Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines

Oncogene

Volumn 21, Issue 30, 2002, Pages 4613-4625

  Muthumani, Karuppiah ^a   Zhang, Donghui ^a   Hwang, Daniel S ^a   Kudchodkar, Sagar ^a   Dayes, Nathanael S ^a   Desai, Brijal M ^a   Malik, Afshan S ^a   Yang, Joo Sung ^a   Chattergoon, Michael A ^a   Maguire Jr , Henry C ^a   Weiner, David B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

adCMV vpr; Apoptosis; Bcl 2; Caspase; Cytochrome c; p53

Indexed keywords

CASPASE 9; CYTOCHROME C; PROTEIN; PROTEIN BCL 2; PROTEIN HIV 1 VPR; PROTEIN P53; REAGENT; UNCLASSIFIED DRUG;

ADENOVIRUS; ANALYTIC METHOD; APOPTOSIS; ARTICLE; CELL DEATH; CELL GROWTH; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN DEFICIENCY; TUMOR CELL LINE; VIRUS RECOMBINANT; WESTERN BLOTTING;

ADENOVIRIDAE; APOPTOSIS; BLOTTING, WESTERN; CASPASE 9; CASPASES; CELL CYCLE; CELL SIZE; CELL SURVIVAL; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE DELETION; GENE EXPRESSION; GENE PRODUCTS, VPR; GENETIC VECTORS; HELA CELLS; HUMANS; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSDUCTION, GENETIC; TRANSGENES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

ADENOVIRIDAE; CUCUMBER MOSAIC VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0037063171     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1205549     Document Type: Article

References (51)