The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway

Cell Death and Differentiation

Volumn 8, Issue 7, 2001, Pages 715-724

  Decker, R H ^a   Dai, Y ^a   Grant, S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Caspase; Cytochrome c; Flavopiridol; Leukemia

Indexed keywords

ACETYLCYSTEINE; CASPASE; CASPASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR; CYTARABINE; CYTOCHROME C; ENZYME PRECURSOR; ETOPOSIDE; FLAVOPIRIDOL; KETONE DERIVATIVE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL STRAIN U937; CELL STRUCTURE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; LEUKEMIA CELL; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING;

APOPTOSIS; CASPASE 8; CASPASE 9; CASPASES; CELL CYCLE; CYCLIN-DEPENDENT KINASES; CYTOCHROME C GROUP; ENZYME ACTIVATION; FLAVONOIDS; HUMANS; INTRACELLULAR MEMBRANES; LEUKEMIA; MEMBRANE POTENTIALS; MITOCHONDRIA; PEROXIDES; PIPERIDINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFECTION; U937 CELLS;

EID: 0034917456     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400868     Document Type: Article

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