HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatment

AIDS

Volumn 13, Issue 6, 1999, Pages 677-683

  Neumann, Avidan U ^a,e   Tubiana, Roland ^b   Calvez, Vincent ^c   Robert, Catherine ^d   Li, Tai Sheng ^e   Agut, Henri ^a   Autran, Brigitte ^b   Katlama, Christine ^a  

^a Laboratoire d'Immunologie Cellulaire et Tissulaire CNRS URA 625   (France)

^b Serv Maladies Infectieuses T   (France)

^c CNRS   (France)

^d BAR ILAN UNIVERSITY   (Israel)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Anti HIV agents therapeutic use; Biological models; CD4 lymphocyte count; HIV 1 infection virology drug therapy; HIV 1 viral dynamics; Regression analysis

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; INDINAVIR; LAMIVUDINE; PROTEINASE INHIBITOR; ZIDOVUDINE;

ARTICLE; CLINICAL ARTICLE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; VIRUS LOAD;

ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; INDINAVIR; LAMIVUDINE; MALE; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE INHIBITORS; RNA, VIRAL; ZIDOVUDINE;

EID: 0032991492     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199904160-00008     Document Type: Article

References (16)

1. De Jong MD, De Boer R), De Wolf F, et al.: Overshoot of HIV-1 viraemia after early discontinuation of antiretroviral treatment. AIDS 1997, 11:F79-F84.
2. Kaufmann D, Pantaleo G, Sudre P, Telenti A: CD4-cell count in HIV-1-infected individuals remaining viremic with highly active antiretroviral therapy (HAART) - Swiss HIV Cohort Study. Lancet 1998, 351:723-724.
3. Stilianakis NI, Boucher ÇA, De Jong MD, Van Leeuwen R, Schuurman R, De Boer RJ: Clinical data sets of human immunodeficiency virus type 1 reverse transcriptase-resistant mutants explained by a mathematical model. ] Virol 1997, 71:161-168.
4. Delwart EL, Pan H, Neumann AU, Markowitz M: Rapid, transient changes at the env locus of plasma human immunodeficiency virus type 1 populations during the emergence of protease inhibitor resistance. J Virol 1998, 72:2416-2421.
5. Eastman PS, Mittler J, Kelso; R, et al.: Cenotypic changes in human immunodeficiency virus type 1 associated with loss of suppression of plasma viral RNA levels in subjects treated with ritonavir (Norvir) monotherapy. 1 Virol 1998, 72:5154-5164.
6. Bonhoeffer S, May RM, Shaw CM, Nowak MA: Virus dynamics and drug therapy. Proc Nat/ Acad Sei USA 1997, 94:6971-6976.
7. Essunger P, Markowitz M, Ho DD, Perelson AS: Efficacy of drug combination and dosing regimen in antiviral therapy. International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication. St Petersburg, FL, June 1997 [abstract 73].
8. Neumann AU, Lam P, Dahari H, et al.; Hepatitis C viral dynamics in-vivo and the anti-viral efficacy of interferon treatment. Science 1998, 282:103-107.
9. Perelson AS, Essunger P, Cao Y, et al.: Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 1997, 387:188-191.
10. Notermanns DVV, Goudsmit J, Danner SA, de Wolf F, Perelson AS, Mittler J: Rate of HIV-1 decline following antiretroviral therapy is related to viral load at baseline and drug regimen. A/DS 1998, 12:1483-1490.
11. Hammer SM, Squires KE, Hugues MD, et al.: A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. N Eng/1 Med 1997, 337:725-733.
12. Gulick RM, Mellors JVV, Havlir D, et al.: Treatment with indinavir, zidovudine and lamivudine in adults with human immunodeficiency virus infection and prior antirctroviral therapy. N Engl] Med 1997, 337:734-739.
13. Autran B, Carcelain G, Li TS, et al.: Positive effects of combined anti-retroviral therapy on CD4'f T cell homeostasis and function in advanced HIV disease. Science 1997, 277:112-116.
14. Pakker NG, Notermans DW, de Boer R), et al.: Biphasic kinetics of peripheral blood T cells after triple combination therapy in H1V-1 infection: a composite of redistribution and proliferation. Nature Med 1998, 4:208-214.
15. Li TS, Tubiana R, Katlama C, Calvez V, Ait Mohand A, Autran B: Long lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease. Lancet 1998, 351:1682-1686.
16. Corochov C, Neumann AU, Kereveur A, et al.: Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy. Nature Med 1998, 4:215-221.