Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses

Cell

Volumn 151, Issue 1, 2012, Pages 138-152

  Spann, Nathanael J ^a   Garmire, Lana X ^b   McDonald, Jeffrey G ^e   Myers, David S ^f   Milne, Stephen B ^f   Shibata, Norihito ^a   Reichart, Donna ^a   Fox, Jesse N ^a   Shaked, Iftach ^j   Heudobler, Daniel ^a   Raetz, Christian R H ^g   Wang, Elaine W ⁱ   Kelly, Samuel L ⁱ   Sullards, M Cameron ⁱ   Murphy, Robert C ^h   Merrill, Alfred H ⁱ   Brown, H Alex ^f   Dennis, Edward A ^c   Li, Andrew C ^d   Ley, Klaus ^j   Tsimikas, Sotirios ^d   Fahy, Eoin ^b   Subramaniam, Shankar ^a,b,c   Quehenberger, Oswald ^d   Russell, David W ^e   Glass, Christopher K ^a,d   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^f VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

ⁱ GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^j LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; DESMOSTEROL; FATTY ACID; LIPID; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTERY WALL; ARTICLE; ATHEROSCLEROSIS; CELL DIFFERENTIATION; CELL MIGRATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIET; FATTY ACID METABOLISM; FOAM CELL; GENE EXPRESSION; GENE REPRESSION; GENE TARGETING; GENOTYPE; GROWTH INHIBITION; HOMEOSTASIS; INFLAMMATION; LIPID ANALYSIS; LIPID METABOLISM; LIPIDOMICS; MALE; MOUSE; NONHUMAN; PERITONEAL CAVITY; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS;

MUS;

EID: 84867031028     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2012.06.054     Document Type: Article

References (47)

