Activation of liver X receptor (LXR) inhibits receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation in an LXRβ-dependent mechanism

Journal of Biological Chemistry

Volumn 286, Issue 38, 2011, Pages 33084-33094

  Robertson Remen, Kirsten M ^a   Henning, Petra ^b   Lerner, Ulf H ^b,c   Gustafsson, Jan Åke ^a,d   Andersson, Göran ^e  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c UMEÅ UNIVERSITY   (Sweden)

^d University of Houston   (United States)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BONE DESTRUCTION; BONE RESORPTION; BONE TURNOVER; CALCITONIN RECEPTORS; CHOLESTEROL METABOLISM; INFLAMMATORY SIGNALING; LIVER X RECEPTORS; METABOLIC DISEASE; NUCLEAR FACTORS; OSTEOCLAST DIFFERENTIATION; OSTEOCLAST FORMATION; OSTEOCLAST PRECURSOR; OSTEOCLAST-ASSOCIATED RECEPTORS; PATHOLOGICAL PROCESS; PROGENITOR CELL; RECEPTOR ACTIVATOR; TARTRATE-RESISTANT ACID PHOSPHATASE;

BONE; LIGANDS; METABOLISM; PHOSPHATASES; PHYSIOLOGY; TRANSCRIPTION FACTORS;

CHEMICAL ACTIVATION;

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CALCITONIN RECEPTOR; CATHEPSIN K; CELL RECEPTOR; LIVER X RECEPTOR BETA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; OSTEOCLAST ASSOCIATED RECEPTOR; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN C FOS; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALVARIA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL;

ACID PHOSPHATASE; ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD14; BENZOIC ACIDS; BENZYLAMINES; BONE MARROW CELLS; BONE RESORPTION; CELL DIFFERENTIATION; CELL LINE; FEMALE; GENE EXPRESSION REGULATION; HUMANS; ISOENZYMES; MACROPHAGES; MICE; MODELS, BIOLOGICAL; ORPHAN NUCLEAR RECEPTORS; OSTEOCLASTS; RANK LIGAND; SKULL;

MURINAE; MUS;

EID: 80052979753     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.235937     Document Type: Article

References (59)

