Anti-HIV effect of iron chelators: Different mechanisms involved

Journal of Clinical Virology

Volumn 20, Issue 3, 2001, Pages 141-147

  Van Asbeck, B S ^a   Georgiou, N A ^a   Van der Bruggen, T ^b   Oudshoorn, M ^a   Nottet, H S L M ^b   Marx, J J M ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Chelation; HIV; Iron; Oxygen radicals

Indexed keywords

BLEOMYCIN; DEFERIPRONE; DEFEROXAMINE; DIDANOSINE; EDETIC ACID; HYDROXAMIC ACID; HYDROXYUREA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRON CHELATING AGENT; REACTIVE OXYGEN METABOLITE;

ANTIVIRAL ACTIVITY; CATALYSIS; CONFERENCE PAPER; DNA SYNTHESIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IRON CHELATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

ANTI-HIV AGENTS; DNA, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; IRON; IRON CHELATING AGENTS; LYMPHOCYTES; NF-KAPPA B; RNA, VIRAL; TRANSCRIPTION, GENETIC; VIRUS REPLICATION;

EID: 0035139253     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6532(00)00122-0     Document Type: Review

References (40)

1. Some physiochemical aspects of iron metabolism
2. A clinical review of bleomycin - a new antineoplastic agent
3. Spectrum and iron content of protein B2 from ribonucleotide diphosphate reductase
4. Site specific cleavage of RNA by Fe(II) bleomycin
5. Bleomycin pulmonary toxicity: current status and future directions
6. The iron chelator L1 potentiates oxidative DNA damage in iron-loaded liver cells
7. Oxygen radicals and human disease
8. Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication
9. Inhibition of human immunodeficiency virus type 1 replication in human mononuclear blood cells by the iron chelators deferoxamine, deferiprone, and bleomycin
10. Facilitation of Fe(II) autoxidation by Fe(III) complexing agents
11. Design of orally active iron chelators
12. Effect of iron deficiency and desferrioxamine on DNA synthesis in human cells
13. Characterization of iron(II) bleomycin-mediated RNA strand scission
14. Subcellular distribution of desferrioxamine and hydroxypyridin-4-one chelators in K562 cells affects chelation of intracellular iron pools
15. The biochemistry of desferrioxamine and its relation to iron metabolism
16. Lack of effect of desferrioxamine on in-vitro HIV-1 replication
17. Lack of metabolism as the biochemical basis of bleomycin-induced pulmonary toxicity
18. Deferoxamine: a reversible S-phase inhibitor of human lymphocyte proliferation
19. Selective inhibition of I kappaB alpha phosphorylation and HIV-1 LTR-directed gene expression by novel antioxidant compounds
20. Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication
21. Long-term suppression of HIV-1 by hydroxyurea and didanosine [letter]
22. The mechanism of the bleomycin-induced cleavage of DNA
23. Metal chelate compounds in homogenous aqueous catalysis
24. Inhibition of ribonucleoside diphosphate reductase by 1-formylisoquinoline thiosemicarbazone and related compounds
25. Iron(II) bleomycin-mediated degradation of a DNA-RNA heteroduplex
26. An inducible transcription factor activates expression of human immunodeficiency virus in T-cells
27. Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators
28. Effect of orally active hydroxypyridinone iron chelators on human lymphocyte function
29. Iron mobilization from hepatocyte monolayer cultures by chelators: the importance of membrane permeability and the iron-binding constant
30. Binding of bleomycin to DNA: interchelation of the bithiazole rings
31. Fundamental concepts for transition metal complexes
32. Iron chelation decreases NK-μB and HIV type 1 activation due to oxidative stress
33. A role for ferrous ion and oxygen in the degradation of DNA by bleomycin
34. Polynuclear complexes of iron and their biological implications
35. Inhibition by desferrioxamine of in-vitro replication of HIV-1
36. Oral iron chelators and HIV-1 inhibition in human peripheral blood lymphocytes
37. 1-year follow-up of the use of hydroxycarbamide and didanosine in HIV infection [letter]
38. The biochemical functions of iron
39. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure