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Volumn 254, Issue 1, 2013, Pages 305-325

The Immunological Synapse: The Gateway To The Hiv Reservoir

Author keywords

Asymmetric cell division; HIV latency; HIV reservoir; Immunological synapse; Virological synapse; Wnt Notch

Indexed keywords

BETA CATENIN; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; NOTCH RECEPTOR; SECONDARY LYMPHOID TISSUE CHEMOKINE; TUMOR NECROSIS FACTOR; WNT PROTEIN;

EID: 84879300349     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12080     Document Type: Article
Times cited : (34)

References (256)
  • 1
    • 0025942043 scopus 로고
    • Lymphoid organs function as major reservoirs for human immunodeficiency virus
    • Pantaleo G, et al. Lymphoid organs function as major reservoirs for human immunodeficiency virus. Proc Natl Acad Sci USA 1991;88:9838-9842.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 9838-9842
    • Pantaleo, G.1
  • 2
    • 0027538456 scopus 로고
    • HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease
    • Pantaleo G, et al. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 1993;362:355-358.
    • (1993) Nature , vol.362 , pp. 355-358
    • Pantaleo, G.1
  • 3
    • 0033179401 scopus 로고    scopus 로고
    • Dissemination of SIV after rectal infection preferentially involves paracolic germinal centers
    • Couedel-Courteille A, Butor C, Juillard V, Guillet JG, Venet A. Dissemination of SIV after rectal infection preferentially involves paracolic germinal centers. Virology 1999;260:277-294.
    • (1999) Virology , vol.260 , pp. 277-294
    • Couedel-Courteille, A.1    Butor, C.2    Juillard, V.3    Guillet, J.G.4    Venet, A.5
  • 4
    • 0032540418 scopus 로고    scopus 로고
    • Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection
    • Veazey RS, et al. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science 1998;280:427-431.
    • (1998) Science , vol.280 , pp. 427-431
    • Veazey, R.S.1
  • 5
    • 0024545655 scopus 로고
    • Detection of HIV-1 RNA in the lamina propria of patients with AIDS and gastrointestinal disease
    • Fox CH, Kotler D, Tierney A, Wilson CS, Fauci AS. Detection of HIV-1 RNA in the lamina propria of patients with AIDS and gastrointestinal disease. J Infect Dis 1989;159:467-471.
    • (1989) J Infect Dis , vol.159 , pp. 467-471
    • Fox, C.H.1    Kotler, D.2    Tierney, A.3    Wilson, C.S.4    Fauci, A.S.5
  • 6
    • 3042810127 scopus 로고    scopus 로고
    • Higher concentration of HIV RNA in rectal mucosa secretions than in blood and seminal plasma, among men who have sex with men, independent of antiretroviral therapy
    • Zuckerman RA, et al. Higher concentration of HIV RNA in rectal mucosa secretions than in blood and seminal plasma, among men who have sex with men, independent of antiretroviral therapy. J Infect Dis 2004;190:156-161.
    • (2004) J Infect Dis , vol.190 , pp. 156-161
    • Zuckerman, R.A.1
  • 7
    • 0030913366 scopus 로고    scopus 로고
    • Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
    • Chun TW, et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 1997;387:183-188.
    • (1997) Nature , vol.387 , pp. 183-188
    • Chun, T.W.1
  • 8
    • 0031911587 scopus 로고    scopus 로고
    • Determinants of human immunodeficiency virus DNA and RNA shedding in the anal-rectal canal of homosexual men
    • Kiviat NB, et al. Determinants of human immunodeficiency virus DNA and RNA shedding in the anal-rectal canal of homosexual men. J Infect Dis 1998;177:571-578.
    • (1998) J Infect Dis , vol.177 , pp. 571-578
    • Kiviat, N.B.1
  • 9
    • 0034119065 scopus 로고    scopus 로고
    • Association of antiretroviral therapy with detection of HIV-1 RNA and DNA in the anorectal mucosa of homosexual men
    • Lampinen TM, et al. Association of antiretroviral therapy with detection of HIV-1 RNA and DNA in the anorectal mucosa of homosexual men. AIDS 2000;14:F69-F75.
    • (2000) AIDS , vol.14
    • Lampinen, T.M.1
  • 10
    • 40549092339 scopus 로고    scopus 로고
    • Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy
    • Chun TW, et al. Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy. J Infect Dis 2008;197:714-720.
    • (2008) J Infect Dis , vol.197 , pp. 714-720
    • Chun, T.W.1
  • 11
    • 33746791047 scopus 로고    scopus 로고
    • Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection
    • Guadalupe M, et al. Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection. J Virol 2006;80:8236-8247.
    • (2006) J Virol , vol.80 , pp. 8236-8247
    • Guadalupe, M.1
  • 12
    • 78149417719 scopus 로고    scopus 로고
    • Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy
    • Yukl SA, et al. Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy. J Infect Dis 2010;202:1553-1561.
    • (2010) J Infect Dis , vol.202 , pp. 1553-1561
    • Yukl, S.A.1
  • 13
    • 80052395837 scopus 로고    scopus 로고
    • Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy
    • Sigal A, et al. Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature 2011;477:95-98.
    • (2011) Nature , vol.477 , pp. 95-98
    • Sigal, A.1
  • 14
    • 84864345953 scopus 로고    scopus 로고
    • Towards an HIV cure: a global scientific strategy
    • Deeks SG, et al. Towards an HIV cure: a global scientific strategy. Nat Rev Immunol 2012;12:607-614.
    • (2012) Nat Rev Immunol , vol.12 , pp. 607-614
    • Deeks, S.G.1
  • 15
    • 84866498069 scopus 로고    scopus 로고
    • Redefining the viral reservoirs that prevent HIV-1 eradication
    • Eisele E, Siliciano RF. Redefining the viral reservoirs that prevent HIV-1 eradication. Immunity 2012;37:377-388.
    • (2012) Immunity , vol.37 , pp. 377-388
    • Eisele, E.1    Siliciano, R.F.2
  • 16
    • 0028792184 scopus 로고
    • In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency
    • Chun TW, Finzi D, Margolick J, Chadwick K, Schwartz D, Siliciano RF. In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency. Nat Med 1995;1:1284-1290.
    • (1995) Nat Med , vol.1 , pp. 1284-1290
    • Chun, T.W.1    Finzi, D.2    Margolick, J.3    Chadwick, K.4    Schwartz, D.5    Siliciano, R.F.6
  • 17
    • 68349139711 scopus 로고    scopus 로고
    • HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    • Chomont N, et al. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med 2009;15:893-900.
    • (2009) Nat Med , vol.15 , pp. 893-900
    • Chomont, N.1
  • 18
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi D, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 1997;278:1295-1300.
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1
  • 19
    • 0030712305 scopus 로고    scopus 로고
    • Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
    • Wong JK, et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 1997;278:1291-1295.
    • (1997) Science , vol.278 , pp. 1291-1295
    • Wong, J.K.1
  • 20
    • 0032953920 scopus 로고    scopus 로고
    • Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
    • Finzi D, et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 1999;5:512-517.
    • (1999) Nat Med , vol.5 , pp. 512-517
    • Finzi, D.1
  • 21
    • 0038579210 scopus 로고    scopus 로고
    • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    • Siliciano JD, et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med 2003;9:727-728.
    • (2003) Nat Med , vol.9 , pp. 727-728
    • Siliciano, J.D.1
  • 22
    • 0242584383 scopus 로고    scopus 로고
    • Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence
    • Strain MC, et al. Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence. Proc Natl Acad Sci USA 2003;100:4819-4824.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4819-4824
    • Strain, M.C.1
  • 23
    • 84859250847 scopus 로고    scopus 로고
    • Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection
    • Ananworanich J, et al. Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. PLoS ONE 2012;7:e33948.
    • (2012) PLoS ONE , vol.7
    • Ananworanich, J.1
  • 24
    • 20244376915 scopus 로고    scopus 로고
    • Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1
    • Strain MC, et al. Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1. J Infect Dis 2005;191:1410-1418.
    • (2005) J Infect Dis , vol.191 , pp. 1410-1418
    • Strain, M.C.1
  • 25
    • 73249136755 scopus 로고    scopus 로고
    • Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies
    • Colin L, Van Lint C. Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies. Retrovirology 2009;6:111.
    • (2009) Retrovirology , vol.6 , pp. 111
    • Colin, L.1    Van Lint, C.2
  • 26
    • 0025342694 scopus 로고
    • HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure
    • Zack JA, Arrigo SJ, Weitsman SR, Go AS, Haislip A, Chen IS. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 1990;61:213-222.
    • (1990) Cell , vol.61 , pp. 213-222
    • Zack, J.A.1    Arrigo, S.J.2    Weitsman, S.R.3    Go, A.S.4    Haislip, A.5    Chen, I.S.6
  • 27
    • 0025238945 scopus 로고
    • HIV-1 replication is controlled at the level of T cell activation and proviral integration
    • Stevenson M, Stanwick TL, Dempsey MP, Lamonica CA. HIV-1 replication is controlled at the level of T cell activation and proviral integration. EMBO J 1990;9:1551-1560.
    • (1990) EMBO J , vol.9 , pp. 1551-1560
    • Stevenson, M.1    Stanwick, T.L.2    Dempsey, M.P.3    Lamonica, C.A.4
  • 28
    • 13444309162 scopus 로고    scopus 로고
    • Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cells
    • Zhou Y, Zhang H, Siliciano JD, Siliciano RF. Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cells. J Virol 2005;79:2199-2210.
    • (2005) J Virol , vol.79 , pp. 2199-2210
    • Zhou, Y.1    Zhang, H.2    Siliciano, J.D.3    Siliciano, R.F.4
  • 29
    • 2642523580 scopus 로고    scopus 로고
    • Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes
    • Han Y, et al. Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes. J Virol 2004;78:6122-6133.
    • (2004) J Virol , vol.78 , pp. 6122-6133
    • Han, Y.1
  • 30
    • 79956082418 scopus 로고    scopus 로고
    • Influence of host gene transcription level and orientation on HIV-1 latency in a primary-cell model
    • Shan L, et al. Influence of host gene transcription level and orientation on HIV-1 latency in a primary-cell model. J Virol 2011;85:5384-5393.
    • (2011) J Virol , vol.85 , pp. 5384-5393
    • Shan, L.1
  • 31
    • 0029919356 scopus 로고    scopus 로고
    • Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation
    • Van Lint C, Emiliani S, Ott M, Verdin E. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J 1996;15:1112-1120.
    • (1996) EMBO J , vol.15 , pp. 1112-1120
    • Van Lint, C.1    Emiliani, S.2    Ott, M.3    Verdin, E.4
  • 33
    • 33748159867 scopus 로고    scopus 로고
    • Effect of SWI/SNF chromatin remodeling complex on HIV-1 Tat activated transcription
    • Agbottah E, Deng L, Dannenberg LO, Pumfery A, Kashanchi F. Effect of SWI/SNF chromatin remodeling complex on HIV-1 Tat activated transcription. Retrovirology 2006;3:48.
