N1-guanyl-1,7,-diamineoheptane, an inhibitor of deoxyhypusine synthase, suppresses differentiation and induces apoptosis via mitochondrial and AMPK pathways in immortalized and malignant human oral keratinocytes

Journal of Oral Pathology and Medicine

Volumn 38, Issue 10, 2009, Pages 792-800

  Lee, S K ^a   Lee, J ^b   Lee, S I ^a   Bae, W J ^a   Lee, Y M ^a   Park, J S ^a   Park, S J ^c   Min, S K ^b   Kim, E C ^a  

^a Wonkwang University   (South Korea)

^b Department of Oral and Maxillofacial Surgery

^c Wonkwang University   (South Korea)

Author keywords

Adenosine monophosphate activated protein kinase; Apoptosis; GC7; Immortalized keratinocytes; Oral cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CYTOCHROME C; DEOXYHYPUSINE SYNTHASE; DNA; FLUORESCEIN ISOTHIOCYANATE; GC 7; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; N1 GUANYL 1,7, DIAMINEOHEPTANE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER THERAPY; CELL CYCLE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HN4; CONTROLLED STUDY; CYTOSOL; DNA FRAGMENTATION; DOSE RESPONSE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMORTALIZED HUMAN ORAL KERATINOCYTE; KERATINOCYTE; MOUTH CANCER; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

AMP-ACTIVATED PROTEIN KINASES; ANNEXIN A5; APOPTOSIS; CARCINOMA; CASPASE 3; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; G1 PHASE; GUANINE; HUMANS; KERATIN-13; KERATIN-19; KERATINOCYTES; MITOCHONDRIA; MOUTH MUCOSA; MOUTH NEOPLASMS; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PROTEIN PRECURSORS;

EID: 70350461873     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2009.00809.x     Document Type: Article

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