1. Boyle, W. J., Simonet, W. S., and Lacey, D. L. (2003) Nature 423, 337-342
2. Teitelbaum, S. L. (2000) Science 289, 1504-1508
3. Asagiri, M., and Takayanagi, H. (2007) Bone 40, 251-264
4. Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J., Wagner, E. F., Mak, T. W., Kodama, T., and Taniguchi, T. (2002) Dev. Cell 3, 889-901
5. Gohda, J., Akiyama, T., Koga, T., Takayanagi, H., Tanaka, S., and Inoue, J. (2005) EMBO J. 24, 790-799
6. Takayanagi, H. (2007) Ann. N.Y. Acad. Sci. 1116, 227-237
7. Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., and Mangelsdorf, D. J. (1996) Nature 383, 728-731
8. Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J. L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., and Willson, T. M. (1997) J. Biol. Chem. 272, 3137-3140
9. Joseph, S. B., McKilligin, E., Pei, L., Watson, M. A., Collins, A. R., Laffitte, B. A., Chen, M., Noh, G., Goodman, J., Hagger, G. N., Tran, J., Tippin, T. K., Wang, X., Lusis, A. J., Hsueh, W. A., Law, R. E., Collins, J. L., Willson, T. M., and Tontonoz, P. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 7604-7609
10. Tangirala, R. K., Bischoff, E. D., Joseph, S. B., Wagner, B. L., Walczak, R., Laffitte, B. A., Daige, C. L., Thomas, D., Heyman, R. A., Mangelsdorf, D. J., Wang, X., Lusis, A. J., Tontonoz, P., and Schulman, I. G. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 11896-11901
11. Levin, N., Bischoff, E. D., Daige, C. L., Thomas, D., Vu, C. T., Heyman, R. A., Tangirala, R. K., and Schulman, I. G. (2005) Arterioscler. Thromb. Vasc. Biol. 25, 135-142
12. Robertson, K. M., Norgård, M., Windahl, S. H., Hultenby, K., Ohlsson, C., Andersson, G., and Gustafsson, J. A. (2006) J. Bone Miner. Res. 21, 1276-1287
13. Prawitt, J., Beil, F. T., Marshall, R. P., Bartelt, A., Ruether, W., Heeren, J., Amling, M., Staels, B., and Niemeier, A. (2011) Bone 48, 339-346
14. Park, M. C., Kwon, Y. J., Chung, S. J., Park, Y. B., and Lee, S. K. (2010) Rheumatology 49, 882-890
15. Chintalacharuvu, S. R., Sandusky, G. E., Burris, T. P., Burmer, G. C., and Nagpal, S. (2007) Arthritis Rheum. 56, 1365-1367
16. Alberti, S., Schuster, G., Parini, P., Feltkamp, D., Diczfalusy, U., Rudling, M., Angelin, B., Björkhem, I., Pettersson, S., and Gustafsson, J. A. (2001) J. Clin. Invest. 107, 565-573
17. Schuster, G. U., Parini, P., Wang, L., Alberti, S., Steffensen, K. R., Hansson, G. K., Angelin, B., and Gustafsson, J. A. (2002) Circulation 106, 1147-1153
18. Granholm, S., Lundberg, P., and Lerner, U. H. (2007) J. Endocrinol. 195, 415-427
19. Takeshita, S., Kaji, K., and Kudo, A. (2000) J. Bone Miner. Res. 15, 1477-1488
20. Lu, S. Y., Li, M., and Lin, Y. L. (2010) Mol. Biol. Cell 21, 1763-1771
21. Kawase, Y., Hoshino, T., Yokota, K., Kuzuhara, A., Nakamura, M., Maeda, Y., Nishiwaki, E., Zenmyo, M., Hiraoka, K., Aizawa, H., and Yoshino, K. (2003) J. Bone Miner. Res. 18, 975-983
22. Kinser, S., Li, M., Jia, Q., and Pestka, J. J. (2005) J. Nutr. Biochem. 16, 88-95
23. Bandyopadhyay, S., Lion, J. M., Mentaverri, R., Ricupero, D. A., Kamel, S., Romero, J. R., and Chattopadhyay, N. (2006) Biochem. Pharmacol. 72, 184-197
24. Yamaza, T., Goto, T., Kamiya, T., Kobayashi, Y., Sakai, H., and Tanaka, T. (1998) Bone 23, 499-509
25. Ek-Rylander, B., Barkhem, T., Ljusberg, J., Ohman, L., Andersson, K. K., and Andersson, G. (1997) Biochem. J. 321, 305-311
26. Ljunggren, O., Ransjö, M., and Lerner, U. H. (1991) J. Bone Miner. Res. 6, 543-550
27. Lerner, U. H. (1987) J. Bone Miner. Res. 2, 375-383
28. Luchin, A., Purdom, G., Murphy, K., Clark, M. Y., Angel, N., Cassady, A. I., Hume, D. A., and Ostrowski, M. C. (2000) J. Bone Miner. Res. 15, 451-460
29. Mansky, K. C., Sulzbacher, S., Purdom, G., Nelsen, L., Hume, D. A., Rehli, M., and Ostrowski, M. C. (2002) J. Leukocyte Biol. 71, 304-310
30. Motyckova, G., Weilbaecher, K. N., Horstmann, M., Rieman, D. J., Fisher, D. Z., and Fisher, D. E. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 5798-5803
