Vaginal microbicides: Detecting toxicities in vivo that paradoxically increase pathogen transmission

BMC Infectious Diseases

Volumn 6, Issue , 2006, Pages

  Cone, Richard A ^a,b   Hoen, Timothy ^a   Wong, Xixi ^a   Abusuwwa, Raed ^a   Anderson, Deborah J ^c   Moench, Thomas R ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b REPROTECT INC   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZALKONIUM CHLORIDE; CARBOPOL 974P; CHLORHEXIDINE; CYTOKINE; DETERGENT; DODECYL SULFATE SODIUM; GESTAGEN; HYDROXYETHYLCELLULOSE; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MICROBICIDE; PLACEBO; POLYSTYRENESULFONIC ACID; RANTES;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL GROWTH; COLPOSCOPY; CONTROLLED STUDY; CORRELATIONAL STUDY; EPITHELIUM CELL; FEMALE; GENITAL HERPES; HERPES SIMPLEX VIRUS 2; HISTOPATHOLOGY; IN VIVO STUDY; INFECTION SENSITIVITY; INOCULATION; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENESIS; VIRUS TRANSMISSION;

ANIMALS; CELLULOSE; DETERGENTS; DISEASE MODELS, ANIMAL; DRUG TOXICITY; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; HUMANS; MICE; NONOXYNOL; POLYSTYRENES; SURFACE-ACTIVE AGENTS; VAGINA;

EID: 33746646763     PISSN: 14712334     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-6-90     Document Type: Article

References (52)