    • (2006) Retrovirology , vol.3 , pp. 48
    • Agbottah, E.1    Deng, L.2    Dannenberg, L.O.3    Pumfery, A.4    Kashanchi, F.5
  • 34
    • 70049090006 scopus 로고    scopus 로고
    • CpG methylation controls reactivation of HIV from latency
    • Blazkova J, et al. CpG methylation controls reactivation of HIV from latency. PLoS Pathog 2009;5:e1000554.
    • (2009) PLoS Pathog , vol.5
    • Blazkova, J.1
  • 35
    • 0023176085 scopus 로고
    • An inducible transcription factor activates expression of human immunodeficiency virus in T cells
    • Nabel G, Baltimore D. An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 1987;326:711-713.
    • (1987) Nature , vol.326 , pp. 711-713
    • Nabel, G.1    Baltimore, D.2
  • 36
    • 0024276882 scopus 로고
    • The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV
    • Bohnlein E, Lowenthal JW, Siekevitz M, Ballard DW, Franza BR, Greene WC. The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV. Cell 1988;53:827-836.
    • (1988) Cell , vol.53 , pp. 827-836
    • Bohnlein, E.1    Lowenthal, J.W.2    Siekevitz, M.3    Ballard, D.W.4    Franza, B.R.5    Greene, W.C.6
  • 37
    • 0028301838 scopus 로고
    • Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts
    • Adams M, et al. Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts. Proc Natl Acad Sci USA 1994;91:3862-3866.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3862-3866
    • Adams, M.1
  • 38
    • 77953313393 scopus 로고    scopus 로고
    • Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction
    • Tyagi M, Pearson RJ, Karn J. Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction. J Virol 2010;84:6425-6437.
    • (2010) J Virol , vol.84 , pp. 6425-6437
    • Tyagi, M.1    Pearson, R.J.2    Karn, J.3
  • 39
    • 84864203255 scopus 로고    scopus 로고
    • Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
    • Archin NM, et al. Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature 2012;487:482-485.
    • (2012) Nature , vol.487 , pp. 482-485
    • Archin, N.M.1
  • 42
    • 78649828376 scopus 로고    scopus 로고
    • APCs expressing high levels of programmed death ligand 2 sustain the development of CD4 T cell memory
    • Ellis JS, et al. APCs expressing high levels of programmed death ligand 2 sustain the development of CD4 T cell memory. J Immunol 2010;185:3149-3157.
    • (2010) J Immunol , vol.185 , pp. 3149-3157
    • Ellis, J.S.1
  • 43
    • 0038487052 scopus 로고    scopus 로고
    • Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells
    • Seddon B, Tomlinson P, Zamoyska R. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol 2003;4:680-686.
    • (2003) Nat Immunol , vol.4 , pp. 680-686
    • Seddon, B.1    Tomlinson, P.2    Zamoyska, R.3
  • 44
    • 65249100690 scopus 로고    scopus 로고
    • Generation and maintenance of memory CD4(+) T Cells
    • van Leeuwen EM, Sprent J, Surh CD. Generation and maintenance of memory CD4(+) T Cells. Curr Opin Immunol 2009;21:167-172.
    • (2009) Curr Opin Immunol , vol.21 , pp. 167-172
    • van Leeuwen, E.M.1    Sprent, J.2    Surh, C.D.3
  • 46
    • 84873044224 scopus 로고    scopus 로고
    • An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cells
    • Wagner TA, McKernan JL, Tobin NH, Tapia KA, Mullins JI, Frenkel LM. An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cells. J Virol 2013;87:1770-1778.
    • (2013) J Virol , vol.87 , pp. 1770-1778
    • Wagner, T.A.1    McKernan, J.L.2    Tobin, N.H.3    Tapia, K.A.4    Mullins, J.I.5    Frenkel, L.M.6
  • 47
    • 33750451933 scopus 로고    scopus 로고
    • Viral and latent reservoir persistence in HIV-1-infected patients on therapy
    • Kim H, Perelson AS. Viral and latent reservoir persistence in HIV-1-infected patients on therapy. PLoS Comp Biol 2006;2:e135.
    • (2006) PLoS Comp Biol , vol.2
    • Kim, H.1    Perelson, A.S.2
  • 48
    • 80055097295 scopus 로고    scopus 로고
    • Homeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cells
    • Bosque A, Famiglietti M, Weyrich AS, Goulston C, Planelles V. Homeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cells. PLoS Pathog 2011;7:e1002288.
    • (2011) PLoS Pathog , vol.7
    • Bosque, A.1    Famiglietti, M.2    Weyrich, A.S.3    Goulston, C.4    Planelles, V.5
  • 49
    • 84874237795 scopus 로고    scopus 로고
    • Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA
    • Gianella S, et al. Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA. J Infect Dis 2013;207:898-902.
    • (2013) J Infect Dis , vol.207 , pp. 898-902
    • Gianella, S.1
  • 50
    • 67650465237 scopus 로고    scopus 로고
    • Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
    • Gattinoni L, et al. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nat Med 2009;15:808-813.
    • (2009) Nat Med , vol.15 , pp. 808-813
    • Gattinoni, L.1
  • 51
    • 81455154955 scopus 로고    scopus 로고
    • Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes
    • Muralidharan S, et al. Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes. J Immunol 2011;187:5221-5232.
    • (2011) J Immunol , vol.187 , pp. 5221-5232
    • Muralidharan, S.1
  • 52
    • 0036893434 scopus 로고    scopus 로고
    • Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype
    • Scripture-Adams DD, Brooks DG, Korin YD, Zack JA. Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype. J Virol 2002;76:13077-13082.
    • (2002) J Virol , vol.76 , pp. 13077-13082
    • Scripture-Adams, D.D.1    Brooks, D.G.2    Korin, Y.D.3    Zack, J.A.4
  • 53
    • 13744259064 scopus 로고    scopus 로고
    • IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART
    • Wang FX, et al. IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART. J Clin Invest 2005;115:128-137.
    • (2005) J Clin Invest , vol.115 , pp. 128-137
    • Wang, F.X.1
  • 54
    • 0032490570 scopus 로고    scopus 로고
    • Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines
    • Chun TW, Engel D, Mizell SB, Ehler LA, Fauci AS. Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines. J Exp Med 1998;188:83-91.
    • (1998) J Exp Med , vol.188 , pp. 83-91
    • Chun, T.W.1    Engel, D.2    Mizell, S.B.3    Ehler, L.A.4    Fauci, A.S.5
  • 55
    • 0037452711 scopus 로고    scopus 로고
    • Gene expression and viral production in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals
    • Chun TW, et al. Gene expression and viral production in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals. Proc Natl Acad Sci USA 2003;100:1908-1913.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1908-1913
    • Chun, T.W.1
  • 56
    • 27644524761 scopus 로고    scopus 로고
    • HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
    • Chun TW, et al. HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir. J Clin Invest 2005;115:3250-3255.
    • (2005) J Clin Invest , vol.115 , pp. 3250-3255
    • Chun, T.W.1
  • 57
    • 75749116720 scopus 로고    scopus 로고
    • HIV-1 causes an imbalance in the production of interleukin-18 and its natural antagonist in HIV-infected individuals: implications for enhanced viral replication
    • Iannello A, et al. HIV-1 causes an imbalance in the production of interleukin-18 and its natural antagonist in HIV-infected individuals: implications for enhanced viral replication. J Infect Dis 2010;201:608-617.
    • (2010) J Infect Dis , vol.201 , pp. 608-617
    • Iannello, A.1
  • 58
    • 77958485320 scopus 로고    scopus 로고
    • Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton
    • Cameron P, et al. Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton. Proc Natl Acad Sci USA 2010;107:16934-16939.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 16934-16939
    • Cameron, P.1
  • 59
    • 80053913294 scopus 로고    scopus 로고
    • Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells
    • Saleh S, et al. Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells. Retrovirology 2011;8:80.
    • (2011) Retrovirology , vol.8 , pp. 80
    • Saleh, S.1
  • 60
    • 0033609373 scopus 로고    scopus 로고
    • Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
    • Zhang L, et al. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med 1999;340:1605-1613.
    • (1999) N Engl J Med , vol.340 , pp. 1605-1613
    • Zhang, L.1
  • 61
    • 41649083599 scopus 로고    scopus 로고
    • Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy
    • Palmer S, et al. Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy. Proc Natl Acad Sci USA 2008;105:3879-3884.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3879-3884
    • Palmer, S.1
  • 62
    • 33745245733 scopus 로고    scopus 로고
    • Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells
    • Bailey JR, et al. Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells. J Virol 2006;80:6441-6457.
    • (2006) J Virol , vol.80 , pp. 6441-6457
    • Bailey, J.R.1
  • 63
    • 2142829435 scopus 로고    scopus 로고
    • Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads
    • Kieffer TL, et al. Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads. The J Infect Dis 2004;189:1452-1465.
    • (2004) The J Infect Dis , vol.189 , pp. 1452-1465
    • Kieffer, T.L.1
  • 64
    • 67249121143 scopus 로고    scopus 로고
    • Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy
    • Dinoso JB, et al. Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc Natl Acad Sci USA 2009;106:9403-9408.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9403-9408
    • Dinoso, J.B.1
  • 65
    • 77956856393 scopus 로고    scopus 로고
    • The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial
    • Gandhi RT, et al. The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial. PLoS Med 2010;7:e1000321.
    • (2010) PLoS Med , vol.7
    • Gandhi, R.T.1
  • 66
    • 78549245806 scopus 로고    scopus 로고
    • Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy
    • Yukl SA, et al. Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy. AIDS 2010;24:2451-2460.
    • (2010) AIDS , vol.24 , pp. 2451-2460
    • Yukl, S.A.1
  • 67
    • 16944365445 scopus 로고    scopus 로고
    • Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
    • Borrow P, et al. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat Med 1997;3:205-211.
    • (1997) Nat Med , vol.3 , pp. 205-211
    • Borrow, P.1
  • 68
    • 84866345786 scopus 로고    scopus 로고
    • A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread
    • Kastenmuller W, Torabi-Parizi P, Subramanian N, Lammermann T, Germain RN. A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell 2012;150:1235-1248.
    • (2012) Cell , vol.150 , pp. 1235-1248
    • Kastenmuller, W.1    Torabi-Parizi, P.2    Subramanian, N.3    Lammermann, T.4    Germain, R.N.5
  • 70
    • 0037036142 scopus 로고    scopus 로고
    • Two-photon imaging of lymphocyte motility and antigen response in intact lymph node
    • Miller MJ, Wei SH, Parker I, Cahalan MD. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 2002;296:1869-1873.
