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Volumn 158, Issue 12, 1997, Pages 5773-5782

Aberrant TCR-Mediated Signaling in CD45-Null Thymocytes Involves Dysfunctional Regulation of Lck, Fyn, TCR-ζ, and ZAP-70

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN T CELL RECEPTOR, ZETA CHAIN; CD45 ANTIGEN; FYN PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; ONCOPROTEIN; PROTEIN KINASE FYN; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; TYROSINE; ZAP70 PROTEIN, MOUSE;

EID: 0031570545     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (89)

References (55)
  • 1
    • 0028406294 scopus 로고
    • Thymic selection: 2 pathways to life and 2 to death
    • Juneway, C. A. 1994. Thymic selection: 2 pathways to life and 2 to death. Immunity 1:3.
    • (1994) Immunity , vol.1 , pp. 3
    • Juneway, C.A.1
  • 2
    • 0028268735 scopus 로고
    • Signaling mechanisms in thymocyte selection
    • Rothenberg, E. V. 1994. Signaling mechanisms in thymocyte selection. Curr. Opin. Immunol. 6:257.
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 257
    • Rothenberg, E.V.1
  • 3
    • 0028032155 scopus 로고
    • Positive selection of lymphocytes
    • Von Boehmer, H. 1994. Positive selection of lymphocytes. Cell 76:219.
    • (1994) Cell , vol.76 , pp. 219
    • Von Boehmer, H.1
  • 4
    • 0028988331 scopus 로고
    • T-cell receptor antagonists and partial agonists
    • Jameson, S. C., and M. J. Bevan. 1995. T-cell receptor antagonists and partial agonists. Immunity 2:1.
    • (1995) Immunity , vol.2 , pp. 1
    • Jameson, S.C.1    Bevan, M.J.2
  • 5
    • 0029966057 scopus 로고    scopus 로고
    • Essential flexibility in the T-cell recognition of antigen
    • Kersh, G. J., and P. M. Allen. 1996. Essential flexibility in the T-cell recognition of antigen. Nature 380:495.
    • (1996) Nature , vol.380 , pp. 495
    • Kersh, G.J.1    Allen, P.M.2
  • 6
    • 0028288927 scopus 로고
    • The role of protein-tyrosine kinases and protein-tyrosine phosphatases in T-cell antigen receptor signal-transduction
    • Chan, A. C., D. M. Desai, and A. Weiss. 1994. The role of protein-tyrosine kinases and protein-tyrosine phosphatases in T-cell antigen receptor signal-transduction. Annu. Rev. Immunol. 12:555.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 555
    • Chan, A.C.1    Desai, D.M.2    Weiss, A.3
  • 8
    • 0024040125 scopus 로고
    • The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human lymphocytes-T
    • Rudd, C. E., J. M. Trevillyan, J. D. Dasgupta, L. L. Wong, and S. F. Schlossman. 1988. The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human lymphocytes-T. Proc. Natl. Acad. Sci. USA 85:5190.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 5190
    • Rudd, C.E.1    Trevillyan, J.M.2    Dasgupta, J.D.3    Wong, L.L.4    Schlossman, S.F.5
  • 9
    • 0026483786 scopus 로고
    • ZAP-70: A 70 Kd protein-tyrosine kinase that associates with the TCR zeta-chain
    • Chan, A. C., M. Iwashima, C. W. Turck, and A. Weiss. 1992. ZAP-70: a 70 Kd protein-tyrosine kinase that associates with the TCR zeta-chain. Cell 71:649.
    • (1992) Cell , vol.71 , pp. 649
    • Chan, A.C.1    Iwashima, M.2    Turck, C.W.3    Weiss, A.4
  • 10
    • 0028216232 scopus 로고
    • Differential expression of ZAP-70 and Syk protein-tyrosine kinases, and the role of this family of protein-tyrosine kinases in TCR signaling
    • Chan, A. C., N. S. C. Van Oers, A. Tran, L. Turka, C. L. Law, J. C. Ryan, E. A. Clark, and A. Weiss. 1994. Differential expression of ZAP-70 and Syk protein-tyrosine kinases, and the role of this family of protein-tyrosine kinases in TCR signaling. J. Immunol. 152:4758.
