Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

Science

Volumn 278, Issue 5341, 1997, Pages 1295-1300

  Finzi, Diana ^a   Hermankova, Monika ^a   Pierson, Theodore ^a   Carruth, Lucy M ^a   Buck, Christopher ^a   Chaisson, Richard E ^a   Quinn, Thomas C ^a   Chadwick, Karen ^b   Margolick, Joseph ^b   Brookmeyer, Ronald ^b   Gallant, Joel ^a   Markowitz, Martin ^c   Ho, David D ^c   Richman, Douglas D ^d   Siliciano, Robert F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c AARON DIAMOND AIDS RESEARCH CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CD4 ANTIGEN; VIRUS DNA;

ARTICLE; GENE FREQUENCY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN TISSUE; PRIORITY JOURNAL; PROTEINASE INHIBITION; RETROVIRUS; VIRUS MUTATION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; CROSS-SECTIONAL STUDIES; DRUG RESISTANCE, MICROBIAL; DRUG THERAPY, COMBINATION; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MUTATION; PROVIRUSES; RNA, VIRAL; TIME FACTORS; VIRAL LOAD; VIREMIA; VIRUS INTEGRATION; VIRUS LATENCY; VIRUS REPLICATION;

DNA VIRUSES; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; UNIDENTIFIED RETROVIRUS;

EID: 14444273439     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.278.5341.1295     Document Type: Article

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40. We thank J. Keruly, P. Pentz, and C. Raines for coordinating patient recruitment; E. Pritchard and K. Cooper for help with collection of the samples; M. Castro for help with the culture experiments; Y.-H. Kuo for assistance with the statistical analysis, and C. Ignacio for help with resistance genotyping. We express special thanks to the patients who participated in this study. Supported by NIH grants Al28108 and Al23871 (R.F.S.); Al27670, Al38858, and Al36214 (Center for AIDS Research); and Al29164 (D.R.) and by the Research Center for AIDS and HIV Infection of the San Diego Veterans Affairs Medical Center.