    • (2002) Science , vol.296 , pp. 1869-1873
    • Miller, M.J.1    Wei, S.H.2    Parker, I.3    Cahalan, M.D.4
  • 71
    • 0037418183 scopus 로고    scopus 로고
    • Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy
    • Miller MJ, Wei SH, Cahalan MD, Parker I. Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc Natl Acad Sci USA 2003;100:2604-2609.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2604-2609
    • Miller, M.J.1    Wei, S.H.2    Cahalan, M.D.3    Parker, I.4
  • 72
    • 0347717903 scopus 로고    scopus 로고
    • T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    • Mempel TR, Henrickson SE, Von Andrian UH. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 2004;427:154-159.
    • (2004) Nature , vol.427 , pp. 154-159
    • Mempel, T.R.1    Henrickson, S.E.2    Von Andrian, U.H.3
  • 74
    • 69449098073 scopus 로고    scopus 로고
    • Multiscale analysis of T cell activation: correlating in vitro and in vivo analysis of the immunogical synpase
    • Dustin ML. Multiscale analysis of T cell activation: correlating in vitro and in vivo analysis of the immunogical synpase. Curr Top Microbiol Immunol 2009;334:47-70.
    • (2009) Curr Top Microbiol Immunol , vol.334 , pp. 47-70
    • Dustin, M.L.1
  • 77
    • 33646468223 scopus 로고    scopus 로고
    • Regulatory T cells inhibit protein kinase C theta recruitment to the immune synapse of naive T cells with the same antigen specificity
    • Sumoza-Toledo A, Eaton AD, Sarukhan A. Regulatory T cells inhibit protein kinase C theta recruitment to the immune synapse of naive T cells with the same antigen specificity. J Immunol 2006;176:5779-5787.
    • (2006) J Immunol , vol.176 , pp. 5779-5787
    • Sumoza-Toledo, A.1    Eaton, A.D.2    Sarukhan, A.3
  • 78
    • 0032480279 scopus 로고    scopus 로고
    • Three-dimensional segregation of supramolecular activation clusters in T cells
    • Monks CR, Freiberg BA, Kupfer H, Sciaky N, Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 1998;395:82-86.
    • (1998) Nature , vol.395 , pp. 82-86
    • Monks, C.R.1    Freiberg, B.A.2    Kupfer, H.3    Sciaky, N.4    Kupfer, A.5
  • 79
    • 85047690554 scopus 로고    scopus 로고
    • Dangerous liaisons at the virological synapse
    • Piguet V, Sattentau QJ. Dangerous liaisons at the virological synapse. J Clin Invest 2004;114:605-610.
    • (2004) J Clin Invest , vol.114 , pp. 605-610
    • Piguet, V.1    Sattentau, Q.J.2
  • 80
    • 0030701952 scopus 로고    scopus 로고
    • Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation
    • Bachmann MF, et al. Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity 1997;7:549-557.
    • (1997) Immunity , vol.7 , pp. 549-557
    • Bachmann, M.F.1
  • 81
    • 0036794399 scopus 로고    scopus 로고
    • Staging and resetting T cell activation in SMACs
    • Freiberg BA, et al. Staging and resetting T cell activation in SMACs. Nat Immunol 2002;3:911-917.
    • (2002) Nat Immunol , vol.3 , pp. 911-917
    • Freiberg, B.A.1
  • 82
    • 30044441433 scopus 로고    scopus 로고
    • Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
    • Yokosuka T, et al. Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nat Immunol 2005;6:1253-1262.
    • (2005) Nat Immunol , vol.6 , pp. 1253-1262
    • Yokosuka, T.1
  • 83
    • 33746011209 scopus 로고    scopus 로고
    • T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
    • Varma R, Campi G, Yokosuka T, Saito T, Dustin ML. T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity 2006;25:117-127.
    • (2006) Immunity , vol.25 , pp. 117-127
    • Varma, R.1    Campi, G.2    Yokosuka, T.3    Saito, T.4    Dustin, M.L.5
  • 84
    • 80051875965 scopus 로고    scopus 로고
    • T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis
    • Martinez-Martin N, et al. T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis. Immunity 2011;35:208-222.
    • (2011) Immunity , vol.35 , pp. 208-222
    • Martinez-Martin, N.1
  • 85
    • 0030927323 scopus 로고    scopus 로고
    • Making the T cell receptor go the distance: a topological view of T cell activation
    • Shaw AS, Dustin ML. Making the T cell receptor go the distance: a topological view of T cell activation. Immunity 1997;6:361-369.
    • (1997) Immunity , vol.6 , pp. 361-369
    • Shaw, A.S.1    Dustin, M.L.2
  • 86
    • 18244364886 scopus 로고    scopus 로고
    • ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synpase
    • Allespach EJ, et al. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synpase. Immunity 2001;15:739-750.
    • (2001) Immunity , vol.15 , pp. 739-750
    • Allespach, E.J.1
  • 87
    • 0035652354 scopus 로고    scopus 로고
    • Exclusion of CD43 from the immunological synpase is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin
    • Delon J, Kaibuchi K, Germain RN. Exclusion of CD43 from the immunological synpase is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity 2001;15:691-701.
    • (2001) Immunity , vol.15 , pp. 691-701
    • Delon, J.1    Kaibuchi, K.2    Germain, R.N.3
  • 88
    • 0028467150 scopus 로고
    • Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium
    • Donnadieu E, Bismuth G, Trautmann A. Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium. Curr Biol 1994;4:584-595.
    • (1994) Curr Biol , vol.4 , pp. 584-595
    • Donnadieu, E.1    Bismuth, G.2    Trautmann, A.3
  • 90
    • 34249013684 scopus 로고    scopus 로고
    • Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse
    • Sims TN, et al. Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell 2007;129:773-785.
    • (2007) Cell , vol.129 , pp. 773-785
    • Sims, T.N.1
  • 91
    • 58849119568 scopus 로고    scopus 로고
    • Regulated movement of CD4 in and out of the immunological synpase
    • Kao H, Lin J, Littman DR, Shaw AS, Allen PM. Regulated movement of CD4 in and out of the immunological synpase. J Immunol 2008;181:8248-8257.
    • (2008) J Immunol , vol.181 , pp. 8248-8257
    • Kao, H.1    Lin, J.2    Littman, D.R.3    Shaw, A.S.4    Allen, P.M.5
  • 92
    • 18244389686 scopus 로고    scopus 로고
    • T cell costimulation by chemokine receptors
    • Molon B, et al. T cell costimulation by chemokine receptors. Nat Immunol 2005;6:465-471.
    • (2005) Nat Immunol , vol.6 , pp. 465-471
    • Molon, B.1
  • 93
    • 50249144544 scopus 로고    scopus 로고
    • T-cell activation by dendritic cells in the lymph node: lessons from the movies
    • Bousso P. T-cell activation by dendritic cells in the lymph node: lessons from the movies. Nat Rev Immunol 2008;8:675-684.
    • (2008) Nat Rev Immunol , vol.8 , pp. 675-684
    • Bousso, P.1
  • 94
    • 38949174996 scopus 로고    scopus 로고
    • Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory
    • Scholer A, Hugues S, Boissonnas A, Fetler L, Amigorena S. Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory. Immunity 2008;28:258-270.
    • (2008) Immunity , vol.28 , pp. 258-270
    • Scholer, A.1    Hugues, S.2    Boissonnas, A.3    Fetler, L.4    Amigorena, S.5
  • 95
    • 0141807008 scopus 로고
    • The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex
    • Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE. The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc Natl Acad Sci USA 1989;86:3277-3281.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 3277-3281
    • Barber, E.K.1    Dasgupta, J.D.2    Schlossman, S.F.3    Trevillyan, J.M.4    Rudd, C.E.5
  • 96
    • 33846246384 scopus 로고    scopus 로고
    • Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells
    • Alon R, Dustin ML. Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells. Immunity 2007;26:17-27.
    • (2007) Immunity , vol.26 , pp. 17-27
    • Alon, R.1    Dustin, M.L.2
  • 97
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: bidirectional, allosteric signaling machines
    • Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002;110:673-687.
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 98
    • 79957621253 scopus 로고    scopus 로고
    • The insider's guide to leukocyte integrin signalling and function
    • Hogg N, Patzak I, Willenbrock F. The insider's guide to leukocyte integrin signalling and function. Nat Rev Immunol 2011;11:416-426.
    • (2011) Nat Rev Immunol , vol.11 , pp. 416-426
    • Hogg, N.1    Patzak, I.2    Willenbrock, F.3
  • 99
    • 18244364123 scopus 로고    scopus 로고
    • Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines
    • Shamri R, et al. Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines. Nat Immunol 2005;6:497-506.
    • (2005) Nat Immunol , vol.6 , pp. 497-506
    • Shamri, R.1
  • 100
    • 23444441823 scopus 로고    scopus 로고
    • CC chemokine ligand 19 secreted by mature dendritic cells increases naive T cell scanning behavior and their response to rare cognate antigen
    • Kaiser A, Donnadieu E, Abastado JP, Trautmann A, Nardin A. CC chemokine ligand 19 secreted by mature dendritic cells increases naive T cell scanning behavior and their response to rare cognate antigen. J Immunol 2005;175:2349-2356.
    • (2005) J Immunol , vol.175 , pp. 2349-2356
    • Kaiser, A.1    Donnadieu, E.2    Abastado, J.P.3    Trautmann, A.4    Nardin, A.5
  • 101
    • 39649100240 scopus 로고    scopus 로고
    • CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency
    • Saleh S, Solomon A, Wightman F, Xhilaga M, Cameron P, Lewin S. CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency. Blood 2007;110:4161-4164.
    • (2007) Blood , vol.110 , pp. 4161-4164
    • Saleh, S.1    Solomon, A.2    Wightman, F.3    Xhilaga, M.4    Cameron, P.5    Lewin, S.6
  • 102
    • 0026698059 scopus 로고
    • The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells
    • Norton SD, Zuckerman L, Urdahl KB, Shefner R, Miller J, Jenkins MK. The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells. J Immunol 1992;149:1556-1561.
    • (1992) J Immunol , vol.149 , pp. 1556-1561
    • Norton, S.D.1    Zuckerman, L.2    Urdahl, K.B.3    Shefner, R.4    Miller, J.5    Jenkins, M.K.6
  • 103
    • 54949103906 scopus 로고    scopus 로고
    • Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation
    • Yokosuka T, et al. Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity 2008;29:589-601.
    • (2008) Immunity , vol.29 , pp. 589-601
    • Yokosuka, T.1
  • 105
    • 0034177510 scopus 로고    scopus 로고
    • Coordinate regulation of T cell activation by CD2 and CD28
    • Green JM, Karpitskiy V, Kimzey SL, Shaw AS. Coordinate regulation of T cell activation by CD2 and CD28. J Immunol 2000;164:3591-3595.
