메뉴 건너뛰기




Volumn 8, Issue 9, 2013, Pages

Drug-Induced Reactivation of Apoptosis Abrogates HIV-1 Infection

(20)  Hanauske Abel, Hartmut M a,b   Saxena, Deepti b,j   Palumbo, Paul E b,j   Hanauske, Axel Rainer c,k   Luchessi, Augusto D a,l   Cambiaghi, Tavane D a,m   Hoque, Mainul a   Spino, Michael d,e   Gandolfi, Darlene D'Alliessi f   Heller, Debra S a   Singh, Sukhwinder a   Park, Myung Hee g   Cracchiolo, Bernadette M a   Tricta, Fernando e   Connelly, John e   Popowicz, Anthony M h   Cone, Richard A i   Holland, Bart a   Pe'ery, Tsafi a   Mathews, Michael B a  


Author keywords

[No Author keywords available]

Indexed keywords

BATRAFEN VAGINALCREME; CASPASE 3; CICLOPIROX; DEFERIPRONE; INITIATION FACTOR 5A; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA;

EID: 84884503910     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074414     Document Type: Article
Times cited : (38)

References (218)
  • 1
    • 84875985311 scopus 로고    scopus 로고
    • Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study
    • Sáez-Cirión A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, et al. (2013) Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study. PLoS Pathog 9: 1 - 12.
    • (2013) PLoS Pathog , vol.9 , pp. 1-12
    • Sáez-Cirión, A.1    Bacchus, C.2    Hocqueloux, L.3    Avettand-Fenoel, V.4    Girault, I.5
  • 2
    • 0032894113 scopus 로고    scopus 로고
    • Apoptosis: an innate immune response to virus infection
    • Everett H, McFadden G, (1999) Apoptosis: an innate immune response to virus infection. Trends Microbiol 7: 160-165.
    • (1999) Trends Microbiol , vol.7 , pp. 160-165
    • Everett, H.1    McFadden, G.2
  • 3
    • 0036852215 scopus 로고    scopus 로고
    • To kill or be killed: viral evasion of apoptosis
    • Benedict CA, Norris PS, Ware CF, (2002) To kill or be killed: viral evasion of apoptosis. Nat Immunol 3: 1013-1018.
    • (2002) Nat Immunol , vol.3 , pp. 1013-1018
    • Benedict, C.A.1    Norris, P.S.2    Ware, C.F.3
  • 4
    • 2342649461 scopus 로고    scopus 로고
    • Resistance to apoptosis: mechanism for the development of HIV reservoirs
    • Lum JJ, Badley AD, (2003) Resistance to apoptosis: mechanism for the development of HIV reservoirs. Curr HIV Res 1: 261-274.
    • (2003) Curr HIV Res , vol.1 , pp. 261-274
    • Lum, J.J.1    Badley, A.D.2
  • 6
    • 13444309162 scopus 로고    scopus 로고
    • Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cells
    • Zhou Y, Zhang H, Siliciano JD, Siliciano RF, (2005) Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cells. J Virol 79: 2199-2210.
    • (2005) J Virol , vol.79 , pp. 2199-2210
    • Zhou, Y.1    Zhang, H.2    Siliciano, J.D.3    Siliciano, R.F.4
  • 7
    • 34848893294 scopus 로고    scopus 로고
    • Apoptotic killing of HIV-1-infected macrophages is subverted by the viral envelope glycoprotein
    • Swingler S, Mann AM, Zhou J, Swingler C, Stevenson M, (2007) Apoptotic killing of HIV-1-infected macrophages is subverted by the viral envelope glycoprotein. PLoS Pathog 3: 1281-1290.
    • (2007) PLoS Pathog , vol.3 , pp. 1281-1290
    • Swingler, S.1    Mann, A.M.2    Zhou, J.3    Swingler, C.4    Stevenson, M.5
  • 8
    • 41749112013 scopus 로고    scopus 로고
    • Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway
    • Fernandez Larrosa PN, Croci DO, Riva DA, Bibini M, Luzzi R, et al. (2008) Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway. Retrovirology 5: 19.
    • (2008) Retrovirology , vol.5 , pp. 19
    • Fernandez Larrosa, P.N.1    Croci, D.O.2    Riva, D.A.3    Bibini, M.4    Luzzi, R.5
  • 9
    • 43749122339 scopus 로고    scopus 로고
    • Human immunodeficiency virus (HIV-1) infection selectively downregulates PD-1 expression in infected cells and protects the cells from early apoptosis in vitro and in vivo
    • Venkatachari NJ, Buchanan WG, Ayyavoo V, (2008) Human immunodeficiency virus (HIV-1) infection selectively downregulates PD-1 expression in infected cells and protects the cells from early apoptosis in vitro and in vivo. Virology 376: 140-153.
    • (2008) Virology , vol.376 , pp. 140-153
    • Venkatachari, N.J.1    Buchanan, W.G.2    Ayyavoo, V.3
  • 10
    • 62749139614 scopus 로고    scopus 로고
    • HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression
    • Klase Z, Winograd R, Davis J, Carpio L, Hildreth R, et al. (2009) HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression. Retrovirology 6: 18.
    • (2009) Retrovirology , vol.6 , pp. 18
    • Klase, Z.1    Winograd, R.2    Davis, J.3    Carpio, L.4    Hildreth, R.5
  • 11
    • 7044223315 scopus 로고    scopus 로고
    • HIV-1 expression protects macrophages and microglia from apoptotic death
    • Cosenza MA, Zhao ML, Lee SC, (2004) HIV-1 expression protects macrophages and microglia from apoptotic death. Neuropathol Appl Neurobiol 30: 478-490.
    • (2004) Neuropathol Appl Neurobiol , vol.30 , pp. 478-490
    • Cosenza, M.A.1    Zhao, M.L.2    Lee, S.C.3
  • 12
    • 64249149366 scopus 로고    scopus 로고
    • Circulating Monocytes in HIV-1-Infected Viremic Subjects Exhibit an Antiapoptosis Gene Signature and Virus- and Host-Mediated Apoptosis Resistance
    • Giri MS, Nebozyhn M, Raymond A, Gekonge B, Hancock A, et al. (2009) Circulating Monocytes in HIV-1-Infected Viremic Subjects Exhibit an Antiapoptosis Gene Signature and Virus- and Host-Mediated Apoptosis Resistance. J Immunol 182: 4459-4470.
    • (2009) J Immunol , vol.182 , pp. 4459-4470
    • Giri, M.S.1    Nebozyhn, M.2    Raymond, A.3    Gekonge, B.4    Hancock, A.5
  • 13
    • 0028912254 scopus 로고
    • Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes
    • Finkel TH, Tudor-Williams G, Banda NK, Cotton MF, Curiel T, et al. (1995) Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nat Med 1: 129-134.
    • (1995) Nat Med , vol.1 , pp. 129-134
    • Finkel, T.H.1    Tudor-Williams, G.2    Banda, N.K.3    Cotton, M.F.4    Curiel, T.5
  • 14
    • 22744448560 scopus 로고    scopus 로고
    • Apoptosis of HIV-specific CD8+ T cells: an HIV evasion strategy
    • Petrovas C, Mueller YM, Katsikis PD, (2005) Apoptosis of HIV-specific CD8+ T cells: an HIV evasion strategy. Cell Death Differ 12Suppl 1: 859-870.
    • (2005) Cell Death Differ , vol.12 , pp. 859-870
    • Petrovas, C.1    Mueller, Y.M.2    Katsikis, P.D.3
  • 15
    • 51649123313 scopus 로고    scopus 로고
    • Priming of T cells to Fas-mediated proliferative signals by interleukin-7
    • Rethi B, Vivar N, Sammicheli S, Fluur C, Ruffin N, et al. (2008) Priming of T cells to Fas-mediated proliferative signals by interleukin-7. Blood 112: 1195-1204.
    • (2008) Blood , vol.112 , pp. 1195-1204
    • Rethi, B.1    Vivar, N.2    Sammicheli, S.3    Fluur, C.4    Ruffin, N.5
  • 16
    • 0025727837 scopus 로고
    • [Demonstration of an engagement process towards cell death by apoptosis in lymphocytes of HIV infected patients]
    • Gougeon ML, Olivier R, Garcia S, Guetard D, Dragic T, et al. (1991) [Demonstration of an engagement process towards cell death by apoptosis in lymphocytes of HIV infected patients]. C R Acad Sci III 312: 529-537.
    • (1991) C R Acad Sci III , vol.312 , pp. 529-537
    • Gougeon, M.L.1    Olivier, R.2    Garcia, S.3    Guetard, D.4    Dragic, T.5
  • 17
    • 0025778615 scopus 로고
    • [Activation of CD4+ T-lymphocytes in asymptomatic HIV infected patients induce the program action of lymphocyte death by apoptosis]
    • Groux H, Monte D, Bourrez JM, Capron A, Ameisen JC, (1991) [Activation of CD4+ T-lymphocytes in asymptomatic HIV infected patients induce the program action of lymphocyte death by apoptosis]. C R Acad Sci III 312: 599-606.
    • (1991) C R Acad Sci III , vol.312 , pp. 599-606
    • Groux, H.1    Monte, D.2    Bourrez, J.M.3    Capron, A.4    Ameisen, J.C.5
  • 18
    • 70349898696 scopus 로고    scopus 로고
    • 25 years after HIV discovery: prospects for cure and vaccine (Nobel lecture)
    • Montagnier L, (2009) 25 years after HIV discovery: prospects for cure and vaccine (Nobel lecture). Angew Chem Int Ed Engl 48: 5815-5826.
    • (2009) Angew Chem Int Ed Engl , vol.48 , pp. 5815-5826
    • Montagnier, L.1
  • 19
    • 0035093156 scopus 로고    scopus 로고
    • Biochemical mechanisms of HIV induced T cell apoptosis
    • Selliah N, Finkel TH, (2001) Biochemical mechanisms of HIV induced T cell apoptosis. Cell Death Differ 8: 127-136.
    • (2001) Cell Death Differ , vol.8 , pp. 127-136
    • Selliah, N.1    Finkel, T.H.2
  • 21
  • 22
    • 0032100652 scopus 로고    scopus 로고
    • Antiretroviral effects of deoxyhypusyl hydroxylase inhibitors: a hypusine-dependent host cell mechanism for replication of human immunodeficiency virus type 1 (HIV-1)
    • Andrus L, Szabo P, Grady RW, Hanauske AR, Huima-Byron T, et al. (1998) Antiretroviral effects of deoxyhypusyl hydroxylase inhibitors: a hypusine-dependent host cell mechanism for replication of human immunodeficiency virus type 1 (HIV-1). Biochem Pharmacol 55: 1807-1818.
    • (1998) Biochem Pharmacol , vol.55 , pp. 1807-1818
    • Andrus, L.1    Szabo, P.2    Grady, R.W.3    Hanauske, A.R.4    Huima-Byron, T.5
  • 23
    • 70450227340 scopus 로고    scopus 로고
    • Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A
    • Hoque M, Hanauske-Abel HM, Palumbo P, Saxena D, D'Alliessi Gandolfi D, et al. (2009) Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A. Retrovirology 6: 90.
    • (2009) Retrovirology , vol.6 , pp. 90
    • Hoque, M.1    Hanauske-Abel, H.M.2    Palumbo, P.3    Saxena, D.4    D'Alliessi Gandolfi, D.5
  • 24
    • 33644858616 scopus 로고    scopus 로고
    • Selective optimization of side activities: the SOSA approach
    • Wermuth CG, (2006) Selective optimization of side activities: the SOSA approach. Drug Discov Today 11: 160-164.
    • (2006) Drug Discov Today , vol.11 , pp. 160-164
    • Wermuth, C.G.1
  • 25
    • 70350686620 scopus 로고    scopus 로고
    • Medicinal inorganic chemistry approaches to passivation and removal of aberrant metal ions in disease
    • Scott LE, Orvig C, (2009) Medicinal inorganic chemistry approaches to passivation and removal of aberrant metal ions in disease. Chem Rev 109: 4885-4910.
    • (2009) Chem Rev , vol.109 , pp. 4885-4910
    • Scott, L.E.1    Orvig, C.2
  • 26
    • 0020488069 scopus 로고
    • A stereochemical concept for the catalytic mechanism of prolyl hydroxlyase. Applicability to classification and design of inhibitors
    • Hanauske-Abel HM, Günzler V, (1982) A stereochemical concept for the catalytic mechanism of prolyl hydroxlyase. Applicability to classification and design of inhibitors. J Theor Biol 94: 421-455.
    • (1982) J Theor Biol , vol.94 , pp. 421-455
    • Hanauske-Abel, H.M.1    Günzler, V.2
  • 27
    • 0021765030 scopus 로고
    • The 2-oxoglutarate binding site of prolyl 4-hydroxylase. Identification of distinct subsites and evidence for 2-oxoglutarate decarboxylation in a ligand reaction at the enzyme-bound ferrous ion
    • Majamaa K, Hanauske-Abel HM, Gunzler V, Kivirikko KI, (1984) The 2-oxoglutarate binding site of prolyl 4-hydroxylase. Identification of distinct subsites and evidence for 2-oxoglutarate decarboxylation in a ligand reaction at the enzyme-bound ferrous ion. Eur J Biochem 138: 239-245.
