The effect of LXR activators on AP-1 proteins in keratinocytes

Journal of Investigative Dermatology

Volumn 123, Issue 1, 2004, Pages 41-48

  Schmuth, Matthias ^a,b,c   Elias, Peter M ^a,b   Hanley, Karen ^a,b   Lau, Peggy ^a,b   Moser, A ^b   Willson, Timothy M ^d   Bikle, Daniel D ^a,b   Feingold, Kenneth R ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^d GLAXOSMITHKLINE   (United States)

Author keywords

Cornified envelope; Differentiation; Involucrin; Nuclear hormone receptor; Transcription factor

Indexed keywords

25 HYDROXYCHOLESTEROL; 3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; BENZENESULFONAMIDE DERIVATIVE; DNA; INVOLUCRIN; LIVER X RECEPTOR; OXYSTEROL; PROTEIN C FOS; PROTEIN C JUN; TO 901317; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FRA 1; TRANSCRIPTION FACTOR FRA 2; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL STIMULATION; CONTROLLED STUDY; DNA BINDING; DNA RESPONSIVE ELEMENT; EPIDERMIS CELL; GEL MOBILITY SHIFT ASSAY; GENE ACTIVATION; HUMAN; HUMAN CELL; INDUCED MUTATION; KERATINOCYTE; NEWBORN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; SKIN CULTURE; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

EID: 3042684719     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.22707.x     Document Type: Article

References (47)

