Discovery of tertiary sulfonamides as potent liver X receptor antagonists

Journal of Medicinal Chemistry

Volumn 53, Issue 8, 2010, Pages 3412-3416

  Zuercher, William J ^a   Buckholz, Richard G ^a,b   Campobasso, Nino ^a   Collins, Jon L ^a   Galardi, Cristin M ^a   Gampe, Robert T ^a   Hyatt, Stephen M ^a   Merrihew, Susan L ^a   Moore, John T ^a   Oplinger, Jeffrey A ^a   Reid, Paul R ^a,c   Spearing, Paul K ^a   Stanley, Thomas B ^a   Stewart, Eugene L ^a   Willson, Timothy M ^a  

^a GLAXOSMITHKLINE   (United States)

^b Talecris Biotherapeutics Inc   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4,6 TRIMETHYL N [[3' (METHYLSULFONYL) 4 BIPHENYL]METHYL] N [[5 (TRIFLUOROMETHYL) 2 FURANYL]METHYL]BENZENESULFONAMIDE; CELL NUCLEUS RECEPTOR; GSK 2033; LIVER X RECEPTOR; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR INTERACTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HAPLORHINI; HUMANS; MODELS, MOLECULAR; ORPHAN NUCLEAR RECEPTORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TRANSCRIPTIONAL ACTIVATION;

EID: 77951116509     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901797p     Document Type: Article

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