    • (1984) Eur J Biochem , vol.138 , pp. 239-245
    • Majamaa, K.1    Hanauske-Abel, H.M.2    Gunzler, V.3    Kivirikko, K.I.4
  • 28
    • 0023021512 scopus 로고
    • Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase
    • Majamaa K, Gunzler V, Hanauske-Abel HM, Myllyla R, Kivirikko KI, (1986) Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase. J Biol Chem 261: 7819-7823.
    • (1986) J Biol Chem , vol.261 , pp. 7819-7823
    • Majamaa, K.1    Gunzler, V.2    Hanauske-Abel, H.M.3    Myllyla, R.4    Kivirikko, K.I.5
  • 29
    • 0038324399 scopus 로고    scopus 로고
    • The HAG mechanism: a molecular rationale for the therapeutic application of iron chelators in human diseases involving the 2-oxoacid utilizing dioxygenases
    • Hanauske-Abel HM, Popowicz AM, (2003) The HAG mechanism: a molecular rationale for the therapeutic application of iron chelators in human diseases involving the 2-oxoacid utilizing dioxygenases. Curr Med Chem 10: 1005-1019.
    • (2003) Curr Med Chem , vol.10 , pp. 1005-1019
    • Hanauske-Abel, H.M.1    Popowicz, A.M.2
  • 30
    • 1542378704 scopus 로고    scopus 로고
    • Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates
    • Costas M, Mehn MP, Jensen MP, Que L Jr, (2004) Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates. Chem Rev 104: 939-986.
    • (2004) Chem Rev , vol.104 , pp. 939-986
    • Costas, M.1    Mehn, M.P.2    Jensen, M.P.3    Que Jr., L.4
  • 31
    • 2442628211 scopus 로고    scopus 로고
    • FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes
    • Hausinger RP, (2004) FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes. Crit Rev Biochem Mol Biol 39: 21-68.
    • (2004) Crit Rev Biochem Mol Biol , vol.39 , pp. 21-68
    • Hausinger, R.P.1
  • 32
    • 33749542309 scopus 로고    scopus 로고
    • Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase
    • Hoffart LM, Barr EW, Guyer RB, Bollinger JM Jr, Krebs C, (2006) Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase. Proc Natl Acad Sci U S A 103: 14738-14743.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14738-14743
    • Hoffart, L.M.1    Barr, E.W.2    Guyer, R.B.3    Bollinger Jr., J.M.4    Krebs, C.5
  • 33
    • 33750935618 scopus 로고    scopus 로고
    • Spectroscopic and electronic structure studies of the role of active site interactions in the decarboxylation reaction of alpha-keto acid-dependent dioxygenases
    • Neidig ML, Brown CD, Kavana M, Choroba OW, Spencer JB, et al. (2006) Spectroscopic and electronic structure studies of the role of active site interactions in the decarboxylation reaction of alpha-keto acid-dependent dioxygenases. J Inorg Biochem 100: 2108-2116.
    • (2006) J Inorg Biochem , vol.100 , pp. 2108-2116
    • Neidig, M.L.1    Brown, C.D.2    Kavana, M.3    Choroba, O.W.4    Spencer, J.B.5
  • 34
    • 0028842107 scopus 로고
    • Specific inhibition of eIF-5A and collagen hydroxylation by a single agent. Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries
    • McCaffrey TA, Pomerantz KB, Sanborn TA, Spokojny AM, Du B, et al. (1995) Specific inhibition of eIF-5A and collagen hydroxylation by a single agent. Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries. J Clin Invest 95: 446-455.
    • (1995) J Clin Invest , vol.95 , pp. 446-455
    • McCaffrey, T.A.1    Pomerantz, K.B.2    Sanborn, T.A.3    Spokojny, A.M.4    Du, B.5
  • 35
    • 0036681259 scopus 로고    scopus 로고
    • The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro
    • Clement PM, Hanauske-Abel HM, Wolff EC, Kleinman HK, Park MH, (2002) The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro. Int J Cancer 100: 491-498.
    • (2002) Int J Cancer , vol.100 , pp. 491-498
    • Clement, P.M.1    Hanauske-Abel, H.M.2    Wolff, E.C.3    Kleinman, H.K.4    Park, M.H.5
  • 37
    • 0028266723 scopus 로고
    • Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation
    • Hanauske-Abel HM, Park MH, Hanauske AR, Popowicz AM, Lalande M, et al. (1994) Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation. Biochim Biophys Acta 1221: 115-124.
    • (1994) Biochim Biophys Acta , vol.1221 , pp. 115-124
    • Hanauske-Abel, H.M.1    Park, M.H.2    Hanauske, A.R.3    Popowicz, A.M.4    Lalande, M.5
  • 38
    • 0029019877 scopus 로고
    • Detection of a sub-set of polysomal mRNAs associated with modulation of hypusine formation at the G1-S boundary. Proposal of a role for eIF-5A in onset of DNA replication
    • Hanauske-Abel HM, Slowinska B, Zagulska S, Wilson RC, Staiano-Coico L, et al. (1995) Detection of a sub-set of polysomal mRNAs associated with modulation of hypusine formation at the G1-S boundary. Proposal of a role for eIF-5A in onset of DNA replication. FEBS Lett 366: 92-98.
    • (1995) FEBS Lett , vol.366 , pp. 92-98
    • Hanauske-Abel, H.M.1    Slowinska, B.2    Zagulska, S.3    Wilson, R.C.4    Staiano-Coico, L.5
  • 39
    • 70349266069 scopus 로고    scopus 로고
    • Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center
    • Vu VV, Emerson JP, Martinho M, Kim YS, Munck E, et al. (2009) Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center. Proc Natl Acad Sci U S A 106: 14814-14819.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 14814-14819
    • Vu, V.V.1    Emerson, J.P.2    Martinho, M.3    Kim, Y.S.4    Munck, E.5
  • 40
    • 0026027968 scopus 로고
    • The active site of deoxyhypusyl hydroxylase: use of catecholpeptides and their component chelator and peptide moieties as molecular probes
    • Abbruzzese A, Hanauske-Abel HM, Park MH, Henke S, Folk JE, (1991) The active site of deoxyhypusyl hydroxylase: use of catecholpeptides and their component chelator and peptide moieties as molecular probes. Biochim Biophys Acta 1077: 159-166.
    • (1991) Biochim Biophys Acta , vol.1077 , pp. 159-166
    • Abbruzzese, A.1    Hanauske-Abel, H.M.2    Park, M.H.3    Henke, S.4    Folk, J.E.5
  • 41
    • 0041810592 scopus 로고    scopus 로고
    • The eukaryotic initiation factor 5A is involved in the regulation of proliferation and apoptosis induced by interferon-alpha and EGF in human cancer cells
    • Caraglia M, Marra M, Giuberti G, D'Alessandro AM, Baldi A, et al. (2003) The eukaryotic initiation factor 5A is involved in the regulation of proliferation and apoptosis induced by interferon-alpha and EGF in human cancer cells. J Biochem 133: 757-765.
    • (2003) J Biochem , vol.133 , pp. 757-765
    • Caraglia, M.1    Marra, M.2    Giuberti, G.3    D'Alessandro, A.M.4    Baldi, A.5
  • 42
    • 0031469938 scopus 로고    scopus 로고
    • Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis
    • Tome ME, Fiser SM, Payne CM, Gerner EW, (1997) Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis. Biochem J 328 (Pt 3): 847-854.
    • (1997) Biochem J , vol.328 , Issue.Pt 3 , pp. 847-854
    • Tome, M.E.1    Fiser, S.M.2    Payne, C.M.3    Gerner, E.W.4
  • 43
    • 0032779375 scopus 로고    scopus 로고
    • Mimosine induces apoptosis in the HL60 human tumor cell line
    • Reno F, Tontini A, Burattini S, Papa S, Falcieri E, et al. (1999) Mimosine induces apoptosis in the HL60 human tumor cell line. Apoptosis 4: 469-477.
    • (1999) Apoptosis , vol.4 , pp. 469-477
    • Reno, F.1    Tontini, A.2    Burattini, S.3    Papa, S.4    Falcieri, E.5
  • 44
    • 33846292223 scopus 로고    scopus 로고
    • Inhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growth
    • Jasiulionis MG, Luchessi AD, Moreira AG, Souza PP, Suenaga AP, et al. (2007) Inhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growth. Cell Biochem Funct 25: 109-114.
    • (2007) Cell Biochem Funct , vol.25 , pp. 109-114
    • Jasiulionis, M.G.1    Luchessi, A.D.2    Moreira, A.G.3    Souza, P.P.4    Suenaga, A.P.5
  • 45
    • 0042066415 scopus 로고    scopus 로고
    • Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A
    • Jin BF, He K, Wang HX, Wang J, Zhou T, et al. (2003) Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A. Oncogene 22: 4819-4830.
    • (2003) Oncogene , vol.22 , pp. 4819-4830
    • Jin, B.F.1    He, K.2    Wang, H.X.3    Wang, J.4    Zhou, T.5
  • 46
    • 70350461873 scopus 로고    scopus 로고
    • N(1)-guanyl-1,7,-diamineoheptane, an inhibitor of deoxyhypusine synthase, suppresses differentiation and induces apoptosis via mitochondrial and AMPK pathways in immortalized and malignant human oral keratinocytes
    • Lee SK, Lee J, Lee SI, Bae WJ, Lee YM, et al. (2009) N(1)-guanyl-1,7,-diamineoheptane, an inhibitor of deoxyhypusine synthase, suppresses differentiation and induces apoptosis via mitochondrial and AMPK pathways in immortalized and malignant human oral keratinocytes. J Oral Pathol Med 38: 792-800.
    • (2009) J Oral Pathol Med , vol.38 , pp. 792-800
    • Lee, S.K.1    Lee, J.2    Lee, S.I.3    Bae, W.J.4    Lee, Y.M.5
  • 47
    • 33846608688 scopus 로고    scopus 로고
    • Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling
    • Taylor CA, Sun Z, Cliche DO, Ming H, Eshaque B, et al. (2007) Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling. Exp Cell Res 313: 437-449.
    • (2007) Exp Cell Res , vol.313 , pp. 437-449
    • Taylor, C.A.1    Sun, Z.2    Cliche, D.O.3    Ming, H.4    Eshaque, B.5
  • 48
    • 77951215536 scopus 로고    scopus 로고
    • Apoptosis induction by eIF5A1 involves activation of the intrinsic mitochondrial pathway
    • Sun Z, Cheng Z, Taylor CA, McConkey BJ, Thompson JE, (2010) Apoptosis induction by eIF5A1 involves activation of the intrinsic mitochondrial pathway. J Cell Physiol 223: 798-809.
    • (2010) J Cell Physiol , vol.223 , pp. 798-809
    • Sun, Z.1    Cheng, Z.2    Taylor, C.A.3    McConkey, B.J.4    Thompson, J.E.5
  • 49
    • 0029916299 scopus 로고    scopus 로고
    • Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A
    • Bevec D, Jaksche H, Oft M, Wohl T, Himmelspach M, et al. (1996) Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A. Science 271: 1858-1860.
    • (1996) Science , vol.271 , pp. 1858-1860
    • Bevec, D.1    Jaksche, H.2    Oft, M.3    Wohl, T.4    Himmelspach, M.5
  • 50
    • 0027767592 scopus 로고
    • Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation
    • Ruhl M, Himmelspach M, Bahr GM, Hammerschmid F, Jaksche H, et al. (1993) Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation. J Cell Biol 123: 1309-1320.
    • (1993) J Cell Biol , vol.123 , pp. 1309-1320
    • Ruhl, M.1    Himmelspach, M.2    Bahr, G.M.3    Hammerschmid, F.4    Jaksche, H.5
  • 51
    • 0027947377 scopus 로고
    • Induced gene expression of the hypusine-containing protein eukaryotic initiation factor 5A in activated human T lymphocytes
    • Bevec D, Klier H, Holter W, Tschachler E, Valent P, et al. (1994) Induced gene expression of the hypusine-containing protein eukaryotic initiation factor 5A in activated human T lymphocytes. Proc Natl Acad Sci U S A 91: 10829-10833.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10829-10833
    • Bevec, D.1    Klier, H.2    Holter, W.3    Tschachler, E.4    Valent, P.5
  • 52
    • 13744254860 scopus 로고    scopus 로고
    • Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy
    • Hauber I, Bevec D, Heukeshoven J, Kratzer F, Horn F, et al. (2005) Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy. J Clin Invest 115: 76-85.
