Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage. Reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis

Osteoarthritis and Cartilage

Volumn 17, Issue 7, 2009, Pages 832-842

  Collins Racie, L A ^a   Yang, Z ^b   Arai, M ^a   Li, N ^b   Majumdar, M K ^b   Nagpal, S ^b   Mounts, W M ^a   Dorner, A J ^a   Morris, E ^b   LaVallie, E R ^a  

^a The Departments of Biological Technologies   (United States)

^b PFIZER INC   (United States)

Author keywords

Gene expression; Liver X receptor; Nuclear receptor; Osteoarthritis; Proteoglycan; Retinoid X receptor

Indexed keywords

ABC TRANSPORTER G1; APOLIPOPROTEIN D; APOLIPOPROTEIN E; CELL NUCLEUS RECEPTOR; COMPLEMENTARY DNA; INTERLEUKIN 1; LIVER X RECEPTOR; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; MESSENGER RNA; PROTEOGLYCAN; RETINOID X RECEPTOR ALPHA; RETINOID X RECEPTOR BETA; CELL RECEPTOR; CYTOKINE; DNA BINDING PROTEIN; FLUORINATED HYDROCARBON; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; ORPHAN NUCLEAR RECEPTOR; RETINOID X RECEPTOR; SULFONAMIDE; TO-901317;

ADULT; AGED; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEOGLYCAN SYNTHESIS; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE MICROARRAY; COMPARATIVE STUDY; DRUG EFFECT; DRUG POTENTIATION; GENETIC TRANSCRIPTION; METABOLISM; MIDDLE AGED;

ADULT; AGED; CARTILAGE, ARTICULAR; CYTOKINES; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; HUMANS; HYDROCARBONS, FLUORINATED; MIDDLE AGED; ORPHAN NUCLEAR RECEPTORS; OSTEOARTHRITIS; PROTEOGLYCANS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RETINOID X RECEPTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SULFONAMIDES; TRANSCRIPTION, GENETIC;

EID: 79959337756     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2008.12.011     Document Type: Article

References (59)

