Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s)

Journal of Biological Chemistry

Volumn 280, Issue 2, 2005, Pages 857-860

  Kamada, Shinji ^a,b,c   Kikkawa, Ushio ^b   Tsujimoto, Yoshihide ^c   Hunter, Tony ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b KOBE UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBODIES; CELLS; FRACTIONATION; MUTAGENESIS; PROTEINS;

APOPTOTIC CELLS; CYTOPLASMIC LOCALIZATION; NUCLEAR TRANSLOCATION; SUBSTRATE RECOGNITION SITE;

ENZYMES;

CASPASE 3; PROCASPASE 3;

APOPTOSIS; ARTICLE; CELL FRACTIONATION; CELL NUCLEUS; CYTOPLASM; ENZYME LOCALIZATION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ACTIVE TRANSPORT, CELL NUCLEUS; APOPTOSIS; CARRIER PROTEINS; CASPASE 3; CASPASES; CELL LINE, TUMOR; CELL NUCLEUS; ENZYME ACTIVATION; HUMANS; MUTATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SUBUNITS; SUBSTRATE SPECIFICITY;

EID: 12544256390     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C400538200     Document Type: Article

References (30)

1. Alnemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G., Thornberry, N. A., Wong, W. W., and Yuan, J. (1996) Cell 87, 171
2. Cryns, V., and Yuan, J. (1998) Genes Dev. 12, 1551-1570
3. Thornberry, N. A., and Lazebnik, Y. (1998) Science 281, 1312-1316
4. Earnshaw, W. C., Martins, L. M., and Kaufmann, S. H. (1999) Annu. Rev. Biochem. 68, 383-424
5. Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S. (1994) J. Biol. Chem. 269, 30761-30764
6. Tewari, M., Quan, L. T., O'Rourke, K, Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S., and Dixit, V. M. (1995) Cell 81, 801-809
7. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., Mungay, N. A., Raju, S. M., Smulson, M. E., Yamin, T.-T., Yu, Y. L., and Miller, D. K. (1995) Nature 376, 37-43
8. Kuida, K, Zheng, T. S., Na, S., Kuan, C., Yang, D., Karasuyama, H., Rakic, P., and Flavell, R. A. (1996) Nature 384, 368-372
9. Woo, M., Hakem, R., Soengas, M. S., Duncan, G. S., Shahinian, A., Kagi, D., Hakem, A., McCurrach, M., Khoo, W., Kaufman, S. A., Senaldi, G., Howard, T., Lowe, S. W., and Mak, T. W. (1998) Genes Dev. 12, 806-819
10. Zheng, T. S., Schlosser, S. F., Dao, T., Hingorani, R., Crispe, I. N., Boyer, J. L., and Flavell, R. A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13618-13623
11. Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., and Nagata, S. (1998) Nature 391, 43-50
12. Liu, X., Li, P., Widlak, P., Zou, H., Luo, X., Garrard, W. T., and Wang, X. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 8461-8466
13. Sahara, S., Aoto, M., Eguchi, Y., Imamoto, N., Yoneda, Y., and Tsujimoto, Y. (1999) Nature 401, 168-173
14. Lechardeur, D., Drzymala, L., Sharma, M., Zylka, D., Kinach, R., Pacia, J., Hicks, C., Usmani, N., Rommens, J. M., and Lukacs, G. L. (2000) J. Cell Biol. 150, 321-334
15. Fischer, U., Janicke, R. U., and Schulze-Osthoff, K. (2003) Cell Death Differ. 10, 76-100
16. Faleiro, L., and Lazebnik, Y. (2000) J. Cell Biol. 151, 951-959
17. Niwa, H., Yamamura, K, and Miyazaki, J. (1991) Gene (Amst.) 108, 193-199
18. Martins, L. M., Mesner, P. W., Kottke, T. J., Basi, G. S., Sinha, S., Tung, J. S., Svingen, P. A., Madden, B. J., Takahashi, A., McCormick, D. J., Earnshaw, W. C., and Kaufmann, S. H. (1997) Blood 90, 4283-4296
19. Mandai, M., Adam, L., and Kumar, R. (1999) Biochem. Biophys. Res. Commun. 260, 775-780
20. Takemoto, K., Nagai, T., Miyawaki, A., and Miura, M. (2003) J. Cell Biol. 160, 235-243
21. Thornberry, N. A., Rano, T. A., Peterson, E. P., Rasper, D. M., Timkey, T., Garcia-Calvo, M., Houtzager, V. M., Nordstrom, P. A., Roy, S., Vaillancourt, J. P., Chapman, K. T., and Nicholson, D. W. (1997) J. Biol. Chem. 272, 17907-17911
22. Garcia-Calvo, M., Peterson, E. P., Leiting, B., Ruel, R., Nicholson, D. W., and Thornberry, N. A. (1998) J. Biol. Chem. 273, 32608-32613
23. Zhivotovsky, B., Samali, A., Ganm, A., and Orrenius, S. (1999) Cell Death Differ. 6, 644-651
24. Huang, H., Joazeiro, C. A., Bonfoco, E., Kamada, S., Leverson, J. D., and Hunter, T. (2000) J. Biol. Chem. 275, 26661-26664
25. Suzuki, Y., Nakabayashi, Y., and Takahashi, R. (2001) Proc. Natl. Acad. Sci. U. S. A. 98,8662-8667
26. Chen, L., Smith, L., Wang, Z., and Smith, J. B. (2003) Mol. Pharmacol. 64, 334-345
27. Rotonda, J., Nicholson, D. W., Fazil, K. M., Gallant, M., Gareau, Y., Labelle, M., Peterson, E. P., Rasper, D. M., Ruel, R., Vaillancourt, J. P., Thornberry, N. A., and Becker, J. W. (1996) Nat. Struct. Biol. 3, 619-625
28. Wei, Y., Fox, T., Chambers, S. P., Sintchak, J., Coll, J. T., Golec, J. M. C., Swenson, L., Wilson, K. P., and Charifson, P. S. (2000) Chem. Biol. 7, 423-432
29. Gorlich, D., and Mattaj, I. W. (1996) Science 271, 1513-1518
30. Yasuhara, N., Eguchi, Y., Tachibana, T., Imamoto, N., Yoneda, Y., and Tsujimoto, Y. (1997) Genes Cells 2, 55-64