    • (2005) J Clin Invest , vol.115 , pp. 76-85
    • Hauber, I.1    Bevec, D.2    Heukeshoven, J.3    Kratzer, F.4    Horn, F.5
  • 53
    • 33748422048 scopus 로고    scopus 로고
    • Inhibition of multidrug-resistant HIV-1 by interference with cellular S-adenosylmethionine decarboxylase activity
    • Schafer B, Hauber I, Bunk A, Heukeshoven J, Dusedau A, et al. (2006) Inhibition of multidrug-resistant HIV-1 by interference with cellular S-adenosylmethionine decarboxylase activity. J Infect Dis 194: 740-750.
    • (2006) J Infect Dis , vol.194 , pp. 740-750
    • Schafer, B.1    Hauber, I.2    Bunk, A.3    Heukeshoven, J.4    Dusedau, A.5
  • 54
    • 0036939706 scopus 로고    scopus 로고
    • Effects of 1,8-Diaminooctane on the FIV Rev Regulatory System
    • Hart R, Billaud JN, Choi SJ, Phillips TR, (2002) Effects of 1,8-Diaminooctane on the FIV Rev Regulatory System. Virology 304: 97-104.
    • (2002) Virology , vol.304 , pp. 97-104
    • Hart, R.1    Billaud, J.N.2    Choi, S.J.3    Phillips, T.R.4
  • 55
    • 0034788224 scopus 로고    scopus 로고
    • Apoptosis, cell volume regulation and volume-regulatory chloride channels
    • Okada Y, Maeno E, (2001) Apoptosis, cell volume regulation and volume-regulatory chloride channels. Comp Biochem Physiol A Mol Integr Physiol 130: 377-383.
    • (2001) Comp Biochem Physiol A Mol Integr Physiol , vol.130 , pp. 377-383
    • Okada, Y.1    Maeno, E.2
  • 56
    • 0034662989 scopus 로고    scopus 로고
    • Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis
    • Maeno E, Ishizaki Y, Kanaseki T, Hazama A, Okada Y, (2000) Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis. Proc Natl Acad Sci U S A 97: 9487-9492.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 9487-9492
    • Maeno, E.1    Ishizaki, Y.2    Kanaseki, T.3    Hazama, A.4    Okada, Y.5
  • 57
    • 77957842603 scopus 로고    scopus 로고
    • Apoptotic volume decrease as a geometric determinant for cell dismantling into apoptotic bodies
    • Nunez R, Sancho-Martinez SM, Novoa JM, Lopez-Hernandez FJ, (2010) Apoptotic volume decrease as a geometric determinant for cell dismantling into apoptotic bodies. Cell Death Differ 17: 1665-1671.
    • (2010) Cell Death Differ , vol.17 , pp. 1665-1671
    • Nunez, R.1    Sancho-Martinez, S.M.2    Novoa, J.M.3    Lopez-Hernandez, F.J.4
  • 59
    • 0037879052 scopus 로고    scopus 로고
    • The mitochondrial membrane potential (Δψ(m)) in apoptosis; an update
    • Ly JD, Grubb DR, Lawen A, (2003) The mitochondrial membrane potential (Δψ(m)) in apoptosis; an update. Apoptosis 8: 115-128.
    • (2003) Apoptosis , vol.8 , pp. 115-128
    • Ly, J.D.1    Grubb, D.R.2    Lawen, A.3
  • 60
    • 0036022402 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update
    • Soldani C, Scovassi AI, (2002) Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. Apoptosis 7: 321-328.
    • (2002) Apoptosis , vol.7 , pp. 321-328
    • Soldani, C.1    Scovassi, A.I.2
  • 61
    • 64849113485 scopus 로고    scopus 로고
    • Control of mitochondrial apoptosis by the Bcl-2 family
    • Brunelle JK, Letai A, (2009) Control of mitochondrial apoptosis by the Bcl-2 family. J Cell Sci 122: 437-441.
    • (2009) J Cell Sci , vol.122 , pp. 437-441
    • Brunelle, J.K.1    Letai, A.2
  • 62
    • 0032971041 scopus 로고    scopus 로고
    • Differential expression profiles of apoptosis-affecting genes in HIV-infected cell lines and patient T cells
    • Scheuring UJ, Sabzevari H, Corbeil J, Theofilopoulos AN, (1999) Differential expression profiles of apoptosis-affecting genes in HIV-infected cell lines and patient T cells. AIDS 13: 167-175.
    • (1999) AIDS , vol.13 , pp. 167-175
    • Scheuring, U.J.1    Sabzevari, H.2    Corbeil, J.3    Theofilopoulos, A.N.4
  • 63
    • 0028810985 scopus 로고
    • The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells
    • Zauli G, Gibellini D, Caputo A, Bassini A, Negrini M, et al. (1995) The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells. Blood 86: 3823-3834.
    • (1995) Blood , vol.86 , pp. 3823-3834
    • Zauli, G.1    Gibellini, D.2    Caputo, A.3    Bassini, A.4    Negrini, M.5
  • 64
    • 34247108285 scopus 로고    scopus 로고
    • HIV Tat protein increases Bcl-2 expression in monocytes which inhibits monocyte apoptosis induced by tumor necrosis factor-alpha-related apoptosis-induced ligand
    • Zheng L, Yang Y, Guocai L, Pauza CD, Salvato MS, (2007) HIV Tat protein increases Bcl-2 expression in monocytes which inhibits monocyte apoptosis induced by tumor necrosis factor-alpha-related apoptosis-induced ligand. Intervirology 50: 224-228.
    • (2007) Intervirology , vol.50 , pp. 224-228
    • Zheng, L.1    Yang, Y.2    Guocai, L.3    Pauza, C.D.4    Salvato, M.S.5
  • 65
    • 0033541959 scopus 로고    scopus 로고
    • Activation of Bcl-2 promoter-directed gene expression by the human immunodeficiency virus type-1 Tat protein
    • Wang Z, Morris GF, Reed JC, Kelly GD, Morris CB, (1999) Activation of Bcl-2 promoter-directed gene expression by the human immunodeficiency virus type-1 Tat protein. Virology 257: 502-510.
    • (1999) Virology , vol.257 , pp. 502-510
    • Wang, Z.1    Morris, G.F.2    Reed, J.C.3    Kelly, G.D.4    Morris, C.B.5
  • 66
    • 1642392156 scopus 로고    scopus 로고
    • DC-SIGN promotes exogenous MHC-I-restricted HIV-1 antigen presentation
    • Moris A, Nobile C, Buseyne F, Porrot F, Abastado JP, et al. (2004) DC-SIGN promotes exogenous MHC-I-restricted HIV-1 antigen presentation. Blood 103: 2648-2654.
    • (2004) Blood , vol.103 , pp. 2648-2654
    • Moris, A.1    Nobile, C.2    Buseyne, F.3    Porrot, F.4    Abastado, J.P.5
  • 67
    • 70350309668 scopus 로고    scopus 로고
    • Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat
    • Sivakumaran H, van der Horst A, Fulcher AJ, Apolloni A, Lin MH, et al. (2009) Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat. J Virol 83: 11694-11703.
    • (2009) J Virol , vol.83 , pp. 11694-11703
    • Sivakumaran, H.1    van der Horst, A.2    Fulcher, A.J.3    Apolloni, A.4    Lin, M.H.5
  • 68
    • 0030040353 scopus 로고    scopus 로고
    • Nuclear preservation and cytoplasmic degradation of human immunodeficiency virus type 1 Rev protein
    • Kubota S, Duan L, Furuta RA, Hatanaka M, Pomerantz RJ, (1996) Nuclear preservation and cytoplasmic degradation of human immunodeficiency virus type 1 Rev protein. J Virol 70: 1282-1287.
    • (1996) J Virol , vol.70 , pp. 1282-1287
    • Kubota, S.1    Duan, L.2    Furuta, R.A.3    Hatanaka, M.4    Pomerantz, R.J.5
  • 69
    • 0025295307 scopus 로고
    • Human immunodeficiency virus vpr product is a virion-associated regulatory protein
    • Cohen EA, Dehni G, Sodroski JG, Haseltine WA, (1990) Human immunodeficiency virus vpr product is a virion-associated regulatory protein. J Virol 64: 3097-3099.
    • (1990) J Virol , vol.64 , pp. 3097-3099
    • Cohen, E.A.1    Dehni, G.2    Sodroski, J.G.3    Haseltine, W.A.4
  • 70
    • 52049095759 scopus 로고    scopus 로고
    • Assembly with the Cul4A-DDB1DCAF1 ubiquitin ligase protects HIV-1 Vpr from proteasomal degradation
    • Le Rouzic E, Morel M, Ayinde D, Belaidouni N, Letienne J, et al. (2008) Assembly with the Cul4A-DDB1DCAF1 ubiquitin ligase protects HIV-1 Vpr from proteasomal degradation. J Biol Chem 283: 21686-21692.
    • (2008) J Biol Chem , vol.283 , pp. 21686-21692
    • Le Rouzic, E.1    Morel, M.2    Ayinde, D.3    Belaidouni, N.4    Letienne, J.5
  • 71
    • 0034665314 scopus 로고    scopus 로고
    • Dual role of the HIV-1 vpr protein in the modulation of the apoptotic response of T cells
    • Conti L, Matarrese P, Varano B, Gauzzi MC, Sato A, et al. (2000) Dual role of the HIV-1 vpr protein in the modulation of the apoptotic response of T cells. J Immunol 165: 3293-3300.
    • (2000) J Immunol , vol.165 , pp. 3293-3300
    • Conti, L.1    Matarrese, P.2    Varano, B.3    Gauzzi, M.C.4    Sato, A.5
  • 72
    • 0037020155 scopus 로고    scopus 로고
    • HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells
    • Muthumani K, Hwang DS, Desai BM, Zhang D, Dayes N, et al. (2002) HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells. J Biol Chem 277: 37820-37831.
    • (2002) J Biol Chem , vol.277 , pp. 37820-37831
    • Muthumani, K.1    Hwang, D.S.2    Desai, B.M.3    Zhang, D.4    Dayes, N.5
  • 73
    • 70350291528 scopus 로고    scopus 로고
    • Virion-associated Vpr of human immunodeficiency virus type 1 triggers activation of apoptotic events and enhances fas-induced apoptosis in human T cells
    • Arokium H, Kamata M, Chen I, (2009) Virion-associated Vpr of human immunodeficiency virus type 1 triggers activation of apoptotic events and enhances fas-induced apoptosis in human T cells. J Virol 83: 11283-11297.
    • (2009) J Virol , vol.83 , pp. 11283-11297
    • Arokium, H.1    Kamata, M.2    Chen, I.3
  • 74
    • 0037063171 scopus 로고    scopus 로고
    • Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines
    • Muthumani K, Zhang D, Hwang DS, Kudchodkar S, Dayes NS, et al. (2002) Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines. Oncogene 21: 4613-4625.
    • (2002) Oncogene , vol.21 , pp. 4613-4625
    • Muthumani, K.1    Zhang, D.2    Hwang, D.S.3    Kudchodkar, S.4    Dayes, N.S.5
  • 75
    • 0035910754 scopus 로고    scopus 로고
    • Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2
    • Jacotot E, Ferri KF, El Hamel C, Brenner C, Druillennec S, et al. (2001) Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2. J Exp Med 193: 509-519.
    • (2001) J Exp Med , vol.193 , pp. 509-519
    • Jacotot, E.1    Ferri, K.F.2    El Hamel, C.3    Brenner, C.4    Druillennec, S.5
  • 76
    • 77951878359 scopus 로고    scopus 로고
    • HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells
    • Snyder A, Alsauskas ZC, Leventhal JS, Rosenstiel PE, Gong P, et al. (2010) HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells. AIDS 24: 1107-1119.
    • (2010) AIDS , vol.24 , pp. 1107-1119
    • Snyder, A.1    Alsauskas, Z.C.2    Leventhal, J.S.3    Rosenstiel, P.E.4    Gong, P.5
  • 77
    • 0003146527 scopus 로고    scopus 로고
    • A C-terminal domain of HIV-1 accessory protein Vpr is involved in penetration, mitochondrial dysfunction and apoptosis of human CD4+ lymphocytes
    • Arunagiri C, Macreadie I, Hewish D, Azad A, (1997) A C-terminal domain of HIV-1 accessory protein Vpr is involved in penetration, mitochondrial dysfunction and apoptosis of human CD4+ lymphocytes. Apoptosis 2: 69-76.
    • (1997) Apoptosis , vol.2 , pp. 69-76
    • Arunagiri, C.1    Macreadie, I.2    Hewish, D.3    Azad, A.4
  • 78
    • 69449108433 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Vpr: functions and molecular interactions
    • Romani B, Engelbrecht S, (2009) Human immunodeficiency virus type 1 Vpr: functions and molecular interactions. J Gen Virol 90: 1795-1805.
