메뉴 건너뛰기




Volumn 25, Issue 1, 2006, Pages 117-127

T Cell Receptor-Proximal Signals Are Sustained in Peripheral Microclusters and Terminated in the Central Supramolecular Activation Cluster

Author keywords

CELLIMMUNO; MOLIMMUNO

Indexed keywords

CALCIUM; F ACTIN; LATRUNCULIN A; PHOSPHATIDIC ACID; T LYMPHOCYTE RECEPTOR;

EID: 33746011209     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2006.04.010     Document Type: Article
Times cited : (697)

References (53)
  • 4
    • 0035075507 scopus 로고    scopus 로고
    • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT
    • Bunnell S.C., Kapoor V., Trible R.P., Zhang W., and Samelson L.E. Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity 14 (2001) 315-329
    • (2001) Immunity , vol.14 , pp. 315-329
    • Bunnell, S.C.1    Kapoor, V.2    Trible, R.P.3    Zhang, W.4    Samelson, L.E.5
  • 6
    • 27544441784 scopus 로고    scopus 로고
    • Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
    • Campi G., Varma R., and Dustin M.L. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J. Exp. Med. 202 (2005) 1031-1036
    • (2005) J. Exp. Med. , vol.202 , pp. 1031-1036
    • Campi, G.1    Varma, R.2    Dustin, M.L.3
  • 7
    • 23144455728 scopus 로고    scopus 로고
    • T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand
    • Choudhuri K., Wiseman D., Brown M.H., Gould K., and van der Merwe P.A. T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand. Nature 436 (2005) 578-582
    • (2005) Nature , vol.436 , pp. 578-582
    • Choudhuri, K.1    Wiseman, D.2    Brown, M.H.3    Gould, K.4    van der Merwe, P.A.5
  • 8
    • 0036853106 scopus 로고    scopus 로고
    • Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse
    • Costello P.S., Gallagher M., and Cantrell D.A. Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse. Nat. Immunol. 3 (2002) 1082-1089
    • (2002) Nat. Immunol. , vol.3 , pp. 1082-1089
    • Costello, P.S.1    Gallagher, M.2    Cantrell, D.A.3
  • 9
    • 0033558102 scopus 로고    scopus 로고
    • Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes
    • D'Oro U., and Ashwell J.D. Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes. J. Immunol. 162 (1999) 1879-1883
    • (1999) J. Immunol. , vol.162 , pp. 1879-1883
    • D'Oro, U.1    Ashwell, J.D.2
  • 10
    • 20444404267 scopus 로고    scopus 로고
    • Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells
    • Douglass A.D., and Vale R.D. Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. Cell 121 (2005) 937-950
    • (2005) Cell , vol.121 , pp. 937-950
    • Douglass, A.D.1    Vale, R.D.2
  • 11
    • 0037174639 scopus 로고    scopus 로고
    • Neural and immunological synaptic relations
    • Dustin M.L., and Colman D.R. Neural and immunological synaptic relations. Science 298 (2002) 785-789
    • (2002) Science , vol.298 , pp. 785-789
    • Dustin, M.L.1    Colman, D.R.2
  • 12
    • 0036906497 scopus 로고    scopus 로고
    • Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation
    • Ehrlich L.I., Ebert P.J., Krummel M.F., Weiss A., and Davis M.M. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity 17 (2002) 809-822
    • (2002) Immunity , vol.17 , pp. 809-822
    • Ehrlich, L.I.1    Ebert, P.J.2    Krummel, M.F.3    Weiss, A.4    Davis, M.M.5
  • 15
    • 0036063264 scopus 로고    scopus 로고
    • Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation
    • Hailman E., Burack W.R., Shaw A.S., Dustin M.L., and Allen P.M. Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation. Immunity 16 (2002) 839-848
    • (2002) Immunity , vol.16 , pp. 839-848
    • Hailman, E.1    Burack, W.R.2    Shaw, A.S.3    Dustin, M.L.4    Allen, P.M.5
  • 16
    • 0029980574 scopus 로고    scopus 로고
    • Sustained T cell receptor-mediated Ca2+ responses rely on dynamic engagement of receptors
    • Hashemi B.B., Slattery J.P., Holowka D., and Baird B. Sustained T cell receptor-mediated Ca2+ responses rely on dynamic engagement of receptors. J. Immunol. 156 (1996) 3660-3667