31. So, H., Rho, J., Jeong, D., Park, R., Fisher, D. E., Ostrowski, M. C., Choi, Y., and Kim, N. (2003) J. Biol. Chem. 278, 24209-24216
32. Liu, Y., Shi, Z., Silveira, A., Liu, J., Sawadogo, M., Yang, H., and Feng, X. (2003) J. Biol. Chem. 278, 20603-20611
33. Kim, J. H., Kim, K., Jin, H. M., Youn, B. U., Song, I., Choi, H. S., and Kim, N. (2008) J. Mol. Biol. 383, 502-511
34. Meadows, N. A., Sharma, S. M., Faulkner, G. J., Ostrowski, M. C., Hume, D. A., and Cassady, A. I. (2007) J. Biol. Chem. 282, 1891-1904
35. Matsuo, K., Galson, D. L., Zhao, C., Peng, L., Laplace, C., Wang, K. Z., Bachler, M. A., Amano, H., Aburatani, H., Ishikawa, H., and Wagner, E. F. (2004) J. Biol. Chem. 279, 26475-26480
36. Kukita, T., Wada, N., Kukita, A., Kakimoto, T., Sandra, F., Toh, K., Nagata, K., Iijima, T., Horiuchi, M., Matsusaki, H., Hieshima, K., Yoshie, O., and Nomiyama, H. (2004) J. Exp. Med. 200, 941-946
37. Zenger, S., Ek-Rylander, B., and Andersson, G. (2010) Biochem. Biophys. Res. Commun. 394, 743-749
38. Shinohara, M., and Takayanagi, H. (2007) Curr. Osteoporos. Rep. 5, 67-72
39. Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T., Ohnishi, H., Matozaki, T., Kodama, T., Taniguchi, T., Takayanagi, H., and Takai, T. (2004) Nature 428, 758-763
40. Kim, N., Takami, M., Rho, J., Josien, R., and Choi, Y. (2002) J. Exp. Med. 195, 201-209
41. Kim, Y., Sato, K., Asagiri, M., Morita, I., Soma, K., and Takayanagi, H. (2005) J. Biol. Chem. 280, 32905-32913
42. Matsumoto, M., Kogawa, M., Wada, S., Takayanagi, H., Tsujimoto, M., Katayama, S., Hisatake, K., and Nogi, Y. (2004) J. Biol. Chem. 279, 45969-45979
43. Kim, K., Kim, J. H., Lee, J., Jin, H. M., Lee, S. H., Fisher, D. E., Kook, H., Kim, K. K., Choi, Y., and Kim, N. (2005) J. Biol. Chem. 280, 35209-35216
44. Luchin, A., Suchting, S., Merson, T., Rosol, T. J., Hume, D. A., Cassady, A. I., and Ostrowski, M. C. (2001) J. Biol. Chem. 276, 36703-36710
45. Hu, R., Sharma, S. M., Bronisz, A., Srinivasan, R., Sankar, U., and Ostrowski, M. C. (2007) Mol. Cell. Biol. 27, 4018-4027
46. Mansky, K. C., Sankar, U., Han, J., and Ostrowski, M. C. (2002) J. Biol. Chem. 277, 11077-11083
47. Yagi, M., Miyamoto, T., Sawatani, Y., Iwamoto, K., Hosogane, N., Fujita, N., Morita, K., Ninomiya, K., Suzuki, T., Miyamoto, K., Oike, Y., Takeya, M., Toyama, Y., and Suda, T. (2005) J. Exp. Med. 202, 345-351
48. Kim, K., Lee, S. H., Ha Kim, J., Choi, Y., and Kim, N. (2008) Mol. Endocrinol. 22, 176-185
49. Lerner, U. H., Johansson, L., Ranjsö, M., Rosenquist, J. B., Reinholt, F. P., and Grubb, A. (1997) Acta Physiol. Scand. 161, 81-92
50. Pettit, A. R., Chang, M. K., Hume, D. A., and Raggatt, L. J. (2008) Bone 43, 976-982
51. Everts, V., de Vries, T. J., and Helfrich, M. H. (2009) Biochim. Biophys. Acta 1792, 757-765
52. Conaway, H. H., Persson, E., Halén, M., Granholm, S., Svensson, O., Pettersson, U., Lie, A., and Lerner, U. H. (2009) FASEB J. 23, 3526-3538
53. Asagiri, M., Sato, K., Usami, T., Ochi, S., Nishina, H., Yoshida, H., Morita, I., Wagner, E. F., Mak, T. W., Serfling, E., and Takayanagi, H. (2005) J. Exp. Med. 202, 1261-1269
54. Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., and Glass, C. K. (2005) Cell 122, 707-721
55. Treuter, E., and Gustafsson, J. A. (2007) Mol. Cell 25, 178-180
56. Ghisletti, S., Huang, W., Ogawa, S., Pascual, G., Lin, M. E., Willson, T. M., Rosenfeld, M. G., and Glass, C. K. (2007) Mol. Cell 25, 57-70
57. Venteclef, N., Jakobsson, T., Ehrlund, A., Damdimopoulos, A., Mikkonen, L., Ellis, E., Nilsson, L. M., Parini, P., Jänne, O. A., Gustafsson, J. A., Steffensen, K. R., and Treuter, E. (2010) Genes Dev. 24, 381-395
58. Schilcher, J., Michaëlsson, K., and Aspenberg, P. (2011) N. Engl. J. Med. 364, 1728-1737
59. Conaway, H. H., Pirhayati, A., Persson, E., Pettersson, U., Svensson, O., Lindholm, C., Henning, P., Tuckermann, J., and Lerner, U. H. (June 29, 2011) J. Biol. Chem. 10.1074/jbc.M111247734