    • (2009) J Gen Virol , vol.90 , pp. 1795-1805
    • Romani, B.1    Engelbrecht, S.2
  • 79
    • 73149083473 scopus 로고    scopus 로고
    • Functions of Tat: the versatile protein of human immunodeficiency virus type 1
    • Romani B, Engelbrecht S, Glashoff RH, (2010) Functions of Tat: the versatile protein of human immunodeficiency virus type 1. J Gen Virol 91: 1-12.
    • (2010) J Gen Virol , vol.91 , pp. 1-12
    • Romani, B.1    Engelbrecht, S.2    Glashoff, R.H.3
  • 80
    • 34247628002 scopus 로고    scopus 로고
    • Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency
    • Sanchez M, Galy B, Muckenthaler MU, Hentze MW, (2007) Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat Struct Mol Biol 14: 420-426.
    • (2007) Nat Struct Mol Biol , vol.14 , pp. 420-426
    • Sanchez, M.1    Galy, B.2    Muckenthaler, M.U.3    Hentze, M.W.4
  • 81
    • 34248648767 scopus 로고    scopus 로고
    • Coordinating responses to iron and oxygen stress with DNA and mRNA promoters: the ferritin story
    • Theil EC, (2007) Coordinating responses to iron and oxygen stress with DNA and mRNA promoters: the ferritin story. Biometals 20: 513-521.
    • (2007) Biometals , vol.20 , pp. 513-521
    • Theil, E.C.1
  • 82
    • 84873629755 scopus 로고    scopus 로고
    • Tools to study distinct metal pools in biology
    • New EJ, (2013) Tools to study distinct metal pools in biology. Dalton Trans 42: 3210-3219.
    • (2013) Dalton Trans , vol.42 , pp. 3210-3219
    • New, E.J.1
  • 83
    • 0024553322 scopus 로고
    • Studies of variations of subcutaneously infused desferrioxamine and iron movements in thalassaemia children
    • Llados i Vallory EA, Girot R, Lenoir G, Payet M, Houze P, et al. (1989) Studies of variations of subcutaneously infused desferrioxamine and iron movements in thalassaemia children. Eur J Pediatr 148: 503-506.
    • (1989) Eur J Pediatr , vol.148 , pp. 503-506
    • Llados i Vallory, E.A.1    Girot, R.2    Lenoir, G.3    Payet, M.4    Houze, P.5
  • 84
    • 33750001927 scopus 로고    scopus 로고
    • Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences
    • Glickstein H, El RB, Link G, Breuer W, Konijn AM, et al. (2006) Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences. Blood 108: 3195-3203.
    • (2006) Blood , vol.108 , pp. 3195-3203
    • Glickstein, H.1    El, R.B.2    Link, G.3    Breuer, W.4    Konijn, A.M.5
  • 85
    • 27644539382 scopus 로고    scopus 로고
    • Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells
    • Glickstein H, El RB, Shvartsman M, Cabantchik ZI, (2005) Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells. Blood 106: 3242-3250.
    • (2005) Blood , vol.106 , pp. 3242-3250
    • Glickstein, H.1    El, R.B.2    Shvartsman, M.3    Cabantchik, Z.I.4
  • 86
    • 67049097553 scopus 로고    scopus 로고
    • Monitoring intracellular labile iron pools: A novel fluorescent iron(III) sensor as a potential non-invasive diagnosis tool
    • Fakih S, Podinovskaia M, Kong X, Schaible UE, Collins HL, et al. (2009) Monitoring intracellular labile iron pools: A novel fluorescent iron(III) sensor as a potential non-invasive diagnosis tool. J Pharm Sci 98: 2212-2226.
    • (2009) J Pharm Sci , vol.98 , pp. 2212-2226
    • Fakih, S.1    Podinovskaia, M.2    Kong, X.3    Schaible, U.E.4    Collins, H.L.5
  • 87
    • 0025938625 scopus 로고
    • Lack of effect of desferrioxamine on in-vitro HIV-1 replication
    • Lazdins JK, Alteri E, Klimkait T, Woods-Cook K, Walker MR, et al. (1991) Lack of effect of desferrioxamine on in-vitro HIV-1 replication. Lancet 338: 1341-1342.
    • (1991) Lancet , vol.338 , pp. 1341-1342
    • Lazdins, J.K.1    Alteri, E.2    Klimkait, T.3    Woods-Cook, K.4    Walker, M.R.5
  • 89
    • 0018647339 scopus 로고
    • The effect of desferrioxamine on fibroblasts and collagen formation in cell cultures
    • Hunt J, Richards RJ, Harwood R, Jacobs A, (1979) The effect of desferrioxamine on fibroblasts and collagen formation in cell cultures. Br J Haematol 41: 69-76.
    • (1979) Br J Haematol , vol.41 , pp. 69-76
    • Hunt, J.1    Richards, R.J.2    Harwood, R.3    Jacobs, A.4
  • 90
    • 0027136260 scopus 로고
    • Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction
    • Wang GL, Semenza GL, (1993) Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood 82: 3610-3615.
    • (1993) Blood , vol.82 , pp. 3610-3615
    • Wang, G.L.1    Semenza, G.L.2
  • 91
    • 0027410369 scopus 로고
    • High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR
    • Piatak M Jr, Saag MS, Yang LC, Clark SJ, Kappes JC, et al. (1993) High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 259: 1749-1754.
    • (1993) Science , vol.259 , pp. 1749-1754
    • Piatak Jr., M.1    Saag, M.S.2    Yang, L.C.3    Clark, S.J.4    Kappes, J.C.5
  • 92
    • 77949565615 scopus 로고    scopus 로고
    • Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression
    • Roberts L, Passmore JA, Williamson C, Little F, Bebell LM, et al. (2010) Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression. AIDS 24: 819-831.
    • (2010) AIDS , vol.24 , pp. 819-831
    • Roberts, L.1    Passmore, J.A.2    Williamson, C.3    Little, F.4    Bebell, L.M.5
  • 93
    • 33748757742 scopus 로고    scopus 로고
    • Elevations in IL-10, TNF-alpha, and IFN-gamma from the earliest point of HIV Type 1 infection
    • Norris PJ, Pappalardo BL, Custer B, Spotts G, Hecht FM, et al. (2006) Elevations in IL-10, TNF-alpha, and IFN-gamma from the earliest point of HIV Type 1 infection. AIDS Res Hum Retroviruses 22: 757-762.
    • (2006) AIDS Res Hum Retroviruses , vol.22 , pp. 757-762
    • Norris, P.J.1    Pappalardo, B.L.2    Custer, B.3    Spotts, G.4    Hecht, F.M.5
  • 94
    • 0030755645 scopus 로고    scopus 로고
    • Low production of interferon gamma is related to disease progression in HIV infection: evidence from a cohort of 347 HIV-infected individuals
    • Ullum H, Cozzi Lepri A, Bendtzen K, Victor J, Gotzsche PC, et al. (1997) Low production of interferon gamma is related to disease progression in HIV infection: evidence from a cohort of 347 HIV-infected individuals. AIDS Res Hum Retroviruses 13: 1039-1046.
    • (1997) AIDS Res Hum Retroviruses , vol.13 , pp. 1039-1046
    • Ullum, H.1    Cozzi Lepri, A.2    Bendtzen, K.3    Victor, J.4    Gotzsche, P.C.5
  • 95
    • 33644833163 scopus 로고    scopus 로고
    • IL-2 and IL-10 serum levels in HIV-1-infected patients with or without active antiretroviral therapy
    • Orsilles MA, Pieri E, Cooke P, Caula C, (2006) IL-2 and IL-10 serum levels in HIV-1-infected patients with or without active antiretroviral therapy. APMIS 114: 55-60.
    • (2006) APMIS , vol.114 , pp. 55-60
    • Orsilles, M.A.1    Pieri, E.2    Cooke, P.3    Caula, C.4
  • 96
    • 0032955893 scopus 로고    scopus 로고
    • IL-10 in HIV infection: increasing serum IL-10 levels with disease progression-down-regulatory effect of potent anti-retroviral therapy
    • Stylianou E, Aukrust P, Kvale D, Muller F, Froland SS, (1999) IL-10 in HIV infection: increasing serum IL-10 levels with disease progression-down-regulatory effect of potent anti-retroviral therapy. Clin Exp Immunol 116: 115-120.
    • (1999) Clin Exp Immunol , vol.116 , pp. 115-120
    • Stylianou, E.1    Aukrust, P.2    Kvale, D.3    Muller, F.4    Froland, S.S.5
  • 98
    • 0034329421 scopus 로고    scopus 로고
    • Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis
    • Halicka HD, Bedner E, Darzynkiewicz Z, (2000) Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis. Exp Cell Res 260: 248-256.
    • (2000) Exp Cell Res , vol.260 , pp. 248-256
    • Halicka, H.D.1    Bedner, E.2    Darzynkiewicz, Z.3
  • 99
    • 0034926031 scopus 로고    scopus 로고
    • Extracellular tyrosinase mRNA within apoptotic bodies is protected from degradation in human serum
    • Hasselmann DO, Rappl G, Tilgen W, Reinhold U, (2001) Extracellular tyrosinase mRNA within apoptotic bodies is protected from degradation in human serum. Clin Chem 47: 1488-1489.
    • (2001) Clin Chem , vol.47 , pp. 1488-1489
    • Hasselmann, D.O.1    Rappl, G.2    Tilgen, W.3    Reinhold, U.4
  • 100
    • 0023489903 scopus 로고
    • Resumption of virus production after human immunodeficiency virus infection of T lymphocytes in the presence of azidothymidine
    • Smith MS, Brian EL, Pagano JS, (1987) Resumption of virus production after human immunodeficiency virus infection of T lymphocytes in the presence of azidothymidine. J Virol 61: 3769-3773.
    • (1987) J Virol , vol.61 , pp. 3769-3773
    • Smith, M.S.1    Brian, E.L.2    Pagano, J.S.3
  • 102
    • 0029044698 scopus 로고
    • Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates
    • Mellors JW, Bazmi HZ, Schinazi RF, Roy BM, Hsiou Y, et al. (1995) Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates. Antimicrob Agents Chemother 39: 1087-1092.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 1087-1092
    • Mellors, J.W.1    Bazmi, H.Z.2    Schinazi, R.F.3    Roy, B.M.4    Hsiou, Y.5
  • 103
    • 0032501984 scopus 로고    scopus 로고
    • Lamivudine resistance of HIV type 1 does not delay development of resistance to nonnucleoside HIV type 1-specific reverse transcriptase inhibitors as compared with wild-type HIV type 1
    • Jonckheere H, Witvrouw M, De Clercq E, Anne J, (1998) Lamivudine resistance of HIV type 1 does not delay development of resistance to nonnucleoside HIV type 1-specific reverse transcriptase inhibitors as compared with wild-type HIV type 1. AIDS Res Hum Retroviruses 14: 249-253.
    • (1998) AIDS Res Hum Retroviruses , vol.14 , pp. 249-253
    • Jonckheere, H.1    Witvrouw, M.2    De Clercq, E.3    Anne, J.4
  • 104
    • 0029079399 scopus 로고
    • Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives)
    • Balzarini J, Perez-Perez MJ, Velazquez S, San-Felix A, Camarasa MJ, et al. (1995) Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives). Proc Natl Acad Sci U S A 92: 5470-5474.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5470-5474
    • Balzarini, J.1    Perez-Perez, M.J.2    Velazquez, S.3    San-Felix, A.4    Camarasa, M.J.5
  • 105
    • 0029944278 scopus 로고    scopus 로고
    • Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1 infected cells
    • Okamoto M, Makino M, Yamada K, Nakade K, Yuasa S, et al. (1996) Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1 infected cells. Antiviral Res 31: 69-77.
    • (1996) Antiviral Res , vol.31 , pp. 69-77
    • Okamoto, M.1    Makino, M.2    Yamada, K.3    Nakade, K.4    Yuasa, S.5
  • 106
    • 0027478561 scopus 로고
    • Use of evolutionary limitations of HIV-1 multidrug resistance to optimize therapy
    • Chow YK, Hirsch MS, Merrill DP, Bechtel LJ, Eron JJ, et al. (1993) Use of evolutionary limitations of HIV-1 multidrug resistance to optimize therapy. Nature 361: 650-654.
    • (1993) Nature , vol.361 , pp. 650-654
    • Chow, Y.K.1    Hirsch, M.S.2    Merrill, D.P.3    Bechtel, L.J.4    Eron, J.J.5
  • 107
    • 0035695372 scopus 로고    scopus 로고
    • Rapid alternation of drug therapy is highly efficient in suppressing the emergence of mutant drug-resistant HIV strains in cell culture
    • Balzarini J, De Clercq E, (2001) Rapid alternation of drug therapy is highly efficient in suppressing the emergence of mutant drug-resistant HIV strains in cell culture. AIDS Res Hum Retroviruses 17: 1625-1634.
    • (2001) AIDS Res Hum Retroviruses , vol.17 , pp. 1625-1634
    • Balzarini, J.1    De Clercq, E.2
  • 108
    • 66349096006 scopus 로고    scopus 로고
    • Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture
    • Paintsil E, Grill SP, Dutschman GE, Cheng YC, (2009) Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture. AIDS Res Ther 6: 5.
