Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: Liver-X-receptor-specific inhibition of inflammation and primary cytokine production

Journal of Investigative Dermatology

Volumn 120, Issue 2, 2003, Pages 246-255

  Fowler, Ashley J ^a,b   Sheu, Mary Y ^a,b   Schmuth, Matthias ^a,b   Kao, Jack ^a,b   Fluhr, Joachim W ^a,b   Rhein, Linda ^d   Collins, Jon L ^c   Willson, Timothy M ^c   Mangelsdorf, David J ^e   Elias, Peter M ^a,b   Feingold, Kenneth R ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c GLAXOSMITHKLINE   (United States)

^d GLAXOSMITHKLINE   (United Kingdom)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Inflammation; Keratinocyte; Nuclear hormone receptors; Oxysterols

Indexed keywords

22 HYDROXYCHOLESTEROL; 25 HYDROXYCHOLESTEROL; 3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; ANTIINFLAMMATORY AGENT; CLOBETASOL; INTERLEUKIN 1ALPHA; LIVER X RECEPTOR; LIVER X RECEPTOR STIMULATING AGENT; OXAZOLONE; OXYSTEROL; PHORBOL 13 ACETATE 12 MYRISTATE; RECEPTOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 22-HYDROXYCHOLESTEROL; 25-HYDROXYCHOLESTEROL; CARCINOGEN; CELL RECEPTOR; CHOLESTEROL DERIVATIVE; DNA BINDING PROTEIN; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPIDERMIS; FEMALE; INFLAMMATION; KERATINOCYTE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN ALLERGY; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; DRUG POTENTIATION; GENETICS; IMMUNOLOGY; IRRITANT DERMATITIS; MOUSE MUTANT; MOUSE STRAIN; PATHOPHYSIOLOGY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARCINOGENS; DERMATITIS, IRRITANT; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; EPIDERMIS; FEMALE; HYDROXYCHOLESTEROLS; INTERLEUKIN-1; MALE; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; OXAZOLONE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TETRADECANOYLPHORBOL ACETATE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037289786     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2003.12033.x     Document Type: Article

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