-
1
-
-
0028025654
-
A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily
-
Apfel R, Benbrook D, Lernhardt E, et al. A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol Cell Biol 1994;14:7025-35
-
(1994)
Mol Cell Biol
, vol.14
, pp. 7025-7035
-
-
Apfel, R.1
Benbrook, D.2
Lernhardt, E.3
-
2
-
-
0028918963
-
OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor
-
Teboul M, Enmark E, Li Q, et al. OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor. Proc Natl Acad Sci USA 1995;92:2096-100
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 2096-2100
-
-
Teboul, M.1
Enmark, E.2
Li, Q.3
-
3
-
-
0029805887
-
An oxysterol signalling pathway mediated by the nuclear receptor LXRα
-
DOI 10.1038/383728a0
-
Janowski BA, Willy PJ, Devi TR, et al. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 1996;383:728-31 (Pubitemid 26360651)
-
(1996)
Nature
, vol.383
, Issue.6602
, pp. 728-731
-
-
Janowski, B.A.1
Willy, P.J.2
Devi, T.R.3
Falck, J.R.4
Mangelsdorf, D.J.5
-
4
-
-
14444285707
-
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
-
DOI 10.1074/jbc.272.6.3137
-
Lehmann JM, Kliewer SA, Moore LB, et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem 1997;272:3137-40 (Pubitemid 27066798)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.6
, pp. 3137-3140
-
-
Lehmann, J.M.1
Kliewer, S.A.2
Moore, L.B.3
Smith-Oliver, T.A.4
Oliver, B.B.5
Su, J.-L.6
Sundseth, S.S.7
Winegar, D.A.8
Blanchard, D.E.9
Spencer, T.A.10
Willson, T.M.11
-
5
-
-
84857139806
-
Selective liver X receptor modulators (SLiMs): What use in human health?
-
Viennois E, Mouzat K, Dufour J, et al. Selective liver X receptor modulators (SLiMs): what use in human health? Mol Cell Endocrinol 2012;351:129-41
-
(2012)
Mol Cell Endocrinol
, vol.351
, pp. 129-141
-
-
Viennois, E.1
Mouzat, K.2
Dufour, J.3
-
6
-
-
0034284918
-
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
-
Repa JJ, Turley SD, Lobaccaro JA, et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 2000;289:1524-9
-
(2000)
Science
, vol.289
, pp. 1524-1529
-
-
Repa, J.J.1
Turley, S.D.2
Lobaccaro, J.A.3
-
7
-
-
0037046543
-
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines
-
DOI 10.1021/jm0255116
-
Collins JL, Fivush AM, Watson MA, et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem 2002;45:1963-6 (Pubitemid 34477709)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.10
, pp. 1963-1966
-
-
Collins, J.L.1
Fivush, A.M.2
Watson, M.A.3
Galardi, C.M.4
Lewis, M.C.5
Moore, L.B.6
Parks, D.J.7
Wilson, J.G.8
Tippin, T.K.9
Binz, J.G.10
Plunket, K.D.11
Morgan, D.G.12
Beaudet, E.J.13
Whitney, K.D.14
Kliewer, S.A.15
Willson, T.M.16
-
8
-
-
77951116509
-
Discovery of tertiary sulfonamides as potent liver X receptor antagonists
-
Zuercher WJ, Buckholz RG, Campobasso N, et al. Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J Med Chem 2010;53:3412-16
-
(2010)
J Med Chem
, vol.53
, pp. 3412-3416
-
-
Zuercher, W.J.1
Buckholz, R.G.2
Campobasso, N.3
-
9
-
-
77951140849
-
Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist
-
Hu B, Unwalla RJ, Goljer I, et al. Identification of phenylsulfone- substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist. J Med Chem 2010;53:3296-304
-
(2010)
J Med Chem
, vol.53
, pp. 3296-3304
-
-
Hu, B.1
Unwalla, R.J.2
Goljer, I.3
-
10
-
-
77950911589
-
Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo
-
Yasuda T, Grillot D, Billheimer JT. Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo. Arterioscler Thromb Vasc Biol 2010;30:781-6
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, pp. 781-786
-
-
Yasuda, T.1
Grillot, D.2
Billheimer, J.T.3
-
11
-
-
34047132823
-
Further modification on phenyl acetic acid based quinolines as liver X receptor modulators
-
DOI 10.1016/j.bmc.2007.03.013, PII S0968089607002027
-
Hu B, Jetter J, Kaufman D, et al. Further modification on phenyl acetic acid based quinolines as liver X receptor modulators. Bioorg Med Chem 2007;15:3321-33 (Pubitemid 46529263)
-
(2007)
Bioorganic and Medicinal Chemistry
, vol.15
, Issue.10
, pp. 3321-3333
-
-
Hu, B.1
Jetter, J.2
Kaufman, D.3
Singhaus, R.4
Bernotas, R.5
Unwalla, R.6
Quinet, E.7
Savio, D.8
Halpern, A.9
Basso, M.10
Keith, J.11
Clerin, V.12
Chen, L.13
Liu, Q.-Y.14
Feingold, I.15
Huselton, C.16
Azam, F.17
Goos-Nilsson, A.18
Wilhelmsson, A.19
Nambi, P.20
Wrobel, J.21
more..
-
12
-
-
52449127472
-
Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity
-
Chao EY, Caravella JA, Watson MA, et al. Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. J Med Chem 2008;51:5758-65
-
(2008)
J Med Chem
, vol.51
, pp. 5758-5765
-
-
Chao, E.Y.1
Caravella, J.A.2
Watson, M.A.3
-
13
-
-
84875171894
-
A liver-selective LXR inverse agonist that suppresses hepatic steatosis
-
Griffett K, Solt LA, El-Gendy Bel D, et al. A liver-selective LXR inverse agonist that suppresses hepatic steatosis. ACS Chem Biol 2013;8:559-67
-
(2013)
ACS Chem Biol
, vol.8
, pp. 559-567
-
-
Griffett, K.1
Solt, L.A.2
El-Gendy Bel, D.3
-
14
-
-
33644651160
-
Liver X receptors as integrators of metabolic and inflammatory signaling
-
DOI 10.1172/JCI27883
-
Zelcer N, Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest 2006;116:607-14 (Pubitemid 43326865)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.3
, pp. 607-614
-
-
Zelcer, N.1
Tontonoz, P.2
-
15
-
-
0142223221
-
The three-dimensional structure of the liver X receptor β reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands
-
DOI 10.1074/jbc.M304842200
-
Farnegardh M, Bonn T, Sun S, et al. The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. J Biol Chem 2003;278:38821-8 (Pubitemid 37229066)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.40
, pp. 38821-38828
-
-
Farnegardh, M.1
Bonn, T.2
Sun, S.3
Ljunggren, J.4
Ahola, H.5
Wilhelmsson, A.6
Gustafsson, J.-A.7
Carlquist, M.8
-
16
-
-
0141737105
-
Crystal structure of the heterodimeric complex of LXRα and RXRβ ligand-binding domains in a fully agonistic conformation
-
DOI 10.1093/emboj/cdg456
-
Svensson S, Ostberg T, Jacobsson M, et al. Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation. Embo J 2003;22:4625-33 (Pubitemid 37162899)
-
(2003)
EMBO Journal
, vol.22
, Issue.18
, pp. 4625-4633
-
-
Svensson, S.1
Ostberg, T.2
Jacobsson, M.3
Norstrom, C.4
Stefansson, K.5
Hallen, D.6
Johansson, I.C.7
Zachrisson, K.8
Ogg, D.9
Jendeberg, L.10
