Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase

Journal of Biological Chemistry

Volumn 281, Issue 16, 2006, Pages 10691-10697

  Hashemy, Seyed Isaac ^a   Ungerstedt, Johanna S ^a   Zahedi Avval, Farnaz ^a   Holmgren, Arne ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FLAVOENZYMES; MITOCHONDRIA; MOTEXAFIN GADOLINIUM (MGD);

CELLS; DISEASES; ENZYME IMMOBILIZATION; NUCLEIC ACIDS; OXIDATION; TUMORS;

DRUG PRODUCTS;

DISULFIDE; FLAVOPROTEIN; GADOLINIUM TEXAPHYRIN; HYDROGEN PEROXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIBONUCLEOTIDE REDUCTASE; SELENOCYSTEINE; SUPEROXIDE; THIOREDOXIN; THIOREDOXIN REDUCTASE;

APOPTOSIS; ARTICLE; CELL GROWTH; CONTROLLED STUDY; CYTOSOL; DNA SYNTHESIS; DRUG TARGETING; ELECTRON; ESCHERICHIA COLI; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CYTOSOL; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; EDETIC ACID; ELECTRONS; ESCHERICHIA COLI; HUMANS; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; INSULIN; KINETICS; METALLOPORPHYRINS; MODELS, CHEMICAL; NADP; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN; PROTEIN BINDING; RATS; REACTIVE OXYGEN SPECIES; RIBONUCLEOTIDE REDUCTASES; SPECTROPHOTOMETRY; THIOREDOXIN; THIOREDOXIN REDUCTASE (NADPH); TIME FACTORS;

ESCHERICHIA COLI; MAMMALIA;

EID: 33744956073     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M511373200     Document Type: Article

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