    • (2000) J Immunol , vol.164 , pp. 3591-3595
    • Green, J.M.1    Karpitskiy, V.2    Kimzey, S.L.3    Shaw, A.S.4
  • 106
    • 33847419853 scopus 로고    scopus 로고
    • CD2 and TCR synergize for the activation of phospholipase Cgamma1/calcium pathway at the immunological synapse
    • Espagnolle N, et al. CD2 and TCR synergize for the activation of phospholipase Cgamma1/calcium pathway at the immunological synapse. Int Immunol 2007;19:239-248.
    • (2007) Int Immunol , vol.19 , pp. 239-248
    • Espagnolle, N.1
  • 107
    • 20444404267 scopus 로고    scopus 로고
    • Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells
    • Douglass AD, Vale RD. Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. Cell 2005;121:937-950.
    • (2005) Cell , vol.121 , pp. 937-950
    • Douglass, A.D.1    Vale, R.D.2
  • 108
    • 0030664027 scopus 로고    scopus 로고
    • The role of CD45 and CD45-associated molecules in T cell activation
    • Altin JG, Sloan EK. The role of CD45 and CD45-associated molecules in T cell activation. Immunol Cell Biol 1997;75:430-445.
    • (1997) Immunol Cell Biol , vol.75 , pp. 430-445
    • Altin, J.G.1    Sloan, E.K.2
  • 109
    • 0030030293 scopus 로고    scopus 로고
    • Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro
    • Ng DH, Watts JD, Aebersold R, Johnson P. Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro. J Biol Chem 1996;271:1295-1300.
    • (1996) J Biol Chem , vol.271 , pp. 1295-1300
    • Ng, D.H.1    Watts, J.D.2    Aebersold, R.3    Johnson, P.4
  • 110
    • 0031570545 scopus 로고    scopus 로고
    • Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70
    • Stone J, et al. Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70. J Immunol 1997;158:5773-5782.
    • (1997) J Immunol , vol.158 , pp. 5773-5782
    • Stone, J.1
  • 111
    • 0035451773 scopus 로고    scopus 로고
    • Negative regulation of the NFAT1 factor by CD45: implication in HIV-1 long terminal repeat activation
    • Barbeau B, Robichaud G, Fortin J, Tremblay M. Negative regulation of the NFAT1 factor by CD45: implication in HIV-1 long terminal repeat activation. J Immunol 2001;167:2700-2713.
    • (2001) J Immunol , vol.167 , pp. 2700-2713
    • Barbeau, B.1    Robichaud, G.2    Fortin, J.3    Tremblay, M.4
  • 112
    • 49649098826 scopus 로고    scopus 로고
    • ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse
    • Fos C, et al. ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse. J Immunol 2008;181:1969-1977.
    • (2008) J Immunol , vol.181 , pp. 1969-1977
    • Fos, C.1
  • 113
    • 4644317252 scopus 로고    scopus 로고
    • Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites
    • Boisvert J, Edmondson S, Krummel MF. Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites. J Immuol 2004;173:3647-3652.
    • (2004) J Immuol , vol.173 , pp. 3647-3652
    • Boisvert, J.1    Edmondson, S.2    Krummel, M.F.3
  • 114
    • 4043115571 scopus 로고    scopus 로고
    • Relevance of CD6-mediated interactions in T cell activation and proliferation
    • Gimferrer I, et al. Relevance of CD6-mediated interactions in T cell activation and proliferation. J Immunol 2004;173:2262-2270.
    • (2004) J Immunol , vol.173 , pp. 2262-2270
    • Gimferrer, I.1
  • 115
    • 22144486561 scopus 로고    scopus 로고
    • CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse
    • Pacheco R, et al. CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse. Proc Natl Acad Sci USA 2005;102:9583-9588.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9583-9588
    • Pacheco, R.1
  • 116
    • 34548680261 scopus 로고    scopus 로고
    • Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction
    • Kaufmann DE, et al. Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction. Nat Immunol 2007;8:1246-1254.
    • (2007) Nat Immunol , vol.8 , pp. 1246-1254
    • Kaufmann, D.E.1
  • 117
    • 45949087129 scopus 로고    scopus 로고
    • Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection
    • Cecchinato V, et al. Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection. J Immunol 2008;180:5439-5447.
    • (2008) J Immunol , vol.180 , pp. 5439-5447
    • Cecchinato, V.1
  • 118
    • 84872804428 scopus 로고    scopus 로고
    • Down-regulation of CTLA-4 by HIV-1 Nef Protein
    • El-Far M, et al. Down-regulation of CTLA-4 by HIV-1 Nef Protein. PLoS ONE 2013;8:e54295.
    • (2013) PLoS ONE , vol.8
    • El-Far, M.1
  • 119
    • 0030176371 scopus 로고    scopus 로고
    • Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
    • Linsley PS, Bradshaw J, Greene J, Peach R, Bennett KL, Mittler RS. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 1996;4:535-543.
    • (1996) Immunity , vol.4 , pp. 535-543
    • Linsley, P.S.1    Bradshaw, J.2    Greene, J.3    Peach, R.4    Bennett, K.L.5    Mittler, R.S.6
  • 120
    • 77957099358 scopus 로고    scopus 로고
    • Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation
    • Yokosuka T, et al. Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation. Immunity 2010;33:326-339.
    • (2010) Immunity , vol.33 , pp. 326-339
    • Yokosuka, T.1
  • 121
    • 78649851459 scopus 로고    scopus 로고
    • Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters
    • Saito T, Yokosuka T, Hashimoto-Tane A. Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters. FEBS Lett 2010;584:4865-4871.
    • (2010) FEBS Lett , vol.584 , pp. 4865-4871
    • Saito, T.1    Yokosuka, T.2    Hashimoto-Tane, A.3
  • 122
    • 33749038866 scopus 로고    scopus 로고
    • Reversal of the TCR stop signal by CTLA-4
    • Schneider H, et al. Reversal of the TCR stop signal by CTLA-4. Science 2006;313:1972-1975.
    • (2006) Science , vol.313 , pp. 1972-1975
    • Schneider, H.1
  • 123
    • 38349074305 scopus 로고    scopus 로고
    • CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization
    • Schneider H, Smith X, Liu H, Bismuth G, Rudd CE. CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization. Eur J Immunol 2008;38:40-47.
    • (2008) Eur J Immunol , vol.38 , pp. 40-47
    • Schneider, H.1    Smith, X.2    Liu, H.3    Bismuth, G.4    Rudd, C.E.5
  • 124
    • 0036798653 scopus 로고    scopus 로고
    • In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern
    • Blanchard N, di Bartolo V, Hivroz C. In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern. Immunity 2002;17:389-399.
    • (2002) Immunity , vol.17 , pp. 389-399
    • Blanchard, N.1    di Bartolo, V.2    Hivroz, C.3
  • 125
    • 33744981370 scopus 로고    scopus 로고
    • HS1 functions as an essential actin-regulatory adpator protein at the immune synapse
    • Gomez TS, et al. HS1 functions as an essential actin-regulatory adpator protein at the immune synapse. Immunity 2006;24:741-752.
    • (2006) Immunity , vol.24 , pp. 741-752
    • Gomez, T.S.1
  • 126
    • 0036928182 scopus 로고    scopus 로고
    • Mechanism of recruitment of WASP to the immunological synapse and its activation following TCR ligation
    • Sasahara Y, et al. Mechanism of recruitment of WASP to the immunological synapse and its activation following TCR ligation. Mol Cell 2002;10:1269-1281.
    • (2002) Mol Cell , vol.10 , pp. 1269-1281
    • Sasahara, Y.1
  • 127
    • 2442511061 scopus 로고    scopus 로고
    • Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes
    • Das V, et al. Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes. Immunity 2004;20:577-588.
    • (2004) Immunity , vol.20 , pp. 577-588
    • Das, V.1
  • 128
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman GJ, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000;192:1027-1034.
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1
  • 129
    • 58149191881 scopus 로고    scopus 로고
    • The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands
    • Kinter AL, et al. The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. J Immunol 2008;181:6738-6746.
    • (2008) J Immunol , vol.181 , pp. 6738-6746
    • Kinter, A.L.1
  • 130
    • 34548191951 scopus 로고    scopus 로고
    • Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction
    • Golden-Mason L, Palmer B, Klarquist J, Mengshol JA, Castelblanco N, Rosen HR. Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol 2007;81:9249-9258.
    • (2007) J Virol , vol.81 , pp. 9249-9258
    • Golden-Mason, L.1    Palmer, B.2    Klarquist, J.3    Mengshol, J.A.4    Castelblanco, N.5    Rosen, H.R.6
  • 131
    • 34247117935 scopus 로고    scopus 로고
    • Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection
    • Boni C, et al. Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J Virol 2007;81:4215-4225.
    • (2007) J Virol , vol.81 , pp. 4215-4225
    • Boni, C.1
  • 132
    • 33749009709 scopus 로고    scopus 로고
    • Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
    • Trautmann L, et al. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med 2006;12:1198-1202.
    • (2006) Nat Med , vol.12 , pp. 1198-1202
    • Trautmann, L.1
  • 133
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • Day CL, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006;443:350-354.
    • (2006) Nature , vol.443 , pp. 350-354
    • Day, C.L.1
  • 134
    • 33749338938 scopus 로고    scopus 로고
    • PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
    • Petrovas C, et al. PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med 2006;203:2281-2292.
    • (2006) J Exp Med , vol.203 , pp. 2281-2292
    • Petrovas, C.1
  • 135
    • 84878542117 scopus 로고    scopus 로고
    • Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells
    • doi:10.1093/infdis/jis630
    • Hatano H, et al. Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells. J Infect Dis 2012; doi:10.1093/infdis/jis630
    • (2012) J Infect Dis
    • Hatano, H.1
  • 137
    • 4444317516 scopus 로고    scopus 로고
    • PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta
    • Sheppard KA, et al. PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. FEBS Lett 2004;574:37-41.
    • (2004) FEBS Lett , vol.574 , pp. 37-41
    • Sheppard, K.A.1
  • 138
    • 29744462591 scopus 로고    scopus 로고
    • PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion
    • Saunders PA, Hendrycks VR, Lidinsky WA, Woods ML. PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion. Eur J Immunol 2005;35:3561-3569.
    • (2005) Eur J Immunol , vol.35 , pp. 3561-3569
    • Saunders, P.A.1    Hendrycks, V.R.2    Lidinsky, W.A.3    Woods, M.L.4
  • 139
    • 27144496045 scopus 로고    scopus 로고
    • CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
    • Parry RV, et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol 2005;25:9543-9553.