    • (1994) J. Immunol. , vol.152 , pp. 4758
    • Chan, A.C.1    Van Oers, N.S.C.2    Tran, A.3    Turka, L.4    Law, C.L.5    Ryan, J.C.6    Clark, E.A.7    Weiss, A.8
  • 11
    • 0024980981 scopus 로고
    • Antigen receptor tail clue
    • Reth, M. 1989. Antigen receptor tail clue. Nature 338:383.
    • (1989) Nature , vol.338 , pp. 383
    • Reth, M.1
  • 12
    • 0024446403 scopus 로고
    • + thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta-chain
    • + thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta-chain. Nature 341:651.
    • (1989) Nature , vol.341 , pp. 651
    • Nakayama, T.1    Singer, A.2    Hsi, E.D.3    Samelson, L.E.4
  • 13
    • 0028535120 scopus 로고
    • ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells
    • Van Oers, N. S. C., N. Killeen, and A. Weiss. 1994. ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells. Immunity 1:675.
    • (1994) Immunity , vol.1 , pp. 675
    • Van Oers, N.S.C.1    Killeen, N.2    Weiss, A.3
  • 15
    • 0029866039 scopus 로고    scopus 로고
    • Lck regulates the tyrosine phosphorylation of the T-cell receptor subunits and ZAP-70 in murine thymocytes
    • Van Oers, N. S. C., N. Killeen, and A. Weiss. 1996. Lck regulates the tyrosine phosphorylation of the T-cell receptor subunits and ZAP-70 in murine thymocytes. J. Exp. Med. 183:1053.
    • (1996) J. Exp. Med. , vol.183 , pp. 1053
    • Van Oers, N.S.C.1    Killeen, N.2    Weiss, A.3
  • 17
    • 0026612411 scopus 로고
    • fyn Mutant mice display differential signaling in thymocytes and peripheral T-cells
    • fyn Mutant mice display differential signaling in thymocytes and peripheral T-cells. Cell 70:741.
    • (1992) Cell , vol.70 , pp. 741
    • Stein, P.L.1    Lee, H.M.2    Rich, S.3    Soriano, P.4
  • 18
    • 0027328526 scopus 로고
    • Tandem SH2 domains of ZAP-70 bind to T-cell antigen receptor-zeta and CD3-epsilon from activated Jurkat T-cells
    • Wange, R. L., S. N. Malek, S. Desiderio, and L. E. Samelson. 1993. Tandem SH2 domains of ZAP-70 bind to T-cell antigen receptor-zeta and CD3-epsilon from activated Jurkat T-cells. J. Biol. Chem. 268:19797.
    • (1993) J. Biol. Chem. , vol.268 , pp. 19797
    • Wange, R.L.1    Malek, S.N.2    Desiderio, S.3    Samelson, L.E.4
  • 19
    • 0028209548 scopus 로고
    • Sequential interactions of the TCR with 2 distinct cytoplasmic tyrosine kinases
    • Iwashima, M., B. A. Irving, N. S. C. Van Oers, A. C. Chan, and A. Weiss. 1994. Sequential interactions of the TCR with 2 distinct cytoplasmic tyrosine kinases. Science 263:1136.
    • (1994) Science , vol.263 , pp. 1136
    • Iwashima, M.1    Irving, B.A.2    Van Oers, N.S.C.3    Chan, A.C.4    Weiss, A.5
  • 21
    • 0029071585 scopus 로고
    • Activation of ZAP-70 kinase-activity by phosphorylation of tyrosine-493 is required for lymphocyte antigen receptor function
    • Chan, A. C., M. Dalton, R. Johnson, G. H. Kong, T. Wang, R. Thoma, and T. Kurosaki. 1995. Activation of ZAP-70 kinase-activity by phosphorylation of tyrosine-493 is required for lymphocyte antigen receptor function. EMBO J. 14: 2499.
    • (1995) EMBO J. , vol.14 , pp. 2499
    • Chan, A.C.1    Dalton, M.2    Johnson, R.3    Kong, G.H.4    Wang, T.5    Thoma, R.6    Kurosaki, T.7
  • 22
    • 0028014460 scopus 로고
    • Signal-transduction by lymphocyte antigen receptors
    • Weiss, A., and D. R. Littman. 1994. Signal-transduction by lymphocyte antigen receptors. Cell 76:263.