1. Angel P, Szabowski A, Schorpp-Kistner M: Function and regulation of AP-1 subunits in skin physiology and pathology. Oncogene 20:2413-2423, 2001
2. Banks EB, Crish JF, Welter JF, Eckert RL: Characterization of human involucrin promoter distal regulatory region transcriptional activator elements - a role for SP1 and AP1 binding sites. Biochem J 331:61-68, 1998
3. Bikle DD, Ng D, Tu CL, Oda Y, Xie Z: Calcium- and vitamin D-regulated keratinocyte differentiation. Mol Cell Endocrinol 177:161-171, 2001
4. Casatorres J, Navarro JM, Blessing M, Jorcano JL: Analysis of the control of expression and tissue specificity of the keratin 5 gene, characteristic of basal keratinocytes. Fundamental role of an AP-1 element. J Biol Chem 269:20489-20496, 1994
5. Collins JL, Fivush AM, Watson MA, et al: Identification of a non-steroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem 45:1963-1966, 2002
6. Crish JF, Bone F, Banks EB, Eckert RL: The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation. Oncogene 21:738-747, 2002
7. Crish JF, Zaim TM, Eckert RL: The distal regulatory region of the human involucrin promoter is required for expression in epidermis. J Biol Chem 273:30460-30465, 1998
8. Denning MF, Dlugosz AA, Williams EK, Szellasi Z, Blumberg PM, Yuspa SH: Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium. Cell Growth Differ 6:149-151, 1995
9. Disepio D, Bicokenbach JR, Longley MA, Bundman DS, Rothnagal JA, Roop DR: Charcterization of loricrin regulation in vitro and in transgenic mice. Differentiation 64:225-235, 1999
10. Disepio D, Jones A, Longley MA, Bundman D, Rothnagal JA, Roop DA: The proximal promoter of the mouse loricrin gene contains a functional AP-1 element and directs keratinocyte-specific but not differentiation-specific expression. J Biol Chem 270:10792-10799, 1995
11. κ) gene expression in cultured primary mouse epidermal keratinocytes induced to terminally differentiate by calcium. J Invest Dermatol 102:409-414, 1994
12. Eckert RL, Crish JR, Robinson WA: The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation. Physiol Rev 77:397-424, 1997
13. Eckert RL, Green H: Structure and evolution of the human involucrin gene. Cell 46:583-589, 1986
14. Elias PM, Ahn SK, Denda M, et al: Modulations in epidermal calcium regulate the expression of differentiation-specific markers. J Invest Dermatol 119:1128-1136, 2002
15. Elias PM, Williams ML, Maloney ME, Bonifas JA, Brown BE, Grayson S, Epstein EH Jr: Stratum corneum lipids in disorders of cornification. Steroid sulfatase and cholesterol sulfate in normal desquamation and the pathogenesis of recessive X-linked ichthyosis. J Clin Invest 74:1414-1421, 1984
16. Feingold KR: The regulation and role of epidermal lipid synthesis. Adv Lipid Res 24:57-82, 1991
17. Fischer DF, Sark MW, Lehtola MM, Gibbs S, van de Putte P, Backendorf C: Structure and evolution of the human SPRR3 gene: Implications for function and regulation. Genomics 55:88-99, 1999
18. Fuchs E: Epidermal differentiation: The bare essentials. J Cell Biol 111:2807-2814, 1990
19. Gibson D, Ratnam AV, Bikle DD: Evidence for separate control mechanisms at the message, protein, and enzyme activation levels for transglutaminase during calcium-induced differentiation of normal and transformed human keratinocytes. J Invest Dermatol 106:154-161, 1996
20. Hanley K, Ng DC, He SS, et al: Oxysterols induce differentiation in human keratinocytes and increase AP-1 dependent involucrin transcription. J Invest Dermatol 114:545-553, 2000
21. Hanley K, Wood L, Ng DC, et al: Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2 and Jun D. J Lipid Res 42:390-398, 2001
22. Jackson SM, Williams ML, Feingold KR, Elias PM: Pathobiology of the stratum corneum. Western J Med 158:279-285, 1993
23. Jang SI, Steinert PM, Markova NG: Activator protein 1 activity is involved in the regulation of the cell type-specific expression from the proximal promoter of the human profilaggrin gene. J Biol Chem 271:24105-24114, 1996
24. Janowski BA, Willy PJ, Deni TR, Falek JK, Mangelsdorf DJ: An oxysterol signalling pathway mediated by the nuclear receptor LXRα. Nature 383:728-731, 1996
25. Jessen BA, Quin Q, Rice RH: Functional AP1 and CRE response elements in the human keratinocyte transglutaminase promoter mediating Whn suppression. Gene 254:77-85, 2000
26. Johansen C, Iversen L, Ryborg A, Kragballe K: 1Alpha,25-dihydroxyvitamin D3 induced differentiation of cultured human keratinocytes is accompanied by a PKC-independent regulation of AP-1 DNA binding activity. J Invest Dermatol 114:1174-1179, 2000
27. Kalinin A, Kayava A, Steinhert P: Epithelial barrier function: Assembly and structural features of the cornified cell envelope. Bioessays 24:789-800, 2002
28. Karin M: The regulation of AP-1 activity by mitogen activated protein kinases. J Biol Chem 270:16483-16486, 1995
29. Komuves LG, Schmuth M, Fowler AJ, et al: Oxysterol stimulation of epidermal differentiation is mediated by Liver X Receptor-beta in murine epidermis. J Invest Dermatol 118:25-34, 2002
30. Lehmann JM, Kliewer SA, Moore LB, et al: Activation of the nuclear receptor LXR by oxysterol defines a new hormone response pathway. J Biol Chem 272:3137-3190, 1997
31. Lohman FR, Gibbs S, Fischer DF, Borgstein AM, van de Putte P, Backendorf C: Involvement of c-JUN in the regulation of terminal differentiation genes in normal and malignant keratinocytes. Oncogene 14:1623-1627, 1997
32. Lu B, Rothnagel JA, Longley MA, Tsai SU, Roop DK: Differentiation- specific expression of human keratin 1 is mediated by a composite AP-1/steroid hormone element. J Biol Chem 269:7443-7449, 1994
33. Ma S, Rao L, Freedberg IM, Blumenberg M: Transcriptional control of K5, K6, K14 and K17 keratin genes by AP-1 and NF-kappaB family members. Gene Expression 6:361-370, 1997
34. Navarro JM, Casatorres J, Jorcano JL: Elements controlling the expression and induction of the skin hyperproliferation-associated keratin K6. J Biol Chem 270:21362-21367, 1995
35. Ng DC, Shakaee S, Lee D, Bikle DD: Requirement of an AP-1 site in the calcium response region of the involucrin promoter. J Biol Chem 275:24080-24088, 2000
36. Phillips MA, Qin Q, Rice RH: Identification of an involucrin promoter transcriptional response element with activity restricted to keratinocytes. Biochem J 348 (Pt 1):45, 2000
37. Rossi A, Jang SI, Cece R, Steinert PM, Markova NG: Effect of AP1 transcription factors on the regulation of transcription in normal human epidermal keratinocytes. J Invest Dermatol 110:34-40, 1998
38. Rothnagel JA, Greenhalgh DA, Gagne TA, Longley MA, Roop DR: Identification of calcium-inductible, epidermal-specific regulatory element in the 3′-flanking region of the human keratin 1 gene. J Invest Dermatol 101: 506-513, 1993
39. Rutberg SE, Saez E, Glick A, Dlugosz AA, Spiegelman BM, Yuspa SH: Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteins. Oncogene 13:167-176, 1996
40. Sark MW, Fischer DF, deMeijer E, vandePutte P, Backendorf C: AP-1 and its transcription factors regulate the expression of the human SPRR1A keratinocyte terminal differentiation marker. J Biol Chem 273:24683-24692, 1998
41. Volz A, Korge BP, Compton JG, Ziegler A, Steinert PM, Mischke D: Physical mapping of a functional cluster of epidermal differentiation genes on chromosome 1q21. Genomics 18:92-99, 1993
42. Welter JF, Crish JF, Agarwal C, Eckert RL: Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity. J Biol Chem 270:12614-12622, 1995
43. Wisdom R: AP-1: One switch for many signals. Exp Cell Res 253:180-185, 1999
44. Yamada K, Tamanishi K, Kakizuka A, et al: Transcriptional regulation of human transglutaminase 1 gene by signaling systems of protein kinase C, RAR/RXR, and Jun/Fos in keratinocytes. Biochem Mol Biol Int 34:827-836, 1994
45. Yates S, Rayner TE: Transcription factor activation in response to cutaneous injury: Role of AP-1 in reepithelialization. Wound Repair Regen 10:5-15, 2002
46. Younus J, Gilchrest BA: Modulation of mRNA levels during human keratinocyte differentiation. J Cell Physiol 152:232-239, 1992
47. Yuspa SH, Kilkenny AE, Steinert PM, Roop DR: Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro. J Cell Biol 109:1207-1217, 1989