-
17
-
-
0043133791
-
Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression
-
DOI 10.1128/MCB.23.16.5780-5789.2003
-
Wagner BL, Valledor AF, Shao G, et al. Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression. Mol Cell Biol 2003;23:5780-9 (Pubitemid 36951340)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.16
, pp. 5780-5789
-
-
Wagner, B.L.1
Valledor, A.F.2
Shao, G.3
Daige, C.L.4
Bischoff, E.D.5
Petrowski, M.6
Jepsen, K.7
Baek, S.H.8
Heyman, R.A.9
Rosenfeld, M.G.10
Schulman, I.G.11
Glass, C.K.12
-
18
-
-
65649129652
-
GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus
-
Jakobsson T, Venteclef N, Toresson G, et al. GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus. Mol Cell 2009;34:510-18
-
(2009)
Mol Cell
, vol.34
, pp. 510-518
-
-
Jakobsson, T.1
Venteclef, N.2
Toresson, G.3
-
19
-
-
84856777771
-
Genome-wide profiling of LXR, RXR and PPARalpha in mouse liver reveals extensive sharing of binding sites
-
Boergesen M, Pedersen TA, Gross B, et al. Genome-wide profiling of LXR, RXR and PPARalpha in mouse liver reveals extensive sharing of binding sites. Mol Cell Biol 2012;32:852-67
-
(2012)
Mol Cell Biol
, vol.32
, pp. 852-867
-
-
Boergesen, M.1
Pedersen, T.A.2
Gross, B.3
-
20
-
-
84856316797
-
Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages
-
Pehkonen P, Welter-Stahl L, Diwo J, et al. Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages. BMC Genomics 2012;13:50
-
(2012)
BMC Genomics
, vol.13
, pp. 50
-
-
Pehkonen, P.1
Welter-Stahl, L.2
Diwo, J.3
-
21
-
-
77952567987
-
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
-
Heinz S, Benner C, Spann N, et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 2010;38:576-89
-
(2010)
Mol Cell
, vol.38
, pp. 576-589
-
-
Heinz, S.1
Benner, C.2
Spann, N.3
-
22
-
-
34948883324
-
SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
-
DOI 10.1016/j.molcel.2007.07.032, PII S109727650700620X
-
Li X, Zhang S, Blander G, et al. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell 2007;28:91-106 (Pubitemid 47531974)
-
(2007)
Molecular Cell
, vol.28
, Issue.1
, pp. 91-106
-
-
Li, X.1
Zhang, S.2
Blander, G.3
Tse, J.G.4
Krieger, M.5
Guarente, L.6
-
23
-
-
64749084839
-
Liver X receptor ligands suppress ubiquitination and degradation of LXRalpha by displacing BARD1/BRCA1
-
Kim KH, Yoon JM, Choi AH, et al. Liver X receptor ligands suppress ubiquitination and degradation of LXRalpha by displacing BARD1/BRCA1. Mol Endocrinol 2009;23:466-74
-
(2009)
Mol Endocrinol
, vol.23
, pp. 466-474
-
-
Kim, K.H.1
Yoon, J.M.2
Choi, A.H.3
-
24
-
-
33747867030
-
Phosphorylation of the liver X receptors
-
DOI 10.1016/j.febslet.2006.07.074, PII S0014579306009306
-
Chen M, Bradley MN, Beaven SW, et al. Phosphorylation of the liver X receptors. FEBS Lett 2006;580:4835-41 (Pubitemid 44286840)
-
(2006)
FEBS Letters
, vol.580
, Issue.20
, pp. 4835-4841
-
-
Chen, M.1
Bradley, M.N.2
Beaven, S.W.3
Tontonoz, P.4
-
25
-
-
42149194355
-
Phosphorylation of liver X receptor α selectively regulates target gene expression in macrophages
-
DOI 10.1128/MCB.01575-07
-
Torra IP, Ismaili N, Feig JE, et al. Phosphorylation of liver X receptor alpha selectively regulates target gene expression in macrophages. Mol Cell Biol 2008;28:2626-36 (Pubitemid 351542363)
-
(2008)
Molecular and Cellular Biology
, vol.28
, Issue.8
, pp. 2626-2636
-
-
Torra, I.P.1
Ismaili, N.2
Feig, J.E.3
Xu, C.-F.4
Cavasotto, C.5
Pancratov, R.6
Rogatsky, I.7
Neubert, T.A.8
Fisher, E.A.9
Garabedian, M.J.10
-
26
-
-
34249721531
-
Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver
-
DOI 10.1074/jbc.M611911200
-
Yamamoto T, Shimano H, Inoue N, et al. Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver. J Biol Chem 2007;282:11687-95 (Pubitemid 47100691)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.16
, pp. 11687-11695
-
-
Yamamoto, T.1
Shimano, H.2
Inoue, N.3
Nakagawa, Y.4
Matsuzaka, T.5
Takahashi, A.6
Yahagi, N.7
Sone, H.8
Suzuki, H.9
Toyoshima, H.10
Yamada, N.11
-
27
-
-
76249092371
-
Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose
-
Anthonisen EH, Berven L, Holm S, et al. Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose. J Biol Chem 2010;285:1607-15
-
(2010)
J Biol Chem
, vol.285
, pp. 1607-1615
-
-
Anthonisen, E.H.1
Berven, L.2
Holm, S.3
-
28
-
-
33845970925
-
Parallel SUMOylation-Dependent Pathways Mediate Gene- and Signal-Specific Transrepression by LXRs and PPARγ
-
DOI 10.1016/j.molcel.2006.11.022, PII S1097276506008161
-
Ghisletti S, Huang W, Ogawa S, et al. Parallel SUMOylation-dependent pathways mediate gene-and signal-specific transrepression by LXRs and PPARgamma. Mol Cell 2007;25:57-70 (Pubitemid 46049061)
-
(2007)
Molecular Cell
, vol.25
, Issue.1
, pp. 57-70
-
-
Ghisletti, S.1
Huang, W.2
Ogawa, S.3
Pascual, G.4
Lin, M.-E.5
Willson, T.M.6
Rosenfeld, M.G.7
Glass, C.K.8
-
29
-
-
79960918745
-
Metabolic nuclear receptor signaling and the inflammatory acute phase response
-
Venteclef N, Jakobsson T, Steffensen KR, et al. Metabolic nuclear receptor signaling and the inflammatory acute phase response. Trends Endocrinol Metab 2011;22:333-43
-
(2011)
Trends Endocrinol Metab
, vol.22
, pp. 333-343
-
-
Venteclef, N.1
Jakobsson, T.2
Steffensen, K.R.3
-
30
-
-
24144465889
-
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
-
DOI 10.1016/j.cell.2005.06.029, PII S0092867405006483
-
Ogawa S, Lozach J, Benner C, et al. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell 2005;122:707-21 (Pubitemid 41242636)
-
(2005)
Cell
, vol.122
, Issue.5
, pp. 707-721
-
-
Ogawa, S.1
Lozach, J.2
Benner, C.3
Pascual, G.4
Tangirala, R.K.5
Westin, S.6
Hoffmann, A.7
Subramaniam, S.8
David, M.9
Rosenfeld, M.G.10
Glass, C.K.11
-
31
-
-
70349191359
-
Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes
-
Lee JH, Park SM, Kim OS, et al. Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes. Mol Cell 2009;35:806-17
-
(2009)
Mol Cell
, vol.35
, pp. 806-817
-
-
Lee, J.H.1
Park, S.M.2
Kim, O.S.3
-
32
-
-
84858796689
-
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR, Nature reviews
-
Calkin AC, Tontonoz P. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR. Nature reviews. Mol Cell Biol 2012;13:213-24
-
(2012)
Mol Cell Biol
, vol.13
, pp. 213-224
-
-
Calkin, A.C.1
Tontonoz, P.2
-
33
-
-
84862687669
-