    • (1994) Cell , vol.76 , pp. 263
    • Weiss, A.1    Littman, D.R.2
  • 23
    • 0027967385 scopus 로고
    • Partial T-cell signaling: Altered phospho-zeta and lack of Zap70 recruitment in Apl-induced T-cell anergy
    • Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T-cell signaling: altered phospho-zeta and lack of Zap70 recruitment in Apl-induced T-cell anergy. Cell 79:913.
    • (1994) Cell , vol.79 , pp. 913
    • Sloan-Lancaster, J.1    Shaw, A.S.2    Rothbard, J.B.3    Allen, P.M.4
  • 24
    • 0028902752 scopus 로고
    • Zeta-phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
    • Madrenas, J., R. L. Wange, J. L. Wang, N. Isakov, L. E. Samelson, and R. N. Germain. 1995. Zeta-phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515.
    • (1995) Science , vol.267 , pp. 515
    • Madrenas, J.1    Wange, R.L.2    Wang, J.L.3    Isakov, N.4    Samelson, L.E.5    Germain, R.N.6
  • 25
    • 0024416009 scopus 로고
    • Evidence that the leukocyte-common antigen is required for antigen-induced lymphocyte-T proliferation
    • Pingel, J. T., and M. L. Thomas. 1989. Evidence that the leukocyte-common antigen is required for antigen-induced lymphocyte-T proliferation. Cell 58:1055.
    • (1989) Cell , vol.58 , pp. 1055
    • Pingel, J.T.1    Thomas, M.L.2
  • 26
    • 0025297050 scopus 로고
    • Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway
    • Koretzky, G. A., J. Picus, M. L. Thomas, and A. Weiss. 1990. Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway. Nature 346:66.
    • (1990) Nature , vol.346 , pp. 66
    • Koretzky, G.A.1    Picus, J.2    Thomas, M.L.3    Weiss, A.4
  • 27
    • 0027050564 scopus 로고
    • fyn couples the T-cell antigen receptor to pathways of diacylglycerol production, protein-kinase-C activation and calcium influx
    • fyn couples the T-cell antigen receptor to pathways of diacylglycerol production, protein-kinase-C activation and calcium influx. EMBO J. 11:4887.
    • (1992) EMBO J. , vol.11 , pp. 4887
    • Shiroo, M.1    Goff, L.2    Biffen, M.3    Shivnan, E.4    Alexander, D.5
  • 28
    • 0027475743 scopus 로고
    • Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor
    • McFarland, E. D. C., T. R. Hurley, J. T. Pingel, B. M. Sefton, A. Shaw, and M. L. Thomas. 1993. Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor. Proc. Natl. Acad. Sci. USA 90:1402.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1402
    • McFarland, E.D.C.1    Hurley, T.R.2    Pingel, J.T.3    Sefton, B.M.4    Shaw, A.5    Thomas, M.L.6
  • 29
    • 0027389272 scopus 로고
    • CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck
    • Sieh, M., J. B. Bolen, and A. Weiss. 1993. CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. EMBO J. 12:315.
    • (1993) EMBO J. , vol.12 , pp. 315
    • Sieh, M.1    Bolen, J.B.2    Weiss, A.3
  • 30
    • 0028346560 scopus 로고
    • CD45: An emerging role as a protein-tyrosine-phosphatase required for lymphocyte-activation and development
    • Trowbridge, I. S., and M. L. Thomas. 1994. CD45: an emerging role as a protein-tyrosine-phosphatase required for lymphocyte-activation and development. Annu. Rev. Immunol. 12:85.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 85
    • Trowbridge, I.S.1    Thomas, M.L.2
  • 31
    • 0030222017 scopus 로고    scopus 로고
    • The role of phosphotyrosine phosphatases in T-lymphocyte development, apoptosis and signalling
    • Frearson, J. A., and D. R. Alexander. 1996. The role of phosphotyrosine phosphatases in T-lymphocyte development, apoptosis and signalling. Immunol. Today 17:385.
