Functional identification of the promoter of the gene encoding the Rhesus monkey β-amyloid precursor protein

Gene

Volumn 217, Issue 1-2, 1998, Pages 165-176

  Song, Weihong ^a   Lahiri, Debomoy K ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

APP intron; APP promoter; Primate; Promoter activity; Regulatory elements; Serial deletion; Transcription factor; Transcriptional regulator; Upstream sequence

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CHLORAMPHENICOL ACETYLTRANSFERASE; RECOMBINANT DNA; TRANSCRIPTION FACTOR AP 2;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL STRAIN; CONTROLLED STUDY; DNA FLANKING REGION; DNA SEQUENCE; DNA TRANSFECTION; EXON; INTRON; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; RHESUS MONKEY; TRANSCRIPTION REGULATION;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CHLORAMPHENICOL O-ACETYLTRANSFERASE; GENE EXPRESSION REGULATION; GENES, REPORTER; INTRONS; MACACA MULATTA; PC12 CELLS; PLASMIDS; PROMOTER REGIONS (GENETICS); RATS; RECOMBINANT FUSION PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; RESTRICTION MAPPING; SEQUENCE DELETION; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA; MACACA MULATTA; PRIMATES;

EID: 0032517094     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(98)00340-0     Document Type: Article

References (33)

1. Adler M.J., Coronel C., Shelton E., Seegmiller J.E., Dewji N.N. Increased gene expression of Alzheimer disease β-amyloid precursor protein in senescent cultured fibroblasts. Proc. Natl. Acad. Sci. USA. 88:1991;16-20.
2. Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucl. Acids Res. 11:1983;1475-1489.
3. Fox N.W., Johnstone E.M., Ward K.E., Schrementi J., Little S.P. APP gene promoter constructs are preferentially expressed in the CNS and testis of transgenic mice. Biochem. Biophys. Res. Commun. 240:1997;759-762.
4. Games D., Adams D., Alessandrini R., Barbour R., Berthelette P., Blackwell C., Carr T., Clemens J.et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F-amyloid precursor protein. Nature. 373:1995;523-527.
5. Gregor P.D., Sawadogo M., Roeder R.G. The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer. Genes Devel. 4:1990;1730-1740.
6. Hoffman P.W., Chernak J.M. DNA binding and regulatory effects of transcription factors SP1 and USF at the rat amyloid precursor protein gene promoter. Nucl. Acids Res. 23:1995;2229-2235.
7. Johnson P., Friedmann T. Limited bidirectional activity of two housekeeping gene promoters: human HPRT and PGK. Gene. 88:1990;207-213.
8. Johnson S.A., McNeill T., Cordell B., Finch C.E. Relation of neuronal APP-751/APP- 695 mRNA ratio and neuritic plaque density in Alzheimer's disease. Science. 248:1990;854-857.
9. Kovacs D.M., Wasco W., Witherby J., Felsenstein K.M., Brunel F., Roeder R.G., Tanzi R.E. The upstream stimulatory factor functionally interacts with the Alzheimer amyloid β-protein precursor gene. Hum. Mol. Genet. 4:1995;1527-1533.
10. La Fauci G., Lahiri D.K., Salton S., Robakis N.K. Characterization of the 5′-end region and the first two exons of the β-protein precursor gene. Biochem. Biophys. Res. Commun. 159:1989;297-304.
11. Lahiri D.K. An upstream region of the gene promoter for the beta-amyloid precursor protein interacts with proteins from nuclear extracts of the human brain and PC12 cells. Mol. Brain Res. 58:1998;112-122.
12. Lahiri D.K., Nall C. Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1. Mol. Brain Res. 32:1995;233-240.
13. Lahiri D.K., Robakis N.K. The promoter activity of the gene encoding Alzheimer beta- amyloid precursor protein (APP) is regulated by two blocks of upstream sequences. Mol. Brain Res. 9:1991;253-257.
14. Murre C., McCaw P.S., Baltimore D. A new DNA binding and dimerization motif in the immunoglobulin enhancer binding, daughterless MyoD and myc proteins. Cell. 56:1989;777-783.
15. Podlisny M.B., Lee G., Selkoe D.J. Gene dosage of the amyloid beta precursor protein in Alzheimer's disease. Science. 238:1987;669-671.
16. Podlisny M.B., Tolan D.R., Selkoe D.J. Homology of the amyloid beta-protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease. Am. J. Pathol. 138:1991;1423-1435.
17. Querfurth H.W., Wijsman E.M., St George-Hyslop P.H., Selkoe D.J. Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family. Mol. Brain Res. 28:1995;319-337.
18. Quitschke W.W., Goldgaber D. The amyloid beta-protein precursor promoter. A region essential for transcriptional activity contains a nuclear factor binding domain. J. Biol. Chem. 267:1992;17362-17368.
19. Roy A.L., Meisterernst M., Pognonec P., Roeder R.G. Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF. Nature. 354:1991;245-248.
20. Sambrook, J., Fritsch, E.F., Maniatis, T., 1989. Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
21. Sawadogo M., Roeder R.G. Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region. Cell. 43:1985;165-175.
22. Scott J.N., Parhand I.M., Clark A.W. Beta-amyloid precursor protein gene is differentially expressed in axotomized sensory and motor systems. Mol. Brain Res. 10:1991;315-325.
23. Selkoe D.J. Amyloid beta-protein and the genetics of Alzheimer's disease. J. Biol. Chem. 271:1996;18295-18298.
24. Selkoe D.J., Bell D.S., Podlisny M.B., Price D.L., Cork L.C. Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. Science. 235:1987;873-877.
25. Sirito M., Lin Q., Maity T., Sawadogo M. Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells. Nucl. Acids Res. 22:1994;427-433.
26. Song W., Lahiri D.K. Efficient transfection of DNA by mixing cells in suspension with calcium phosphate. Nucl. Acids Res. 23:1995;3609-3611.
27. Song W., Lahiri D.K. Molecular cloning of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein: structural characterization and a comparative study with other species. Gene. 217:1998;151-164.
28. St George-Hyslop P.H., Tanzi R.E., Polinsky R.J., Neve R.L., Pollen D.D., Growdon J., Cupples L.A., Nee L., Myers R.H.et al. Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease. Science. 238:1987;664-666.
29. Sturchler-Pierrat C., Abramowski D., Duke M., Wiederhold K.-H., Mistl C., Rothacher S., Lederman B., Burki K. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc. Natl. Acad. Sci. USA. 94:1997;13287-13292.
30. Tanzi R.E., Bird E.D., Latt S.A., Neve R.L. The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease. Science. 238:1987;666-669.
31. Tapscott S.J., Davis R.L., Thayer M.J., Cheng P.-F., Weintraub H., Lassar A.B. MyoD1: a nuclear phosphoprotein requiring a myc homology region to convert fibroblasts to myoblasts. Science. 242:1988;405-411.
32. Walker L.C., Masters C., Beyreuther K., Price D.L. Amyloid in the brains of aged squirrel monkeys. Acta Neuropathol. 80:1990;381-387.
33. Wisniewski H.M., Ghetti B., Terry R.D. Neuritic (senile) plaques and filamentous changes in aged rhesus monkeys. J. Neuropathol. Exp. Neurol. 32:1973;566-584.