Liver X receptor biology and pharmacology: New pathways, challenges and opportunities
-
Jakobsson T, Treuter E, Gustafsson JA, et al. Liver X receptor biology and pharmacology: new pathways, challenges and opportunities. Trends Pharmacol Sci 2012;33:394-404
-
(2012)
Trends Pharmacol Sci
, vol.33
, pp. 394-404
-
-
Jakobsson, T.1
Treuter, E.2
Gustafsson, J.A.3
-
34
-
-
84870783499
-
Lipid metabolism and neuroinflammation in Alzheimer's disease: A role for liver X receptors
-
Kang J, Rivest S. Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors. Endocr Rev 2012;33:715-46
-
(2012)
Endocr Rev
, vol.33
, pp. 715-746
-
-
Kang, J.1
Rivest, S.2
-
35
-
-
84871871419
-
Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis
-
Zhang L, Reue K, Fong LG, et al. Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis. Arterioscler Thromb Vasc Biol 2012;32:2541-6
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 2541-2546
-
-
Zhang, L.1
Reue, K.2
Fong, L.G.3
-
36
-
-
36849011221
-
Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice
-
DOI 10.1172/JCI33372
-
Yvan-Charvet L, Ranalletta M, Wang N, et al. Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J Clin Invest 2007;117:3900-8 (Pubitemid 350224099)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.12
, pp. 3900-3908
-
-
Yvan-Charvet, L.1
Ranalletta, M.2
Wang, N.3
Han, S.4
Terasaka, N.5
Li, R.6
Welch, C.7
Tall, A.R.8
-
37
-
-
34547700634
-
Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo
-
DOI 10.1172/JCI32057
-
Wang X, Collins HL, Ranalletta M, et al. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest 2007;117:2216-24 (Pubitemid 47219566)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.8
, pp. 2216-2224
-
-
Wang, X.1
Collins, H.L.2
Ranalletta, M.3
Fuki, I.V.4
Billheimer, J.T.5
Rothblat, G.H.6
Tall, A.R.7
Rader, D.J.8
-
38
-
-
33644865172
-
Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo
-
DOI 10.1161/CIRCULATIONAHA.105.560177, PII 0000301720060103000015
-
Naik SU, Wang X, Da Silva JS, et al. Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo. Circulation 2006;113:90-7 (Pubitemid 43958493)
-
(2006)
Circulation
, vol.113
, Issue.1
, pp. 90-97
-
-
Naik, S.U.1
Wang, X.2
Da Silva, J.S.3
Jaye, M.4
Macphee, C.H.5
Reilly, M.P.6
Billheimer, J.T.7
Rothblat, G.H.8
Rader, D.J.9
-
39
-
-
0034669025
-
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
-
Repa JJ, Liang G, Ou J, et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 2000;14:2819-30
-
(2000)
Genes Dev
, vol.14
, pp. 2819-2830
-
-
Repa, J.J.1
Liang, G.2
Ou, J.3
-
40
-
-
34547652884
-
Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoE
-
DOI 10.1172/JCI31909
-
Bradley MN, Hong C, Chen M, et al. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest 2007;117:2337-46 (Pubitemid 47219578)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.8
, pp. 2337-2346
-
-
Bradley, M.N.1
Hong, C.2
Chen, M.3
Joseph, S.B.4
Wilpitz, D.C.5
Wang, X.6
Lusis, A.J.7
Collins, A.8
Hseuh, W.A.9
Collins, J.L.10
Tangirala, R.K.11
Tontonoz, P.12
-
41
-
-
77950911589
-
Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo
-
Yasuda T, Grillot D, Billheimer JT, et al. Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo. Arterioscler Thromb Vasc Biol 2010;30:781-6
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, pp. 781-786
-
-
Yasuda, T.1
Grillot, D.2
Billheimer, J.T.3
-
42
-
-
78651346813
-
Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis
-
Lo Sasso G, Murzilli S, Salvatore L, et al. Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis. Cell Metab 2010;12:187-93
-
(2010)
Cell Metab
, vol.12
, pp. 187-193
-
-
Lo Sasso, G.1
Murzilli, S.2
Salvatore, L.3
-
43
-
-
78649867645
-
LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression
-
Feig JE, Pineda-Torra I, Sanson M, et al. LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression. J Clin Invest 2010;120:4415-24
-
(2010)
J Clin Invest
, vol.120
, pp. 4415-4424
-
-
Feig, J.E.1
Pineda-Torra, I.2
Sanson, M.3
-
44
-
-
5444235922
-
LXR-dependent gene expression is important for macrophage survival and the innate immune response
-
DOI 10.1016/j.cell.2004.09.032, PII S0092867404009419
-
Joseph SB, Bradley MN, Castrillo A, et al. LXR-Dependent Gene Expression Is Important for Macrophage Survival and the Innate Immune Response. Cell 2004;119:299-309 (Pubitemid 39360910)
-
(2004)
Cell
, vol.119
, Issue.2
, pp. 299-309
-
-
Joseph, S.B.1
Bradley, M.N.2
Castrillo, A.3
Bruhn, K.W.4
Mak, P.A.5
Pei, L.6
Hogenesch, J.7
O'Connell, R.M.8
Cheng, G.9
Saez, E.10
Miller, J.F.11
Tontonoz, P.12
-
45
-
-
0037324340
-
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
-
DOI 10.1038/nm820
-
Joseph SB, Castrillo A, Laffitte BA, et al. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 2003;9:213-19 (Pubitemid 36227724)
-
(2003)
Nature Medicine
, vol.9
, Issue.2
, pp. 213-219
-
-
Joseph, S.B.1
Castrillo, A.2
Laffitte, B.A.3
Mangelsdorf, D.J.4
Tontonoz, P.5
-
46
-
-
11144221176
-
Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis
-
DOI 10.1073/pnas.0407749101
-
Valledor AF, Hsu LC, Ogawa S, et al. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci USA 2004;101:17813-18 (Pubitemid 40051969)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.51
, pp. 17813-17818
-
-
Valledor, A.F.1
Hsu, L.-C.2
Ogawa, S.3
Sawka-Verhelle, D.4
Karin, M.5
Glass, C.K.6
-
48
-
-
68949145931
-
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR
-
A-Gonzalez N, Bensinger SJ, Hong C, et al. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity 2009;31:245-58
-
(2009)
Immunity
, vol.31
, pp. 245-258
-
-
A-Gonzalez, N.1
Bensinger, S.J.2
Hong, C.3
-
49
-
-
84855427447
-
Coordinate regulation of neutrophil homeostasis by liver X receptors in mice
-
Hong C, Kidani Y, A-Gonzalez N, et al. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J Clin Invest 2012;122:337-47
-
(2012)
J Clin Invest
, vol.122
, pp. 337-347
-
-
Hong, C.1
Kidani, Y.2
A-Gonzalez, N.3
-
50
-
-
33845635077
-
A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor
-
DOI 10.1161/01.RES.0000252878.34269.06, PII 0000301220061222000020
-
Blaschke F, Takata Y, Caglayan E. A nuclear receptor corepressor- dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor. Circ Res 2006;99:e88-99 (Pubitemid 44949660)
-
(2006)
Circulation Research
, vol.99
, Issue.12
-
-
Blaschke, F.1
Takata, Y.2
Caglayan, E.3
Collins, A.4