    • (2009) AIDS Res Ther , vol.6 , pp. 5
    • Paintsil, E.1    Grill, S.P.2    Dutschman, G.E.3    Cheng, Y.C.4
  • 110
    • 0022640412 scopus 로고
    • Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex
    • Yarchoan R, Klecker RW, Weinhold KJ, Markham PD, Lyerly HK, et al. (1986) Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex. Lancet 327: 575-580.
    • (1986) Lancet , vol.327 , pp. 575-580
    • Yarchoan, R.1    Klecker, R.W.2    Weinhold, K.J.3    Markham, P.D.4    Lyerly, H.K.5
  • 111
    • 33746646763 scopus 로고    scopus 로고
    • Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission
    • Cone RA, Hoen T, Wong X, Abusuwwa R, Anderson DJ, et al. (2006) Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission. BMC Infect Dis 6: 90.
    • (2006) BMC Infect Dis , vol.6 , pp. 90
    • Cone, R.A.1    Hoen, T.2    Wong, X.3    Abusuwwa, R.4    Anderson, D.J.5
  • 112
    • 34247534517 scopus 로고    scopus 로고
    • A comprehensive murine model to evaluate topical vaginal microbicides: mucosal inflammation and susceptibility to genital herpes as surrogate markers of safety
    • Galen BT, Martin AP, Hazrati E, Garin A, Guzman E, et al. (2007) A comprehensive murine model to evaluate topical vaginal microbicides: mucosal inflammation and susceptibility to genital herpes as surrogate markers of safety. J Infect Dis 195: 1332-1339.
    • (2007) J Infect Dis , vol.195 , pp. 1332-1339
    • Galen, B.T.1    Martin, A.P.2    Hazrati, E.3    Garin, A.4    Guzman, E.5
  • 113
    • 73449131509 scopus 로고    scopus 로고
    • Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety
    • Wilson SS, Cheshenko N, Fakioglu E, Mesquita PM, Keller MJ, et al. (2009) Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety. Antivir Ther 14: 1113-1124.
    • (2009) Antivir Ther , vol.14 , pp. 1113-1124
    • Wilson, S.S.1    Cheshenko, N.2    Fakioglu, E.3    Mesquita, P.M.4    Keller, M.J.5
  • 114
    • 0034855798 scopus 로고    scopus 로고
    • Ciclopirox: an overview
    • Gupta AK, (2001) Ciclopirox: an overview. Int J Dermatol 40: 305-310.
    • (2001) Int J Dermatol , vol.40 , pp. 305-310
    • Gupta, A.K.1
  • 115
    • 12544256390 scopus 로고    scopus 로고
    • Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s)
    • Kamada S, Kikkawa U, Tsujimoto Y, Hunter T, (2005) Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s). J Biol Chem 280: 857-860.
    • (2005) J Biol Chem , vol.280 , pp. 857-860
    • Kamada, S.1    Kikkawa, U.2    Tsujimoto, Y.3    Hunter, T.4
  • 116
    • 69149100237 scopus 로고    scopus 로고
    • Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety
    • Mesquita PM, Cheshenko N, Wilson SS, Mhatre M, Guzman E, et al. (2009) Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety. J Infect Dis 200: 599-608.
    • (2009) J Infect Dis , vol.200 , pp. 599-608
    • Mesquita, P.M.1    Cheshenko, N.2    Wilson, S.S.3    Mhatre, M.4    Guzman, E.5
  • 117
    • 0025007785 scopus 로고
    • Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one
    • Kontoghiorghes GJ, Goddard JG, Bartlett AN, Sheppard L, (1990) Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one. Clin Pharmacol Ther 48: 255-261.
    • (1990) Clin Pharmacol Ther , vol.48 , pp. 255-261
    • Kontoghiorghes, G.J.1    Goddard, J.G.2    Bartlett, A.N.3    Sheppard, L.4
  • 119
    • 0033013888 scopus 로고    scopus 로고
    • Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein
    • Vocero-Akbani AM, Heyden NV, Lissy NA, Ratner L, Dowdy SF, (1999) Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein. Nat Med 5: 29-33.
    • (1999) Nat Med , vol.5 , pp. 29-33
    • Vocero-Akbani, A.M.1    Heyden, N.V.2    Lissy, N.A.3    Ratner, L.4    Dowdy, S.F.5
  • 120
    • 0036289047 scopus 로고    scopus 로고
    • A time to kill: viral manipulation of the cell death program
    • Hay S, Kannourakis G, (2002) A time to kill: viral manipulation of the cell death program. J Gen Virol 83: 1547-1564.
    • (2002) J Gen Virol , vol.83 , pp. 1547-1564
    • Hay, S.1    Kannourakis, G.2
  • 121
    • 44649139364 scopus 로고    scopus 로고
    • HIV-1 accessory proteins-ensuring viral survival in a hostile environment
    • Malim MH, Emerman M, (2008) HIV-1 accessory proteins-ensuring viral survival in a hostile environment. Cell Host Microbe 3: 388-398.
    • (2008) Cell Host Microbe , vol.3 , pp. 388-398
    • Malim, M.H.1    Emerman, M.2
  • 122
    • 34648833271 scopus 로고    scopus 로고
    • Vpr is required for efficient Nef expression from unintegrated human immunodeficiency virus type 1 DNA
    • Poon B, Chang MA, Chen IS, (2007) Vpr is required for efficient Nef expression from unintegrated human immunodeficiency virus type 1 DNA. J Virol 81: 10515-10523.
    • (2007) J Virol , vol.81 , pp. 10515-10523
    • Poon, B.1    Chang, M.A.2    Chen, I.S.3
  • 123
    • 0035173735 scopus 로고    scopus 로고
    • HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals
    • Wolf D, Witte V, Laffert B, Blume K, Stromer E, et al. (2001) HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals. Nat Med 7: 1217-1224.
    • (2001) Nat Med , vol.7 , pp. 1217-1224
    • Wolf, D.1    Witte, V.2    Laffert, B.3    Blume, K.4    Stromer, E.5
  • 124
    • 0037377709 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA
    • Poon B, Chen IS, (2003) Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA. J Virol 77: 3962-3972.
    • (2003) J Virol , vol.77 , pp. 3962-3972
    • Poon, B.1    Chen, I.S.2
  • 125
    • 77953356718 scopus 로고    scopus 로고
    • The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase
    • Casey L, Wen X, de Noronha CM, (2010) The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase. Cytokine 51: 1-9.
    • (2010) Cytokine , vol.51 , pp. 1-9
    • Casey, L.1    Wen, X.2    de Noronha, C.M.3
  • 126
    • 0036205491 scopus 로고    scopus 로고
    • HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta
    • Bennasser Y, Bahraoui E, (2002) HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and-delta. FASEB J 16: 546-554.
    • (2002) FASEB J , vol.16 , pp. 546-554
    • Bennasser, Y.1    Bahraoui, E.2
  • 127
    • 0029986177 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production
    • Schols D, De Clercq E, (1996) Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production. J Virol 70: 4953-4960.
    • (1996) J Virol , vol.70 , pp. 4953-4960
    • Schols, D.1    De Clercq, E.2
  • 129
    • 0032566649 scopus 로고    scopus 로고
    • Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
    • Marzo I, Brenner C, Zamzami N, Jurgensmeier JM, Susin SA, et al. (1998) Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 281: 2027-2031.
    • (1998) Science , vol.281 , pp. 2027-2031
    • Marzo, I.1    Brenner, C.2    Zamzami, N.3    Jurgensmeier, J.M.4    Susin, S.A.5
  • 130
    • 0037133332 scopus 로고    scopus 로고
    • Motexafin gadolinium (Gd-Tex) selectively induces apoptosis in HIV-1 infected CD4+ T helper cells
    • Perez OD, Nolan GP, Magda D, Miller RA, Herzenberg LA, (2002) Motexafin gadolinium (Gd-Tex) selectively induces apoptosis in HIV-1 infected CD4+ T helper cells. Proc Natl Acad Sci U S A 99: 2270-2274.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 2270-2274
    • Perez, O.D.1    Nolan, G.P.2    Magda, D.3    Miller, R.A.4    Herzenberg, L.A.5
  • 131
    • 24644441687 scopus 로고    scopus 로고
    • Motexafin gadolinium induces mitochondrially-mediated caspase-dependent apoptosis
    • Chen J, Ramos J, Sirisawad M, Miller R, Naumovski L, (2005) Motexafin gadolinium induces mitochondrially-mediated caspase-dependent apoptosis. Apoptosis 10: 1131-1142.
    • (2005) Apoptosis , vol.10 , pp. 1131-1142
    • Chen, J.1    Ramos, J.2    Sirisawad, M.3    Miller, R.4    Naumovski, L.5
  • 132
    • 33744956073 scopus 로고    scopus 로고
    • Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase
    • Hashemy SI, Ungerstedt JS, Zahedi Avval F, Holmgren A, (2006) Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase. J Biol Chem 281: 10691-10697.
    • (2006) J Biol Chem , vol.281 , pp. 10691-10697
    • Hashemy, S.I.1    Ungerstedt, J.S.2    Zahedi Avval, F.3    Holmgren, A.4
  • 133
    • 22744443858 scopus 로고    scopus 로고
    • The thioredoxin system in retroviral infection and apoptosis
    • Masutani H, Ueda S, Yodoi J, (2005) The thioredoxin system in retroviral infection and apoptosis. Cell Death Differ 12Suppl 1: 991-998.
    • (2005) Cell Death Differ , vol.12 , pp. 991-998
    • Masutani, H.1    Ueda, S.2    Yodoi, J.3
  • 134
    • 0642303647 scopus 로고    scopus 로고
    • Imatinib induces mitochondria-dependent apoptosis of the Bcr-Abl-positive K562 cell line and its differentiation toward the erythroid lineage
    • Jacquel A, Herrant M, Legros L, Belhacene N, Luciano F, et al. (2003) Imatinib induces mitochondria-dependent apoptosis of the Bcr-Abl-positive K562 cell line and its differentiation toward the erythroid lineage. FASEB J 17: 2160-2162.
    • (2003) FASEB J , vol.17 , pp. 2160-2162
    • Jacquel, A.1    Herrant, M.2    Legros, L.3    Belhacene, N.4    Luciano, F.5
  • 135
    • 0034917456 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway
    • Decker RH, Dai Y, Grant S, (2001) The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway. Cell Death Differ 8: 715-724.
    • (2001) Cell Death Differ , vol.8 , pp. 715-724
    • Decker, R.H.1    Dai, Y.2    Grant, S.3
  • 136
    • 42449097201 scopus 로고    scopus 로고
    • Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium
    • Hussain SR, Lucas DM, Johnson AJ, Lin TS, Bakaletz AP, et al. (2008) Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium. Blood 111: 3190-3199.
    • (2008) Blood , vol.111 , pp. 3190-3199
    • Hussain, S.R.1    Lucas, D.M.2    Johnson, A.J.3    Lin, T.S.4    Bakaletz, A.P.5
  • 137
    • 34247255381 scopus 로고    scopus 로고
    • Identifying the membrane proteome of HIV-1 latently infected cells
    • Berro R, de la Fuente C, Klase Z, Kehn K, Parvin L, et al. (2007) Identifying the membrane proteome of HIV-1 latently infected cells. J Biol Chem 282: 8207-8218.
    • (2007) J Biol Chem , vol.282 , pp. 8207-8218
    • Berro, R.1    de la Fuente, C.2    Klase, Z.3    Kehn, K.4    Parvin, L.5
  • 138
    • 34548016988 scopus 로고    scopus 로고
    • Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex
    • Biglione S, Byers SA, Price JP, Nguyen VT, Bensaude O, et al. (2007) Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex. Retrovirology 4: 47.
    • (2007) Retrovirology , vol.4 , pp. 47
    • Biglione, S.1    Byers, S.A.2    Price, J.P.3    Nguyen, V.T.4    Bensaude, O.5
  • 140
    • 0030956308 scopus 로고    scopus 로고
    • Hydroxyurea for treatment of unresectable and recurrent meningiomas. I. Inhibition of primary human meningioma cells in culture and in meningioma transplants by induction of the apoptotic pathway
    • Schrell UM, Rittig MG, Anders M, Kiesewetter F, Marschalek R, et al. (1997) Hydroxyurea for treatment of unresectable and recurrent meningiomas. I. Inhibition of primary human meningioma cells in culture and in meningioma transplants by induction of the apoptotic pathway. J Neurosurg 86: 845-852.