    • (2005) Mol Cell Biol , vol.25 , pp. 9543-9553
    • Parry, R.V.1
  • 140
    • 84864324543 scopus 로고    scopus 로고
    • Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
    • Yokosuka T, Takamatsu M, Kobayashi-Imanishi W, Hashimoto-Tane A, Azuma M, Saito T. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J Exp Med 2012;209:1201-1217.
    • (2012) J Exp Med , vol.209 , pp. 1201-1217
    • Yokosuka, T.1    Takamatsu, M.2    Kobayashi-Imanishi, W.3    Hashimoto-Tane, A.4    Azuma, M.5    Saito, T.6
  • 141
    • 0032736718 scopus 로고    scopus 로고
    • The MHC class II ligand lymphocyte activation gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes
    • Hannier S, Triebel F. The MHC class II ligand lymphocyte activation gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes. Int Immunol 1999;11:1745-1752.
    • (1999) Int Immunol , vol.11 , pp. 1745-1752
    • Hannier, S.1    Triebel, F.2
  • 142
    • 36849087525 scopus 로고    scopus 로고
    • B and T lymphocyte attenuator interacts with CD3zeta and inhibits tyrosine phosphorylation of TCRzeta complex during T-cell activation
    • Wu TH, Zhen Y, Zeng C, Yi HF, Zhao Y. B and T lymphocyte attenuator interacts with CD3zeta and inhibits tyrosine phosphorylation of TCRzeta complex during T-cell activation. Immunol Cell Biol 2007;85:590-595.
    • (2007) Immunol Cell Biol , vol.85 , pp. 590-595
    • Wu, T.H.1    Zhen, Y.2    Zeng, C.3    Yi, H.F.4    Zhao, Y.5
  • 143
    • 80053137239 scopus 로고    scopus 로고
    • Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells
    • Youngblood B, et al. Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells. Immunity 2011;35:400-412.
    • (2011) Immunity , vol.35 , pp. 400-412
    • Youngblood, B.1
  • 144
    • 77949412821 scopus 로고    scopus 로고
    • Virological synapse-mediated spread of human immunodeficiency virus type 1 between T cells is sensitive to entry inhibition
    • Martin N, Welsch S, Jolly C, Briggs JA, Vaux D, Sattentau QJ. Virological synapse-mediated spread of human immunodeficiency virus type 1 between T cells is sensitive to entry inhibition. J Virol 2010;84:3516-3527.
    • (2010) J Virol , vol.84 , pp. 3516-3527
    • Martin, N.1    Welsch, S.2    Jolly, C.3    Briggs, J.A.4    Vaux, D.5    Sattentau, Q.J.6
  • 145
    • 36049037370 scopus 로고    scopus 로고
    • Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses
    • Chen P, Hubner W, Spinelli MA, Chen BK. Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses. J Virol 2007;81:12582-12595.
    • (2007) J Virol , vol.81 , pp. 12582-12595
    • Chen, P.1    Hubner, W.2    Spinelli, M.A.3    Chen, B.K.4
  • 146
    • 1642540589 scopus 로고    scopus 로고
    • HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse
    • Jolly C, Kashefi K, Hollinshead M, Sattentau QJ. HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse. J Exp Med 2004;199:283-293.
    • (2004) J Exp Med , vol.199 , pp. 283-293
    • Jolly, C.1    Kashefi, K.2    Hollinshead, M.3    Sattentau, Q.J.4
  • 147
    • 35648969165 scopus 로고    scopus 로고
    • Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses
    • Dustin ML. Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses. Curr Opin Cell Biol 2007;19:529-533.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 529-533
    • Dustin, M.L.1
  • 148
    • 70350317465 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse
    • Vasiliver-Shamis G, Cho MW, Hioe CE, Dustin ML. Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse. J Virol 2009;83:11341-11355.
    • (2009) J Virol , vol.83 , pp. 11341-11355
    • Vasiliver-Shamis, G.1    Cho, M.W.2    Hioe, C.E.3    Dustin, M.L.4
  • 149
    • 52649132391 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells
    • Vasiliver-Shamis G, et al. Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells. J Virol 2008;82:9445-9457.
    • (2008) J Virol , vol.82 , pp. 9445-9457
    • Vasiliver-Shamis, G.1
  • 150
    • 27544441784 scopus 로고    scopus 로고
    • Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
    • Campi G, Varma R, Dustin ML. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J Exp Med 2005;202:1031-1036.
    • (2005) J Exp Med , vol.202 , pp. 1031-1036
    • Campi, G.1    Varma, R.2    Dustin, M.L.3
  • 151
    • 10944250512 scopus 로고    scopus 로고
    • High level of coreceptor-independent HIV transfer induced by contacts between primary CD4 T cells
    • Blanco J, Bosch B, Fernandez-Figueras MT, Barretina J, Clotet B, Este JA. High level of coreceptor-independent HIV transfer induced by contacts between primary CD4 T cells. J Biol Chem 2004;279:51305-51314.
    • (2004) J Biol Chem , vol.279 , pp. 51305-51314
    • Blanco, J.1    Bosch, B.2    Fernandez-Figueras, M.T.3    Barretina, J.4    Clotet, B.5    Este, J.A.6
  • 152
    • 79952092894 scopus 로고    scopus 로고
    • HIV-1 virological synapse is not simply a copycat of the immunological synapse
    • Vasiliver-Shamis G, Dustin ML, Hioe CE. HIV-1 virological synapse is not simply a copycat of the immunological synapse. Virus 2010;2:1239-1260.
    • (2010) Virus , vol.2 , pp. 1239-1260
    • Vasiliver-Shamis, G.1    Dustin, M.L.2    Hioe, C.E.3
  • 153
    • 84861324413 scopus 로고    scopus 로고
    • HIV cell-to-cell transmission requires the production of infectious virus particles and does not proceed through env-mediated fusion pores
    • Monel B, Beaumont E, Vendrame D, Schwartz O, Brand D, Mammano F. HIV cell-to-cell transmission requires the production of infectious virus particles and does not proceed through env-mediated fusion pores. J Virol 2012;86:3924-3933.
    • (2012) J Virol , vol.86 , pp. 3924-3933
    • Monel, B.1    Beaumont, E.2    Vendrame, D.3    Schwartz, O.4    Brand, D.5    Mammano, F.6
  • 154
    • 63449126562 scopus 로고    scopus 로고
    • Quantitative 3D video microscopy of HIV transfer across T cell virological synapses
    • Hubner W, et al. Quantitative 3D video microscopy of HIV transfer across T cell virological synapses. Science 2009;323:1743-1747.
    • (2009) Science , vol.323 , pp. 1743-1747
    • Hubner, W.1
  • 155
    • 66149137185 scopus 로고    scopus 로고
    • Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses
    • Rudnicka D, et al. Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses. J Virol 2009;83:6234-6246.
    • (2009) J Virol , vol.83 , pp. 6234-6246
    • Rudnicka, D.1
  • 156
    • 34547105037 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 assembly, budding, and cell-cell spread in T cells take place in tetraspanin-enriched plasma membrane domains
    • Jolly C, Sattentau QJ. Human immunodeficiency virus type 1 assembly, budding, and cell-cell spread in T cells take place in tetraspanin-enriched plasma membrane domains. J Virol 2007;81:7873-7884.
    • (2007) J Virol , vol.81 , pp. 7873-7884
    • Jolly, C.1    Sattentau, Q.J.2
  • 157
    • 24644491180 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 virological synapse formation in T cells requires lipid raft integrity
    • Jolly C, Sattentau QJ. Human immunodeficiency virus type 1 virological synapse formation in T cells requires lipid raft integrity. J Virol 2005;79:12088-12094.
    • (2005) J Virol , vol.79 , pp. 12088-12094
    • Jolly, C.1    Sattentau, Q.J.2
  • 158
    • 37049018852 scopus 로고    scopus 로고
    • Adhesion molecule interactions facilitate human immunodeficiency virus type 1-induced virological synapse formation between T cells
    • Jolly C, Mitar I, Sattentau QJ. Adhesion molecule interactions facilitate human immunodeficiency virus type 1-induced virological synapse formation between T cells. J Virol 2007;81:13916-13921.
    • (2007) J Virol , vol.81 , pp. 13916-13921
    • Jolly, C.1    Mitar, I.2    Sattentau, Q.J.3
  • 159
    • 39449098115 scopus 로고    scopus 로고
    • HIV-1 envelope protein binds to and signals through integrin alpah4beta7, the gut mucosal homing receptor for peripheral T cells
    • Arthos J, et al. HIV-1 envelope protein binds to and signals through integrin alpah4beta7, the gut mucosal homing receptor for peripheral T cells. Nat Immunol 2008;9:301-309.
    • (2008) Nat Immunol , vol.9 , pp. 301-309
    • Arthos, J.1
  • 160
    • 4344613594 scopus 로고    scopus 로고
    • Susceptibility of HIV type 1 to the fusion inhibitor T-20 is reduced on insertion of host intercellular adhesion molecule 1 in the virus membrane
    • Y B, Tremblay MJ. Susceptibility of HIV type 1 to the fusion inhibitor T-20 is reduced on insertion of host intercellular adhesion molecule 1 in the virus membrane. J Infect Dis 2004;190:894-902.
    • (2004) J Infect Dis , vol.190 , pp. 894-902
    • Y, B.1    Tremblay, M.J.2
  • 161
    • 0031594498 scopus 로고    scopus 로고
    • Progression to the G1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cells
    • Korin YD, Zack JA. Progression to the G1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cells. J Virol 1998;72:3161-3168.
    • (1998) J Virol , vol.72 , pp. 3161-3168
    • Korin, Y.D.1    Zack, J.A.2
  • 162
    • 0034610368 scopus 로고    scopus 로고
    • Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity
    • Rousso I, Mixon MB, Chen BK, Kim PS. Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity. Proc Natl Acad Sci USA 2000;97:13523-13525.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13523-13525
    • Rousso, I.1    Mixon, M.B.2    Chen, B.K.3    Kim, P.S.4
  • 163
    • 0035923525 scopus 로고    scopus 로고
    • Plasma membrane rafts play a critical role in HIV-1 assembly and release
    • Ono A, Freed EO. Plasma membrane rafts play a critical role in HIV-1 assembly and release. Proc Natl Acad Sci USA 2001;98:13925-13930.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13925-13930
    • Ono, A.1    Freed, E.O.2
  • 164
    • 0034015604 scopus 로고    scopus 로고
    • Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts
    • Nguyen DH, Hildreth JE. Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts. J Virol 2000;74:3264-3272.
    • (2000) J Virol , vol.74 , pp. 3264-3272
    • Nguyen, D.H.1    Hildreth, J.E.2
  • 165
    • 0034864631 scopus 로고    scopus 로고
    • Multimerization of human immunodeficiency virus type 1 Gag promotes its localization to barges, raft-like membrane microdomains
    • Lindwasser OW, Resh MD. Multimerization of human immunodeficiency virus type 1 Gag promotes its localization to barges, raft-like membrane microdomains. J Virol 2001;75:7913-7924.
