Priming of T cells to Fas-mediated proliferative signals by interleukin-7

Blood

Volumn 112, Issue 4, 2008, Pages 1195-1204

  Rethi, Bence ^a,b   Vivar, Nancy ^a   Sammicheli, Stefano ^a   Fluur, Caroline ^a   Ruffin, Nicolas ^a   Atlas, Ann ^c   Rajnavolgyi, Eva ^b   Chiodi, Francesca ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; FAS ANTIGEN; INTERLEUKIN 7; T LYMPHOCYTE RECEPTOR;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL EXPANSION; CELL PROLIFERATION; CELL REGENERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T CELL DEPLETION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANTIGEN PRESENTATION; CASE CONTROL STUDY; CYTOLOGY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; LYMPHOCYTOPENIA; METABOLISM;

ANTIGEN PRESENTATION; ANTIGENS, CD95; APOPTOSIS; CASE-CONTROL STUDIES; CELL PROLIFERATION; FEMALE; HIV INFECTIONS; HUMANS; INTERLEUKIN-7; LYMPHOPENIA; MALE; T-LYMPHOCYTES;

EID: 51649123313     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-12-126698     Document Type: Article

References (62)

1. Goldrath AW, Bevan MJ. Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity. 1999;11:183-190.
2. Kieper WC. Jameson SC. Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands. Proc Natl Acad Sci U SA. 1999;96:13306-13311.
3. Hakim FT, Gress RE. Reconstitution of the lymphocyte compartment after lymphocyte depletion: a key issue in clinical immunology. Eur J Immunol. 2005;35:3099-3102.
4. Fry TJ, Christensen BL, Komschlies KL, Gress RE, Mackall CL. lnterleukin-7 restores immunity in athymic T-cell-depleted hosts. Blood. 2001 ;97:1525-1533.
5. Stockinger B, Kassiotis G, Bourgeois C. Homeostasis and T cell regulation. Curr Opin Immunol. 2004;16:775-779.
6. Krupica T Jr, Fry TJ, Mackall CL. Autoimmunity during lymphopenia: a two-hit model. Clin Immunol. 2006;120:121-128.
7. Wu Z, Bensinger SJ, Zhang J, et al. Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med. 2004;10:87-92.
8. Hakim FT, Cepeda R, Kaimei S, et al. Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells. Blood. 1997;90:3789-3798.
9. Brugnoni D, Airo P, Pennacchio M, et al. Immune reconstitution after bone marrow transplantation for combined immunodeficiencies: down-modulation of Bcl-2 and high expression of CD95/Fas account for increased susceptibility to spontaneous and activation-induced lymphocyte cell death. Bone Marrow Transplant. 1999;23:451-457.
10. Mazzucchelli R, Durum SK. lnterleukin-7 receptor expression: intelligent design. Nat Rev Immunol. 2007;7:144-154.
11. Stranges PB, Watson J, Gooper CJ, et al. Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity. 2007;26:629-641.
12. Boudet F, Lecoeur H, Gougeon ML. Apoptosis associated with ex vivo down-regulation of Bcl-2 and up-regulation of Fas in potential cytotoxic CD8+ T lymphocytes during HIV infection. J Immunol. 1996:156:2282-2293.
13. Baumler CB, BohlerT, Herr I, Benner A, Krammer PH, Debatin KM. Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children. Blood. 1996;88:1741-1746.
14. Fluur C, De Milito A, Fry TJ, et al. Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection. J Immunol. 2007;178:5340-5350.
15. Silvestris F, Cafforio P, Frassanito MA, et al. Overexpression of Fas antigen on T cells in advanced HIV-1 infection: differential ligation constantly induces apoptosis. AIDS. 1996;10:131-141.
16. Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA, Herzenberg LA. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med. 1995;181:2029-2036.
17. Sloand EM, Young NS, Kumar P, Weichold FF, Sato T Maciejewski J P. Role of Fas ligand and receptor in the mechanism of T-cell depletion in acquired immunodeficiency syndrome: effect on CD4+ lymphocyte depletion and human immunodeficiency virus replication. Blood. 1997;89:1357-1363.