    • (1997) J Neurosurg , vol.86 , pp. 845-852
    • Schrell, U.M.1    Rittig, M.G.2    Anders, M.3    Kiesewetter, F.4    Marschalek, R.5
  • 141
    • 0031002235 scopus 로고    scopus 로고
    • Hydroxyurea for treatment of unresectable and recurrent meningiomas. II. Decrease in the size of meningiomas in patients treated with hydroxyurea
    • Schrell UM, Rittig MG, Anders M, Koch UH, Marschalek R, et al. (1997) Hydroxyurea for treatment of unresectable and recurrent meningiomas. II. Decrease in the size of meningiomas in patients treated with hydroxyurea. J Neurosurg 86: 840-844.
    • (1997) J Neurosurg , vol.86 , pp. 840-844
    • Schrell, U.M.1    Rittig, M.G.2    Anders, M.3    Koch, U.H.4    Marschalek, R.5
  • 142
    • 1442354057 scopus 로고    scopus 로고
    • Hydroxyurea-induced apoptosis in an EBV-immortalized lymphoblastoid cell line
    • Huyghe P, Dassonneville L, Fenaux P, Bailly C, (2004) Hydroxyurea-induced apoptosis in an EBV-immortalized lymphoblastoid cell line. Oncol Res 14: 235-245.
    • (2004) Oncol Res , vol.14 , pp. 235-245
    • Huyghe, P.1    Dassonneville, L.2    Fenaux, P.3    Bailly, C.4
  • 143
    • 84874959699 scopus 로고    scopus 로고
    • Givinostat and hydroxyurea synergize in vitro to induce apoptosis of cells from JAK2(V617F) myeloproliferative neoplasm patients
    • e252
    • Amaru Calzada A, Pedrini O, Finazzi G, Leoni F, Mascagni P, et al. (2013) Givinostat and hydroxyurea synergize in vitro to induce apoptosis of cells from JAK2(V617F) myeloproliferative neoplasm patients. Exp Hematol 41: 253-260 e252.
    • (2013) Exp Hematol , vol.41 , pp. 253-260
    • Amaru Calzada, A.1    Pedrini, O.2    Finazzi, G.3    Leoni, F.4    Mascagni, P.5
  • 144
    • 0034125405 scopus 로고    scopus 로고
    • Hydroxyurea inhibits the transactivation of the HIV-long-terminal repeat (LTR) promoter
    • Calzado MA, MacHo A, Lucena C, Munoz E, (2000) Hydroxyurea inhibits the transactivation of the HIV-long-terminal repeat (LTR) promoter. Clin Exp Immunol 120: 317-323.
    • (2000) Clin Exp Immunol , vol.120 , pp. 317-323
    • Calzado, M.A.1    MacHo, A.2    Lucena, C.3    Munoz, E.4
  • 145
    • 0027948936 scopus 로고
    • Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication
    • Lori F, Malykh A, Cara A, Sun D, Weinstein JN, et al. (1994) Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication. Science 266: 801-805.
    • (1994) Science , vol.266 , pp. 801-805
    • Lori, F.1    Malykh, A.2    Cara, A.3    Sun, D.4    Weinstein, J.N.5
  • 146
    • 0037414987 scopus 로고    scopus 로고
    • A cytostatic drug improves control of HIV-1 replication during structured treatment interruptions: a randomized study
    • Garcia F, Plana M, Arnedo M, Ortiz GM, Miro JM, et al. (2003) A cytostatic drug improves control of HIV-1 replication during structured treatment interruptions: a randomized study. AIDS 17: 43-51.
    • (2003) AIDS , vol.17 , pp. 43-51
    • Garcia, F.1    Plana, M.2    Arnedo, M.3    Ortiz, G.M.4    Miro, J.M.5
  • 147
    • 0035986051 scopus 로고    scopus 로고
    • The HYDILE trial: efficacy and tolerance of a quadruple combination of reverse transcriptase inhibitors versus the same regimen plus hydroxyurea or hydroxyurea and interleukin-2 in HIV-infected patients failing protease inhibitor-based combinations
    • Lafeuillade A, Hittinger G, Chadapaud S, Maillefet S, Rieu A, et al. (2002) The HYDILE trial: efficacy and tolerance of a quadruple combination of reverse transcriptase inhibitors versus the same regimen plus hydroxyurea or hydroxyurea and interleukin-2 in HIV-infected patients failing protease inhibitor-based combinations. HIV Clin Trials 3: 263-271.
    • (2002) HIV Clin Trials , vol.3 , pp. 263-271
    • Lafeuillade, A.1    Hittinger, G.2    Chadapaud, S.3    Maillefet, S.4    Rieu, A.5
  • 148
    • 0030771289 scopus 로고    scopus 로고
    • Absence of viral rebound after treatment of HIV-infected patients with didanosine and hydroxycarbamide
    • Vila J, Nugier F, Bargues G, Vallet T, Peyramond D, et al. (1997) Absence of viral rebound after treatment of HIV-infected patients with didanosine and hydroxycarbamide. Lancet 350: 635-636.
    • (1997) Lancet , vol.350 , pp. 635-636
    • Vila, J.1    Nugier, F.2    Bargues, G.3    Vallet, T.4    Peyramond, D.5
  • 149
    • 0028116945 scopus 로고
    • Synergistic anti-human immunodeficiency virus type 1 effect of hydroxamate compounds with 2',3'-dideoxyinosine in infected resting human lymphocytes
    • Malley SD, Grange JM, Hamedi-Sangsari F, Vila JR, (1994) Synergistic anti-human immunodeficiency virus type 1 effect of hydroxamate compounds with 2',3'-dideoxyinosine in infected resting human lymphocytes. Proc Natl Acad Sci U S A 91: 11017-11021.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 11017-11021
    • Malley, S.D.1    Grange, J.M.2    Hamedi-Sangsari, F.3    Vila, J.R.4
  • 150
    • 0020490856 scopus 로고
    • The biosynthesis of protein-bound hypusine (N epsilon -(4-amino-2-hydroxybutyl)lysine). Lysine as the amino acid precursor and the intermediate role of deoxyhypusine (N epsilon -(4-aminobutyl)lysine)
    • Park MH, Cooper HL, Folk JE, (1982) The biosynthesis of protein-bound hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine). Lysine as the amino acid precursor and the intermediate role of deoxyhypusine (N epsilon-(4-aminobutyl)lysine). J Biol Chem 257: 7217-7222.
    • (1982) J Biol Chem , vol.257 , pp. 7217-7222
    • Park, M.H.1    Cooper, H.L.2    Folk, J.E.3
  • 151
    • 0027197906 scopus 로고
    • Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation
    • Park MH, Wolff EC, Folk JE, (1993) Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation. Biofactors 4: 95-104.
    • (1993) Biofactors , vol.4 , pp. 95-104
    • Park, M.H.1    Wolff, E.C.2    Folk, J.E.3
  • 152
    • 68149168652 scopus 로고    scopus 로고
    • Microarray Analysis of Lymphatic Tissue Reveals Stage-Specific, Gene Expression Signatures in HIV-1 Infection
    • Li Q, Smith AJ, Schacker TW, Carlis JV, Duan L, et al. (2009) Microarray Analysis of Lymphatic Tissue Reveals Stage-Specific, Gene Expression Signatures in HIV-1 Infection. J Immunol 183: 1975-1982.
    • (2009) J Immunol , vol.183 , pp. 1975-1982
    • Li, Q.1    Smith, A.J.2    Schacker, T.W.3    Carlis, J.V.4    Duan, L.5
  • 153
    • 0025852280 scopus 로고
    • Inhibition of prolyl hydroxylation and procollagen processing in chick-embryo calvaria by a derivative of pyridine-2,4-dicarboxylate. Characterization of the diethyl ester as a proinhibitor
    • Tschank G, Brocks DG, Engelbart K, Mohr J, Baader E, et al. (1991) Inhibition of prolyl hydroxylation and procollagen processing in chick-embryo calvaria by a derivative of pyridine-2,4-dicarboxylate. Characterization of the diethyl ester as a proinhibitor. Biochem J 275 (Pt 2): 469-476.
    • (1991) Biochem J , vol.275 , Issue.Pt 2 , pp. 469-476
    • Tschank, G.1    Brocks, D.G.2    Engelbart, K.3    Mohr, J.4    Baader, E.5
  • 154
    • 3242721547 scopus 로고    scopus 로고
    • Eukaryotic initiation factor 5A-1 (eIF5A-1) as a diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva
    • Cracchiolo BM, Heller DS, Clement PM, Wolff EC, Park MH, et al. (2004) Eukaryotic initiation factor 5A-1 (eIF5A-1) as a diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva. Gynecol Oncol 94: 217-222.
    • (2004) Gynecol Oncol , vol.94 , pp. 217-222
    • Cracchiolo, B.M.1    Heller, D.S.2    Clement, P.M.3    Wolff, E.C.4    Park, M.H.5
  • 155
    • 78049512724 scopus 로고    scopus 로고
    • The antitumor activity of the fungicide ciclopirox
    • Zhou H, Shen T, Luo Y, Liu L, Chen W, et al. (2010) The antitumor activity of the fungicide ciclopirox. Int J Cancer 127: 2467-2477.
    • (2010) Int J Cancer , vol.127 , pp. 2467-2477
    • Zhou, H.1    Shen, T.2    Luo, Y.3    Liu, L.4    Chen, W.5
  • 156
    • 84874698903 scopus 로고    scopus 로고
    • Role of cellular iron and oxygen in the regulation of HIV-1 infection
    • Nekhai S, Kumari N, Dhawan S, (2013) Role of cellular iron and oxygen in the regulation of HIV-1 infection. Future Virol 8: 301-311.
    • (2013) Future Virol , vol.8 , pp. 301-311
    • Nekhai, S.1    Kumari, N.2    Dhawan, S.3
  • 158
    • 84868544558 scopus 로고    scopus 로고
    • CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90
    • Breuer D, Kotelkin A, Ammosova T, Kumari N, Ivanov A, et al. (2012) CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90. Retrovirology 9: 94.
    • (2012) Retrovirology , vol.9 , pp. 94
    • Breuer, D.1    Kotelkin, A.2    Ammosova, T.3    Kumari, N.4    Ivanov, A.5
  • 159
    • 78651341949 scopus 로고    scopus 로고
    • Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9
    • Debebe Z, Ammosova T, Breuer D, Lovejoy DB, Kalinowski DS, et al. (2011) Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9. Mol Pharmacol 79: 185-196.
    • (2011) Mol Pharmacol , vol.79 , pp. 185-196
    • Debebe, Z.1    Ammosova, T.2    Breuer, D.3    Lovejoy, D.B.4    Kalinowski, D.S.5
  • 161
    • 0034006433 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 replication in human mononuclear blood cells by the iron chelators deferoxamine, deferiprone, and bleomycin
    • Georgiou NA, van der Bruggen T, Oudshoorn M, Nottet HS, Marx JJ, et al. (2000) Inhibition of human immunodeficiency virus type 1 replication in human mononuclear blood cells by the iron chelators deferoxamine, deferiprone, and bleomycin. J Infect Dis 181: 484-490.
    • (2000) J Infect Dis , vol.181 , pp. 484-490
    • Georgiou, N.A.1    van der Bruggen, T.2    Oudshoorn, M.3    Nottet, H.S.4    Marx, J.J.5
  • 162
    • 0345291720 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 replication inhibition by the bidentate iron chelators CP502 and CP511 is caused by proliferation inhibition and the onset of apoptosis
    • Georgiou NA, van der Bruggen T, Oudshoorn M, Hider RC, Marx JJ, et al. (2002) Human immunodeficiency virus type 1 replication inhibition by the bidentate iron chelators CP502 and CP511 is caused by proliferation inhibition and the onset of apoptosis. Eur J Clin Invest 32Suppl 1: 91-96.
    • (2002) Eur J Clin Invest , vol.32 , pp. 91-96
    • Georgiou, N.A.1    van der Bruggen, T.2    Oudshoorn, M.3    Hider, R.C.4    Marx, J.J.5
  • 163
    • 9644268962 scopus 로고    scopus 로고
    • The effect of iron overload on in vitro HIV-1 infection
    • Traore HN, Meyer D, (2004) The effect of iron overload on in vitro HIV-1 infection. J Clin Virol 31Suppl 1: S92-98.
    • (2004) J Clin Virol , vol.31
    • Traore, H.N.1    Meyer, D.2
  • 164
    • 27744528421 scopus 로고    scopus 로고
    • Molecular mechanisms of iron uptake by cells and the use of iron chelators for the treatment of cancer
    • Richardson DR, (2005) Molecular mechanisms of iron uptake by cells and the use of iron chelators for the treatment of cancer. Curr Med Chem 12: 2711-2729.
    • (2005) Curr Med Chem , vol.12 , pp. 2711-2729
    • Richardson, D.R.1
  • 165
    • 4243271145 scopus 로고
    • Catalytically active ferrous ions are not released from prolyl 4-hydroxylase under turnover conditions
    • Günzler V, Majamaa K, Hanauske-Abel HM, Kivirikko KI, (1986) Catalytically active ferrous ions are not released from prolyl 4-hydroxylase under turnover conditions. Biochim Biophys Acta 873: 36-44.