1. N. A-Gonzalez, S.J. Bensinger, C. Hong, S. Beceiro, M.N. Bradley, N. Zelcer, J. Deniz, C. Ramirez, M. Díaz, and G. Gallardo Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR Immunity 31 2009 245 258
2. J. Avigan, D. Steinberg, M.J. Thompson, and E. Mosettig Mechanism of action of MER-29, an inhibitor of cholesterol biosynthesis Biochem. Biophys. Res. Commun. 2 1960 63 65
3. G.D. Barish, R.T. Yu, M.S. Karunasiri, D. Becerra, J. Kim, T.W. Tseng, L.J. Tai, M. Leblanc, C. Diehl, and L. Cerchietti The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis Cell Metab. 15 2012 554 562
4. G.J. Blake, and P.M. Ridker C-reactive protein and other inflammatory risk markers in acute coronary syndromes J. Am. Coll. Cardiol. 41 4, Suppl S 2003 37S 42S
5. H. Cao, K. Gerhold, J.R. Mayers, M.M. Wiest, S.M. Watkins, and G.S. Hotamisligil Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism Cell 134 2008 933 944
6. I.F. Charo, and M.B. Taubman Chemokines in the pathogenesis of vascular disease Circ. Res. 95 2004 858 866
7. W. Chen, G. Chen, D.L. Head, D.J. Mangelsdorf, and D.W. Russell Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice Cell Metab. 5 2007 73 79
8. S.H. Choi, R. Harkewicz, J.H. Lee, A. Boullier, F. Almazan, A.C. Li, J.L. Witztum, Y.S. Bae, and Y.I. Miller Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake Circ. Res. 104 2009 1355 1363
9. M.Y. Chou, K. Hartvigsen, L.F. Hansen, L. Fogelstrand, P.X. Shaw, A. Boullier, C.J. Binder, and J.L. Witztum Oxidation-specific epitopes are important targets of innate immunity J. Intern. Med. 263 2008 479 488
10. P. Duewell, H. Kono, K.J. Rayner, C.M. Sirois, G. Vladimer, F.G. Bauernfeind, G.S. Abela, L. Franchi, G. Nuñez, and M. Schnurr NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals Nature 464 2010 1357 1361
11. Z.S. Galis, G.K. Sukhova, R. Kranzhöfer, S. Clark, and P. Libby Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases Proc. Natl. Acad. Sci. USA 92 1995 402 406
12. G.S. Getz, and C.A. Reardon Diet and murine atherosclerosis Arterioscler. Thromb. Vasc. Biol. 26 2006 242 249
13. S. Ghisletti, W. Huang, S. Ogawa, G. Pascual, M.E. Lin, T.M. Willson, M.G. Rosenfeld, and C.K. Glass Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma Mol. Cell 25 2007 57 70
14. C.K. Glass, and J.L. Witztum Atherosclerosis. the road ahead Cell 104 2001 503 516
15. J.L. Goldstein, Y.K. Ho, S.K. Basu, and M.S. Brown Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition Proc. Natl. Acad. Sci. USA 76 1979 333 337
16. G.K. Hansson, A.K. Robertson, and C. Söderberg-Nauclér Inflammation and atherosclerosis Annu. Rev. Pathol. 1 2006 297 329
17. S. Heinz, C. Benner, N. Spann, E. Bertolino, Y.C. Lin, P. Laslo, J.X. Cheng, C. Murre, H. Singh, and C.K. Glass Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities Mol. Cell 38 2010 576 589
18. B.A. Janowski, P.J. Willy, T.R. Devi, J.R. Falck, and D.J. Mangelsdorf An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha Nature 383 1996 728 731
19. J.L. Johnson, and A.C. Newby Macrophage heterogeneity in atherosclerotic plaques Curr. Opin. Lipidol. 20 2009 370 378
20. S.B. Joseph, A. Castrillo, B.A. Laffitte, D.J. Mangelsdorf, and P. Tontonoz Reciprocal regulation of inflammation and lipid metabolism by liver X receptors Nat. Med. 9 2003 213 219
21. A. Kadl, A.K. Meher, P.R. Sharma, M.Y. Lee, A.C. Doran, S.R. Johnstone, M.R. Elliott, F. Gruber, J. Han, and W. Chen Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2 Circ. Res. 107 2010 737 746
22. M.A. Kennedy, A. Venkateswaran, P.T. Tarr, I. Xenarios, J. Kudoh, N. Shimizu, and P.A. Edwards Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein J. Biol. Chem. 276 2001 39438 39447
23. T.J. Kirby Cataracts produced by triparanol. (MER-29) Trans. Am. Ophthalmol. Soc. 65 1967 494 543
24. M. Krieger, and J. Herz Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP) Annu. Rev. Biochem. 63 1994 601 637
25. A.C. Li, C.J. Binder, A. Gutierrez, K.K. Brown, C.R. Plotkin, J.W. Pattison, A.F. Valledor, R.A. Davis, T.M. Willson, and J.L. Witztum Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma J. Clin. Invest. 114 2004 1564 1576
26. K.S. Michelsen, M.H. Wong, P.K. Shah, W. Zhang, J. Yano, T.M. Doherty, S. Akira, T.B. Rajavashisth, and M. Arditi Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E Proc. Natl. Acad. Sci. USA 101 2004 10679 10684
27. Y.I. Miller, M.K. Chang, C.J. Binder, P.X. Shaw, and J.L. Witztum Oxidized low density lipoprotein and innate immune receptors Curr. Opin. Lipidol. 14 2003 437 445
28. C. Monaco, S.M. Gregan, T.J. Navin, B.M. Foxwell, A.H. Davies, and M. Feldmann Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis Circulation 120 2009 2462 2469
29. A.E. Mullick, K. Soldau, W.B. Kiosses, T.A. Bell 3rd, P.S. Tobias, and L.K. Curtiss Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events J. Exp. Med. 205 2008 373 383
30. C.R. Raetz, T.A. Garrett, C.M. Reynolds, W.A. Shaw, J.D. Moore, D.C. Smith Jr.; A.A. Ribeiro, R.C. Murphy, R.J. Ulevitch, and C. Fearns Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4 J. Lipid Res. 47 2006 1097 1111
31. B.D. Reed, A.E. Charos, A.M. Szekely, S.M. Weissman, and M. Snyder Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes PLoS Genet. 4 2008 e1000133
32. J.J. Repa, G. Liang, J. Ou, Y. Bashmakov, J.M. Lobaccaro, I. Shimomura, B. Shan, M.S. Brown, J.L. Goldstein, and D.J. Mangelsdorf Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta Genes Dev. 14 2000 2819 2830
33. M. Ricote, A.C. Li, T.M. Willson, C.J. Kelly, and C.K. Glass The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation Nature 391 1998 79 82
34. V.Z. Rocha, and P. Libby Obesity, inflammation, and atherosclerosis Nat Rev Cardiol 6 2009 399 409
35. T.Y. Roh, G. Wei, C.M. Farrell, and K. Zhao Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns Genome Res. 17 2007 74 81
36. R. Ross The pathogenesis of atherosclerosis: a perspective for the 1990s Nature 362 1993 801 809
37. D. Steinberg The LDL modification hypothesis of atherogenesis: an update J. Lipid Res. 50 Suppl 2009 S376 S381
38. I. Tabas Macrophage death and defective inflammation resolution in atherosclerosis Nat. Rev. Immunol. 10 2010 36 46
39. F. Tacke, D. Alvarez, T.J. Kaplan, C. Jakubzick, R. Spanbroek, J. Llodra, A. Garin, J. Liu, M. Mack, and N. van Rooijen Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques J. Clin. Invest. 117 2007 185 194
40. A. Venkateswaran, B.A. Laffitte, S.B. Joseph, P.A. Mak, D.C. Wilpitz, P.A. Edwards, and P. Tontonoz Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha Proc. Natl. Acad. Sci. USA 97 2000 12097 12102
41. X.H. Xu, P.K. Shah, E. Faure, O. Equils, L. Thomas, M.C. Fishbein, D. Luthringer, X.P. Xu, T.B. Rajavashisth, and J. Yano Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL Circulation 104 2001 3103 3108
42. C. Yang, J.G. McDonald, A. Patel, Y. Zhang, M. Umetani, F. Xu, E.J. Westover, D.F. Covey, D.J. Mangelsdorf, J.C. Cohen, and H.H. Hobbs Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands J. Biol. Chem. 281 2006 27816 27826
43. N. Zelcer, C. Hong, R. Boyadjian, and P. Tontonoz LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor Science 325 2009 100 104
44. Dennis, G.; Jr.; Sherman, B.T.; Hosack, D.A.; Yang, J.; Gao, W.; Lane, H.C.; and Lempicki, R.A. (2003). DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4, 3.
45. Heinz, S.; Benner, C.; Spann, N.; Bertolino, E.; Lin, Y.C.; Laslo, P.; Cheng, J.X.; Murre, C.; Singh, H.; and Glass, C.K. (2010). Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576-589.
46. Sásik, R.; Calvo, E.; and Corbeil, J. (2002). Statistical analysis of high-density oligonucleotide arrays: a multiplicative noise model. Bioinformatics 18, 1633-1640.
47. Schmitz-Peiffer, C.; Craig, D.L.; and Biden, T.J. (1999). Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J. Biol. Chem. 274, 24202-24210.