Low production of interferon γ is related to disease progression in HIV infection: Evidence from a cohort of 347 HIV-infected individuals

AIDS Research and Human Retroviruses

Volumn 13, Issue 12, 1997, Pages 1039-1046

  Ullum, Henrik ^a   Lepri, Alessandro Cozzi ^b   Benutzen, Klaus ^a   Victor, Jette ^a   Gøtzsche, Peter C ^a   Phillips, Andrew N ^b   Skinhøj, Peter ^a   Pedersen, Bente Klarlund ^a  

^a Rigshospitalet   (Denmark)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CD16 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADOLESCENT; ADULT; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERFERON PRODUCTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL; RISK FACTOR; SURVIVAL;

EID: 0030755645     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.1997.13.1039     Document Type: Article

References (22)

1. Howard CM, Miyajima A, and Coffman R: T-cell-derived cytokines and their receptors. In: Fundamental Immunology (Paul WE III, ed.). Raven Press, New York, 1993, pp. 763-778.
2. Poli G and Fauci AS: Role of cytokines in the pathogenesis of human immunodeficiency virus infection. In: Human Cytokines and Their Role in Health and Human Disease (Aggarwal BB and Puri RK, eds.). Blackwell Scientific, Cambridge, Massachusetts, 1995, pp. 421-450.
3. Vyakarnam A, Matear P, Meager A, et al.: Altered production of tumour necrosis factors alpha and beta and interferon gamma by HIV-infected individuals. Clin Exp Immunol 1991;84:109-115.
4. Graziosi C, Pantaleo G, Gantt KR, et al.: Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. Science 1994;265:248-252.
5. Navikas V, Link J, Wahren B, Persson C, and Link H: Increased levels of interferon-gamma (IFN-gamma), IL-4 and transforming growth factor-beta (TGF-beta) mRNA expressing blood mononuclear cells in human HIV infection. Clin Exp Immunol 1994;96:59-63.
6. Fan J, Bass HZ, and Fahey JL: Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection. J Immunol 1993;151:5031-5040.
7. Caruso A, Canaris AD, Licenziati S, et al.: CD4+ and CD8+ lymphocytes of patients with AIDS synthesize increased amounts of interferon-gamma. J Acquir Immune Defic Syndr Hum Retroviral 1995;10:462-470.
8. Rossol S, Voth R, Laubenstein HP, et al.: Interferon production in patients infected with HIV-1. J Infect Dis 1989;159:815-821.
9. Voth R, Rossol S, Klein K, et al.: Differential gene expression of IFN-alpha and tumor necrosis factor-alpha in peripheral blood mononuclear cells from patients with AIDS related complex and AIDS. J Immunol 1990;144:970-975.
10. Barcellini W, Rizzardi GP, Borghi MO, Fain C, Lazzarin A, and Meroni PL: TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients. AIDS 1994; 8:757-762.
11. Diaz Mitoma F, Kumar A, Karimi S, et al.: Expression of IL-10, IL-4 and interferon-gamma in unstimulated and mitogen-stimulated peripheral blood lymphocytes from HIV-seropositive patients. Clin Exp Immunol 1995;102:31-39.
12. Salvaggio A, Balotta C, Galli M, and Clerici M: CD4 count in HIV infection is positively correlated to interferon-gamma and negatively correlated interleukin-10 in vitro production. AIDS 1996; 10:449-451.
13. Barcellini W, Rizzardi GP, Velati C, et al.: In vitro production of type 1 and 2 cytokines by peripheral blood mononuclear cells from high-risk HIV-negative intravenous drug users. AIDS 1995; 9:691-694.
14. Gerosa F, Paganin C, Peritt D, et al.: Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10. J Exp Med 1996;183:2559-2569.
15. Ullum H, Gøtzsche PC, Victor J, Dickmeiss E, Skinhøj P, and Pedersen BK: Defective natural immunity - an early manifestation of human immunodeficiency virus infection. J Exp Med 1995; 182:789-800.
16. Phillips AN, Lazzarin A, Gonzales Lahoz J, et al.: Factors associated with the CD4+ lymphocyte count at diagnosis of acquired immunodeficiency syndrome. The AIDS in Europe Study Group. J Clin Epidemiol 1996;49:1253-1258.
17. Jassoy C, Harrer T, Rosenthal T, et al.: Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens. J Virol 1993;67:2844-2852.
18. Lolli F, Chen LB, Sundqvist VA, Link H, Holmberg V, and Wahren B: HIV antigen-reactive T cells detected by antigen-induced interferon gamma secretion. AIDS Res Hum Retroviruses 1994;10:115-120.
19. Jassoy C, Heinkelein M, Klinker H, and Walker BD: HIV type 1-specific cytotoxic T lymphocytes stimulate HLA class I and intercellular adhesion molecule type 1 expression and increase beta 2-microglobulin levels in vitro. AIDS Res Hum Retroviruses 1994; 10:1685-1693.
20. Price P, Johnson RP, Scadden DT, et al.: Cytotoxic CD8+ T lymphocytes reactive with human immunodeficiency virus-1 produce granulocyte/macrophage colony-stimulating factor and variable amounts of interleukins 2, 3, and 4 following stimulation with the cognate epitope. Clin Immunol Immunopathol 1995;74:100-106.
21. Brookmeyer R, Gail MH, and Polk BF: The prevalent cohort study and the acquired immunodeficiency syndrome. Am J Epidemiol 1987;126:14-24.
22. Phillips AN, Pezzotti P, Cozzi Lepri A, and Rezza G: CD4 lymphocyte count as a determinant of the time from HIV seroconversion to AIDS and death from AIDS: Evidence from the Italian Seroconversion Study. AIDS 1994;8:1299-1305.