    • (1996) J. Immunol. , vol.156 , pp. 3660-3667
    • Hashemi, B.B.1    Slattery, J.P.2    Holowka, D.3    Baird, B.4
  • 17
    • 0041695164 scopus 로고    scopus 로고
    • Continuous T cell receptor signaling required for synapse maintenance and full effector potential
    • Huppa J.B., Gleimer M., Sumen C., and Davis M.M. Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat. Immunol. 4 (2003) 749-755
    • (2003) Nat. Immunol. , vol.4 , pp. 749-755
    • Huppa, J.B.1    Gleimer, M.2    Sumen, C.3    Davis, M.M.4
  • 18
    • 0031884839 scopus 로고    scopus 로고
    • The duration of antigenic stimulation determines the fate of naive and effector T cells
    • Iezzi G., Karjalainen K., and Lanzavecchia A. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8 (1998) 89-95
    • (1998) Immunity , vol.8 , pp. 89-95
    • Iezzi, G.1    Karjalainen, K.2    Lanzavecchia, A.3
  • 19
    • 0037318863 scopus 로고    scopus 로고
    • CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling
    • Irles C., Symons A., Michel F., Bakker T.R., van der Merwe P.A., and Acuto O. CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling. Nat. Immunol. 4 (2003) 189-197
    • (2003) Nat. Immunol. , vol.4 , pp. 189-197
    • Irles, C.1    Symons, A.2    Michel, F.3    Bakker, T.R.4    van der Merwe, P.A.5    Acuto, O.6
  • 20
    • 0037167816 scopus 로고    scopus 로고
    • Direct observation of ligand recognition by T cells
    • Irvine D.J., Purbhoo M.A., Krogsgaard M., and Davis M.M. Direct observation of ligand recognition by T cells. Nature 419 (2002) 845-849
    • (2002) Nature , vol.419 , pp. 845-849
    • Irvine, D.J.1    Purbhoo, M.A.2    Krogsgaard, M.3    Davis, M.M.4
  • 21
    • 0034730188 scopus 로고    scopus 로고
    • A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation
    • Johnson K.G., Bromley S.K., Dustin M.L., and Thomas M.L. A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation. Proc. Natl. Acad. Sci. USA 97 (2000) 10138-10143
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10138-10143
    • Johnson, K.G.1    Bromley, S.K.2    Dustin, M.L.3    Thomas, M.L.4
  • 23
    • 0025297050 scopus 로고
    • Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway
    • Koretzky G.A., Picus J., Thomas M.L., and Weiss A. Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway. Nature 346 (1990) 66-68
    • (1990) Nature , vol.346 , pp. 66-68
    • Koretzky, G.A.1    Picus, J.2    Thomas, M.L.3    Weiss, A.4
  • 24
    • 0348047600 scopus 로고    scopus 로고
    • Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation
    • Krogsgaard M., Prado N., Adams E.J., He X.L., Chow D.C., Wilson D.B., Garcia K.C., and Davis M.M. Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol. Cell 12 (2003) 1367-1378
    • (2003) Mol. Cell , vol.12 , pp. 1367-1378
    • Krogsgaard, M.1    Prado, N.2    Adams, E.J.3    He, X.L.4    Chow, D.C.5    Wilson, D.B.6    Garcia, K.C.7    Davis, M.M.8
  • 25
    • 15044358353 scopus 로고    scopus 로고
    • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity
    • Krogsgaard M., Li Q.J., Sumen C., Huppa J.B., Huse M., and Davis M.M. Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature 434 (2005) 238-243
    • (2005) Nature , vol.434 , pp. 238-243
    • Krogsgaard, M.1    Li, Q.J.2    Sumen, C.3    Huppa, J.B.4    Huse, M.5    Davis, M.M.6
  • 26
    • 0034714184 scopus 로고    scopus 로고
    • Differential clustering of CD4 and CD3zeta during T cell recognition
    • Krummel M.F., Sjaastad M.D., Wulfing C., and Davis M.M. Differential clustering of CD4 and CD3zeta during T cell recognition. Science 289 (2000) 1349-1352
    • (2000) Science , vol.289 , pp. 1349-1352
    • Krummel, M.F.1    Sjaastad, M.D.2    Wulfing, C.3    Davis, M.M.4
  • 27
  • 29
    • 0034624809 scopus 로고    scopus 로고
    • Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes
