The TREM receptor family and signal integration

Nature Immunology

Volumn 7, Issue 12, 2006, Pages 1266-1273

  Klesney Tait, Julia ^a   Turnbull, Isaiah R ^a   Colonna, Marco ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CELL SURFACE RECEPTOR; LIGAND; PATTERN RECOGNITION RECEPTOR; PROTEIN TREM; PROTEIN TREM 1; PROTEIN TREM 2; PROTEIN TREM 3; PROTEIN TREM LIKE TRANSCRIPT 1; UNCLASSIFIED DRUG;

BACTERIAL INFECTION; BONE MARROW CELL; CELL DIFFERENTIATION; CHROMOSOME 17; CHROMOSOME 6P; CROSS LINKING; CYTOKINE RELEASE; GENE CLUSTER; GENETIC DISORDER; GENOMICS; GRANULOMATOSIS; HUMAN; IMMUNE RESPONSE; INFLAMMATION; MACROPHAGE; MEMBRANOUS LIPODYSTROPHY; MICROGLIA; NEUTROPHIL; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SEPSIS; SIGNAL TRANSDUCTION; THROMBOCYTE FUNCTION; UPREGULATION;

ANIMALS; HUMANS; MEMBRANE GLYCOPROTEINS; MODELS, IMMUNOLOGICAL; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 33846316333     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1411     Document Type: Review

References (83)