    • (2001) J Virol , vol.75 , pp. 7913-7924
    • Lindwasser, O.W.1    Resh, M.D.2
  • 166
    • 0037384986 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 assembly and lipid rafts: Pr55(gag) associates with membrane domains that are largely resistant to Brij98 but sensitive to Triton X-100
    • Holm K, Weclewicz K, Hewson R, Suomalainen M. Human immunodeficiency virus type 1 assembly and lipid rafts: Pr55(gag) associates with membrane domains that are largely resistant to Brij98 but sensitive to Triton X-100. J Virol 2003;77:4805-4817.
    • (2003) J Virol , vol.77 , pp. 4805-4817
    • Holm, K.1    Weclewicz, K.2    Hewson, R.3    Suomalainen, M.4
  • 167
    • 0037302342 scopus 로고    scopus 로고
    • Independent segregation of human immunodeficiency virus type 1 Gag protein complexes and lipid rafts
    • Ding L, Derdowski A, Wang JJ, Spearman P. Independent segregation of human immunodeficiency virus type 1 Gag protein complexes and lipid rafts. J Virol 2003;77:1916-1926.
    • (2003) J Virol , vol.77 , pp. 1916-1926
    • Ding, L.1    Derdowski, A.2    Wang, J.J.3    Spearman, P.4
  • 168
    • 0034853037 scopus 로고    scopus 로고
    • Lipid rafts and HIV-1: from viral entry to assembly of progeny virions
    • Campbell SM, Crowe SM, Mak J. Lipid rafts and HIV-1: from viral entry to assembly of progeny virions. J Clin Virol 2001;22:217-227.
    • (2001) J Clin Virol , vol.22 , pp. 217-227
    • Campbell, S.M.1    Crowe, S.M.2    Mak, J.3
  • 169
    • 2342539802 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 envelope glycoproteins that lack cytoplasmic domain cysteines: impact on association with membrane lipid rafts and incorporation onto budding virus particles
    • Bhattacharya J, Peters PJ, Clapham PR. Human immunodeficiency virus type 1 envelope glycoproteins that lack cytoplasmic domain cysteines: impact on association with membrane lipid rafts and incorporation onto budding virus particles. J Virol 2004;78:5500-5506.
    • (2004) J Virol , vol.78 , pp. 5500-5506
    • Bhattacharya, J.1    Peters, P.J.2    Clapham, P.R.3
  • 170
    • 34249823098 scopus 로고    scopus 로고
    • Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1
    • Jolly C, Mitar I, Sattentau QJ. Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1. J Virol 2007;81:5547-5560.
    • (2007) J Virol , vol.81 , pp. 5547-5560
    • Jolly, C.1    Mitar, I.2    Sattentau, Q.J.3
  • 171
    • 34347379258 scopus 로고    scopus 로고
    • Filamin-A regulates actin-dependent clustering of HIV receptorts
    • Jimenez-Baranda S, et al. Filamin-A regulates actin-dependent clustering of HIV receptorts. Nat Cell Biol 2007;9:838-846.
    • (2007) Nat Cell Biol , vol.9 , pp. 838-846
    • Jimenez-Baranda, S.1
  • 172
    • 0031902924 scopus 로고    scopus 로고
    • Actin-dependent receptor colocalization required for human immunodeficiency virus entry into host cells
    • Iyengar S, Hildreth JE, Schwartz DH. Actin-dependent receptor colocalization required for human immunodeficiency virus entry into host cells. J Virol 1998;72:5251-5255.
    • (1998) J Virol , vol.72 , pp. 5251-5255
    • Iyengar, S.1    Hildreth, J.E.2    Schwartz, D.H.3
  • 173
    • 62149083847 scopus 로고    scopus 로고
    • Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes
    • Barrero-Villar M, et al. Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes. J Cell Sci 2009;122:103-113.
    • (2009) J Cell Sci , vol.122 , pp. 103-113
    • Barrero-Villar, M.1
  • 174
    • 50249107532 scopus 로고    scopus 로고
    • HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells
    • Yoder A, et al. HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell 2008;134:782-792.
    • (2008) Cell , vol.134 , pp. 782-792
    • Yoder, A.1
  • 175
    • 2442707757 scopus 로고    scopus 로고
    • Disruption of the actin cytoskeleton can complement the ability of Nef to enhance human immunodeficiency virus type 1 infectivity
    • Campbell EM, Nunez R, Hope TJ. Disruption of the actin cytoskeleton can complement the ability of Nef to enhance human immunodeficiency virus type 1 infectivity. J Virol 2004;78:5745-5755.
    • (2004) J Virol , vol.78 , pp. 5745-5755
    • Campbell, E.M.1    Nunez, R.2    Hope, T.J.3
  • 176
    • 33846036832 scopus 로고    scopus 로고
    • Inefficient human immunodeficiency virus replication in mobile lymphocytes
    • Sourisseau M, Sol-Foulon N, Porrot F, Blanchet F, Schwartz O. Inefficient human immunodeficiency virus replication in mobile lymphocytes. J Virol 2007;81:1000-1012.
    • (2007) J Virol , vol.81 , pp. 1000-1012
    • Sourisseau, M.1    Sol-Foulon, N.2    Porrot, F.3    Blanchet, F.4    Schwartz, O.5
  • 178
    • 0033590168 scopus 로고    scopus 로고
    • Rapid and efficient cell-to-cell transmission of human immunodeficiency virus infection from monocyte-derived macrophages to peripheral blood lymphocytes
    • Carr JM, Hocking H, Li P, Burrell CJ. Rapid and efficient cell-to-cell transmission of human immunodeficiency virus infection from monocyte-derived macrophages to peripheral blood lymphocytes. Virology 1999;265:319-329.
    • (1999) Virology , vol.265 , pp. 319-329
    • Carr, J.M.1    Hocking, H.2    Li, P.3    Burrell, C.J.4
  • 179
    • 0037062939 scopus 로고    scopus 로고
    • Recombination: multiply infected spleen cells in HIV patients
    • Jung A, et al. Recombination: multiply infected spleen cells in HIV patients. Nature 2002;418:144.
    • (2002) Nature , vol.418 , pp. 144
    • Jung, A.1
  • 182
    • 68049136145 scopus 로고    scopus 로고
    • Assembly of the murine leukemia virus is directed towards sites of cell-cell contact
    • Jin J, Sherer NM, Heidecker G, Derse D, Mothes W. Assembly of the murine leukemia virus is directed towards sites of cell-cell contact. PLoS Biol 2009;7:e1000163.
    • (2009) PLoS Biol , vol.7
    • Jin, J.1    Sherer, N.M.2    Heidecker, G.3    Derse, D.4    Mothes, W.5
  • 183
    • 79960569795 scopus 로고    scopus 로고
    • Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule
    • Josefsson L, et al. Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule. Proc Natl Acad Sci USA 2011;108:11199-11204.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 11199-11204
    • Josefsson, L.1
  • 184
    • 84867329009 scopus 로고    scopus 로고
    • HIV-infected T cells are migratory vehicles for viral dissemination
    • Murooka TT, et al. HIV-infected T cells are migratory vehicles for viral dissemination. Nature 2012;490:283-287.
    • (2012) Nature , vol.490 , pp. 283-287
    • Murooka, T.T.1
  • 185
    • 77649242985 scopus 로고    scopus 로고
    • Quantitative comparison of HTLV-1 and HIV-1 cell-to-cell infection with new replication dependent vectors
    • Mazurov D, Ilinskaya A, Heidecker G, Lloyd P, Derse D. Quantitative comparison of HTLV-1 and HIV-1 cell-to-cell infection with new replication dependent vectors. PLoS Pathog 2010;6:e1000788.
    • (2010) PLoS Pathog , vol.6
    • Mazurov, D.1    Ilinskaya, A.2    Heidecker, G.3    Lloyd, P.4    Derse, D.5
  • 186
    • 33749509032 scopus 로고    scopus 로고
    • Tetraspanins CD9 and CD81 modulate HIV-1-induced membrane fusion
    • Gordon-Alonso M, et al. Tetraspanins CD9 and CD81 modulate HIV-1-induced membrane fusion. J Immunol 2006;177:5129-5137.
    • (2006) J Immunol , vol.177 , pp. 5129-5137
    • Gordon-Alonso, M.1
  • 187
    • 67650886007 scopus 로고    scopus 로고
    • Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cells
    • Weng J, Krementsov DN, Khurana S, Roy NH, Thali M. Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cells. J Virol 2009;83:7467-7474.
    • (2009) J Virol , vol.83 , pp. 7467-7474
    • Weng, J.1    Krementsov, D.N.2    Khurana, S.3    Roy, N.H.4    Thali, M.5
  • 189
    • 0032742547 scopus 로고    scopus 로고
    • Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells
    • Zhang Z, et al. Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells. Science 1999;286:1353-1357.
    • (1999) Science , vol.286 , pp. 1353-1357
    • Zhang, Z.1
  • 190
    • 0026054892 scopus 로고
    • Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection
    • Bukrinsky MI, Stanwick TL, Dempsey MP, Stevenson M. Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection. Science 1991;254:423-427.
    • (1991) Science , vol.254 , pp. 423-427
    • Bukrinsky, M.I.1    Stanwick, T.L.2    Dempsey, M.P.3    Stevenson, M.4
  • 191
    • 84863766436 scopus 로고    scopus 로고
    • Neutralization resistance of virological synapse-mediated HIV-1 Infection is regulated by the gp41 cytoplasmic tail
    • Durham ND, et al. Neutralization resistance of virological synapse-mediated HIV-1 Infection is regulated by the gp41 cytoplasmic tail. J Virol 2012;86:7484-7495.
    • (2012) J Virol , vol.86 , pp. 7484-7495
    • Durham, N.D.1
  • 192
    • 84861205063 scopus 로고    scopus 로고
    • Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies
    • Abela IA, et al. Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies. PLoS Pathog 2012;8:e1002634.
    • (2012) PLoS Pathog , vol.8
    • Abela, I.A.1
  • 193
    • 84866735170 scopus 로고    scopus 로고
    • Paths to stemness: building the ultimate antitumour T cell
    • Gattinoni L, Klebanoff CA, Restifo NP. Paths to stemness: building the ultimate antitumour T cell. Nat Rev Cancer 2012;12:671-684.
    • (2012) Nat Rev Cancer , vol.12 , pp. 671-684
    • Gattinoni, L.1    Klebanoff, C.A.2    Restifo, N.P.3
  • 194
    • 80053997259 scopus 로고    scopus 로고
    • A human memory T cell subset with stem cell-like properties
    • Gattinoni L, et al. A human memory T cell subset with stem cell-like properties. Nat Med 2011;17:1290-1297.
