Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 40, 2006, Pages 14738-14743

  Hoffart, Lee M ^a   Barr, Eric W ^a   Guyer, Robert B ^a   Bollinger Jr , J Martin ^a   Krebs, Carsten ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Fe(IV) oxo intermediates; Hydroxylation; Nonheme iron enzymes; Oxygen activation

Indexed keywords

2 OXOGLUTARIC ACID; CARBON DIOXIDE; COLLAGEN; IRON DERIVATIVE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; SUCCINIC ACID; TAURINE;

ARTICLE; CATALYSIS; COLLAGEN SYNTHESIS; COMPLEX FORMATION; DECARBOXYLATION; ENZYME SUBSTRATE; HYDROXYLATION; MOSSBAUER SPECTROSCOPY; PRIORITY JOURNAL; SPECTROSCOPY;

ABSORPTION; AMINO ACID SEQUENCE; CARBON; HUMANS; HYDROGEN; IRON; KETOGLUTARIC ACIDS; KINETICS; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; PEPTIDES; PHYCODNAVIRIDAE; PROCOLLAGEN-PROLINE DIOXYGENASE; SPECTROSCOPY, MOSSBAUER; SUBSTRATE SPECIFICITY; TITRIMETRY;

EID: 33749542309     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0604005103     Document Type: Article

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