The HAG mechanism: A molecular rationale for the therapeutic application of iron chelators in human diseases involving the 2-oxoacid utilizing dioxygenases

Current Medicinal Chemistry

Volumn 10, Issue 12, 2003, Pages 1005-1019

  Hanauske Abel, Hartmut M ^a   Popowicz, Anthony M ^b  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Cancer; Cell cycle; Dioxygenase; Drug design; Fibrosis; HIV; Non heme iron; Prolyl 4 hydroxylase

Indexed keywords

2 OXOACID; 2 OXOGLUTARIC ACID; 4 HYDROXYPHENYLPYRUVATE DIOXYGENASE; ANTIDIABETIC AGENT; ANTIFIBROTIC AGENT; APOENZYME; ASCORBIC ACID; ATROPINE; CARNITINE; CEPHALOSPORIN DERIVATIVE; CICLOPIROX; COLLAGEN; DEFERIPRONE; DEFEROXAMINE; DIURETIC AGENT; ENDOTOXIN; ENZYME INHIBITOR; FIBRILLIN; GIBBERELLIN; GROWTH HORMONE; HEME; IRON; IRON CHELATING AGENT; LIDOCAINE; LIGAND; MESSENGER RNA; OXYGENASE; PHYTOHORMONE; SULFONAMIDE; UNINDEXED DRUG;

ANGIOGENESIS; BETA THALASSEMIA; BIOCATALYST; CARCINOGENESIS; CATALYSIS; CELL HYPOXIA; CITRIC ACID CYCLE; CLINICAL TRIAL; COMPLEX FORMATION; DNA ALKYLATION; DNA REPAIR; DNA REPLICATION; DRUG DESIGN; DRUG MECHANISM; FAMILIAL DISEASE; FIBROSIS; HUMAN; IRON CHELATION; NONHUMAN; OXYGEN CONSUMPTION; PHYSICAL CHEMISTRY; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; REVIEW; RNA TRANSLATION; SCAR FORMATION; VIRUS INFECTION;

ANIMALS; CATALYSIS; CHEMISTRY, PHYSICAL; ENZYME INHIBITORS; HUMANS; IRON CHELATING AGENTS; METAL METABOLISM, INBORN ERRORS; OXYGEN; OXYGENASES;

EID: 0038324399     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867033457601     Document Type: Review

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