    • (1986) Biochim Biophys Acta , vol.873 , pp. 36-44
    • Günzler, V.1    Majamaa, K.2    Hanauske-Abel, H.M.3    Kivirikko, K.I.4
  • 166
    • 0037390915 scopus 로고    scopus 로고
    • The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis
    • Linden T, Katschinski DM, Eckhardt K, Scheid A, Pagel H, et al. (2003) The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis. FASEB J 17: 761-763.
    • (2003) FASEB J , vol.17 , pp. 761-763
    • Linden, T.1    Katschinski, D.M.2    Eckhardt, K.3    Scheid, A.4    Pagel, H.5
  • 167
    • 0002748539 scopus 로고    scopus 로고
    • Fibrosis: Representative molecular elements, a basic concept, and emerging targets for suppressive treatment
    • In: Zakim D, Boyer TD, editors, Philadelphia: W.B. Saunders
    • Hanauske-Abel HM (1996) Fibrosis: Representative molecular elements, a basic concept, and emerging targets for suppressive treatment. In: Zakim D, Boyer TD, editors. Hepatology A Textbook of Liver Disease. Philadelphia: W.B. Saunders. pp. 465-506.
    • (1996) Hepatology A Textbook of Liver Disease , pp. 465-506
    • Hanauske-Abel, H.M.1
  • 168
    • 84857479601 scopus 로고    scopus 로고
    • Lymphoid tissue damage in HIV-1 infection depletes naive T cells and limits T cell reconstitution after antiretroviral therapy
    • Zeng M, Southern PJ, Reilly CS, Beilman GJ, Chipman JG, et al. (2012) Lymphoid tissue damage in HIV-1 infection depletes naive T cells and limits T cell reconstitution after antiretroviral therapy. PLoS Pathog 8: e1002437.
    • (2012) PLoS Pathog , vol.8
    • Zeng, M.1    Southern, P.J.2    Reilly, C.S.3    Beilman, G.J.4    Chipman, J.G.5
  • 169
    • 27944487152 scopus 로고    scopus 로고
    • Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count
    • Schacker TW, Reilly C, Beilman GJ, Taylor J, Skarda D, et al. (2005) Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count. AIDS 19: 2169-2171.
    • (2005) AIDS , vol.19 , pp. 2169-2171
    • Schacker, T.W.1    Reilly, C.2    Beilman, G.J.3    Taylor, J.4    Skarda, D.5
  • 170
    • 77149125234 scopus 로고    scopus 로고
    • Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53
    • Saletta F, Suryo Rahmanto Y, Noulsri E, Richardson DR, (2010) Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53. Mol Pharmacol 77: 443-458.
    • (2010) Mol Pharmacol , vol.77 , pp. 443-458
    • Saletta, F.1    Suryo Rahmanto, Y.2    Noulsri, E.3    Richardson, D.R.4
  • 171
    • 66449137818 scopus 로고    scopus 로고
    • Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression
    • Deshmane SL, Mukerjee R, Fan S, Del Valle L, Michiels C, et al. (2009) Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression. J Biol Chem 284: 11364-11373.
    • (2009) J Biol Chem , vol.284 , pp. 11364-11373
    • Deshmane, S.L.1    Mukerjee, R.2    Fan, S.3    Del Valle, L.4    Michiels, C.5
  • 172
    • 0037631496 scopus 로고    scopus 로고
    • Iron chelators for the treatment of iron overload disease: relationship between structure, redox activity, and toxicity
    • Chaston TB, Richardson DR, (2003) Iron chelators for the treatment of iron overload disease: relationship between structure, redox activity, and toxicity. Am J Hematol 73: 200-210.
    • (2003) Am J Hematol , vol.73 , pp. 200-210
    • Chaston, T.B.1    Richardson, D.R.2
  • 173
    • 84875748108 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: novel structure-activity relationships underpinning their anti-proliferative and chelation efficacy
    • Lukmantara AY, Kalinowski DS, Kumar N, Richardson DR, (2013) Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: novel structure-activity relationships underpinning their anti-proliferative and chelation efficacy. Bioorg Med Chem Lett 23: 967-974.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 967-974
    • Lukmantara, A.Y.1    Kalinowski, D.S.2    Kumar, N.3    Richardson, D.R.4
  • 175
    • 0035437183 scopus 로고    scopus 로고
    • The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: The mechanisms involved in inhibiting cell-cycle progression
    • Gao J, Richardson DR, (2001) The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: The mechanisms involved in inhibiting cell-cycle progression. Blood 98: 842-850.
    • (2001) Blood , vol.98 , pp. 842-850
    • Gao, J.1    Richardson, D.R.2
  • 176
    • 77953060465 scopus 로고    scopus 로고
    • Evidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site
    • Cano VS, Medrano FJ, Park MH, Valentini SR, (2010) Evidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site. Amino Acids 38: 479-490.
    • (2010) Amino Acids , vol.38 , pp. 479-490
    • Cano, V.S.1    Medrano, F.J.2    Park, M.H.3    Valentini, S.R.4
  • 177
    • 1842737648 scopus 로고    scopus 로고
    • HIV-1 auxiliary regulatory protein Vpr promotes ubiquitination and turnover of Vpr mutants containing the L64P mutation
    • Zhao LJ, Jian H, Zhu H, (2004) HIV-1 auxiliary regulatory protein Vpr promotes ubiquitination and turnover of Vpr mutants containing the L64P mutation. FEBS Lett 563: 170-178.
    • (2004) FEBS Lett , vol.563 , pp. 170-178
    • Zhao, L.J.1    Jian, H.2    Zhu, H.3
  • 178
    • 79953848334 scopus 로고    scopus 로고
    • HIV-1 Accessory Protein Vpr: Relevance in the Pathogenesis of HIV and Potential for Therapeutic Intervention
    • Kogan M, Rappaport J, (2011) HIV-1 Accessory Protein Vpr: Relevance in the Pathogenesis of HIV and Potential for Therapeutic Intervention. Retrovirology 8: 25.
    • (2011) Retrovirology , vol.8 , pp. 25
    • Kogan, M.1    Rappaport, J.2
  • 179
    • 43249084803 scopus 로고    scopus 로고
    • The HIV-1 Vif protein mediates degradation of Vpr and reduces Vpr-induced cell cycle arrest
    • Wang J, Shackelford JM, Selliah N, Shivers DK, O'Neill E, et al. (2008) The HIV-1 Vif protein mediates degradation of Vpr and reduces Vpr-induced cell cycle arrest. DNA Cell Biol 27: 267-277.
    • (2008) DNA Cell Biol , vol.27 , pp. 267-277
    • Wang, J.1    Shackelford, J.M.2    Selliah, N.3    Shivers, D.K.4    O'Neill, E.5
  • 180
    • 69849099204 scopus 로고    scopus 로고
    • The human immunodeficiency virus type 1 Vpr protein and its carboxy-terminally truncated form induce apoptosis in tumor cells
    • Nonaka M, Hashimoto Y, Takeshima SN, Aida Y, (2009) The human immunodeficiency virus type 1 Vpr protein and its carboxy-terminally truncated form induce apoptosis in tumor cells. Cancer Cell Int 9: 20.
    • (2009) Cancer Cell Int , vol.9 , pp. 20
    • Nonaka, M.1    Hashimoto, Y.2    Takeshima, S.N.3    Aida, Y.4
  • 182
    • 67651087322 scopus 로고    scopus 로고
    • IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells
    • Brockman MA, Kwon DS, Tighe DP, Pavlik DF, Rosato PC, et al. (2009) IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood 114: 346-356.
    • (2009) Blood , vol.114 , pp. 346-356
    • Brockman, M.A.1    Kwon, D.S.2    Tighe, D.P.3    Pavlik, D.F.4    Rosato, P.C.5
  • 183
    • 64049116643 scopus 로고    scopus 로고
    • Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections
    • Stacey AR, Norris PJ, Qin L, Haygreen EA, Taylor E, et al. (2009) Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections. J Virol 83: 3719-3733.
    • (2009) J Virol , vol.83 , pp. 3719-3733
    • Stacey, A.R.1    Norris, P.J.2    Qin, L.3    Haygreen, E.A.4    Taylor, E.5
  • 184
    • 34047172640 scopus 로고    scopus 로고
    • IL-10, T cell exhaustion and viral persistence
    • Blackburn SD, Wherry EJ, (2007) IL-10, T cell exhaustion and viral persistence. Trends Microbiol 15: 143-146.
    • (2007) Trends Microbiol , vol.15 , pp. 143-146
    • Blackburn, S.D.1    Wherry, E.J.2
  • 185
    • 33845978054 scopus 로고    scopus 로고
    • Intracellular HIV-Tat expression induces IL-10 synthesis by the CREB-1 transcription factor through Ser133 phosphorylation and its regulation by the ERK1/2 MAPK in human monocytic cells
    • Gee K, Angel JB, Ma W, Mishra S, Gajanayaka N, et al. (2006) Intracellular HIV-Tat expression induces IL-10 synthesis by the CREB-1 transcription factor through Ser133 phosphorylation and its regulation by the ERK1/2 MAPK in human monocytic cells. J Biol Chem 281: 31647-31658.
    • (2006) J Biol Chem , vol.281 , pp. 31647-31658
    • Gee, K.1    Angel, J.B.2    Ma, W.3    Mishra, S.4    Gajanayaka, N.5
  • 186
    • 0030874781 scopus 로고    scopus 로고
    • Interleukin-10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl-2
    • Cohen SB, Crawley JB, Kahan MC, Feldmann M, Foxwell BM, (1997) Interleukin-10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl-2. Immunology 92: 1-5.
    • (1997) Immunology , vol.92 , pp. 1-5
    • Cohen, S.B.1    Crawley, J.B.2    Kahan, M.C.3    Feldmann, M.4    Foxwell, B.M.5
  • 187
    • 0032472865 scopus 로고    scopus 로고
    • Interleukin 10 increases CCR5 expression and HIV infection in human monocytes
    • Sozzani S, Ghezzi S, Iannolo G, Luini W, Borsatti A, et al. (1998) Interleukin 10 increases CCR5 expression and HIV infection in human monocytes. J Exp Med 187: 439-444.
    • (1998) J Exp Med , vol.187 , pp. 439-444
    • Sozzani, S.1    Ghezzi, S.2    Iannolo, G.3    Luini, W.4    Borsatti, A.5
  • 188
    • 0032991492 scopus 로고    scopus 로고
    • HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatment. Comet Study Group
    • Neumann AU, Tubiana R, Calvez V, Robert C, Li TS, et al. (1999) HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatment. Comet Study Group. AIDS 13: 677-683.
    • (1999) AIDS , vol.13 , pp. 677-683
    • Neumann, A.U.1    Tubiana, R.2    Calvez, V.3    Robert, C.4    Li, T.S.5
  • 189
    • 0033004630 scopus 로고    scopus 로고
    • Rate of HIV-1 RNA rebound upon stopping antiretroviral therapy
    • Harrigan PR, Whaley M, Montaner JS, (1999) Rate of HIV-1 RNA rebound upon stopping antiretroviral therapy. AIDS 13: F59-62.
    • (1999) AIDS , vol.13
    • Harrigan, P.R.1    Whaley, M.2    Montaner, J.S.3
  • 190
    • 78549235738 scopus 로고    scopus 로고
    • Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication
    • Chun TW, Justement JS, Murray D, Hallahan CW, Maenza J, et al. (2010) Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication. AIDS 24: 2803-2808.
    • (2010) AIDS , vol.24 , pp. 2803-2808
    • Chun, T.W.1    Justement, J.S.2    Murray, D.3    Hallahan, C.W.4    Maenza, J.5
  • 191
    • 0038579210 scopus 로고    scopus 로고
    • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    • Siliciano JD, Kajdas J, Finzi D, Quinn TC, Chadwick K, et al. (2003) Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med 9: 727-728.
    • (2003) Nat Med , vol.9 , pp. 727-728
    • Siliciano, J.D.1    Kajdas, J.2    Finzi, D.3    Quinn, T.C.4    Chadwick, K.5
  • 192
    • 67249121143 scopus 로고    scopus 로고
    • Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy
    • Dinoso JB, Kim SY, Wiegand AM, Palmer SE, Gange SJ, et al. (2009) Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc Natl Acad Sci U S A 106: 9403-9408.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9403-9408
    • Dinoso, J.B.1    Kim, S.Y.2    Wiegand, A.M.3    Palmer, S.E.4    Gange, S.J.5
  • 193
    • 0032953920 scopus 로고    scopus 로고
    • Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
    • Finzi D, Blankson J, Siliciano JD, Margolick JB, Chadwick K, et al. (1999) Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 5: 512-517.
    • (1999) Nat Med , vol.5 , pp. 512-517
    • Finzi, D.1    Blankson, J.2    Siliciano, J.D.3    Margolick, J.B.4    Chadwick, K.5
  • 194
    • 60549090253 scopus 로고    scopus 로고
    • Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation
    • Hutter G, Nowak D, Mossner M, Ganepola S, Mussig A, et al. (2009) Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med 360: 692-698.
