Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice

American Journal of Pathology

Volumn 149, Issue 5, 1996, Pages 1607-1615

  Müller Ladner, Ulf ^a,c   Kriegsmann, Jörg ^a   Franklin, Barry N ^a   Matsumoto, Shigeru ^a   Geiler, Thomas ^a   Gay, Renate E ^a,b   Gay, Steffen ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN; COLLAGENASE; STROMELYSIN;

ANIMAL TISSUE; ARTICLE; CARTILAGINOUS TISSUE; CELL ADHESION; CELL INTERACTION; CELL METABOLISM; CELL TRANSFORMATION; COMBINED IMMUNODEFICIENCY; ENZYME DEGRADATION; FIBROBLAST; GENE ACTIVATION; HISTOLOGY; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PANNUS; PRIORITY JOURNAL; PROTO ONCOGENE; RHEUMATOID ARTHRITIS;

ANIMALS; ARTHRITIS, RHEUMATOID; CARTILAGE, ARTICULAR; CATHEPSINS; CELL ADHESION; CELL DIVISION; FIBROBLASTS; HUMANS; MICE; MICE, SCID; OSTEOARTHRITIS; SYNOVIAL MEMBRANE; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0029855587     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Gay S, Gay RE, Koopman WJ: Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction? Ann Rheum Dis 1993, 52:S39-S47
2. Zvaifler NJ, Firestein GS: Pannus and pannocytes: alternative models of joint destruction. Arthritis Rheum 1994, 37:783-789
3. Woolley DE, Crossley MJ, Evanson JM: Collagenase at sites of cartilage erosion in the rheumatoid joint. Arthritis Rheum 1977, 20:1231-1239
4. McCachren SS, Haynes BF, Niedel JE: Localization of collagenase mRNA in rheumatoid arthritis synovium by in situ hybridization histochemistry. J Clin Immunol 1990, 10:19-27
5. Krane SM, Conca W, Stephenson ML, Amento EP, Goldring MB: Mechanisms of matrix degradation in rheumatoid arthritis. Ann NY Acad Sci USA 1990, 580: 350-354
6. Maciewicz RA, Wotton SF, Etherington DJ, Duance VJ: Susceptibility of the cartilage collagens type II, IX, and XI to degradation by the cysteine proteinases, cathepsin B and L. FEBS Lett 1990, 269:189-193
7. Nguyen Q, Mort JS, Roughley PJ: Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B. Biochem J 1990, 266:569-573
8. Trabandt A, Aicher WK, Gay RE, Sukhatme VP, Nilson-Hamilton M, Hamilton RT, McGhee JR, Fassbender HG, Gay S: Expression of the collagenolytic and ras-induced cysteine protease cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis. Matrix 1990, 10:349-361
9. Trabandt A, Gay RE, Fassbender HG, Gay S: Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis. Arthritis Rheum 1991, 34:1444-1451
10. Firestein GS, Paine M: Expression of stromelysin and TIMP in rheumatoid arthritis synovium. Am J Pathol 1992, 140:1309-1314
11. Keyszer GM, Heer AH, Kriegsmann J, Geiler T, Trabandt A, Keysser M, Gay RE, Gay S: Comparative investigation of cathepsin L, cathepsin D, and collagenase mRNA expression in synovial tissue of patients with rheumatoid arthritis and osteoarthritis by in situ hybridization. Arthritis Rheum 1995, 38:976-984
12. Koch AE, Burrows JC, Haines GK, Carlos TM, Harlan JM, Leibovich SJ: Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and and osteoarthritic synovial tissues. Lab Invest 1991, 64:313-320
13. Wilkinson LS, Edwards JCW, Poston RN, Hascard DO: Expression of vascular cell adhesion molecule-1 in normal and inflamed synovium. Lab Invest 1993, 68:682-688
14. Kriegsmann J, Keyszer GM, Geiler T, Bräuer R, Gay RE, Gay S: Expression of vascular cell adhesion molecule-1 mRNA and protein in rheumatoid arthritis synovium demonstrated by in situ hybridization and immunohistochemistry. Lab Invest 1995, 72:209-213