    • Leupin O., Zaru R., Laroche T., Muller S., and Valitutti S. Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes. Curr. Biol. 10 (2000) 277-280
    • (2000) Curr. Biol. , vol.10 , pp. 277-280
    • Leupin, O.1    Zaru, R.2    Laroche, T.3    Muller, S.4    Valitutti, S.5
  • 30
    • 16844375707 scopus 로고    scopus 로고
    • Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1
    • Lin Y., Kimpler L.A., Naismith T.V., Lauer J.M., and Hanson P.I. Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. J. Biol. Chem. 280 (2005) 12799-12809
    • (2005) J. Biol. Chem. , vol.280 , pp. 12799-12809
    • Lin, Y.1    Kimpler, L.A.2    Naismith, T.V.3    Lauer, J.M.4    Hanson, P.I.5
  • 31
    • 0033638003 scopus 로고    scopus 로고
    • On the dynamics of TCR:CD3 complex cell surface expression and downmodulation
    • Liu H., Rhodes M., Wiest D.L., and Vignali D.A. On the dynamics of TCR:CD3 complex cell surface expression and downmodulation. Immunity 13 (2000) 665-675
    • (2000) Immunity , vol.13 , pp. 665-675
    • Liu, H.1    Rhodes, M.2    Wiest, D.L.3    Vignali, D.A.4
  • 32
    • 8444236620 scopus 로고    scopus 로고
    • Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties
    • Malherbe L., Hausl C., Teyton L., and McHeyzer-Williams M.G. Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties. Immunity 21 (2004) 669-679
    • (2004) Immunity , vol.21 , pp. 669-679
    • Malherbe, L.1    Hausl, C.2    Teyton, L.3    McHeyzer-Williams, M.G.4
  • 35
    • 0038620205 scopus 로고    scopus 로고
    • Recycling compartments and the internal vesicles of multivesicular bodies harbor most of the cholesterol found in the endocytic pathway
    • Mobius W., van Donselaar E., Ohno-Iwashita Y., Shimada Y., Heijnen H.F., Slot J.W., and Geuze H.J. Recycling compartments and the internal vesicles of multivesicular bodies harbor most of the cholesterol found in the endocytic pathway. Traffic 4 (2003) 222-231
    • (2003) Traffic , vol.4 , pp. 222-231
    • Mobius, W.1    van Donselaar, E.2    Ohno-Iwashita, Y.3    Shimada, Y.4    Heijnen, H.F.5    Slot, J.W.6    Geuze, H.J.7
  • 36
    • 0032480279 scopus 로고    scopus 로고
    • Three-dimensional segregation of supramolecular activation clusters in T cells
    • Monks C.R., Freiberg B.A., Kupfer H., Sciaky N., and Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395 (1998) 82-86
    • (1998) Nature , vol.395 , pp. 82-86
    • Monks, C.R.1    Freiberg, B.A.2    Kupfer, H.3    Sciaky, N.4    Kupfer, A.5
  • 37
    • 27944442353 scopus 로고    scopus 로고
    • Altered TCR signaling from geometrically repatterned immunological synapses
    • Mossman K.D., Campi G., Groves J.T., and Dustin M.L. Altered TCR signaling from geometrically repatterned immunological synapses. Science 310 (2005) 1191-1193
    • (2005) Science , vol.310 , pp. 1191-1193
    • Mossman, K.D.1    Campi, G.2    Groves, J.T.3    Dustin, M.L.4
  • 39
    • 0034041461 scopus 로고    scopus 로고
    • Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies
    • Reay P.A., Matsui K., Haase K., Wulfing C., Chien Y.H., and Davis M.M. Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies. J. Immunol. 164 (2000) 5626-5634
    • (2000) J. Immunol. , vol.164 , pp. 5626-5634
    • Reay, P.A.1    Matsui, K.2    Haase, K.3    Wulfing, C.4    Chien, Y.H.5    Davis, M.M.6
  • 40
    • 0035070797 scopus 로고    scopus 로고
    • A kinetic window constricts the T cell receptor repertoire in the thymus
    • Savage P.A., and Davis M.M. A kinetic window constricts the T cell receptor repertoire in the thymus. Immunity 14 (2001) 243-252
    • (2001) Immunity , vol.14 , pp. 243-252
    • Savage, P.A.1    Davis, M.M.2
  • 42
    • 0030927323 scopus 로고    scopus 로고
    • Making the T cell receptor go the distance: a topological view of T cell activation
    • Shaw A.S., and Dustin M.L. Making the T cell receptor go the distance: a topological view of T cell activation. Immunity 6 (1997) 361-369
    • (1997) Immunity , vol.6 , pp. 361-369