1. Robinson-Rechavi M., Carpentier A.S., Duffraisse M., and Laudet V. How many nuclear hormone receptors are there in the human genome?. Trends Genet 17 (2001) 554-556
2. Pearce K.H., Iannone M.A., Simmons C.A., and Gray J.G. Discovery of novel nuclear receptor modulating ligands: an integral role for peptide interaction profiling. Drug Discov Today 9 (2004) 741-751
3. Tsuchida A., Yamauchi T., and Kadowaki T. Nuclear receptors as targets for drug development: molecular mechanisms for regulation of obesity and insulin resistance by peroxisome proliferator-activated receptor gamma, CREB-binding protein, and adiponectin. J Pharmacol Sci 97 (2005) 164-170
4. Tobin J.F., and Freedman L.P. Nuclear receptors as drug targets in metabolic diseases: new approaches to therapy. Trends Endocrinol Metab 17 (2006) 284-290
5. Margolis R. Nuclear receptors and bone. Ann N Y Acad Sci (2007)
6. Heinlein C.A., and Chang C. Androgen receptor in prostate cancer. Endocr Rev 25 (2004) 276-308
7. Vrbanec D., and Petricevic B. Estrogen and progesterone receptor status in primary breast cancer - a study of 11,273 patients from the year 1990 to 2002. Coll Antropol 31 (2007) 535-540
8. Mullican S.E., Zhang S., Konopleva M., Ruvolo V., Andreeff M., Milbrandt J., et al. Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia. Nat Med 13 (2007) 730-735
9. Saez E., Tontonoz P., Nelson M.C., Alvarez J.G., Ming U.T., Baird S.M., et al. Activators of the nuclear receptor PPARgamma enhance colon polyp formation. Nat Med 4 (1998) 1058-1061
10. Hart D.J., Doyle D.V., and Spector T.D. Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study. Arthritis Rheum 42 (1999) 17-24
11. Spector T.D., Nandra D., Hart D.J., and Doyle D.V. Is hormone replacement therapy protective for hand and knee osteoarthritis in women? The Chingford Study. Ann Rheum Dis 56 (1997) 432-434
12. Sowers M.F., Hochberg M., Crabbe J.P., Muhich A., Crutchfield M., and Updike S. Association of bone mineral density and sex hormone levels with osteoarthritis of the hand and knee in premenopausal women. Am J Epidemiol 143 (1996) 38-47
13. Samanta A., Jones A., Regan M., Wilson S., and Doherty M. Is osteoarthritis in women affected by hormonal changes or smoking?. Br J Rheumatol 32 (1993) 366-370
14. Hannan M.T., Felson D.T., Anderson J.J., Naimark A., and Kannel W.B. Estrogen use and radiographic osteoarthritis of the knee in women. The Framingham Osteoarthritis Study. Arthritis Rheum 33 (1990) 525-532
15. Nevitt M.C., Cummings S.R., Lane N.E., Hochberg M.C., Scott J.C., Pressman A.R., et al. Association of estrogen replacement therapy with the risk of osteoarthritis of the hip in elderly white women. Study of Osteoporotic Fractures Research Group. Arch Intern Med 156 (1996) 2073-2080
16. Zhang Y., McAlindon T.E., Hannan M.T., Chaisson C.E., Klein R., Wilson P.W., et al. Estrogen replacement therapy and worsening of radiographic knee osteoarthritis: the Framingham Study. Arthritis Rheum 41 (1998) 1867-1873
17. Oliveria S.A., Felson D.T., Klein R.A., Reed J.I., and Walker A.M. Estrogen replacement therapy and the development of osteoarthritis. Epidemiology 7 (1996) 415-419
18. Bergink A.P., van Meurs J.B., Loughlin J., Arp P.P., Fang Y., Hofman A., et al. Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women. Arthritis Rheum 48 (2003) 1913-1922
19. Ushiyama T., Ueyama H., Inoue K., Nishioka J., Ohkubo I., and Hukuda S. Estrogen receptor gene polymorphism and generalized osteoarthritis. J Rheumatol 25 (1998) 134-137
20. Tetlow L.C., and Woolley D.E. Expression of vitamin D receptors and matrix metalloproteinases in osteoarthritic cartilage and human articular chondrocytes in vitro. Osteoarthritis Cartilage 9 (2001) 423-431
21. Solovieva S., Hirvonen A., Siivola P., Vehmas T., Luoma K., Riihimaki H., et al. Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish women. Arthritis Res Ther 8 (2006) R20
22. Jordan K.M., Syddall H., Dennison E.M., Cooper C., and Arden N.K. Birthweight, vitamin D receptor gene polymorphism, and risk of lumbar spine osteoarthritis. J Rheumatol 32 (2005) 678-683
23. Fahmi H., Di Battista J.A., Pelletier J.P., Mineau F., Ranger P., and Martel-Pelletier J. Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes. Arthritis Rheum 44 (2001) 595-607
24. Fahmi H., Pelletier J.P., Di Battista J.A., Cheung H.S., Fernandes J.C., and Martel-Pelletier J. Peroxisome proliferator-activated receptor gamma activators inhibit MMP-1 production in human synovial fibroblasts likely by reducing the binding of the activator protein 1. Osteoarthritis Cartilage 10 (2002) 100-108
25. Kobayashi T., Notoya K., Naito T., Unno S., Nakamura A., Martel-Pelletier J., et al. Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs. Arthritis Rheum 52 (2005) 479-487
26. Boileau C., Martel-Pelletier J., Fahmi H., Mineau F., Boily M., and Pelletier J.P. The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and catabolic pathways. Arthritis Rheum 56 (2007) 2288-2298
27. DiBattista J.A., Martel-Pelletier J., Antakly T., Tardif G., Cloutier J.M., and Pelletier J.P. Reduced expression of glucocorticoid receptor levels in human osteoarthritic chondrocytes. Role in the suppression of metalloprotease synthesis. J Clin Endocrinol Metab 76 (1993) 1128-1134
28. Stove J., Schoniger R., Huch K., Brenner R., Gunther K.P., Puhl W., et al. Effects of dexamethasone on proteoglycan content and gene expression of IL-1beta-stimulated osteoarthrotic chondrocytes in vitro. Acta Orthop Scand 73 (2002) 562-567