    • (2009) N Engl J Med , vol.360 , pp. 692-698
    • Hutter, G.1    Nowak, D.2    Mossner, M.3    Ganepola, S.4    Mussig, A.5
  • 195
    • 79953117041 scopus 로고    scopus 로고
    • Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation
    • Allers K, Hutter G, Hofmann J, Loddenkemper C, Rieger K, et al. (2011) Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation. Blood 117: 2791-2799.
    • (2011) Blood , vol.117 , pp. 2791-2799
    • Allers, K.1    Hutter, G.2    Hofmann, J.3    Loddenkemper, C.4    Rieger, K.5
  • 196
    • 70350072669 scopus 로고    scopus 로고
    • Neutralizing activity and cellular immune responses induced in mice after immunization with apoptotic HIV-1/murine leukemia virus infected cells
    • Hinkula J, Walther-Jallow L, Lauren A, Makitalo B, Oberg M, et al. (2009) Neutralizing activity and cellular immune responses induced in mice after immunization with apoptotic HIV-1/murine leukemia virus infected cells. Vaccine 27: 6424-6431.
    • (2009) Vaccine , vol.27 , pp. 6424-6431
    • Hinkula, J.1    Walther-Jallow, L.2    Lauren, A.3    Makitalo, B.4    Oberg, M.5
  • 197
    • 0037111306 scopus 로고    scopus 로고
    • Induction of HIV-1-specific immunity after vaccination with apoptotic HIV-1/murine leukemia virus-infected cells
    • Spetz AL, Sorensen AS, Walther-Jallow L, Wahren B, Andersson J, et al. (2002) Induction of HIV-1-specific immunity after vaccination with apoptotic HIV-1/murine leukemia virus-infected cells. J Immunol 169: 5771-5779.
    • (2002) J Immunol , vol.169 , pp. 5771-5779
    • Spetz, A.L.1    Sorensen, A.S.2    Walther-Jallow, L.3    Wahren, B.4    Andersson, J.5
  • 198
    • 34548654130 scopus 로고    scopus 로고
    • Triggering of dendritic cell responses after exposure to activated, but not resting, apoptotic PBMCs
    • Johansson U, Walther-Jallow L, Smed-Sorensen A, Spetz AL, (2007) Triggering of dendritic cell responses after exposure to activated, but not resting, apoptotic PBMCs. J Immunol 179: 1711-1720.
    • (2007) J Immunol , vol.179 , pp. 1711-1720
    • Johansson, U.1    Walther-Jallow, L.2    Smed-Sorensen, A.3    Spetz, A.L.4
  • 199
    • 0034094839 scopus 로고    scopus 로고
    • Safety profile of the oral iron chelator deferiprone: a multicentre study
    • Cohen AR, Galanello R, Piga A, Dipalma A, Vullo C, et al. (2000) Safety profile of the oral iron chelator deferiprone: a multicentre study. Br J Haematol 108: 305-312.
    • (2000) Br J Haematol , vol.108 , pp. 305-312
    • Cohen, A.R.1    Galanello, R.2    Piga, A.3    Dipalma, A.4    Vullo, C.5
  • 200
    • 84884526662 scopus 로고    scopus 로고
    • Children with thalassemia at risk for HIV
    • Available at
    • Jones K (2011) Children with thalassemia at risk for HIV. Med India. Available at http://wwwmedindianet/news/Children-With-Thalassemia-at-Risk-for-HIV-79142-1htm.
    • (2011) Med India
    • Jones, K.1
  • 201
    • 84885943680 scopus 로고    scopus 로고
    • Prevalence of HIV, Hepatitis B and Hepatitis C infection in Thalassemia major patients in tertiary care hospital, Gujarat
    • Bhavsar H, Patel K, Vegad M, Madan M, Pandey A, et al. (2011) Prevalence of HIV, Hepatitis B and Hepatitis C infection in Thalassemia major patients in tertiary care hospital, Gujarat. Nat J Integr Res Med 2: 47-50.
    • (2011) Nat J Integr Res Med , vol.2 , pp. 47-50
    • Bhavsar, H.1    Patel, K.2    Vegad, M.3    Madan, M.4    Pandey, A.5
  • 202
    • 43249092312 scopus 로고    scopus 로고
    • Seroprevalence of HIV, hepatitis C and hepatitis B in multitransfused thalassemics
    • Mathur M, Wanjari K, Turbadkar D (2008) Seroprevalence of HIV, hepatitis C and hepatitis B in multitransfused thalassemics. Ind J Med Microbiol: 205-206.
    • (2008) Ind J Med Microbiol , pp. 205-206
    • Mathur, M.1    Wanjari, K.2    Turbadkar, D.3
  • 203
    • 0027572877 scopus 로고
    • Acquired immunodeficiency syndrome (AIDS) in multitransfused children with thalassemia
    • Sen S, Mishra NM, Giri T, Pande I, Khare SD, et al. (1993) Acquired immunodeficiency syndrome (AIDS) in multitransfused children with thalassemia. Indian Pediatr 30: 455-460.
    • (1993) Indian Pediatr , vol.30 , pp. 455-460
    • Sen, S.1    Mishra, N.M.2    Giri, T.3    Pande, I.4    Khare, S.D.5
  • 204
    • 0029079707 scopus 로고
    • Results of long-term deferiprone (L1) therapy: a report by the International Study Group on Oral Iron Chelators
    • al-Refaie FN, Hershko C, Hoffbrand AV, Kosaryan M, Olivieri NF, et al. (1995) Results of long-term deferiprone (L1) therapy: a report by the International Study Group on Oral Iron Chelators. Br J Haematol 91: 224-229.
    • (1995) Br J Haematol , vol.91 , pp. 224-229
    • al-Refaie, F.N.1    Hershko, C.2    Hoffbrand, A.V.3    Kosaryan, M.4    Olivieri, N.F.5
  • 205
    • 14644409770 scopus 로고    scopus 로고
    • The effect of vaginal candidiasis on the shedding of human immunodeficiency virus in cervicovaginal secretions
    • Spinillo A, Zara F, Gardella B, Preti E, Mainini R, et al. (2005) The effect of vaginal candidiasis on the shedding of human immunodeficiency virus in cervicovaginal secretions. Am J Obstet Gynecol 192: 774-779.
    • (2005) Am J Obstet Gynecol , vol.192 , pp. 774-779
    • Spinillo, A.1    Zara, F.2    Gardella, B.3    Preti, E.4    Mainini, R.5
  • 206
    • 0038779227 scopus 로고    scopus 로고
    • Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors
    • Niewerth M, Kunze D, Seibold M, Schaller M, Korting HC, et al. (2003) Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors. Antimicrob Agents Chemother 47: 1805-1817.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1805-1817
    • Niewerth, M.1    Kunze, D.2    Seibold, M.3    Schaller, M.4    Korting, H.C.5
  • 207
    • 0033064766 scopus 로고    scopus 로고
    • In vitro activity of rilopirox against fluconazole-susceptible and fluconazole-resistant Candida isolates from patients with HIV infection
    • Nenoff P, Taneva E, Pfeil B, Oswald U, Haustein UF, (1999) In vitro activity of rilopirox against fluconazole-susceptible and fluconazole-resistant Candida isolates from patients with HIV infection. Mycoses 42: 55-60.
    • (1999) Mycoses , vol.42 , pp. 55-60
    • Nenoff, P.1    Taneva, E.2    Pfeil, B.3    Oswald, U.4    Haustein, U.F.5
  • 208
    • 84255199531 scopus 로고    scopus 로고
    • Wnt inhibitor screen reveals iron dependence of beta-catenin signaling in cancers
    • Song S, Christova T, Perusini S, Alizadeh S, Bao RY, et al. (2011) Wnt inhibitor screen reveals iron dependence of beta-catenin signaling in cancers. Cancer Res 71: 7628-7639.
    • (2011) Cancer Res , vol.71 , pp. 7628-7639
    • Song, S.1    Christova, T.2    Perusini, S.3    Alizadeh, S.4    Bao, R.Y.5
  • 209
    • 84884504900 scopus 로고    scopus 로고
    • Clinical Proof of Concept Trial of Oral Ciclopirox Olamine in Patients with Relapsed/ Refractory Hematologic Malignancy
    • 54th ASH Annual Meeting. Atlanta, GA, Dec. 8-11, 2012; #1372. See
    • Minden MD, Hogge DE, Weir SJ, Kasper J, Patton L, et al. (2012) Clinical Proof of Concept Trial of Oral Ciclopirox Olamine in Patients with Relapsed/ Refractory Hematologic Malignancy. 54th ASH Annual Meeting. Atlanta, GA, Dec. 8-11, 2012; #1372. See https://ash.confex.com/ash/2012/webprogram/Paper46498.html.
    • (2012)
    • Minden, M.D.1    Hogge, D.E.2    Weir, S.J.3    Kasper, J.4    Patton, L.5
  • 210
    • 70449466605 scopus 로고    scopus 로고
    • Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells
    • Eberhard Y, McDermott SP, Wang X, Gronda M, Venugopal A, et al. (2009) Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood 114: 3064-3073.
    • (2009) Blood , vol.114 , pp. 3064-3073
    • Eberhard, Y.1    McDermott, S.P.2    Wang, X.3    Gronda, M.4    Venugopal, A.5
  • 212
    • 0030740277 scopus 로고    scopus 로고
    • Modulation of stress protein (hsp27 and hsp70) expression in CD4+ lymphocytic cells following acute infection with human immunodeficiency virus type-1
    • Wainberg Z, Oliveira M, Lerner S, Tao Y, Brenner BG, (1997) Modulation of stress protein (hsp27 and hsp70) expression in CD4+ lymphocytic cells following acute infection with human immunodeficiency virus type-1. Virology 233: 364-373.
    • (1997) Virology , vol.233 , pp. 364-373
    • Wainberg, Z.1    Oliveira, M.2    Lerner, S.3    Tao, Y.4    Brenner, B.G.5
  • 213
    • 84980231088 scopus 로고
    • The direct thionation and aminoalkylation of pyridine 1-oxides and related reaction
    • Abramovitch RA, Knaus EE, (1975) The direct thionation and aminoalkylation of pyridine 1-oxides and related reaction. J Heterocycl Chem 12: 683-690.
    • (1975) J Heterocycl Chem , vol.12 , pp. 683-690
    • Abramovitch, R.A.1    Knaus, E.E.2
  • 214
    • 84884517205 scopus 로고    scopus 로고
    • ACTG Laboratory Technologist Committee, Available at
    • ACTG Laboratory Technologist Committee (2004) Preparation of PHA-stimulated uninfected donor peripheral blood mononuclear cells. Available at https://www.hanc.info/labs/labresources/procedures/ACTGIMPAACT%20Lab%20Manual/Preparation%20of%20PHA-Stimulated%20Uninfected%20Donor%20PBMCs.pdf.
    • (2004) Preparation of PHA-stimulated uninfected donor peripheral blood mononuclear cells
  • 215
    • 0028009774 scopus 로고
    • Distinct modes of human immunodeficiency virus type 1 proviral latency revealed by superinfection of nonproductively infected cell lines with recombinant luciferase-encoding viruses
    • Chen BK, Saksela K, Andino R, Baltimore D, (1994) Distinct modes of human immunodeficiency virus type 1 proviral latency revealed by superinfection of nonproductively infected cell lines with recombinant luciferase-encoding viruses. J Virol 68: 654-660.
    • (1994) J Virol , vol.68 , pp. 654-660
    • Chen, B.K.1    Saksela, K.2    Andino, R.3    Baltimore, D.4
  • 216
    • 33750487496 scopus 로고    scopus 로고
    • Histopathology of the thymus
    • Pearse G, (2006) Histopathology of the thymus. Toxicol Pathol 34: 515-547.
    • (2006) Toxicol Pathol , vol.34 , pp. 515-547
    • Pearse, G.1
  • 217
    • 0036216892 scopus 로고    scopus 로고
    • Caspase-3 is a pivotal mediator of apoptosis during regression of the ovarian corpus luteum
    • Carambula SF, Matikainen T, Lynch MP, Flavell RA, Goncalves PB, et al. (2002) Caspase-3 is a pivotal mediator of apoptosis during regression of the ovarian corpus luteum. Endocrinology 143: 1495-1501.
    • (2002) Endocrinology , vol.143 , pp. 1495-1501
    • Carambula, S.F.1    Matikainen, T.2    Lynch, M.P.3    Flavell, R.A.4    Goncalves, P.B.5
  • 218
    • 33845559030 scopus 로고
    • Coordination chemistry ans microbial iron transport
    • Raymond KN, Cattano CJ, (1979) Coordination chemistry ans microbial iron transport. Acc Chem Res 12: 183-227.
    • (1979) Acc Chem Res , vol.12 , pp. 183-227
    • Raymond, K.N.1    Cattano, C.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.