    • Shaw, A.S.1    Dustin, M.L.2
  • 43
    • 0025195765 scopus 로고
    • Roles of adhesion molecules in T-cell recognition: fundamental similarities between four integrins on resting human T cells (LFA-1, VLA-4, VLA-5, VLA-6) in expression, binding, and costimulation
    • Shimizu Y., van Seventer G.A., Horgan K.J., and Shaw S. Roles of adhesion molecules in T-cell recognition: fundamental similarities between four integrins on resting human T cells (LFA-1, VLA-4, VLA-5, VLA-6) in expression, binding, and costimulation. Immunol. Rev. 114 (1990) 109-143
    • (1990) Immunol. Rev. , vol.114 , pp. 109-143
    • Shimizu, Y.1    van Seventer, G.A.2    Horgan, K.J.3    Shaw, S.4
  • 44
    • 0032534304 scopus 로고    scopus 로고
    • TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact site
    • Sperling A.I., Sedy J.R., Manjunath N., Kupfer A., Ardman B., and Burkhardt J.K. TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact site. J. Immunol. 161 (1998) 6459-6462
    • (1998) J. Immunol. , vol.161 , pp. 6459-6462
    • Sperling, A.I.1    Sedy, J.R.2    Manjunath, N.3    Kupfer, A.4    Ardman, B.5    Burkhardt, J.K.6
  • 45
    • 0025182959 scopus 로고
    • Adhesion receptors of the immune system
    • Springer T.A. Adhesion receptors of the immune system. Nature 346 (1990) 425-434
    • (1990) Nature , vol.346 , pp. 425-434
    • Springer, T.A.1
  • 46
    • 0031452944 scopus 로고    scopus 로고
    • Compartmentalized IgE receptor-mediated signal transduction in living cells
    • Stauffer T.P., and Meyer T. Compartmentalized IgE receptor-mediated signal transduction in living cells. J. Cell Biol. 139 (1997) 1447-1454
    • (1997) J. Cell Biol. , vol.139 , pp. 1447-1454
    • Stauffer, T.P.1    Meyer, T.2
  • 47
    • 0018193251 scopus 로고
    • Interspecies spleen-myeloma hybrid producing monoclonal antibodies against mouse lymphocyte surface glycoprotein, T200
    • Trowbridge I.S. Interspecies spleen-myeloma hybrid producing monoclonal antibodies against mouse lymphocyte surface glycoprotein, T200. J. Exp. Med. 148 (1978) 313-323
    • (1978) J. Exp. Med. , vol.148 , pp. 313-323
    • Trowbridge, I.S.1
  • 48
    • 0028961573 scopus 로고
    • Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton
    • Valitutti S., Dessing M., Aktories K., Gallati H., and Lanzavecchia A. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J. Exp. Med. 181 (1995) 577-584
    • (1995) J. Exp. Med. , vol.181 , pp. 577-584
    • Valitutti, S.1    Dessing, M.2    Aktories, K.3    Gallati, H.4    Lanzavecchia, A.5
  • 49
    • 0034728966 scopus 로고    scopus 로고
    • Observing FcepsilonRI signaling from the inside of the mast cell membrane
    • Wilson B.S., Pfeiffer J.R., and Oliver J.M. Observing FcepsilonRI signaling from the inside of the mast cell membrane. J. Cell Biol. 149 (2000) 1131-1142
    • (2000) J. Cell Biol. , vol.149 , pp. 1131-1142
    • Wilson, B.S.1    Pfeiffer, J.R.2    Oliver, J.M.3
  • 50
    • 0035817631 scopus 로고    scopus 로고
    • High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT
    • Wilson B.S., Pfeiffer J.R., Surviladze Z., Gaudet E.A., and Oliver J.M. High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT. J. Cell Biol. 154 (2001) 645-658
    • (2001) J. Cell Biol. , vol.154 , pp. 645-658
    • Wilson, B.S.1    Pfeiffer, J.R.2    Surviladze, Z.3    Gaudet, E.A.4    Oliver, J.M.5
  • 53
    • 0036568944 scopus 로고    scopus 로고
    • Cutting edge: TCR engagement and triggering in the absence of large-scale molecular segregation at the T cell-APC contact site
    • Zaru R., Cameron T.O., Stern L.J., Muller S., and Valitutti S. Cutting edge: TCR engagement and triggering in the absence of large-scale molecular segregation at the T cell-APC contact site. J. Immunol. 168 (2002) 4287-4291
    • (2002) J. Immunol. , vol.168 , pp. 4287-4291
    • Zaru, R.1    Cameron, T.O.2    Stern, L.J.3    Muller, S.4    Valitutti, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.