Spectroscopic and electronic structure studies of the role of active site interactions in the decarboxylation reaction of α-keto acid-dependent dioxygenases

Journal of Inorganic Biochemistry

Volumn 100, Issue 12, 2006, Pages 2108-2116

  Neidig, Michael L ^a   Brown, Christina D ^a   Kavana, Michael ^c   Choroba, Oliver W ^b   Spencer, Jonathan B ^b   Moran, Graham R ^c   Solomon, Edward I ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

Ketoglutarate dependent dioxygenases; Decarboxylation; Density functional theory; Magnetic circular dichroism

Indexed keywords

(4 HYDROXY)MANDELATE SYNTHASE; (4 HYDROXYPHENYL)PYRUVATE DIOXYGENASE; 2 OXOACID; CARBON DIOXIDE; CARBOXYLIC ACID; DIOXYGENASE; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; DECARBOXYLATION; DENSITY; ELECTRON; ELECTRONICS; ENZYME ACTIVE SITE; ENZYME MECHANISM; HYDROGEN BOND;

3-METHYL-2-OXOBUTANOATE DEHYDROGENASE (LIPOAMIDE); BINDING SITES; CARBOXYLIC ACIDS; CIRCULAR DICHROISM; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

STREPTOMYCES AVERMITILIS;

EID: 33750935618     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2006.08.021     Document Type: Article

References (27)

1. Solomon E.I., Brunold T.C., Davis M.I., Kemsley J.N., Lee S.-K., Lehnert N., Neese F., Skulan A.J., Yang Y.-S., and Zhou J. Chem. Rev. 100 (2000) 235-349
2. Neidig M.L., and Solomon E.I. Chem. Commun. (2005) 5843-5863
3. Choroba O.W., Williams D.H., and Spencer J.B. J. Am. Chem. Soc. 122 (2000) 5389-5390
4. Johnson-Winters K., Purpero V.M., Kavana M., Nelson T., and Moran G.R. Biochemistry 42 (2003) 2072-2080
5. Hanauske-Abel H.M., and Gunzler V. J. Theor. Biol. 94 (1982) 421-455
6. Price J.C., Barr E.W., Tirupati B., Bollinger J.M., and Krebs C. Biochemistry 42 (2003) 7497-7508
7. Proshlyakov D.A., Henshaw T.F., Monterosso G.R., Ryle M.J., and Hausinger R.P. J. Am. Chem. Soc. 126 (2004) 1022-1023
8. Riggs-Gelasco P.J., Price J.C., Guyer R.B., Brehm J.H., Barr E.W., Bollinger J.M., and Krebs C. J. Am. Chem. Soc. 126 (2004) 8108-8109
9. Neidig M.L., Decker A., Choroba O.W., Huang F., Kavana M., Moran G.R., Spencer J.B., and Solomon E.I. Proc. Natl. Acd. Sci., U.S.A. 103 (2006) 12966-12973
10. Neidig M.L., Kavana M., Moran G.R., and Solomon E.I. J. Am. Chem. Soc. 126 (2004) 4486-4487
11. Lin E.C.C., Pitt B.M., Civen M., and Knox W.E. J. Biol. Chem. 233 (1958) 668-673
12. Frisch M.J., Trucks G.W., Schlegel H.B., Scuseria G.E., Robb M.A., Cheeseman J.R., Montgomery Jr. J.A., Vreven T., Kudin K.N., Burant J.C., Millam J.M., Iyengar S.S., Tomasi J., Barone V., Mennucci B., Cossi M., Scalmani G., Rega N., Petersson G.A., Nakatsuji H., Hada M., Ehara M., Toyota K., Fukuda R., Hasegawa J., Ishida M., Nakajima T., Honda Y., Kitao O., Nakai H., Klene M., Li X., Knox J.E., Hratchian H.P., Cross J.B., Bakken V., Adamo C., Jaramillo J., Gomperts R., Stratmann R.E., Yazyev O., Austin A.J., Cammi R., Pomelli C., Ochterski J.W., Ayala P.Y., Morokuma K., Voth G.A., Salvador P., Dannenberg J.J., Zakrzewski V.G., Dapprich S., Daniels A.D., Strain M.C., Farkas O., Malick D.K., Rabuck A.D., Raghavachari K., Foresman J.B., Ortiz J.V., Cui Q., Baboul A.G., Clifford S., Cioslowski J., Stefanov B.B., Liu G., Liashenko A., Piskorz P., Komaromi I., Martin R.L., Fox D.J., Keith T., Al-Laham M.A., Peng C.Y., Nanayakkara A., Challacombe M., Gill P.M.W., Johnson B., Chen W., Wong M.W., Gonzalez C., and Pople J.A. R.C. Gaussian 03 (2004), Gaussian, Inc., Wallingford CT
13. Perdew J.P. Phys. Rev. B 33 (1986) 8822-8824
14. Becke A.D. Phys. Rev. A 38 (1988) 3098-3100
15. Schenk G., Pau M.Y.M., and Solomon E.I. J. Am. Chem. Soc. 126 (2004) 505-515
16. S.I. Gorelsky, AOMix program, rev. 6.04. Available from: .
17. Gorelsky S.I., and Lever A.B.P. J. Organomet. Chem. 635 (2001) 187-196
18. Schaftenaar G., and Noordik J.H. J. Comput.-Aided Mol. Des. 14 (2000) 123-134
19. Brownlee J.M., Johnson-Winters K., Harrison D.H.T., and Moran G.R. Biochemistry 43 (2004) 6370-6377
20. Hanes C.S. Biochem. J. 26 (1932) 1406-1421
21. J.B.S. Haldane, K.G. Stern, in Allgemeine Chemie der Enzyme, Steinkopff, Dresden, Leipzig, 1932, pp. 119-120.
22. Pavel E.G., Kitajima N., and Solomon E.I. J. Am. Chem. Soc. 120 (1998) 3949-3962
23. Solomon E.I., Pavel E.G., Loeb K.E., and Campochiaro C. Coord. Chem. Rev. 144 (1995) 369-460
24. Pavel E.G., Zhou J., Busby R.W., Gunsior M., Townsend C.A., and Solomon E.I. J. Am. Chem. Soc. 120 (1998) 743-753
25. Zhou J., Kelly W.L., Bachman B.O., Gunsior M., Townsend C.A., and Solomon E.I. J. Am. Chem. Soc. 123 (2001) 7388-7398
26. Zhang Z., Ren J., Stammers D.K., Baldwin J.E., Harlos K., and Schofield C.J. Nat. Struct. Biol. 7 (2000) 127-133
27. Zhang Z., Ren J.-S., Harlos K., McKinnon C.H., Clifton I.J., and Schofield C.J. FEBS Lett. 517 (2002) 7-12