15. Fassbender HG: Histomorphologic basis of articular cartilage destruction in rheumatoid arthritis. Coll Relat Res 1983, 3:141-155
16. Müller-Ladner U, Kriegsmann J, Gay RE, Gay S: Oncogenes in rheumatoid arthritis. Rheum Dis Clin N Am 1995, 21:675-690
17. Brinckerhoff CE, Harris ED: Survival of rheumatoid synovium implanted into nude mice. Am J Pathol 1981, 103:411-419
18. Dodge GR, Jimenez S: An in vitro model of synovial cell adhesion and invasiveness into human articular cartilage. Arthritis Rheum 1994, 37:S311
19. Ramachandrula M, Tiku K, Tiku ML: Tripeptide RGD-dependent adhesion of articular chondrocytes to synovial fibroblasts. J Cell Sci 1992, 101:859-871
20. Geiler T, Kriegsmann J, Keyszer G, Gay RE, Gay S: A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice. Arthritis Rheum 1994, 37:1664-1671
21. Höyhtyä M. Myllylä R, Piuva J. Kivirikko KI, Tryggvason K: Monoclonal antibody to human prolyl 4-hydroxylase. Eur J Biochem 1984, 141:477-482
22. Müller-Ladner U, Kriegsmann J, Tschopp J, Gay RE, Gay S: Demonstration of granzyme A and perforin mRNA in synovium of patients with rheumatoid arthritis. Arthritis Rheum 1995, 38:477-484
23. Gay S, Fine JD: Characterization and isolation of polyand monoclonal antibodies against collagen for use in immunohistochemistry. Methods Enzymol 1987, 145: 148-167
24. Firestein GS, Yeo M, Zvaifler NJ: Apoptosis in rheumatoid arthritis synovium. J Clin Invest 1995, 96:1631-1639
25. Rendt KE, Barry TS, Jones DM, Richter CB, McCachren SS, Haynes BF: Engraftment of human synovium into severe combined immune deficient (SCID) mice: migration of human peripheral blood T-cells to engrafted human synovium and to mouse lymph nodes. J Immunol 1993, 151:7324-7336
26. Aicher WK, Heer AH, Trabandt A, Bridges SL Jr, Schroeder HW Jr, Stransky G, Gay RE, Eibel H, Peter HH, Siebenlist U, Koopman WJ, Gay S: Overexpression of zinc-finger transcription factor Z-225/Egr-1 in synoviocytes from rheumatoid arthritis patients. J Immunol 1994, 152:5940-5948
27. Lemaire R, Flipo R-M, Monte D, Dupressoir T. Duquesnoy B, Chesbron J-Y, Janin A, Capron A, Lafyatis R: Synovial fibroblast-like cell transfection with the SV40 large T antigen induces a transformed phenotype and permits transient tumor formation in immunodeficient mice. J Rheumatol 1994, 21:1409-1419
28. Tanuguchi S, Nishimura T, Takahashi T, Baba T, Kato K: Augmented excretion of preprocathepsin L of a fos-transferred highly metastatic cell line. Biochem Biophys Res Commun 1990, 168:520-526
29. Elices MJ, Osborn L, Takada Y, Grouse C, Luhowskyi S, Hemler ME, Lobb RR: VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 1990, 60:577-584
30. Van Dinther-Janssen ACHM, Horst E, Koopman G, Newman W, Scheper RJ, Meijer CLJM, Pals ST: The VLA-4/VCAM-1 pathway is involved in lymphocyte adhesion to endothelium in rheumatoid synovium. J Immunol 1991, 147:4207-4210
31. Elices M, Tsai V, Strahl D, Goel AS, Tollefson V, Arrhenius T, Wayner EA, Gaeta FCA, Fikes JD, Firestein GS: Expression and functional significance of alternatively spliced CS-1 fibronectin in rheumatoid arthritis microvasculature. J Clin Invest 1994, 93:405-416
32. Müller-Ladner U: T cell independent pathways in rheumatoid arthritis. Curr Opin Rheumatol 1995, 7: 222-228