    • (2011) Nat Med , vol.17 , pp. 1290-1297
    • Gattinoni, L.1
  • 195
    • 84873395620 scopus 로고    scopus 로고
    • Superior T memory stem cell persistence supports long-lived T cell memory
    • Lugli E, et al. Superior T memory stem cell persistence supports long-lived T cell memory. J Clin Invest 2013;123:594-599.
    • (2013) J Clin Invest , vol.123 , pp. 594-599
    • Lugli, E.1
  • 196
    • 77953040994 scopus 로고    scopus 로고
    • The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
    • Lian I, et al. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev 2010;24:1106-1118.
    • (2010) Genes Dev , vol.24 , pp. 1106-1118
    • Lian, I.1
  • 197
    • 84865197576 scopus 로고    scopus 로고
    • Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell
    • Thaventhiran JE, et al. Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell. Proc Natl Acad Sci USA 2012;109:E2223-E2229.
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Thaventhiran, J.E.1
  • 198
    • 84859516537 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells
    • Konsavage WM Jr, Kyler SL, Rennoll SA, Jin G, Yochum GS. Wnt/beta-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells. J Biol Chem 2012;287:11730-11739.
    • (2012) J Biol Chem , vol.287 , pp. 11730-11739
    • Konsavage Jr., W.M.1    Kyler, S.L.2    Rennoll, S.A.3    Jin, G.4    Yochum, G.S.5
  • 199
    • 84871789026 scopus 로고    scopus 로고
    • Restriction of intestinal stem cell expansion and the regenerative response by YAP
    • Barry ER, et al. Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature 2013;493:106-110.
    • (2013) Nature , vol.493 , pp. 106-110
    • Barry, E.R.1
  • 200
    • 0032127977 scopus 로고    scopus 로고
    • Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
    • Niwa H, Burdon T, Chambers I, Smith A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev 1998;12:2048-2060.
    • (1998) Genes Dev , vol.12 , pp. 2048-2060
    • Niwa, H.1    Burdon, T.2    Chambers, I.3    Smith, A.4
  • 201
    • 0033517123 scopus 로고    scopus 로고
    • STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
    • Matsuda T, et al. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J 1999;18:4261-4269.
    • (1999) EMBO J , vol.18 , pp. 4261-4269
    • Matsuda, T.1
  • 202
    • 82055163110 scopus 로고    scopus 로고
    • A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory
    • Siegel AM, et al. A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory. Immunity 2011;35:806-818.
    • (2011) Immunity , vol.35 , pp. 806-818
    • Siegel, A.M.1
  • 203
    • 1242267927 scopus 로고    scopus 로고
    • Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
    • Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 2004;10:55-63.
    • (2004) Nat Med , vol.10 , pp. 55-63
    • Sato, N.1    Meijer, L.2    Skaltsounis, L.3    Greengard, P.4    Brivanlou, A.H.5
  • 204
    • 79959950773 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation
    • Wray J, et al. Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. Nat Cell Biol 2011;13:838-845.
    • (2011) Nat Cell Biol , vol.13 , pp. 838-845
    • Wray, J.1
  • 205
    • 79959963618 scopus 로고    scopus 로고
    • Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal
    • Yi F, et al. Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol 2011;13:762-770.
    • (2011) Nat Cell Biol , vol.13 , pp. 762-770
    • Yi, F.1
  • 206
    • 80052475509 scopus 로고    scopus 로고
    • Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells
    • ten Berge DKD, et al. Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol 2011;13:1070-1075.
    • (2011) Nat Cell Biol , vol.13 , pp. 1070-1075
    • ten Berge, D.K.D.1
  • 208
    • 84873048662 scopus 로고    scopus 로고
    • Wnt/β-catenin signalling: from plasma membrane to nucleus
    • Kim W, Kim M, Jho E. Wnt/β-catenin signalling: from plasma membrane to nucleus. Biochem J 2013;450:9-21.
    • (2013) Biochem J , vol.450 , pp. 9-21
    • Kim, W.1    Kim, M.2    Jho, E.3
  • 209
    • 84870932517 scopus 로고    scopus 로고
    • Hematopoietic stem cell fate decisions are regulated by Wnt antagonists: comparisons and current controversies
    • Cain CJ, Manilay JO. Hematopoietic stem cell fate decisions are regulated by Wnt antagonists: comparisons and current controversies. Exp Hematol 2013;41:3-16.
    • (2013) Exp Hematol , vol.41 , pp. 3-16
    • Cain, C.J.1    Manilay, J.O.2
  • 210
    • 33846396811 scopus 로고    scopus 로고
    • Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility
    • Seifert JR, Mlodzik M. Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility. Nat Rev Genet 2007;8:126-138.
    • (2007) Nat Rev Genet , vol.8 , pp. 126-138
    • Seifert, J.R.1    Mlodzik, M.2
  • 211
    • 0041695485 scopus 로고    scopus 로고
    • A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling
    • Veeman MTAJ, Moon RT. A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell 2003;5:367-377.
    • (2003) Dev Cell , vol.5 , pp. 367-377
    • Veeman, M.T.A.J.1    Moon, R.T.2
  • 212
    • 57349099365 scopus 로고    scopus 로고
    • CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors
    • Shah KV, Chien AJ, Yee C, Moon RT. CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors. J Invest Dermatol 2008;128:2870-2879.
    • (2008) J Invest Dermatol , vol.128 , pp. 2870-2879
    • Shah, K.V.1    Chien, A.J.2    Yee, C.3    Moon, R.T.4
  • 213
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling and disease
    • Clevers H, Nusse R. Wnt/beta-catenin signaling and disease. Cell 2012;149:1192-1205.
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 214
    • 84861972831 scopus 로고    scopus 로고
    • Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex
    • Li Vivian SW, et al. Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell 2012;149:1245-1256.
    • (2012) Cell , vol.149 , pp. 1245-1256
    • Li Vivian, S.W.1
  • 216
    • 0032526401 scopus 로고    scopus 로고
    • Differential nuclear translocation and transactivation potential of b-catenin and plakoglobin
    • Simcha I, et al. Differential nuclear translocation and transactivation potential of b-catenin and plakoglobin. J Cell Biol 1998;141:1433-1448.
    • (1998) J Cell Biol , vol.141 , pp. 1433-1448
    • Simcha, I.1
  • 217
    • 77949313889 scopus 로고    scopus 로고
    • Constitutive activation of Wnt signaling favors generation of memory CD8 T cells
    • Zhao DM, et al. Constitutive activation of Wnt signaling favors generation of memory CD8 T cells. J Immunol 2010;184:1191-1199.
    • (2010) J Immunol , vol.184 , pp. 1191-1199
    • Zhao, D.M.1
  • 218
    • 77953107073 scopus 로고    scopus 로고
    • Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory
    • Jeannet G, Boudousquie C, Gardiol N, Kang J, Huelsken J, Held W. Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory. Proc Natl Acad Sci USA 2010;107:9777-9782.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 9777-9782
    • Jeannet, G.1    Boudousquie, C.2    Gardiol, N.3    Kang, J.4    Huelsken, J.5    Held, W.6
  • 219
    • 77955869484 scopus 로고    scopus 로고
    • Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1
    • Zhou X, Yu S, Zhao DM, Harty JT, Badovinac VP, Xue HH. Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1. Immunity 2010;33:229-240.
    • (2010) Immunity , vol.33 , pp. 229-240
    • Zhou, X.1    Yu, S.2    Zhao, D.M.3    Harty, J.T.4    Badovinac, V.P.5    Xue, H.H.6
  • 220
    • 84873185664 scopus 로고    scopus 로고
    • Stem cells living with a Notch
    • Koch U, Lehal R, Radtke F. Stem cells living with a Notch. Development 2013;140:689-704.
    • (2013) Development , vol.140 , pp. 689-704
    • Koch, U.1    Lehal, R.2    Radtke, F.3
  • 221
    • 84864130184 scopus 로고    scopus 로고
    • Noncanonical Notch signaling modulates cytokine responses of dendritic cells to inflammatory stimuli
    • Gentle ME, Rose A, Bugeon L, Dallman MJ. Noncanonical Notch signaling modulates cytokine responses of dendritic cells to inflammatory stimuli. J Immunol 2012;189:1274-1284.
    • (2012) J Immunol , vol.189 , pp. 1274-1284
    • Gentle, M.E.1    Rose, A.2    Bugeon, L.3    Dallman, M.J.4
  • 222
    • 80051531363 scopus 로고    scopus 로고
    • Notch signaling: simplicity in design, versatility in function
    • Andersson ER, Sandberg R, Lendahl U. Notch signaling: simplicity in design, versatility in function. Development 2011;138:3593-3612.
    • (2011) Development , vol.138 , pp. 3593-3612
    • Andersson, E.R.1    Sandberg, R.2    Lendahl, U.3
  • 224
    • 41549140462 scopus 로고    scopus 로고
    • Oscillations in notch signaling regulate maintenance of neural progenitors
    • Shimojo H, Ohtsuka T, Kageyama R. Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron 2008;58:52-64.
    • (2008) Neuron , vol.58 , pp. 52-64
    • Shimojo, H.1    Ohtsuka, T.2    Kageyama, R.3
  • 226
    • 84859367110 scopus 로고    scopus 로고
    • Different levels of Notch signaling regulate quiescence, renewal and differentiation in pancreatic endocrine progenitors
    • Ninov N, Borius M, Stainier DYR. Different levels of Notch signaling regulate quiescence, renewal and differentiation in pancreatic endocrine progenitors. Development 2012;139:1557-1567.
    • (2012) Development , vol.139 , pp. 1557-1567
    • Ninov, N.1    Borius, M.2    Stainier, D.Y.R.3
  • 227
    • 80052700259 scopus 로고    scopus 로고
    • Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine
    • Perdigoto CN, Schweisguth F, Bardin AJ. Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine. Development 2011;138:4585-4595.
    • (2011) Development , vol.138 , pp. 4585-4595
    • Perdigoto, C.N.1    Schweisguth, F.2    Bardin, A.J.3
  • 228
    • 77950441537 scopus 로고    scopus 로고
    • Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells
    • Mazzone M, et al. Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci USA 2010;107:5012-5017.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 5012-5017
    • Mazzone, M.1
  • 229
    • 84861893409 scopus 로고    scopus 로고
    • Notch controls the magnitude of T helper cell responses by promoting cellular longevity
    • Helbig C, et al. Notch controls the magnitude of T helper cell responses by promoting cellular longevity. Proc Natl Acad Sci USA 2012;109:9041-9046.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 9041-9046
    • Helbig, C.1
  • 230
    • 33845892748 scopus 로고    scopus 로고
    • Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis
    • Estrach S, Ambler CA, Lo Celso C, Hozumi K, Watt FM. Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development 2006;133:4427-4438.