1. Bouchon, A., Dietrich, J. & Colonna, M. Cutting edge: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J. Immunol. 164, 4991-4995 (2000).
2. Daws, M.R., Lanier, L.L., Seaman, W.E. & Ryan, J.C. Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. Eur. J. Immunol. 31, 783-791 (2001).
3. Chung, D.H., Seaman, W.E. & Daws, M.R. Characterization of TREM-3, an activating receptor on mouse macrophages: Definition of a family of single Ig domain receptors on mouse chromosome 17. Eur. J. Immunol. 32, 59-66 (2002).
4. Gordon, S. & Taylor, P.R. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5, 953-964 (2005).
5. Schmid, C.D. et al. Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia. J. Neurochem. 83, 1309-1320 (2002).
6. Sessa, G. et al. Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia. Eur. J. Neurosci. 20, 2617-2628 (2004).
7. Bouchon, A., Hernandez-Munain, C., Cella, M. & Colonna, M.A. DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells. J. Exp. Med. 194, 1111-1122 (2001).
8. Paloneva, J. et al. TREM-2 mutations in presenile dementia, PLOSL. Am. J. Hum. Genet. 71, 656-662 (2002).
9. Paloneva, J. et al. DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features. J. Exp. Med. 198, 669-675 (2003).
10. Cella, M. et al. Impaired differentiation of osteoclasts in TREM-2-deficient individuals. J. Exp. Med. 198, 645-651 (2003).
11. Washington, A.V., Quigley, L. & McVicar, D.W. Initial characterization of TREM-like transcript (TLT)-1: A putative inhibitory receptor within the TREM cluster. Blood 100, 3822-3824 (2002).
12. Allcock, R.J., Barrow, A.D., Forbes, S., Beck, S. & Trowsdale, J. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur. J. Immunol. 33, 567-577 (2003).
13. Clark, G.J., Green, B.J. & Hart, D.N. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. Tissue Antigens 55, 101-109 (2000).
14. Green, B.J., Clark, G.J. & Hart, D.N. The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor. Int. Immunol. 10, 891-899 (1998).
15. Aguilar, H. et al. Molecular characterization of a novel immune receptor restricted to the monocytic lineage. J. Immunol. 173, 6703-6711 (2004).
16. Chung, D.H. et al. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. J. Immunol. 171, 6541-6548 (2003).
17. Jackson, D.G., Hart, D.N., Starling, G. & Bell, J.I. Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor. Eur. J. Immunol. 22, 1157-1163 (1992).
18. Viertlboeck, B.C., Schmitt, R. & Göbel, T.W. The chicken immunoregulatory receptor families SIRP, TREM, and CMRF35/CD300L. Immunogenetics 58, 180-190 (2006).
19. Stet, R.J. et al. Novel immunoglobulin-like transcripts in teleost fish encode polymorphic receptors with cytoplasmic ITAM or ITIM and a new structural Ig domain similar to the natural cytotoxicity receptor NKp44. Immunogenetics 57, 77-89 (2005).
20. Radaev, S., Kattah, M., Rostro, B., Colonna, M. & Sun, P.D. Crystal structure of the human myeloid cell activating receptor TREM-1. Structure 11, 1527-1535 (2003).
21. Kelker, M.S. et al. Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A. J. Mol. Biol. 342, 1237-1248 (2004).
22. Kelker, M.S., Debler, E.W. & Wilson, I.A. Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A. J. Mol. Biol. 344, 1175-1181 (2004).
23. Gattis, J.L. et al. The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment. J. Biol. Chem. 281, 13396-13403 (2006).
24. Vivier, E., Nunes, J.A. & Vely, F. Natural killer cell signaling pathways. Science 306, 1517-1519 (2004).
25. McVicar, D.W. & Bursht, D.N. Intracellular signaling by the killer immunoglobulin-like receptors and Ly49. Sci. STKE 2001, RE1 (2001).
26. Lanier, L.L. Natural killer cell receptor signaling. Curr. Opin. Immunol. 15, 308-314 (2003).
27. Hamerman, J.A. et al. Cutting edge: Inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J. Immunol. 177, 2051-2055 (2006).
28. Turnbull, I.R. et al. Cutting edge: TREM-2 attenuates macrophage activation. J. Immunol. 177, 3520-3524 (2006).
29. Hamerman, J.A. & Lanier, L.L. Inhibition of immune responses by ITAM-bearing receptors. Sci. STKE 2006, re1 (2006).
30. Blasius, A.L. & Colonna, M. Sampling and signaling in plasmacytoid dendritic cells: The potential roles of Siglec-H. Trends Immunol. 27, 255-260 (2006).
31. Barrow, A.D. & Trowsdale, J. You say ITAM and I say ITIM, let's call the whole thing off: The ambiguity of immunoreceptor signalling. Eur. J. Immunol. 36, 1646-1653 (2006).
32. Washington, A.V., Quigley, L. & McVicar, D.W. Initial characterization of TREM-like transcript (TLT)-1: A putative inhibitory receptor within the TREM cluster. Triggering receptors expressed on myeloid cells. Blood 100, 3822-3824 (2002).
33. Barrow, A.D. et al. Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2. J. Immunol. 172, 5838-5842 (2004).
34. Bouchon, A., Facchetti, F., Weigand, M.A. & Colonna, M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 410, 1103-1107 (2001).
35. Nathan, C. & Ding, A. TREM-1: A new regulator of innate immunity in sepsis syndrome. Nat. Med. 7, 530-532 (2001).
36. Bleharski, J.R. et al. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J. Immunol. 170, 3812-3818 (2003).
37. Netea, M.G. et al. Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors. J. Leukocyte Biol. (in the press).
38. Wang, H. et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 285, 248-251 (1999).
39. Yang, H., Wang, H. & Tracey, K.J. HMG-1 rediscovered as a cytokine. Shock 15, 247-253 (2001).
40. Calandra, T. et al. Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nat. Med. 6, 164-170 (2000).
41. Bozza, M. et al. Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis. J. Exp. Med. 189, 341-346 (1999).
42. Dinarello, C.A. Proinflammatory cytokines. Chest 118, 503-508 (2000).