18. Fortner KA, Budd RC. The death receptor Fas (CD95/APO-1) mediates the deletion of T lymphocytes undergoing homeostatic proliferation. J Immunol. 2005;175:4374-4382.
19. Desbarats J, Birge RB, Mimouni-Rongy M, Weinstein DE, Palerme JS, Newell MK. Fas engagement induces neurite growth through ERK activation and p35 upregulation. Nat Cell Biol. 2003;5:118-125.
20. Desbarats J, Newell MK. Fas engagement accelerates liver regeneration after partial hepatec-toiny. Nat Med. 2000;6:920-923.
21. Effros RB. Impact of the Hayflick Limit on T cell responses to infection: lessons from aging and HIV disease. Mech Ageing Dev. 2004;125:103-106.
22. Rescigno M. Piguet V, Valzasina B. et al. Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1 beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory responses. J Exp Med. 2000:192:1661-1668.
23. Guo Z, Zhang M, Tang H, Cao X. Fas signal links innate and adaptive immunity by promoting dendritic-cell secretion of CC and CXC chemokines. Blood. 2005;106:2033-2041.
24. Alderson MR, Armitage RJ, Maraskovsky E, et al. Fas transduces activation signals in normal human T lymphocytes. J Exp Med. 1993;178:2231-2235.
25. Kennedy NJ, Kataoka T. Tschopp J, Budd RC. Caspase activation is required for T cell proliferation. J Exp Med. 1999;190:1891-1896.
26. Alam A, Cohen LY, Aouad S, Sekaly RP. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells. J Exp Med. 1999;190:1879-1890.
27. Maksimow M, Soderstrom TS, Jalkanen S, Eriksson JE, Hanninen A. Fas costimulation of naive CD4T cells is controlled by NF-kappaB signaling and caspase activity. J Leukoc Biol. 2006;79:369-377.
28. Maksimow M, Santanen M, Jalkanen S, Hanninen A. Responding naive T cells differ in their sensitivity to Fas engagement: early death of many T cells is compensated by costimulation of surviving T cells. Blood. 2003; 101:4022-4028.
29. Klas C, Debatin KM, Jonker RR, Krammer PH. Activation interferes with the APO-1 pathway in mature human Tcells. Int Immunol. 1993;5:625-630.
30. Latinis KM, Carr LL, Peterson EJ, Norian LA, Eliason SL, Koretzky GA. Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events. J Immunol. 1997;158:4602-4611.
31. Muppidi JR. Siegel RM. Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death. Nat Immunol. 2004;5:182-189.
32. Parlato S, Giammarioli AM, Logozzi M. et al. CD95 (APO-1/Fas) linkage to the actin cytoskel-eton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway. EMBO J. 2000; 19:5123-5134.
33. Refaeli Y, Van Parijs L, London CA, Tschopp J, Abbas AK. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity. 1998;8:615-623.
34. Jaleco S, Swainson L, Dardalhon V, Burjanadze M, Kinet S, Taylor N. Homeostasis of naive and memory GD4+ T cells: IL-2 and IL-7 differentially regulate the balance between proliferation and Fas-mediated apoptosis. J Immunol. 2003;171:61-68.
35. Lelievre JD, Petit F, Arnoult D, Ameisen JC, Estaquier J. Interleukin 7 increases human immunodeficiency virus type 1 LAI-mediated Fas-induced T-cell death. J Virol. 2005;79:3195-3199.
36. Bolotin E, Annett G, Parkman R, Weinberg K. Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant. 1999;23:783-788.
37. LlanoA, Barretina J, GutierrezA, et al. lnterleukin-7 in plasma correlates with CD4 T-cell depletion and may be associated with emergence of syncytium-inducing variants in human immunodeficiency virus type 1 -positive individuals. J Virol. 2001 ;75:10319-10325.
38. Mastroianni CM, Forcina G, d'Ettorre G, et al. Circulating levels of interleukin-7 in anti retro viral-naive and highly active anti retroviral therapy-treated HIV-infected patients. HIV Clin Trials. 2001 ;2:108-112.