Tontonoz, P.5
Hsueh, W.A.6
Tangirala, R.K.7
-
51
-
-
76749125430
-
GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response
-
Venteclef N, Jakobsson T, Ehrlund A, et al. GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response. Gen Dev 2010;24:381-95
-
(2010)
Gen Dev
, vol.24
, pp. 381-395
-
-
Venteclef, N.1
Jakobsson, T.2
Ehrlund, A.3
-
52
-
-
36148964738
-
Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses
-
DOI 10.1074/jbc.M703278200
-
Birrell MA, Catley MC, Hardaker E, et al. Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses. J Biol Chem 2007;282:31882-90 (Pubitemid 350106460)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.44
, pp. 31882-31890
-
-
Birrell, M.A.1
Catley, M.C.2
Hardaker, E.3
Wong, S.4
Willson, T.M.5
McCluskie, K.6
Leonard, T.7
Farrow, S.N.8
Collins, J.L.9
Haj-Yahia, S.10
Belvisi, M.G.11
-
53
-
-
47949126821
-
Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense
-
Smoak K, Madenspacher J, Jeyaseelan S, et al. Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense. J Immunol 2008;180:3305-12
-
(2008)
J Immunol
, vol.180
, pp. 3305-3312
-
-
Smoak, K.1
Madenspacher, J.2
Jeyaseelan, S.3
-
54
-
-
67650996739
-
Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice
-
Korf H, Vander Beken S, Romano M, et al. Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice. J Clin Invest 2009;119:1626-37
-
(2009)
J Clin Invest
, vol.119
, pp. 1626-1637
-
-
Korf, H.1
Vander Beken, S.2
Romano, M.3
-
55
-
-
78649777345
-
LXR deficiency confers increased protection against visceral Leishmania infection in mice
-
Bruhn KW, Marathe C, Maretti-Mira AC, et al. LXR deficiency confers increased protection against visceral Leishmania infection in mice. PLoS Negl Trop Dis 2010;4:e886
-
(2010)
PLoS Negl Trop Dis
, vol.4
-
-
Bruhn, K.W.1
Marathe, C.2
Maretti-Mira, A.C.3
-
56
-
-
70350213114
-
Liver X receptor agonist GW3965 dose-dependently regulates LPSmediated liver injury and modulates post-transcriptional TNFalpha production and p38 MAPK activation in liver macrophages
-
Wang YY, Dahle MK, Steffensen KR, et al. Liver X receptor agonist GW3965 dose-dependently regulates LPSmediated liver injury and modulates post-transcriptional TNFalpha production and p38 MAPK activation in liver macrophages. Shock 2009;32:548-53
-
(2009)
Shock
, vol.32
, pp. 548-553
-
-
Wang, Y.Y.1
Dahle, M.K.2
Steffensen, K.R.3
-
57
-
-
84863861008
-
Understanding the dynamics: Pathways involved in the pathogenesis of rheumatoid arthritis
-
Choy E. Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology 2012;51(Suppl 5):v3-11
-
(2012)
Rheumatology
, vol.51
, Issue.SUPPL. 5
-
-
Choy, E.1
-
58
-
-
79959337756
-
Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage: Reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis
-
Collins-Racie LA, Yang Z, Arai M, et al. Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage: reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis. Osteoarthritis Cartilage 2009;17:832-42
-
(2009)
Osteoarthritis Cartilage
, vol.17
, pp. 832-842
-
-
Collins-Racie, L.A.1
Yang, Z.2
Arai, M.3
-
59
-
-
77649241985
-
LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model
-
Li N, Rivera-Bermudez MA, Zhang M, et al. LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model. Proc Natl Acad Sci USA 2010;107:3734-9
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 3734-3739
-
-
Li, N.1
Rivera-Bermudez, M.A.2
Zhang, M.3
-
60
-
-
79952481326
-
Liver X receptor agonist prevents the evolution of collagen-induced arthritis in mice
-
Park MC, Kwon YJ, Chung SJ, et al. Liver X receptor agonist prevents the evolution of collagen-induced arthritis in mice. Rheumatology 2010;49:882-90
-
(2010)
Rheumatology
, vol.49
, pp. 882-890
-
-
Park, M.C.1
Kwon, Y.J.2
Chung, S.J.3
-
61
-
-
0029855587
-
Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice
-
Muller-Ladner U, Kriegsmann J, Franklin BN, et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol 1996;149:1607-15 (Pubitemid 26363967)
-
(1996)
American Journal of Pathology
, vol.149
, Issue.5
, pp. 1607-1615
-
-
Muller-Ladner, U.1
Kriegsmann, J.2
Franklin, B.N.3
Matsumoto, S.4
Geiler, T.5
Gay, R.E.6
Gay, S.7
-
62
-
-
84873318484
-
Liver X receptor regulates rheumatoid arthritis fibroblast-like synoviocyte invasiveness, matrix metalloproteinase 2 activation, interleukin-6 and CXCL10
-
Laragione T, Gulko PS. Liver X receptor regulates rheumatoid arthritis fibroblast-like synoviocyte invasiveness, matrix metalloproteinase 2 activation, interleukin-6 and CXCL10. Mol Med 2012;18:1009-17
-
(2012)
Mol Med
, vol.18
, pp. 1009-1017
-
-
Laragione, T.1
Gulko, P.S.2
-
63
-
-
84876424490
-
Activation of liver x receptors suppresses inflammatory gene expressions and transcriptional corepressor clearance in rheumatoid arthritis fibroblast like synoviocytes
-
Yoon CH, Kwon YJ, Lee SW, et al. Activation of liver x receptors suppresses inflammatory gene expressions and transcriptional corepressor clearance in rheumatoid arthritis fibroblast like synoviocytes. J Clin Immunol 2013;33:190-9
-
(2013)
J Clin Immunol
, vol.33
, pp. 190-199
-
-
Yoon, C.H.1
Kwon, Y.J.2
Lee, S.W.3
-
64
-
-
69449087868
-
Liver X receptor agonism promotes articular inflammation in murine collagen-induced arthritis
-
Asquith D, Miller AM, Hueber AJ, et al. Liver X receptor agonism promotes articular inflammation in murine collagen-induced arthritis. Arthritis Rheum 2009;60:2655-65
-
(2009)
Arthritis Rheum
, vol.60
, pp. 2655-2665
-
-
Asquith, D.1
Miller, A.M.2
Hueber, A.J.3
-
65
-
-
82755185141
-
Simultaneous activation of the liver X receptors (LXRalpha and LXRbeta) drives murine collagen-induced arthritis disease pathology
-
Asquith DL, Miller AM, Reilly J, et al. Simultaneous activation of the liver X receptors (LXRalpha and LXRbeta) drives murine collagen-induced arthritis disease pathology. Ann Rheum Dis 2011;70:2225-8
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 2225-2228
-
-
Asquith, D.L.1
Miller, A.M.2
Reilly, J.3
-
66
-
-
84887451261
-
The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release
-
[Epub ahead of print]
-
Asquith DL, Ballantine LE, Nijjar JS, et al. The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release. Ann Rheum Dis 2013; [Epub ahead of print]
-
(2013)
Ann Rheum Dis
-
-
Asquith, D.L.1
Ballantine, L.E.2