1. Sodora DL, Gettie A, Miller CJ, Marx PA: Vaginal transmission of SIV: assessing infectivity and hormonal influences in macaques inoculated with cell-free and cell-associated viral stocks. AIDS Res Hum Retroviruses 1998, 14(Suppl 1):S119-123.
2. Chakraborty H, Sen PK, Helms RW, Vernazza PL, Fiscus SA, Eron JJ, Patterson BK, Coombs RW, Krieger JN, Cohen MS: Viral burden in genital secretions determines male-to-female sexual transmission of HIV-1: a probabilistic empiric model. Aids 2001, 15(5):621-627.
3. Wawer MJ, Gray RH, Sewankambo NK, Serwadda D, Li X, Laeyendecker O, Kiwanuka N, Kigozi G, Kiddugavu M, Lutalo T, et al.: Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis 2005, 191(9):1403-1409.
4. Catalone BJ, Miller SR, Ferguson ML, Malamud D, Kish-Catalone T, Thakkar NJ, Krebs FC, Howett MK, Wigdahl B: Toxicity, inflammation, and anti-human inmmunodeficiency virus type 1 activity following exposure to chemical moieties of C31G. Biomedicine & Pharmacotherapy 2005, 59:430-437.
5. Catalone BJ, Kish-Catalone TM, Budgeon LR, Neely EB, Ferguson M, Krebs FC, Howett MK, Labib M, Rando R, Wigdahl B: Mouse model of cervicovaginal toxicity and inflammation for preclinical evaluation of topical vaginal microbicides. Antimicrob Agents Chemother 2004, 48(5):1837-1847.
6. Catalone BJ, Kish-Catalone TM, Neely EB, Budgeon LR, Ferguson ML, Stiller C, Miller SR, Malamud D, Krebs FC, Howett MK, Wigdahl B: Comparative safety evaluation of the candidate vaginal microbicide C31G. Antimicrob Agents Chemother 2005, 49(4):1509-1520.
7. Maguire RA, Bergman N, Phillips DM: Comparison of microbicides for efficacy in protecting mice against vaginal challenge with herpes simplex virus type 2, cytotoxicity, antibacterial properties, and sperm immobilization. Sex Transm Dis 2001, 28(5):259-265.
8. Milligan GN, Dudley KL, Bourne N, Reece A, Stanberry LR: Entry of inflammatory cells into the mouse vagina following application of candidate microbicides: comparison of detergent-based and sulfated polymer-based agents. Sex Transm Dis 2002, 29(10):597-605.
9. Dayal MB, Wheeler J, Williams CJ, Barnhart KT: Disruption of the upper female reproductive tract epithelium by nonoxynol-9. Contraception 2003, 68(4):273-279.
10. Fichorova RN, Bajpai M, Chandra N, Hsiu JG, Spangler M, Ratnam V, Doncel GF: Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives. Biol Reprod 2004, 71(3):761-769.
11. Patton DL, Kidder GG, Sweeney YC, Rabe LK, Clark AM, Hillier SL: Effects of nonoxynol-9 on vaginal microflora and chlamydial infection in a monkey model. Sex Transm Dis 1996, 23(6):461-464.
12. Patton DL, Sweeney YC, Rabe LK, Hillier SL: The vaginal micro-flora of pig-tailed macaques and the effects of chlorhexidine and benzalkonium on this ecosystem. Sex Transm Dis 1996, 23(6):489-493.
13. Corey L, Wald A, Celum CL, Quinn TC: The Effects of Herpes Simplex Virus-2 on HIV-1 Acquisition and Transmission: A Review of Two Overlapping Epidemics. J Acquir Immune Defic Syndr 2004, 35(5):435-445.
14. Spear PG: Herpes simplex virus: receptors and ligands for cell entry. Cell Microbiol 2004, 6(5):401-410.
15. Witvrouw M, De Clercq E: Sulfated polysaccharides extracted from sea algae as potential antiviral drugs. Gen Pharmacol 1997, 29(4):497-511.
16. Lewis MG, Wagner W, Yalley-Ogunro J, Greenhouse J, Profy AT: Efficacy of PRO 2000 gel in a macaque model for vaginal HIV transmission. Microbicides 2002: Antwerp, Belgium 2002, 2002:. Abstract A-191
17. Bourne N, Bernstein DI, Ireland J, Sonderfan AJ, Profy AT, Stanberry LR: The topical microbicide PRO 2000 protects against genital herpes infection in a mouse model. J Infect Dis 1999, 180(1):203-205.
18. Keller M: Abstract 535. In 12th Conference on Retroviruses and Opportunistic Infections: 2005 Boston, MA; 2005.
19. Neyts J, De Clercq E: Effect of polyanionic compounds on intracutaneous and intravaginal herpesvirus infection in mice: impact on the search for vaginal microbicides with anti-HIV activity. J Acquir Immune Defic Syndr Hum Retrovirol 1995, 10(1):8-12.
20. Phillips DM, Zacharopoulos VR: Nonoxynol-9 enhances rectal infection by herpes simplex virus in mice. Contraception 1998, 57(5):341-348.
21. Phillips DM, Taylor CL, Zacharopoulos VR, Maguire RA: Nonoxynol-9 causes rapid exfoliation of sheets of rectal epithelium. Contraception 2000, 62(3):149-154.
22. Phillips DM, Sudol KM, Taylor CL, Guichard L, Eisen R, Maguire RA: Lubricants containing N-9 may enhance rectal transmission of HIV and other STIs. Contraception 2004, 70(2):107-110.
23. Achilles SL, Shete PB, Whaley KJ, Moench TR, Cone RA: Microbicide efficacy and toxicity tests in a mouse model for vaginal transmission of Chlamydia trachomatis. Sex Transm Dis 2002, 29(11):655-664.
24. Bourne N, Zaneveld LJ, Ward JA, Ireland JP, Stanberry LR: Poly(sodium 4-styrene sulfonate): evaluation of a topical microbicide gel against herpes simplex virus type 2 and Chlamydia trachomatis infections in mice. Clin Microbiol Infect 2003, 9(8):816-822.
25. Bernstein DI, Stanberry LR, Sacks S, Ayisi NK, Gong YH, Ireland J, Mumper RJ, Holan G, Matthews B, McCarthy T, et al.: Evaluations of unformulated and formulated dendrimer-based microbicide candidates in mouse and guinea pig models of genital herpes. Antimicrob Agents Chemother 2003, 47(12):3784-3788.