43. Riewald, M., Petrovan, R.J., Donner, A., Mueller, B.M. & Ruf, W. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 296, 1880-1882 (2002).
44. Cohen, J. The immunopathogenesis of sepsis. Nature 420, 885-891 (2002).
45. Turnbull, I.R. et al. DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis. J. Exp. Med. 202, 363-369 (2005).
46. Gibot, S. et al. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J. Exp. Med. 200, 1419-1426 (2004).
47. Agarwal, P.K. & Kumari, R. Sepsis-theory and therapies. N. Engl. J. Med. 348, 1600-1602 (2003).
48. Mohamadzadeh, M. et al. Activation of triggering receptor expressed on myeloid cells-1 on human neutrophils by marburg and ebola viruses. J. Virol. 80, 7235-7244 (2006).
49. Liu-Bryan, R. & Terkeltaub, R. Evil humors take their toll as innate immunity makes gouty joints TREM-ble. Arthritis Rheum. 54, 383-386 (2006).
50. Murakami, Y. et al. Induction of triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals. Arthritis Rheum. 54, 455-462 (2006).
51. Gibot, S. et al. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N. Engl. J. Med. 350, 451-458 (2004).
52. Gibot, S. et al. Plasma level of a triggering receptor expressed on myeloid cells-1: Its diagnostic accuracy in patients with suspected sepsis. Ann. Intern. Med. 141, 9-15 (2004).
53. Koussoulas, V. et al. Soluble triggering receptor expressed on myeloid cells (sTREM-1): A new mediator involved in the pathogenesis of peptic ulcer disease. Eur. J. Gastroenterol. Hepatol. 18, 375-379 (2006).
54. Schenk, M., Bouchon, A., Birrer, S., Colonna, M. & Mueller, C. Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. J. Immunol. 174, 517-524 (2005).
55. Tzivras, M. & et.al Role of soluble triggering receptor expressed on myeloid cells in inflammatory bowel disease. World J. Gastroenterol. 12, 3416-3419 (2006).
56. Nochi, H. et al. Modulation of hepatic granulomatous responses by transgene expression of DAP12 or TREM-1-Ig molecules. Am. J. Pathol. 162, 1191-1201 (2003).
57. Mahdy, A.M. et al. Production of soluble triggering receptor expressed on myeloid cells by lipopolysacccharide-stimulated human neutrophils involves de novo protein synthesis. Clin. Vaccine Immunol. 13, 492-495 (2006).
58. Gingras, M.C., Lapillonne, H. & Margolin, J.F. TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. Mol. Immunol. 38, 817-824 (2002).
59. Begum, N.A. et al. Mycobacterium bovis BCG cell wall-specific differentially expressed genes identified by differential display and cDNA subtraction in human macrophages. Infect. Immun. 72, 937-948 (2004).
60. Tanaka, J. Nasu-Hakola disease: A review of its leukoencephalopathic and membranolipodystrophic features. Neuropathology 20, S25-S29 (2000).
61. Verloes, A. et al. Nasu-Hakola syndrome: Polycystic lipomembranous osteodysplasia with sclerosing leucoencephalopathy and presenile dementia. J. Med. Genet. 34, 753-757 (1997).
62. Kitajima, I. et al. Nasu-Hakola disease (membranous lipodystrophy). Clinical, histopathological and biochemical studies of three cases. J. Neurol. Sci. 91, 35-52 (1989).
63. Paloneva, J. et al. Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts. Nat. Genet. 25, 357-361 (2000).
64. Kondo, T. et al. Heterogeneity of presenile dementia with bone cysts (Nasu-Hakola disease): Three genetic forms. Neurology 59, 1105-1107 (2002).
65. Teitelbaum, S.L. Bone resorption by osteoclasts. Science 289, 1504-1508 (2000).
66. Kaifu, T. et al. Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J. Clin. Invest. 111, 323-332 (2003).
67. Koga, T. et al. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 428, 758-763 (2004).
68. Walsh, M.C. et al. Osteoimmunology: Interplay between the immune system and bone metabolism. Annu. Rev. Immunol. 24, 33-63 (2006).
69. Humphrey, M.B. et al. The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. J. Bone Miner. Res. 19, 224-234 (2004).
70. Faccio, R., Zou, W., Colaianni, G., Teitelbaum, S.L. & Ross, F.P. High dose M-CSF partialLy rescues the Dap12-/- osteoclast phenotype. J. Cell. Biochem. 90, 871-883 (2003).
71. Nataf, S. et al. Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages. Am. J. Pathol. 166, 275-286 (2005).
72. Humphrey, M.B. et al. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. J. Bone Miner. Res. 21, 237-245 (2006).
73. Takahashi, K., Rochford, C.D.P. & Neumann, H. Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J. Exp. Med. 201, 647-657 (2005).
74. Hamerman, J.A., Tchao, N.K., Lowell, C.A. & Lanier, L.L. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat. Immunol. 6, 579-586 (2005).
75. Aoki, N., Zganiacz, A., Margetts, P. & Xing, Z. Differential regulation of DAP12 and molecules associated with DAP12 during host responses to mycobacterial infection. Infect. Immun. 72, 2477-2483 (2004).
76. Barrow, A.D. et al. Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2. J. Immunol. 172, 5838-5842 (2004).
77. Washington, A.V. et al. A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets. Blood 104, 1042-1047 (2004).
78. King, R.G., Herrin, B.R. & Justement, L.B. Trem-like transcript 2 is expressed on cells of the myeloid/granuloid and B lymphoid lineage and is up-regulated in response to inflammation. J. Immunol. 176, 6012-6021 (2006).
79. Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 282, 2085-2088 (1998).
80. Daws, M.R. et al. Pattern recognition by TREM-2: Binding of anionic ligands. J. Immunol. 171, 594-599 (2003).
81. Takegahara, N. et al. Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Nat. Cell Biol. 8, 615-622 (2006).
82. Tamagnone, L. & Giordano, S. Semaphorin pathways orchestrate osteogenesis. Nat. Cell Biol. 8, 545-547 (2006).
83. Karpanen, T. et al. Functional interaction of VEGF-C and VEGF-D with neuropilin receptors. FASEB J. 20, 1462-1472 (2006).