Nijjar, J.S.3
-
67
-
-
33746390468
-
Cholesterol-sensing receptors, liver X receptor α and β, have novel and distinct roles in osteoclast differentiation and activation
-
DOI 10.1359/jbmr.060503
-
Robertson KM, Norgard M, et al. Cholesterol-sensing receptors, liver X receptor alpha and beta, have novel and distinct roles in osteoclast differentiation and activation. J Bone Miner Res 2006;21:1276-87 (Pubitemid 44128341)
-
(2006)
Journal of Bone and Mineral Research
, vol.21
, Issue.8
, pp. 1276-1287
-
-
Robertson, K.M.1
Norgard, M.2
Windahl, S.H.3
Hultenby, K.4
Ohlsson, C.5
Andersson, G.6
Gustafsson, J.-A.7
-
68
-
-
78650968344
-
Short-term activation of liver X receptors inhibits osteoblasts but long-term activation does not have an impact on murine bone in vivo
-
Prawitt J, Beil FT, Marshall RP, et al. Short-term activation of liver X receptors inhibits osteoblasts but long-term activation does not have an impact on murine bone in vivo. Bone 2011;48:339-46
-
(2011)
Bone
, vol.48
, pp. 339-346
-
-
Prawitt, J.1
Beil, F.T.2
Marshall, R.P.3
-
69
-
-
33846031926
-
The molecular understanding of osteoclast differentiation
-
DOI 10.1016/j.bone.2006.09.023, PII S8756328206007009
-
Asagiri M, Takayanagi H. The molecular understanding of osteoclast differentiation. Bone 2007;40:251-64 (Pubitemid 46054562)
-
(2007)
Bone
, vol.40
, Issue.2
, pp. 251-264
-
-
Asagiri, M.1
Takayanagi, H.2
-
70
-
-
80052979753
-
Activation of liver X receptor (LXR) inhibits receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclast differentiation in an LXRbeta-dependent mechanism
-
Remen KM, Henning P, Lerner UH, et al. Activation of liver X receptor (LXR) inhibits receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclast differentiation in an LXRbeta-dependent mechanism. J Biol Chem 2011;286:33084-94
-
(2011)
J Biol Chem
, vol.286
, pp. 33084-33094
-
-
Remen, K.M.1
Henning, P.2
Lerner, U.H.3
-
71
-
-
84869454050
-
Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss
-
Kleyer A, Scholtysek C, Bottesch E, et al. Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss. J Bone Miner Res 2012;27:2442-51
-
(2012)
J Bone Miner Res
, vol.27
, pp. 2442-2451
-
-
Kleyer, A.1
Scholtysek, C.2
Bottesch, E.3
-
72
-
-
84871955501
-
Activation of the liver X receptor-beta potently inhibits osteoclastogenesis from lipopolysaccharide-exposed bone marrow-derived macrophages
-
Robertson-Remen KM, Lerner UH, Gustafsson JA, et al. Activation of the liver X receptor-beta potently inhibits osteoclastogenesis from lipopolysaccharide-exposed bone marrow-derived macrophages. J Leukoc Biol 2013;93:71-82
-
(2013)
J Leukoc Biol
, vol.93
, pp. 71-82
-
-
Robertson-Remen, K.M.1
Lerner, U.H.2
Gustafsson, J.A.3
-
73
-
-
84872418886
-
The liver X receptor promotes macrophage differentiation and suppresses osteoclast formation in mouse RAW264.7 promyelocytic leukemia cells exposed to bacterial lipopolysaccharide
-
Robertson-Remen KM, Gustafsson JA, Andersson G. The liver X receptor promotes macrophage differentiation and suppresses osteoclast formation in mouse RAW264.7 promyelocytic leukemia cells exposed to bacterial lipopolysaccharide. Biochem Biophys Res Commun 2013;430:375-80
-
(2013)
Biochem Biophys Res Commun
, vol.430
, pp. 375-380
-
-
Robertson-Remen, K.M.1
Gustafsson, J.A.2
Andersson, G.3
-
74
-
-
67849119581
-
Bone loss in inflammatory disorders
-
Hardy R, Cooper MS. Bone loss in inflammatory disorders. J Endocrinol 2009;201:309-20
-
(2009)
J Endocrinol
, vol.201
, pp. 309-320
-
-
Hardy, R.1
Cooper, M.S.2
-
75
-
-
80052494631
-
Suppression of chronic damage in renal allografts by Liver X receptor (LXR) activation relevant contribution of macrophage LXRalpha
-
Kiss E, Popovic Z, Bedke J, et al. Suppression of chronic damage in renal allografts by Liver X receptor (LXR) activation relevant contribution of macrophage LXRalpha. Am J Pathol 2011;179:92-103
-
(2011)
Am J Pathol
, vol.179
, pp. 92-103
-
-
Kiss, E.1
Popovic, Z.2
Bedke, J.3
-
76
-
-
84874526219
-
Lipid droplet accumulation is associated with an increase in hyperglycemia-induced renal damage: Prevention by liver X receptors
-
Kiss E, Kranzlin B, Wagenblabeta K, et al. Lipid droplet accumulation is associated with an increase in hyperglycemia-induced renal damage: prevention by liver X receptors. Am J Pathol 2013;182:727-41
-
(2013)
Am J Pathol
, vol.182
, pp. 727-741
-
-
Kiss, E.1
Kranzlin, B.2
Wagenblabeta, K.3
-
77
-
-
84868626246
-
Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy
-
Tachibana H, Ogawa D, Matsushita Y, et al. Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy. J Am Soc Nephrol 2012;23:1835-46
-
(2012)
J Am Soc Nephrol
, vol.23
, pp. 1835-1846
-
-
Tachibana, H.1
Ogawa, D.2
Matsushita, Y.3
-
78
-
-
77951703599
-
Pathobiology of chronic inflammatory skin diseases: Interplay between keratinocytes and immune cells as a target for anti-inflammatory drugs
-
Albanesi C, Pastore S. Pathobiology of chronic inflammatory skin diseases: interplay between keratinocytes and immune cells as a target for anti-inflammatory drugs. Curr Drug Metab 2010;11:210-27
-
(2010)
Curr Drug Metab
, vol.11
, pp. 210-227
-
-
Albanesi, C.1
Pastore, S.2
-
79
-
-
0036156083
-
Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-β in murine epidermis
-
DOI 10.1046/j.0022-202x.2001.01628.x
-
Komuves LG, Schmuth M, Fowler AJ, et al. Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. J Investi Dermatol 2002;118:25-34 (Pubitemid 34107420)
-
(2002)
Journal of Investigative Dermatology
, vol.118
, Issue.1
, pp. 25-34
-
-
Komuves, L.G.1
Schmuth, M.2
Fowler, A.J.3
Elias, P.M.4
Hanley, K.5
Man, M.-Q.6
Moser, A.H.7
Lobaccaro, J.-M.A.8
Williams, M.L.9
Mangelsdorf, D.J.10
Feingold, K.R.11
-
80
-
-
3042684719
-
The effect of LXR activators on AP-1 proteins in keratinocytes
-
DOI 10.1111/j.0022-202X.2004.22707.x
-
Schmuth M, Elias PM, Hanley K, et al. The effect of LXR activators on AP-1 proteins in keratinocytes. J Investi Dermatol 2004;123:41-8 (Pubitemid 38833461)
-
(2004)
Journal of Investigative Dermatology
, vol.123
, Issue.1
, pp. 41-48
-
-
Schmuth, M.1
Elias, P.M.2
Hanley, K.3
Lau, P.4
Moser, A.5
Willson, T.M.6
Bikle, D.D.7
Feingold, K.R.8
-
81
-
-
0037289786
-
Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: Liver-X-receptor-specific inhibition of inflammation and primary cytokine production