26. Zeitlin L, Whaley KJ, Hegarty TA, Moench TR, Cone RA: Tests of vaginal microbicides in the mouse genital herpes model. Contraception 1997, 56(5):329-335.
27. Burillo CA, Fontenot JD, Phillips DM: Sulfated polysaccharides block chlamydia infection in vitro, but do not protect mice from vaginal inoculation. Microb Pathog 1998, 24(4):253-256.
28. Whaley KJ, Barratt RA, Zeitlin L, Hoen TE, Cone RA: Nonoxynol-9 protects mice against vaginal transmission of genital herpes infections. J Infect Dis 1993, 168(4):1009-1011.
29. Zeitlin L, Hoen TE, Achilles SL, Hegarty TA, Jerse AE, Kreider JW, Olmsted SS, Whaley KJ, Cone RA, Moench TR: Tests of Buffergel for contraception and prevention of sexually transmitted diseases in animal models. Sex Transm Dis 2001, 28(7):417-423.
30. Bax R, Douville K, McCormick D, Rosenberg M, Higgins J, Bowden M: Microbicides - evaluating multiple formulations of C31G. Contraception 2002, 66(5):365-368.
31. Krebs FC, Miller SR, Malamud D, Howett MK, Wigdahl B: Inactivation of human immunodeficiency virus type 1 by nonoxynol-9, C31G, or an alkyl sulfate, sodium dodecyl sulfate. Antivirol Res 1999, 43:157-173.
32. Howett MK, Neely EB, Christensen ND, Wigdahl B, Krebs FC, Malamud D, Patrick SD, Pickel MD, Welsh PA, Reed CA, et al.: A broad-spectrum microbicide with virucidal activity against sexually transmitted viruses. Antimicrob Agents Chemother 1999, 43(2):314-321.
33. Jennings R, Clegg A: The inhibitory effect of spermicidal agents on replication of HSV-2 and HIV-1 in-vitro. J Antimicrob Chemother 1993, 32(1):71-82.
34. Lee CH: Review: in vitro spermicidal tests. Contraception 1996, 54(3):131-147.
35. Tien D, Schnaare RL, Kang F, Cohl G, McCormick TJ, Moench TR, Doncel G, Watson K, Buckheit RW Jr, Lewis MG, Schwartz J, Douville K, Romano JW: In vitro and in vivo characterization of a potential universal placebo designed for use in vaginal microbicide clinical trials. AIDS Res Hum Retroviruses 2005, 21(10):845-53.
36. Eis AM, Schneweis KE: Pathogenesis of genital herpes simplex virus infection in mice. IV. Quantitative aspects of viral latency. Med Microbiol Immunol (Berl) 1986, 175(5):281-292.
37. Kaushic C, Ashkar AA, Reid LA, Rosenthal KL: Progesterone increases susceptibility and decreases immune responses to genital herpes infection. J Virol 2003, 77(8):4558-4565.
38. Fichorova RN, Tucker LD, Anderson DJ: The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission. J Infect Dis 2001, 184(4):418-428.
39. Veazey RS, Klasse PJ, Ketas TJ, Reeves JD, Piatak M Jr, Kunstman K, Kuhmann SE, Marx PA, Lifson JD, Dufour J, et al.: Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection. J Exp Med 2003, 198(10):1551-1562.
40. Veazey RS, Shattock RJ, Pope M, Kirijan JC, Jones J, Hu Q, Ketas T, Marx PA, Klasse PJ, Burton DR, et al.: Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp 120. Nat Med 2003, 9(3):343-346.
41. Raymond EG, Chen PL, Luoto J: Contraceptive effectiveness and safety of five nonoxynol-9 spermicides: a randomized trial. Obstet Gynecol 2004, 103(3):430-439.
42. Wilkinson D, Ramjee G, Tholandi M, Rutherford G: Nonoxynol-9 for preventing vaginal acquisition of sexually transmitted infections by women from men. Cochrane Database Syst Rev 2002:CD003939.
43. Van Damme L, Ramjee G, Alary M, Vuylsteke B, Chandeying V, Rees H, Sirivongrangson P, Mukenge-Tshibaka L, Ettiegne-Traore V, Uaheowitchai C, et al.: Effectiveness of COL- a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial. Lancet 1492, 360(9338):971-977.
44. Sherwood JK, Zeitlin L, Chen X, Whaley KJ, Cone RA, Saltzman WM: Residence Half-Life of IgG Administered Topically to the Mouse Vagina. Biology of Reproduction 1996, 54:264-269.
45. Linehan MM, Richman S, Krummenacher C, Eisenberg RJ, Cohen GH, Iwasaki A: In vivo role of nectin-1 in entry of herpes simplex virus type 1 (HSV-1) and HSV-2 through the vaginal mucosa. J Virol 2004, 78(5):2530-2536.
46. Yoon M, Spear PG: Disruption of adherens junctions liberates nectin-1 to serve as receptor for herpes simplex virus and pseudorabies; virus entry. J Virol 2002, 76(14):7203-7208.
47. Moench TR, Chipato T, Padian NS: Preventing disease by protecting the cervix: the unexplored promise of internal vaginal barrier devices. Aids 2001, 15(13):1595-1602.
48. Pretorius ES, Timbers K, Malamud D, Barnhart K: Magnetic resonance imaging to determine the distribution of a vaginal gel: before, during, and after both simulated and real intercourse. Contraception 2002, 66(6):443-451.
49. Barnhart KT, Stalpen A, Pretorius ES, Malamud D: Distribution of a spermicide containing Nonoxynol-9 in the vaginal canal and the upper female reproductive tract. Hum Reprod 2001, 16(6):1151-1154.
50. Barnhart KT, Pretorius ES, Malamud D: Lesson learned and dispelled myths: three-dimensional imaging of the human vagina. Fertil Steril 2004, 81(5):1383-1384.
51. Barnhart KT, Pretorius ES, Timbers K, Shera D, Shabbout M, Malamud D: In vivo distribution of a vaginal gel: MRI evaluation of the effects of gel volume, time and simulated intercourse. Contraception 2004, 70(6):498-505.
52. Hosseini K, Kholodnykh AI, Petrova IY, Esenaliev RO, Hendrikse F, Motamedi M: Monitoring of rabbit cornea response to dehydration stress by optical coherence tomography. Invest Ophthalmol Vis Sci 2004, 45(8):2555-2562.