LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 8, 2010, Pages 3734-3739

  Li, Ning ^a   Rivéra Bermúdez, Moisés A ^a   Zhang, Mei ^a   Tejada, Julio ^a   Glasson, Sonya S ^a   Collins Racie, Lisa A ^b   LaVallie, Edward R ^b   Wang, Yihe ^a   Chang, Ken C N ^a   Nagpal, Sunil ^a   Morris, Elisabeth A ^a   Flannery, Carl R ^a   Yang, Zhiyong ^a  

^a PFIZER INC   (United States)

^b Pfizer Research   (United States)

Author keywords

Cartilage; Pain; Prostaglandin E2

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; ADAMTS4; AGGRECANASE; CELL NUCLEUS RECEPTOR; INTERLEUKIN 1BETA; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; PROSTAGLANDIN E2; PROTEOGLYCAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRALGIA; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; EXPLANT; GENE DISRUPTION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MODULATION; NOCICEPTION; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ADAM PROTEINS; ANIMALS; BENZOIC ACIDS; BENZYLAMINES; CARTILAGE, ARTICULAR; CELL LINE, TUMOR; CYCLOOXYGENASE 2; DINOPROSTONE; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LIGANDS; MICE; MICE, MUTANT STRAINS; ORPHAN NUCLEAR RECEPTORS; OSTEOARTHRITIS; PAIN; PROCOLLAGEN N-ENDOPEPTIDASE; RATS;

RATTUS;

EID: 77649241985     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0911377107     Document Type: Article

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