-
DOI 10.1046/j.1523-1747.2003.12033.x
-
Fowler AJ, Sheu MY, Schmuth M, et al. Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Investi Dermatol 2003;120:246-55 (Pubitemid 36513075)
-
(2003)
Journal of Investigative Dermatology
, vol.120
, Issue.2
, pp. 246-255
-
-
Fowler, A.J.1
Sheu, M.Y.2
Schmuth, M.3
Kao, J.4
Fluhr, J.W.5
Rhein, L.6
Collins, J.L.7
Willson, T.M.8
Mangelsdorf, D.J.9
Elias, P.M.10
Feingold, K.R.11
-
82
-
-
84871896125
-
Altered levels of LXR-alpha: Crucial implications in the pathogenesis of vitiligo
-
Kumar R, Parsad D, Kanwar A, et al. Altered levels of LXR-alpha: crucial implications in the pathogenesis of vitiligo. Exp Dermatol 2012;21:853-8
-
(2012)
Exp Dermatol
, vol.21
, pp. 853-858
-
-
Kumar, R.1
Parsad, D.2
Kanwar, A.3
-
83
-
-
84875226505
-
Liver X receptor activation inhibits melanogenesis through the acceleration of ERK-mediated MITF degradation
-
Lee CS, Park M, Han J, et al. Liver X receptor activation inhibits melanogenesis through the acceleration of ERK-mediated MITF degradation. J Invest Dermatol 2013;33:1063-71
-
(2013)
J Invest Dermatol
, vol.33
, pp. 1063-1071
-
-
Lee, C.S.1
Park, M.2
Han, J.3
-
85
-
-
3242803587
-
Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: A systematic review
-
DOI 10.1159/000078501
-
Szekely CA, Thorne JE, Zandi PP, et al. Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review. Neuroepidemiology 2004;23:159-69 (Pubitemid 38980441)
-
(2004)
Neuroepidemiology
, vol.23
, Issue.4
, pp. 159-169
-
-
Szekely, C.A.1
Thorne, J.E.2
Zandi, P.P.3
Ek, M.4
Messias, E.5
Breitner, J.C.S.6
Goodman, S.N.7
-
86
-
-
14244255485
-
The liver X receptor ligaun T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease
-
DOI 10.1074/jbc.M411420200
-
Koldamova RP, Lefterov IM, Staufenbiel M, et al. The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. J Biol Chem 2005;280:4079-88 (Pubitemid 40288571)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.6
, pp. 4079-4088
-
-
Koldamova, R.P.1
Lefterov, I.M.2
Staufenbiel, M.3
Wolfe, D.4
Huang, S.5
Glorioso, J.C.6
Walter, M.7
Roth, M.G.8
Lazo, J.S.9
-
87
-
-
34547531201
-
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors
-
DOI 10.1073/pnas.0701096104
-
Zelcer N, Khanlou N, Clare R, et al. Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proc Natl Acad Sci USA 2007;104:10601-6 (Pubitemid 47185711)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.25
, pp. 10601-10606
-
-
Zelcer, N.1
Khanlou, N.2
Clare, R.3
Jiang, Q.4
Reed-Geaghan, E.G.5
Landreth, G.E.6
Vinters, H.V.7
Tontonoz, P.8
-
88
-
-
84861201122
-
Liver X receptor activation attenuates inflammatory response and protects cholinergic neurons in APP/PS1 transgenic mice
-
Cui W, Sun Y, Wang Z, et al. Liver X receptor activation attenuates inflammatory response and protects cholinergic neurons in APP/PS1 transgenic mice. Neuroscience 2012;210:200-10
-
(2012)
Neuroscience
, vol.210
, pp. 200-210
-
-
Cui, W.1
Sun, Y.2
Wang, Z.3
-
89
-
-
37549037886
-
Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse
-
Repa JJ, Li H, Frank-Cannon TC, et al. Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse. J Neurosci 2007;27:14470-80
-
(2007)
J Neurosci
, vol.27
, pp. 14470-14480
-
-
Repa, J.J.1
Li, H.2
Frank-Cannon, T.C.3
-
90
-
-
79956311751
-
Critical role of astroglial apolipoprotein e and liver X receptor-alpha expression for microglial abeta phagocytosis
-
Terwel D, Steffensen KR, Verghese PB, et al. Critical role of astroglial apolipoprotein E and liver X receptor-alpha expression for microglial abeta phagocytosis. J Neurosci 2011;31:7049-59
-
(2011)
J Neurosci
, vol.31
, pp. 7049-7059
-
-
Terwel, D.1
Steffensen, K.R.2
Verghese, P.B.3
-
91
-
-
84862747867
-
The genetics of multiple sclerosis: An up-to-date review
-
Gourraud PA, Harbo HF, Hauser SL, et al. The genetics of multiple sclerosis: an up-to-date review. Immunol Rev 2012;248:87-103
-
(2012)
Immunol Rev
, vol.248
, pp. 87-103
-
-
Gourraud, P.A.1
Harbo, H.F.2
Hauser, S.L.3
-
92
-
-
77955911207
-
Nuclear receptors, inflammation, and neurodegenerative diseases
-
Saijo K, Crotti A, Glass CK. Nuclear receptors, inflammation, and neurodegenerative diseases. Adv Immunol 2010;106:21-59
-
(2010)
Adv Immunol
, vol.106
, pp. 21-59
-
-
Saijo, K.1
Crotti, A.2
Glass, C.K.3
-
93
-
-
33750463060
-
Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis
-
DOI 10.1002/jnr.21038
-
Hindinger C, Hinton DR, Kirwin SJ, et al. Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis. J Neurosci Res 2006;84:1225-34 (Pubitemid 44654446)
-
(2006)
Journal of Neuroscience Research
, vol.84
, Issue.6
, pp. 1225-1234
-
-
Hindinger, C.1
Hinton, D.R.2
Kirwin, S.J.3
Atkinson, R.D.4
Burnett, M.E.5
Bergmann, C.C.6
Stohlman, S.A.7
-
94
-
-
69449090770
-
Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity
-
Xu J, Wagoner G, Douglas JC, et al. Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity. J Leukoc Biol 2009;86:401-9
-
(2009)
J Leukoc Biol
, vol.86
, pp. 401-409
-
-
Xu, J.1
Wagoner, G.2
Douglas, J.C.3
-
95
-
-
79551545978
-
Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation
-
Cui G, Qin X, Wu L, et al. Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation. J Clin Invest 2011;121:658-70
-
(2011)
J Clin Invest
, vol.121
, pp. 658-670
-
-
Cui, G.1
Qin, X.2
Wu, L.3
-
96
-
-
84866342641
-
Myelin-derived lipids modulate macrophage activity by liver X receptor activation
-
Bogie JF, Timmermans S, Huynh-Thu VA, et al. Myelin-derived lipids modulate macrophage activity by liver X receptor activation. PLoS One 2012;7:e44998
-
(2012)
PLoS One
, vol.7
-
-
Bogie, J.F.1
Timmermans, S.2
Huynh-Thu, V.A.3
-
97
-
-
53049109169
-
Treatment with LXR agonists after focal cerebral ischemia prevents brain damage
-
Sironi L, Mitro N, Cimino M, et al. Treatment with LXR agonists after focal cerebral ischemia prevents brain damage. FEBS Lett 2008;582:3396-400
-
(2008)
FEBS Lett
, vol.582
, pp. 3396-3400
-
-
Sironi, L.1
Mitro, N.2
Cimino, M.3
-
98
-
-
54049115560
-
Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke
-
Morales JR, Ballesteros I, Deniz JM, et al. Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke. Circulation 2008;118:1450-9
-
(2008)
Circulation
, vol.118
, pp. 1450-1459
-
-
Morales, J.R.1
Ballesteros, I.2
Deniz, J.M.3
-
99
-
-