29. Mix K.S., Attur M.G., Al-Mussawir H., Abramson S.B., Brinckerhoff C.E., and Murphy E.P. Transcriptional repression of matrix metalloproteinase gene expression by the orphan nuclear receptor NURR1 in cartilage. J Biol Chem 282 (2007) 9492-9504
30. Chaturvedi P., Pratta M., Steplewski K., Connor J., and Kumar S. Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis. Arthritis Rheum 54 (2006) 3513-3522
31. Repa J.J., Turley S.D., Lobaccaro J.A., Medina J., Li L., Lustig K., et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289 (2000) 1524-1529
32. Schultz J.R., Tu H., Luk A., Repa J.J., Medina J.C., Li L., et al. Role of LXRs in control of lipogenesis. Genes Dev 14 (2000) 2831-2838
33. LaVallie E.R., Chockalingam P.S., Collins-Racie L.A., Freeman B.A., Keohan C.C., Leitges M., et al. Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes. J Biol Chem 281 (2006) 24124-24137
34. Grau S., Richards P.J., Kerr B., Hughes C., Caterson B., Williams A.S., et al. The role of human HtrA1 in arthritic disease. J Biol Chem 281 (2006) 6124-6129
35. Wu J., Liu W., Bemis A., Wang E., Qiu Y., Morris E.A., et al. Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis. Arthritis Rheum 56 (2007) 3675-3684
36. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
37. Farndale R.W., Buttle D.J., and Barrett A.J. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 883 (1986) 173-177
38. Schwartz K., Lawn R.M., and Wade D.P. ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR. Biochem Biophys Res Commun 274 (2000) 794-802
39. Laffitte B.A., Repa J.J., Joseph S.B., Wilpitz D.C., Kast H.R., Mangelsdorf D.J., et al. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophags and adipocytes. Proc Natl Acad Sci U S A 98 (2001) 507-512
40. Venkateswaran A., Repa J.J., Lobaccaro J.M., Bronson A., Mangelsdorf D.J., and Edwards P.A. Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. J Biol Chem 275 (2000) 14700-14707
41. Hummasti S., Laffitte B.A., Watson M.A., Galardi C., Chao L.C., Ramamurthy L., et al. Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target. J Lipid Res 45 (2004) 616-625
42. Kobayashi M., Takezawa S., Hara K., Yu R.T., Umesono Y., Agata K., et al. Identification of a photoreceptor cell-specific nuclear receptor. Proc Natl Acad Sci U S A 96 (1999) 4814-4819
43. Hedbom E., and Hauselmann H.J. Molecular aspects of pathogenesis in osteoarthritis: the role of inflammation. Cell Mol Life Sci 59 (2002) 45-53
44. Aigner T., Kurz B., Fukui N., and Sandell L. Roles of chondrocytes in the pathogenesis of osteoarthritis. Curr Opin Rheumatol 14 (2002) 578-584
45. Goldring M.B. The role of the chondrocyte in osteoarthritis. Arthritis Rheum 43 (2000) 1916-1926
46. Goldring M.B. Osteoarthritis and cartilage: the role of cytokines. Curr Rheumatol Rep 2 (2000) 459-465
47. Fernandes J.C., Martel-Pelletier J., and Pelletier J.P. The role of cytokines in osteoarthritis pathophysiology. Biorheology 39 (2002) 237-246
48. Hanna F.S., Wluka A.E., Bell R.J., Davis S.R., and Cicuttini F.M. Osteoarthritis and the postmenopausal woman: epidemiological, magnetic resonance imaging, and radiological findings. Semin Arthritis Rheum 34 (2004) 631-636
49. Lu T., Achari Y., Sciore P., and Hart D.A. Estrogen receptor alpha regulates matrix metalloproteinase-13 promoter activity primarily through the AP-1 transcriptional regulatory site. Biochim Biophys Acta 1762 (2006) 719-731
50. Richette P., Dumontier M.F., Francois M., Tsagris L., Korwin-Zmijowska C., Rannou F., et al. Dual effects of 17beta-oestradiol on interleukin 1beta-induced proteoglycan degradation in chondrocytes. Ann Rheum Dis 63 (2004) 191-199
51. Afif H., Benderdour M., Mfuna-Endam L., Martel-Pelletier J., Pelletier J.P., Duval N., et al. Peroxisome proliferator-activated receptor gamma1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1beta in articular chondrocytes. Arthritis Res Ther 9 (2007) R31
52. Gentili C., Tutolo G., Pianezzi A., Cancedda R., and Descalzi Cancedda F. Cholesterol secretion and homeostasis in chondrocytes: a liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein A1 expression. Matrix Biol 24 (2005) 35-44
53. Ohno S., Im H.J., Knudson C.B., and Knudson W. Hyaluronan oligosaccharide-induced activation of transcription factors in bovine articular chondrocytes. Arthritis Rheum 52 (2005) 800-809
54. Germain P., Chambon P., Eichele G., Evans R.M., Lazar M.A., Leid M., et al. International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev 58 (2006) 760-772
55. Burrage P.S., Huntington J.T., Sporn M.B., and Brinckerhoff C.E. Regulation of matrix metalloproteinase gene expression by a retinoid X receptor-specific ligand. Arthritis Rheum 56 (2007) 892-904
56. Castrillo A., Joseph S.B., Marathe C., Mangelsdorf D.J., and Tontonoz P. Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem 278 (2003) 10443-10449
57. Joseph S.B., Castrillo A., Laffitte B.A., Mangelsdorf D.J., and Tontonoz P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 9 (2003) 213-219
58. Tsutsumi R., Ito H., Hiramitsu T., Nishitani K., Akiyoshi M., Kitaori T., et al. Celecoxib inhibits production of MMP and NO via down-regulation of NF-kappaB and JNK in a PGE2 independent manner in human articular chondrocytes. Rheumatol Int (2007)
59. Attur M.G., Dave M., Akamatsu M., Katoh M., and Amin A.R. Osteoarthritis or osteoarthrosis: the definition of inflammation becomes a semantic issue in the genomic era of molecular medicine. Osteoarthritis Cartilage 10 (2002) 1-4