    • (1996) Immunol. Today , vol.17 , pp. 385
    • Frearson, J.A.1    Alexander, D.R.2
  • 32
    • 0028339795 scopus 로고
    • CD45 regulation of tyrosine phosphorylation and enzyme-activity of Src family kinases
    • Burns, C. M., K. Sakaguchi, E. Appella, and J. D. Ashwell. 1994. CD45 regulation of tyrosine phosphorylation and enzyme-activity of Src family kinases. J. Biol. Chem. 269:13594.
    • (1994) J. Biol. Chem. , vol.269 , pp. 13594
    • Burns, C.M.1    Sakaguchi, K.2    Appella, E.3    Ashwell, J.D.4
  • 34
    • 0026330922 scopus 로고
    • The CD45 protein tyrosine phosphatase is required for the completion of the activation program leading to lymphokine production in the Jurkat human T-cell line
    • Peyron, J. F., S. Verma, R. D. Malefyt, J. Sancho, C. Terhorst, and H. Spits. 1991. The CD45 protein tyrosine phosphatase is required for the completion of the activation program leading to lymphokine production in the Jurkat human T-cell line. Int. Immunol. 3:1357.
    • (1991) Int. Immunol. , vol.3 , pp. 1357
    • Peyron, J.F.1    Verma, S.2    Malefyt, R.D.3    Sancho, J.4    Terhorst, C.5    Spits, H.6
  • 35
    • 0028426282 scopus 로고
    • Isoforms of the transmembrane tyrosine phosphatase CD45 differentially affect T-cell recognition
    • Novak, T. J., D. Farber, D. Leitenberg, S. C. Hong, P. Johnson, and K. Bottomly. 1994. Isoforms of the transmembrane tyrosine phosphatase CD45 differentially affect T-cell recognition. Immunity 1:109.
    • (1994) Immunity , vol.1 , pp. 109
    • Novak, T.J.1    Farber, D.2    Leitenberg, D.3    Hong, S.C.4    Johnson, P.5    Bottomly, K.6
  • 36
    • 0029864147 scopus 로고    scopus 로고
    • CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and in B-cell maturation
    • Byth, K. F., L. A. Conroy, S. Howlett, A. J. H. Smith, J. May, D. R. Alexander, and N. Holmes. 1996. CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and in B-cell maturation. J. Exp. Med. 183:1707.
    • (1996) J. Exp. Med. , vol.183 , pp. 1707
    • Byth, K.F.1    Conroy, L.A.2    Howlett, S.3    Smith, A.J.H.4    May, J.5    Alexander, D.R.6    Holmes, N.7
  • 37
    • 0023790515 scopus 로고
    • A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex
    • Tomonari, K. 1988. A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex. Immunogenetics 28:455.
    • (1988) Immunogenetics , vol.28 , pp. 455
    • Tomonari, K.1
  • 39
    • 0029067104 scopus 로고
    • Phosphatidylinositol 4,5-bisphosphate hydrolysis accompanies T-cell receptor-induced apoptosis of murine thymocytes within the thymus
    • Conroy, L. A., E. J. Jenkinson, J. J. T. Owen, and R. H. Michell. 1995. Phosphatidylinositol 4,5-bisphosphate hydrolysis accompanies T-cell receptor-induced apoptosis of murine thymocytes within the thymus. Eur. J. Immunol. 25: 1828.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1828
    • Conroy, L.A.1    Jenkinson, E.J.2    Owen, J.J.T.3    Michell, R.H.4
  • 40
    • 0024377114 scopus 로고
    • INCA: Software for Consort-30 analysis of flow cytometric calcium determinations
    • Keij, J. F., A. W. Griffioen, T. H. The, and G. T. Rijkers. 1989. INCA: software for Consort-30 analysis of flow cytometric calcium determinations. Cytometry 10:814.
    • (1989) Cytometry , vol.10 , pp. 814
    • Keij, J.F.1    Griffioen, A.W.2    The, T.H.3    Rijkers, G.T.4
  • 42
    • 0028027169 scopus 로고
    • The protein product of the C-Cbl protooncogene is the 120-Kda tyrosine-phosphorylated protein in Jurkat cells activated via the T-cell antigen receptor
    • Donovan, J. A., R. L. Wange, W. Y. Langdon, and L. E. Samelson. 1994. The protein product of the C-Cbl protooncogene is the 120-Kda tyrosine-phosphorylated protein in Jurkat cells activated via the T-cell antigen receptor. J. Biol. Chem. 269:22921.