    • (2006) Development , vol.133 , pp. 4427-4438
    • Estrach, S.1    Ambler, C.A.2    Lo Celso, C.3    Hozumi, K.4    Watt, F.M.5
  • 231
    • 77955977167 scopus 로고    scopus 로고
    • The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling
    • Corada M, et al. The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell 2010;18:938-949.
    • (2010) Dev Cell , vol.18 , pp. 938-949
    • Corada, M.1
  • 232
    • 79952801951 scopus 로고    scopus 로고
    • The Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cells
    • Ungerbäck JEN, Grünberg J, Sigvardsson M, Söderkvist P. The Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cells. PLoS ONE 2011;6:e17957.
    • (2011) PLoS ONE , vol.6
    • Ungerbäck, J.E.N.1    Grünberg, J.2    Sigvardsson, M.3    Söderkvist, P.4
  • 233
    • 0029670476 scopus 로고    scopus 로고
    • Interaction between Wingless and Notch signaling pathways mediated by Dishevelled
    • Axelrod JDMK, Artavanis-Tsakonas S, Perrimon N. Interaction between Wingless and Notch signaling pathways mediated by Dishevelled. Science 1996;271:1826-1832.
    • (1996) Science , vol.271 , pp. 1826-1832
    • Axelrod, J.D.M.K.1    Artavanis-Tsakonas, S.2    Perrimon, N.3
  • 234
    • 33749242260 scopus 로고    scopus 로고
    • Notch synergizes with axin to regulate the activity of armadillo in Drosophila
    • Hayward P, Balayo T, Martinez Arias A. Notch synergizes with axin to regulate the activity of armadillo in Drosophila. Dev Dyn 2006;235:2656-2666.
    • (2006) Dev Dyn , vol.235 , pp. 2656-2666
    • Hayward, P.1    Balayo, T.2    Martinez Arias, A.3
  • 235
    • 79955398515 scopus 로고    scopus 로고
    • Modulation of the ligand-independent traffic of Notch by Axin and Apc contributes to the activation of Armadillo in Drosophila
    • Munoz-Descalzo S, Tkocz K, Balayo T, Arias AM. Modulation of the ligand-independent traffic of Notch by Axin and Apc contributes to the activation of Armadillo in Drosophila. Development 2011;138:1501-1506.
    • (2011) Development , vol.138 , pp. 1501-1506
    • Munoz-Descalzo, S.1    Tkocz, K.2    Balayo, T.3    Arias, A.M.4
  • 236
    • 0041856097 scopus 로고    scopus 로고
    • Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways
    • Espinosa L, Ingles-Esteve J, Aguilera C, Bigas A. Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways. J Biol Chem 2003;278:32227-32235.
    • (2003) J Biol Chem , vol.278 , pp. 32227-32235
    • Espinosa, L.1    Ingles-Esteve, J.2    Aguilera, C.3    Bigas, A.4
  • 237
    • 0037172661 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta modulates notch signaling and stability
    • Foltz DRSM, Berechid BE, Nye JS. Glycogen synthase kinase-3beta modulates notch signaling and stability. Curr Biol 2002;12:1006-1011.
    • (2002) Curr Biol , vol.12 , pp. 1006-1011
    • Foltz, D.R.S.M.1    Berechid, B.E.2    Nye, J.S.3
  • 238
    • 0035911156 scopus 로고    scopus 로고
    • Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing
    • Soriano SKD, Fu M, Pestell R, Chevallier N, Zheng H, Koo EH. Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing. J Cell Biol 2001;152:785-794.
    • (2001) J Cell Biol , vol.152 , pp. 785-794
    • Soriano, S.K.D.1    Fu, M.2    Pestell, R.3    Chevallier, N.4    Zheng, H.5    Koo, E.H.6
  • 239
    • 0034669031 scopus 로고    scopus 로고
    • A common enzyme connects Notch signaling and Alzheimer's disease
    • Kopan R, Goate A. A common enzyme connects Notch signaling and Alzheimer's disease. Genes Dev 2000;14:2799-2806.
    • (2000) Genes Dev , vol.14 , pp. 2799-2806
    • Kopan, R.1    Goate, A.2
  • 240
    • 33947730608 scopus 로고    scopus 로고
    • Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    • Chang JT, et al. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 2007;315:1687-1691.
    • (2007) Science , vol.315 , pp. 1687-1691
    • Chang, J.T.1
  • 241
    • 77956201049 scopus 로고    scopus 로고
    • Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms
    • Oliaro J, et al. Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms. J Immunol 2010;185:367-375.
    • (2010) J Immunol , vol.185 , pp. 367-375
    • Oliaro, J.1
  • 242
    • 84859650020 scopus 로고    scopus 로고
    • Intralineage directional notch signaling regulates self-renewal and differentiation of asymmetrically dividing radial glia
    • Dong Z, Yang N, Yeo S-Y, Chitnis A, Guo S. Intralineage directional notch signaling regulates self-renewal and differentiation of asymmetrically dividing radial glia. Neuron 2012;74:65-78.
    • (2012) Neuron , vol.74 , pp. 65-78
    • Dong, Z.1    Yang, N.2    Yeo, S.-Y.3    Chitnis, A.4    Guo, S.5
  • 243
    • 37149031062 scopus 로고    scopus 로고
    • CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency
    • Tyagi M, Karn J. CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency. EMBO J 2007;26:4985-4995.
    • (2007) EMBO J , vol.26 , pp. 4985-4995
    • Tyagi, M.1    Karn, J.2
  • 244
    • 40149101557 scopus 로고    scopus 로고
    • Active beta-catenin signaling is an inhibitory pathway for human immunodeficiency virus replication in peripheral blood mononuclear cells
    • Kumar A, Zloza A, Moon RT, Watts J, Tenorio AR, Al-Harthi L. Active beta-catenin signaling is an inhibitory pathway for human immunodeficiency virus replication in peripheral blood mononuclear cells. J Virol 2008;82:2813-2820.
    • (2008) J Virol , vol.82 , pp. 2813-2820
    • Kumar, A.1    Zloza, A.2    Moon, R.T.3    Watts, J.4    Tenorio, A.R.5    Al-Harthi, L.6
  • 245
    • 84863116736 scopus 로고    scopus 로고
    • Role of beta-catenin and TCF/LEF family members in transcriptional activity of HIV in astrocytes
    • Narasipura SD, Henderson LJ, Fu SW, Chen L, Kashanchi F, Al-Harthi L. Role of beta-catenin and TCF/LEF family members in transcriptional activity of HIV in astrocytes. J Virol 2012;86:1911-1921.
    • (2012) J Virol , vol.86 , pp. 1911-1921
    • Narasipura, S.D.1    Henderson, L.J.2    Fu, S.W.3    Chen, L.4    Kashanchi, F.5    Al-Harthi, L.6
  • 246
    • 84866182299 scopus 로고    scopus 로고
    • Identification of novel T cell factor 4 (TCF-4) binding sites on the HIV long terminal repeat which associate with TCF-4, beta-catenin, and SMAR1 to repress HIV transcription
    • Henderson LJ, Narasipura SD, Adarichev V, Kashanchi F, Al-Harthi L. Identification of novel T cell factor 4 (TCF-4) binding sites on the HIV long terminal repeat which associate with TCF-4, beta-catenin, and SMAR1 to repress HIV transcription. J Virol 2012;86:9495-9503.
    • (2012) J Virol , vol.86 , pp. 9495-9503
    • Henderson, L.J.1    Narasipura, S.D.2    Adarichev, V.3    Kashanchi, F.4    Al-Harthi, L.5
  • 247
    • 0036839056 scopus 로고    scopus 로고
    • Evidence for regulation of long terminal repeat transcription by Wnt transcription factor TCF-4 in human astrocytic cells
    • Wortman B, Darbinian N, Sawaya BE, Khalili K, Amini S. Evidence for regulation of long terminal repeat transcription by Wnt transcription factor TCF-4 in human astrocytic cells. J Virol 2002;76:11159-11165.
    • (2002) J Virol , vol.76 , pp. 11159-11165
    • Wortman, B.1    Darbinian, N.2    Sawaya, B.E.3    Khalili, K.4    Amini, S.5
  • 248
    • 79959570407 scopus 로고    scopus 로고
    • IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner
    • Li W, Henderson LJ, Major EO, Al-Harthi L. IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner. J Immunol 2011;186:6771-6778.
    • (2011) J Immunol , vol.186 , pp. 6771-6778
    • Li, W.1    Henderson, L.J.2    Major, E.O.3    Al-Harthi, L.4
  • 249
    • 84867363816 scopus 로고    scopus 로고
    • The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells
    • Goulas S, Conder R, Knoblich JA. The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells. Cell Stem Cell 2012;11:529-540.
    • (2012) Cell Stem Cell , vol.11 , pp. 529-540
    • Goulas, S.1    Conder, R.2    Knoblich, J.A.3
  • 250
    • 39149130360 scopus 로고    scopus 로고
    • Mechanisms of asymmetric stem cell division
    • Knoblich JA. Mechanisms of asymmetric stem cell division. Cell 2008;132:583-597.
    • (2008) Cell , vol.132 , pp. 583-597
    • Knoblich, J.A.1
  • 251
    • 79954906546 scopus 로고    scopus 로고
    • Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division
    • Chang JT, et al. Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity 2011;34:492-504.
    • (2011) Immunity , vol.34 , pp. 492-504
    • Chang, J.T.1
  • 252
  • 253
    • 57749177930 scopus 로고    scopus 로고
    • Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips
    • Rong L, Perelson AS. Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips. Math Biosci 2009;217:77-87.
    • (2009) Math Biosci , vol.217 , pp. 77-87
    • Rong, L.1    Perelson, A.S.2
  • 254
    • 0041331708 scopus 로고    scopus 로고
    • TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells
    • Palaga TML, Golde TE, Osborne BA. TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. J Immunol 2003;171:3019-3024.
    • (2003) J Immunol , vol.171 , pp. 3019-3024
    • Palaga, T.M.L.1    Golde, T.E.2    Osborne, B.A.3
  • 255
    • 0042834334 scopus 로고    scopus 로고
    • Notch signaling augments T cell responsiveness by enhancing CD25 expression
    • Adler SHCE, et al. Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol 2003;171:2896-2903.
    • (2003) J Immunol , vol.171 , pp. 2896-2903
    • Adler, S.H.C.E.1
  • 256
    • 84875456720 scopus 로고    scopus 로고
    • A localized Wnt signal orients asymmetric stem cell division in vitro
    • Habib SJ, et al. A localized Wnt signal orients asymmetric stem cell division in vitro. Science 2013;339:1445-1448.
    • (2013) Science , vol.339 , pp. 1445-1448
    • Habib, S.J.1


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