Iron chelators for the treatment of iron overload disease: Relationship between structure, redox activity, and toxicity

American Journal of Hematology

Volumn 73, Issue 3, 2003, Pages 200-210

  Chaston, Timothy B ^a   Richardson, Des R ^a  

^a CHILDREN S CANCER INSTITUTE AUSTRALIA FOR MEDICAL RESEARCH   (Australia)

Author keywords

thalassemia; Desferrioxamine; Iron; Iron chelators

Indexed keywords

2 HYDROXY 1 NAPHTHALDEHYDE 4,4 DIMETHYL 3 THIOSEMICARBAZONE; 2 HYDROXY 1 NAPHTHALDEHYDE ISONICOTINOYLHYDRAZONE; 2 PYRIDYLCARBOXALDEHYDE ISONICOTINOYLHYDRAZONE; 3 AMINOPICOLINALDEHYDE THIOSEMICARBAZONE; ALPHA KETOHYDROXYPYRIDONE; CHELATING AGENT; CYTOTOXIC AGENT; DEFERIPRONE; DEFEROXAMINE; DI 2 PYRIDYLKETONE ISONICOTINOYLHYDRAZONE; DOXORUBICIN; EDETIC ACID; HYDRAZONE DERIVATIVE; IRON; IRON 59; IRON COMPLEX; N,N' BIS(2 HYDROXYBENZYL)ETHYLENEDIAMINE N,N' DIACETIC ACID; N44MT; PYRIDOXAL ISONICOTINOYLHYDRAZONE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; BETA THALASSEMIA; CELL CYCLE; CELL METABOLISM; CHELATION; CLINICAL TRIAL; DNA DAMAGE; DRUG HYPERSENSITIVITY; DRUG MECHANISM; GENE MUTATION; HUMAN; IRON CHELATION; IRON METABOLISM; IRON OVERLOAD; LIGAND BINDING; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; REVIEW; THALASSEMIA; TOXICITY TESTING;

DEFEROXAMINE; HUMANS; IRON; IRON CHELATING AGENTS; IRON OVERLOAD;

EID: 0037631496     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.10348     Document Type: Review

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