84872564252
-
The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein e
-
Namjoshi DR, Martin G, Donkin J, et al. The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E. PLoS One 2013;8:e53529
-
(2013)
PLoS One
, vol.8
-
-
Namjoshi, D.R.1
Martin, G.2
Donkin, J.3
-
100
-
-
84872071699
-
The neurorestorative benefit of GW3965 treatment of stroke in mice
-
Cui X, Chopp M, Zacharek A, et al. The neurorestorative benefit of GW3965 treatment of stroke in mice. Stroke 2013;44:153-61
-
(2013)
Stroke
, vol.44
, pp. 153-161
-
-
Cui, X.1
Chopp, M.2
Zacharek, A.3
-
101
-
-
0037731674
-
The interaction of immunodeficiency viruses with dendritic cells
-
Steinman RM, Granelli-Piperno A, Pope M, et al. The interaction of immunodeficiency viruses with dendritic cells. Curr Top Microbiol Immunol 2003;276:1-30 (Pubitemid 36538345)
-
(2003)
Current Topics in Microbiology and Immunology
, vol.276
, pp. 1-30
-
-
Steinman, R.M.1
Granelli-Piperno, A.2
Pope, M.3
Trumpfheller, C.4
Ignatius, R.5
Arrode, G.6
Racz, P.7
Tenner-Racz, K.8
-
102
-
-
77957690135
-
PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection
-
Hanley TM, Blay Puryear W, Gummuluru S, et al. PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection. PLoS Pathog 2010;6:e1000981
-
(2010)
PLoS Pathog
, vol.6
-
-
Hanley, T.M.1
Blay Puryear, W.2
Gummuluru, S.3
-
103
-
-
77954944601
-
Stimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1
-
Morrow MP, Grant A, Mujawar Z, et al. Stimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1. Mol Pharmacol 2010;78:215-25
-
(2010)
Mol Pharmacol
, vol.78
, pp. 215-225
-
-
Morrow, M.P.1
Grant, A.2
Mujawar, Z.3
-
104
-
-
80055002235
-
Nuclear receptor signaling inhibits HIV-1 replication in macrophages through multiple trans-repression mechanisms
-
Hanley TM, Viglianti GA. Nuclear receptor signaling inhibits HIV-1 replication in macrophages through multiple trans-repression mechanisms. J Virol 2011;85:10834-50
-
(2011)
J Virol
, vol.85
, pp. 10834-10850
-
-
Hanley, T.M.1
Viglianti, G.A.2
-
105
-
-
84857651766
-
Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection
-
Dubrovsky L, Van Duyne R, Senina S, et al. Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection. Biochem Biophys Res Commun 2012;419:95-8
-
(2012)
Biochem Biophys Res Commun
, vol.419
, pp. 95-98
-
-
Dubrovsky, L.1
Van Duyne, R.2
Senina, S.3
-
106
-
-
84861857191
-
Retinoic acid and liver X receptor agonist synergistically inhibit HIV infection in CD4+ T cells by up-regulating ABCA1-mediated cholesterol efflux
-
Jiang H, Badralmaa Y, Yang J, et al. Retinoic acid and liver X receptor agonist synergistically inhibit HIV infection in CD4+ T cells by up-regulating ABCA1-mediated cholesterol efflux. Lipids Health Dis 2012;11:69
-
(2012)
Lipids Health Dis
, vol.11
, pp. 69
-
-
Jiang, H.1
Badralmaa, Y.2
Yang, J.3
-
107
-
-
58149291663
-
Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha
-
Kim K, Kim KH, Kim HH, et al. Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha. Biochem J 2008;416:219-30
-
(2008)
Biochem J
, vol.416
, pp. 219-230
-
-
Kim, K.1
Kim, K.H.2
Kim, H.H.3
-
108
-
-
65449149413
-
Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma
-
Na TY, Shin YK, Roh KJ, et al. Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma. Hepatology 2009;49:1122-31
-
(2009)
Hepatology
, vol.49
, pp. 1122-1131
-
-
Na, T.Y.1
Shin, Y.K.2
Roh, K.J.3
-
109
-
-
79251639639
-
Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C
-
Lima-Cabello E, Garcia-Mediavilla MV, Miquilena-Colina ME, et al. Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C. Clin Sci 2011;120:239-50
-
(2011)
Clin Sci
, vol.120
, pp. 239-250
-
-
Lima-Cabello, E.1
Garcia-Mediavilla, M.V.2
Miquilena-Colina, M.E.3
-
110
-
-
84864475305
-
Liver X receptor alpha-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication
-
Garcia-Mediavilla MV, Pisonero-Vaquero S, Lima-Cabello E, et al. Liver X receptor alpha-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication. Lab Invest 2012;92:1191-202
-
(2012)
Lab Invest
, vol.92
, pp. 1191-1202
-
-
Garcia-Mediavilla, M.V.1
Pisonero-Vaquero, S.2
Lima-Cabello, E.3
-
111
-
-
84865302624
-
Liver X receptors agonists impede hepatitis C virus infection in an Idol-dependent manner
-
Zeng J, Wu Y, Liao Q, et al. Liver X receptors agonists impede hepatitis C virus infection in an Idol-dependent manner. Antiviral Res 2012;95:245-56
-
(2012)
Antiviral Res
, vol.95
, pp. 245-256
-
-
Zeng, J.1
Wu, Y.2
Liao, Q.3
-
112
-
-
41149099068
-
Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy
-
Kern TS. Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy. Exp Diabetes Research 2007;2007:95103
-
(2007)
Exp Diabetes Research
, vol.2007
, pp. 95103
-
-
Kern, T.S.1
-
113
-
-
51649089406
-
Inhibition of retinopathy and retinal metabolic abnormalities in diabetic rats with AREDS-based micronutrients
-
Kowluru RA, Kanwar M, Chan PS, et al. Inhibition of retinopathy and retinal metabolic abnormalities in diabetic rats with AREDS-based micronutrients. Arch Ophthalmol 2008;126:1266-72
-
(2008)
Arch Ophthalmol
, vol.126
, pp. 1266-1272
-
-
Kowluru, R.A.1
Kanwar, M.2
Chan, P.S.3
-
114
-
-
84870368611
-
Liver X receptor modulates diabetic retinopathy outcome in a mouse model of streptozotocin-induced diabetes
-
Hazra S, Rasheed A, Bhatwadekar A, et al. Liver X receptor modulates diabetic retinopathy outcome in a mouse model of streptozotocin-induced diabetes. Diabetes 2012;61:3270-9
-
(2012)
Diabetes
, vol.61
, pp. 3270-3279
-
-
Hazra, S.1
Rasheed, A.2
Bhatwadekar, A.3
-
115
-
-
33947259319
-
Immunosuppressive strategies that are mediated by tumor cells
-
DOI 10.1146/annurev.immunol.25.022106.141609
-
Rabinovich GA, Gabrilovich D, Sotomayor EM. Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol 2007;25:267-96 (Pubitemid 46697910)
-
(2007)
Annual Review of Immunology
, vol.25
, pp. 267-296
-
-
Rabinovich, G.A.1
Gabrilovich, D.2
Sotomayor, E.M.3
-
116
-
-
73849096869
-
Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
-
Villablanca EJ, Raccosta L, Zhou D, et al. Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses. Nat Med 2010;16:98-105
-
(2010)
Nat Med
, vol.16
, pp. 98-105
-
-
Villablanca, E.J.1
Raccosta, L.2
Zhou, D.3
-
117
-
-
47949094965
-
Integration of metabolism and inflammation by lipid-activated nuclear receptors
