Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor elF-5A

Science

Volumn 271, Issue 5257, 1996, Pages 1858-1860

  Bevec, Dorian ^a   Jaksche, Herbert ^a   Oft, Martin ^b   Wöhl, Thorsten ^c   Himmelspach, Michèle ^a   Pacher, Alexandra ^a   Schebesta, Michael ^a   Koettnitz, Karl ^a   Dobrovnik, Marika ^a   Csonga, Robert ^a   Lottspeich, Friedrich ^c   Hauber, Joachim ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR; MUTANT PROTEIN; TRANSACTIVATOR PROTEIN;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; T LYMPHOCYTE; VIRUS REPLICATION; YEAST CELL;

AMINO ACID SEQUENCE; CELL NUCLEUS; CELLS, CULTURED; GENE PRODUCTS, REV; GENES, ENV; HELA CELLS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE INITIATION FACTORS; RECOMBINANT FUSION PROTEINS; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; T-LYMPHOCYTES; TRANS-ACTIVATION (GENETICS); VIRUS REPLICATION;

EUKARYOTA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0029916299     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5257.1858     Document Type: Article

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46. This work is dedicated to the memory of our friend and colleague Peter Dukor. We are indebted to V Magdolen for his initial help and intellectual input and to B. Kappel, L. Hofer, and J. Pertl for their technical assistance. We thank G. Palfi for his advice and help with fluorescence-activated cell sorting analyses and S L. Thomas for her comments on the manuscript Supported in part (M O ) by grant of the Deutsche Forschungsgemeinschaft.