    • (1994) J. Biol. Chem. , vol.269 , pp. 22921
    • Donovan, J.A.1    Wange, R.L.2    Langdon, W.Y.3    Samelson, L.E.4
  • 43
    • 0029939787 scopus 로고    scopus 로고
    • SH2 domain function is essential for the role of the Lck tyrosine kinase in T-cell receptor signal-transduction
    • Straus, D. B., A. C. Chan, B. Patai, and A. Weiss. 1996. SH2 domain function is essential for the role of the Lck tyrosine kinase in T-cell receptor signal-transduction. J. Biol. Chem. 271:9976.
    • (1996) J. Biol. Chem. , vol.271 , pp. 9976
    • Straus, D.B.1    Chan, A.C.2    Patai, B.3    Weiss, A.4
  • 44
    • 0029556045 scopus 로고
    • Receptors and signals in early thymic selection
    • Levelt, C. N., and K. Eichmann. 1995. Receptors and signals in early thymic selection. Immunity 3:667.
    • (1995) Immunity , vol.3 , pp. 667
    • Levelt, C.N.1    Eichmann, K.2
  • 45
    • 0028467163 scopus 로고
    • An activated lck transgene promotes thymocyte development in RAG-1 mutant mice
    • Mombaerts, P., S. J. Anderson, R. M. Perlmutter, T. W. Mak, and S. Tonegawa. 1994. An activated lck transgene promotes thymocyte development In RAG-1 mutant mice. Immunity 1:261.
    • (1994) Immunity , vol.1 , pp. 261
    • Mombaerts, P.1    Anderson, S.J.2    Perlmutter, R.M.3    Mak, T.W.4    Tonegawa, S.5
  • 48
    • 0029933309 scopus 로고    scopus 로고
    • Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
    • Sloan-Lancaster, J., and P. M. Allen. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 1
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 50
    • 0028294682 scopus 로고
    • Positive and negative thymocyte selection induced by different concentrations of a single peptide
    • Sebzda, E., V. A. Wallace, J. Mayer, R. S. M. Yeung, T. W. Mak, and P. S. Ohashi. 1994. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263:1615.
    • (1994) Science , vol.263 , pp. 1615
    • Sebzda, E.1    Wallace, V.A.2    Mayer, J.3    Yeung, R.S.M.4    Mak, T.W.5    Ohashi, P.S.6
  • 51
    • 0029952988 scopus 로고    scopus 로고
    • The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling
    • Chu, D. H., H. Spits, J.-F. Peyron, R. B. Rowley, J. B. Bolen, and A. Weiss. 1996. The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. EMBO J. 15:6251.
    • (1996) EMBO J. , vol.15 , pp. 6251
    • Chu, D.H.1    Spits, H.2    Peyron, J.-F.3    Rowley, R.B.4    Bolen, J.B.5    Weiss, A.6
  • 52
    • 0029151248 scopus 로고
    • Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases
    • Taniuchi, L. D. Kitamura, Y. Maekawa, T. Fukuda, H. Kishi, and T. Watanabe. 1995. Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases. EMBO J. 14:3664.
    • (1995) EMBO J. , vol.14 , pp. 3664
    • Taniuchi1    Kitamura, L.D.2    Maekawa, Y.3    Fukuda, T.4    Kishi, H.5    Watanabe, T.6
  • 53
    • 0029086739 scopus 로고
    • Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma-cells by HS1, a protein-tyrosine kinase substrate
    • Fukuda, T., D. Kitamura, I. Taniuchi, Y. Maekawa, L. E. Benhamou, P. Sarthou, and T. Watanabe. 1995. Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma-cells by HS1, a protein-tyrosine kinase substrate. Proc. Natl. Acad. Sci. USA 92:7302.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7302
    • Fukuda, T.1    Kitamura, D.2    Taniuchi, I.3    Maekawa, Y.4    Benhamou, L.E.5    Sarthou, P.6    Watanabe, T.7


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