-
Bensinger SJ, Tontonoz P. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature 2008;454:470-7
-
(2008)
Nature
, vol.454
, pp. 470-477
-
-
Bensinger, S.J.1
Tontonoz, P.2
-
118
-
-
84867904787
-
LXRbeta activation increases intestinal cholesterol absorption leading to an atherogenic lipoprotein profile
-
Hu X, Steffensen KR, Jiang ZY, et al. LXRbeta activation increases intestinal cholesterol absorption leading to an atherogenic lipoprotein profile. J Intern Med 2012;272:452-64
-
(2012)
J Intern Med
, vol.272
, pp. 452-464
-
-
Hu, X.1
Steffensen, K.R.2
Jiang, Z.Y.3
-
119
-
-
84860548049
-
Liver LXRalpha expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice
-
Zhang Y, Breevoort SR, Angdisen J. Liver LXRalpha expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest 2012;122:1688-99
-
(2012)
J Clin Invest
, vol.122
, pp. 1688-1699
-
-
Zhang, Y.1
Breevoort, S.R.2
Angdisen, J.3
-
120
-
-
33748792007
-
Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands
-
DOI 10.1074/jbc.M603781200
-
Yang C, McDonald JG, Patel A, et al. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem 2006;281:27816-26 (Pubitemid 44414494)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.38
, pp. 27816-27826
-
-
Yang, C.1
McDonald, J.G.2
Patel, A.3
Zhang, Y.4
Umetani, M.5
Xu, F.6
Westover, E.J.7
Covey, D.F.8
Mangelsdorf, D.J.9
Cohen, J.C.10
Hobbs, H.H.11
-
121
-
-
84867031028
-
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses
-
Spann NJ, Garmire LX, McDonald JG, et al. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell 2012;151:138-52
-
(2012)
Cell
, vol.151
, pp. 138-152
-
-
Spann, N.J.1
Garmire, L.X.2
McDonald, J.G.3
-
122
-
-
84872677234
-
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
-
Theofilopoulos S, Wang Y, Kitambi SS, et al. Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nat Chem Biol 2012;9:126-33
-
(2012)
Nat Chem Biol
, vol.9
, pp. 126-133
-
-
Theofilopoulos, S.1
Wang, Y.2
Kitambi, S.S.3
-
123
-
-
70849088458
-
LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse
-
Quinet EM, Basso MD, Halpern AR, et al. LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J Lipid Res 2009;50:2358-70
-
(2009)
J Lipid Res
, vol.50
, pp. 2358-2370
-
-
Quinet, E.M.1
Basso, M.D.2
Halpern, A.R.3
-
124
-
-
67049144914
-
Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants
-
Katz A, Udata C, Ott E, et al. Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants. J Clin Pharmacol 2009;49:643-9
-
(2009)
J Clin Pharmacol
, vol.49
, pp. 643-649
-
-
Katz, A.1
Udata, C.2
Ott, E.3
-
125
-
-
70349309626
-
Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells
-
Sacchetti P, Sousa KM, Hall AC, et al. Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Cell Stem Cell 2009;5:409-19
-
(2009)
Cell Stem Cell
, vol.5
, pp. 409-419
-
-
Sacchetti, P.1
Sousa, K.M.2
Hall, A.C.3
-
126
-
-
51649114789
-
Expression of liver X receptor beta is essential for formation of superficial cortical layers and migration of later-born neurons
-
Fan X, Kim HJ, Bouton D, et al. Expression of liver X receptor beta is essential for formation of superficial cortical layers and migration of later-born neurons. Proc Natl Acad Sci USA 2008;105:13445-50
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 13445-13450
-
-
Fan, X.1
Kim, H.J.2
Bouton, D.3
-
127
-
-
41149111376
-
Liver X receptor β (LXRβ): A link between β-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia
-
DOI 10.1073/pnas.0711599105
-
Kim HJ, Fan X, Gabbi C, et al. Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia. Proc Natl Acad Sci USA 2008;105:2094-9 (Pubitemid 351439470)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.6
, pp. 2094-2099
-
-
Kim, H.-J.1
Fan, X.2
Gabbi, C.3
Yakimchuk, K.4
Parini, P.5
Warner, M.6
Gustafsson, J.-A.7
-
128
-
-
84864672430
-
Liver X receptor beta protects dopaminergic neurons in a mouse model of Parkinson disease
-
Dai YB, Tan XJ, Wu WF, et al. Liver X receptor beta protects dopaminergic neurons in a mouse model of Parkinson disease. Proc Natl Acad Sci USA 2012;109:13112-17
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 13112-13117
-
-
Dai, Y.B.1
Tan, X.J.2
Wu, W.F.3
-
129
-
-
14844359386
-
Inactivation of liver X receptor β leads to adult-onset motor neuron degeneration in male mice
-
DOI 10.1073/pnas.0500634102
-
Andersson S, Gustafsson N, Warner M, et al. Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice. Proc Natl Acad Sci USA 2005;102:3857-62 (Pubitemid 40354701)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.10
, pp. 3857-3862
-
-
Andersson, S.1
Gustafsson, N.2
Warner, M.3
Gustafsson, J.-A.4
-
130
-
-
77953126604
-
Neuropathologic and biochemical changes during disease progression in liver X receptor beta-/-mice, a model of adult neuron disease
-
Bigini P, Steffensen KR, Ferrario A, et al. Neuropathologic and biochemical changes during disease progression in liver X receptor beta-/-mice, a model of adult neuron disease. J Neuropathol Exp Neurol 2010;69:593-605
-
(2010)
J Neuropathol Exp Neurol
, vol.69
, pp. 593-605
-
-
Bigini, P.1
Steffensen, K.R.2
Ferrario, A.3
-
131
-
-
84878857960
-
Analysis of oxysterols and cholesterol in prefrontal cortex of suicides
-
[Epub ahead of print]
-
Freemantle E, Chen GG, Cruceanu C, et al. Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. Int J Neuropsychopharmacol 2013; [Epub ahead of print]
-
(2013)
Int J Neuropsychopharmacol
-
-
Freemantle, E.1
Chen, G.G.2
Cruceanu, C.3
-
132
-
-
34748836338
-
Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3- trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride (GW3965)
-
DOI 10.1124/mol.107.037358
-
Kotokorpi P, Ellis E, Parini P, et al. Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyl oxy] phenylacetic acid hydrochloride (GW3965). Mol Pharmacol 2007;72:947-55 (Pubitemid 47481417)
-
(2007)
Molecular Pharmacology
, vol.72
, Issue.4
, pp. 947-955
-
-
Kotokorpi, P.1
Ellis, E.2
Parini, P.3
Nilsson, L.-M.4
Strom, S.5
Steffensen, K.R.6
Gustafsson, J.-A.7
Mode, A.8
-
133
-
-
34547730702
-
Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/-mice
-
Azuma H, Paulk N, Ranade A, et al. Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/-mice. Nat Biotechnol 2007;25:903-10
-
(2007)
Nat Biotechnol
, vol.25
, pp. 903-910
-
-
Azuma, H.1
Paulk, N.2
Ranade, A.3
|