39. Napolitano LA, Grant RM, Deeks SG, et al. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med. 2001 ;7:73-79.
40. Rethi B, Fluur C, Atlas A, et al. Loss of IL-7Ralpha is associated with CD4T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients. AIDS. 2005;19:2077-2086.
41. Margolick JB, Munoz A, Donnenberg AD, et al. Failure of T-cell homeostasis preceding AIDS in HIV-1 infection: The Multicenter AIDS Cohort Study. Nat Med. 1995;1:674-680.
42. Managlia EZ, Landay A, Al-Harthi L. Interleukin-7 signalling is sufficient to phenotypically and functionally prime human GD4 naive Tcells. Immunology. 2005;114:322-335.
43. Carini C, McLane MF, Mayer KH, Essex M. Dys-regulation of interleukin-7 receptor may generate loss of cytotoxic T cell response in human immunodeficiency virus type 1 infection. Eur J Immunol. 1994;24:2927-2934.
44. MacPherson PA, Fex C, Sanchez-Dardon J, Hawley-Foss N, Angel JB. Interleukin-7 receptor expression on CD8( + ) T cells is reduced in HIV infection and partially restored with effective anti-retroviral therapy. J Acquir Immune Defic Syndr. 2001 ;28:454-457.
45. Paiardini M, Cervasi B, Albrecht H, et al. Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals. J Immunol. 2005;174:2900-2909.
46. Revy P, Sospedra M, Barbour B, Trautmann A. Functional antigen-independent synapses formed between Tcells and dendritic cells. Nat Immunol. 2001;2:925-931.
47. KondoT, Cortese I, Markovic-Plese S, et al. Dendritic cells signal T cells in the absence of exogenous antigen. Nat Immunol. 2001 ;2:932-938.
48. Ameisen JC, Capron A. Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis. Immunol Today. 1991;12:102-105.
49. Gougeon ML. To kill or be killed: how HIV exhausts the immune system. Cell Death Differ. 2005;12(suppl 1):845-854.
50. Meyaard L, Otto SA, Jonker RR, Mijnster MJ, Keet RP, Miedema F. Programmed death of Tcells in HIV-1 infection. Science. 1992;257:217-219.
51. Finkel TH, Tudor-Williams G, Banda NK, et al. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV-and SIV-infected lymph nodes. Nat Med. 1995:1:129-134.
52. Giorgi JV, Hultin LE, McKeating JA, et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis. 1999;179:859-870.
53. Sousa AE, Carneiro J. Meier-Schellersheim M, Grossman Z, Victorino RM. CD4Tcell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load. J Immunol. 2002;169:3400-3406.
54. Gordon SN, Klatt NR, Bosinger SE, et al. Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. J Immunol. 2007;179:3026-3034.
55. Silvestri G, Sodora DL, Koup RA, et al. Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopa-thology despite chronic high-level viremia. Immunity. 2003;18:441-452.
56. Gleeson PA, Toh BH, van Driel IR. Organ-specific autoimmunity induced by lymphopenia. Immunol Rev. 1996;149:97-125.
57. Sleasman JW. The association between immunodeficiency and the development of autoimmune disease. Adv Dent Res. 1996;10:57-61.
58. Rosenberg SA, Sportes C, Ahmadzadeh M, et al. IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells. J Immunother (1997). 2006:29:313-319.
59. Beq S, Nugeyre MT, Ho Tsong Fang R, et al. IL-7 induces immunological improvement in SIV-infected rhesus macaques under antiviral therapy. J Immunol. 2006;176:914-922.
60. Nugeyre MT, Monceaux V, Beq S, et al. IL-7 stimulates T cell renewal without increasing viral replication in simian immunodeficiency virus-infected macaques. J Immunol. 2003;171:4447-4453.
61. Mackall CL, Fleisher TA, Brown MR, et al. Distinctions between GD8+ and CD4+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy. Blood. 1997:89:3700-3707.
62. Alderson MR, ToughTW, Braddy S, et al. Regulation of apoptosis and T cell activation by Fas-specific mAb. Int Immunol. 1994;6:1799-1806.