-
-
0035970301
-
Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR
-
DOI 10.1006/jmbi.2001.4535
-
Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR. TA Ramelot LK Nicholson, J Mol Biol 2001 307 871 84 10.1006/jmbi.2001.4535 11273707 (Pubitemid 33027665)
-
(2001)
Journal of Molecular Biology
, vol.307
, Issue.3
, pp. 871-884
-
-
Ramelot, T.A.1
Nicholson, L.K.2
-
42
-
-
77956303159
-
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease
-
10.1038/nature09325. 20811458
-
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. G He W Luo P Li C Remmers WJ Netzer J Hendrick K Bettayeb M Flajolet F Gorelick LP Wennogle P Greengard, Nature 2010 467 95 8 10.1038/nature09325 20811458
-
(2010)
Nature
, vol.467
, pp. 95-8
-
-
He, G.1
Luo, W.2
Li, P.3
Remmers, C.4
Netzer, W.J.5
Hendrick, J.6
Bettayeb, K.7
Flajolet, M.8
Gorelick, F.9
Wennogle, L.P.10
Greengard, P.11
-
43
-
-
19944430034
-
Longer forms of amyloid β protein: Implications for the mechanism of intramembrane cleavage by γ-secretase
-
DOI 10.1523/JNEUROSCI.1575-04.2005
-
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. Y Qi-Takahara M Morishima-Kawashima Y Tanimura G Dolios N Hirotani Y Horikoshi F Kametani M Maeda TC Saido R Wang Y Ihara, J Neurosci 2005 25 436 45 10.1523/JNEUROSCI.1575-04.2005 15647487 (Pubitemid 40105614)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.2
, pp. 436-445
-
-
Qi-Takahara, Y.1
Morishima-Kawashima, M.2
Tanimura, Yu.3
Dolios, G.4
Hirotani, N.5
Horikoshi, Y.6
Kametani, F.7
Maeda, M.8
Saido, T.C.9
Wang, R.10
Ihara, Y.11
-
44
-
-
70350451482
-
Gamma-Secretase: Successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment
-
10.1523/JNEUROSCI.2362-09.2009. 19828817
-
gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. M Takami Y Nagashima Y Sano S Ishihara M Morishima-Kawashima S Funamoto Y Ihara, J Neurosci 2009 29 13042 52 10.1523/JNEUROSCI.2362-09.2009 19828817
-
(2009)
J Neurosci
, vol.29
, pp. 13042-52
-
-
Takami, M.1
Nagashima, Y.2
Sano, Y.3
Ishihara, S.4
Morishima-Kawashima, M.5
Funamoto, S.6
Ihara, Y.7
-
46
-
-
0033775709
-
Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells
-
10.1038/35017105. 10878813
-
Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. A Herreman L Serneels W Annaert D Collen L Schoonjans B De Strooper, Nat Cell Biol 2000 2 461 2 10.1038/35017105 10878813
-
(2000)
Nat Cell Biol
, vol.2
, pp. 461-2
-
-
Herreman, A.1
Serneels, L.2
Annaert, W.3
Collen, D.4
Schoonjans, L.5
De Strooper, B.6
|