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Volumn 115, Issue 11, 2005, Pages 3250-3255

HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; ANTIRETROVIRUS AGENT; EFAVIRENZ; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; NELFINAVIR; NEVIRAPINE; RITONAVIR; SAQUINAVIR; TENOFOVIR; VIRUS DNA; VIRUS ENVELOPE PROTEIN; VIRUS RNA; ZIDOVUDINE;

EID: 27644524761     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI26197     Document Type: Article
Times cited : (237)

References (36)
  • 1
    • 0003185318 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention
    • Department of Health and Human Services Public Health Service. 2000. HIV/AIDS surveillance report. Centers for Disease Control and Prevention. 12:1-44.
    • (2000) HIV/AIDS Surveillance Report , vol.12 , pp. 1-44
  • 2
    • 0030659177 scopus 로고    scopus 로고
    • Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    • Chun, T.W., et al. 1997. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc. Natl. Acad. Sci. U. S. A. 94:13193-13197.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 13193-13197
    • Chun, T.W.1
  • 3
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi, D., et al. 1997. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science. 278:1295-1300.
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1
  • 4
    • 0030712305 scopus 로고    scopus 로고
    • Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
    • Wong, J.K., et al. 1997. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science. 278:1291-1295.
    • (1997) Science , vol.278 , pp. 1291-1295
    • Wong, J.K.1
  • 5
    • 0038579210 scopus 로고    scopus 로고
    • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    • Siliciano, J.D., et al. 2003. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat. Med. 9:727-728.
    • (2003) Nat. Med. , vol.9 , pp. 727-728
    • Siliciano, J.D.1
  • 6
    • 0033609373 scopus 로고    scopus 로고
    • Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
    • Zhang, L., et al. 1999. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N. Engl. J. Med. 340:1605-1613.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1605-1613
    • Zhang, L.1
  • 7
    • 0033609374 scopus 로고    scopus 로고
    • Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy
    • Furtado, M.R., et al. 1999. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy. N. Engl. J. Med. 340:1614-1622.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1614-1622
    • Furtado, M.R.1
  • 8
    • 0038468339 scopus 로고    scopus 로고
    • Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo
    • Hermankova, M., et al. 2003. Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo. J. Virol. 77:7383-7392.
    • (2003) J. Virol. , vol.77 , pp. 7383-7392
    • Hermankova, M.1
  • 9
    • 0033914367 scopus 로고    scopus 로고
    • Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy
    • Chun, T.W., et al. 2000. Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy. Nat. Med. 6:757-761.
    • (2000) Nat. Med. , vol.6 , pp. 757-761
    • Chun, T.W.1
  • 10
    • 0033984045 scopus 로고    scopus 로고
    • The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy
    • Ramratnam, B., et al. 2000. The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nat Med. 6:82-85.
    • (2000) Nat Med. , vol.6 , pp. 82-85
    • Ramratnam, B.1
  • 11
    • 0036138852 scopus 로고    scopus 로고
    • Evidence for human immunodeficiency virus type 1 replication in vivo in CD14(+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy
    • Zhu, T., et al. 2002. Evidence for human immunodeficiency virus type 1 replication in vivo in CD14(+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy. J. Virol. 76:707-716.
    • (2002) J. Virol. , vol.76 , pp. 707-716
    • Zhu, T.1
  • 12
    • 9144265028 scopus 로고    scopus 로고
    • Intensification of anti-retroviral therapy accelerates the decay of the HIV-1 latent reservoir and decreases, but does not eliminate, ongoing virus replication
    • Ramratnam, B., et al. 2004. Intensification of anti-retroviral therapy accelerates the decay of the HIV-1 latent reservoir and decreases, but does not eliminate, ongoing virus replication. J. Acquir. Immune. Defic. Syndr. 35:33-37.
    • (2004) J. Acquir. Immune. Defic. Syndr. , vol.35 , pp. 33-37
    • Ramratnam, B.1
  • 13
    • 0033966504 scopus 로고    scopus 로고
    • Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy
    • Sharkey, M.E., et al. 2000. Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy. Nat. Med. 6:76-81.
    • (2000) Nat. Med. , vol.6 , pp. 76-81
    • Sharkey, M.E.1
  • 14
    • 16244362723 scopus 로고    scopus 로고
    • In vivo evidence for instability of episomal human immunodeficiency virus type 1 cDNA
    • Sharkey, M., Triques, K., Kuritzkes, D.R., and Stevenson, M. 2005. In vivo evidence for instability of episomal human immunodeficiency virus type 1 cDNA. J. Virol. 79:5203-5210.
    • (2005) J. Virol. , vol.79 , pp. 5203-5210
    • Sharkey, M.1    Triques, K.2    Kuritzkes, D.R.3    Stevenson, M.4
  • 15
    • 0033537355 scopus 로고    scopus 로고
    • HIV-1 replication in patients with undetectable plasma virus receiving HAART
    • Natarajan, V., et al. 1999. HIV-1 replication in patients with undetectable plasma virus receiving HAART. Lancet. 353:119-120.
    • (1999) Lancet , vol.353 , pp. 119-120
    • Natarajan, V.1
  • 16
    • 0035822946 scopus 로고    scopus 로고
    • Persistence of intracellular HIV-1 mRNA correlates with HIV-1-specific immune responses in infected subjects on stable HAART
    • Patterson, B.K., et al. 2001. Persistence of intracellular HIV-1 mRNA correlates with HIV-1-specific immune responses in infected subjects on stable HAART. AIDS. 15:1635-1641.
    • (2001) AIDS , vol.15 , pp. 1635-1641
    • Patterson, B.K.1
  • 17
    • 0141676556 scopus 로고    scopus 로고
    • Productive infection maintains a dynamic steady state of residual viremia in human immunodeficiency virus type 1-infected persons treated with suppressive antiretroviral therapy for five years
    • Havlir, D.V., et al. 2003. Productive infection maintains a dynamic steady state of residual viremia in human immunodeficiency virus type 1-infected persons treated with suppressive antiretroviral therapy for five years. J. Virol. 77:11212-11219.
    • (2003) J. Virol. , vol.77 , pp. 11212-11219
    • Havlir, D.V.1
  • 18
    • 0037452711 scopus 로고    scopus 로고
    • Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals
    • Chun, T.W., et al. 2003. Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals. Proc. Natl. Acad. Sci. U. S. A. 100:1908-1913.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 1908-1913
    • Chun, T.W.1
  • 19
    • 0027968068 scopus 로고
    • CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    • Thompson, J.D., Higgins, D.G., and Gibson, T.J. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3
  • 20
    • 0031436890 scopus 로고    scopus 로고
    • Phylogeny estimation and hypothesis testing using maximum likelihood
    • Huelsenbeck, J.P., and Crandall, K.A. 1997. Phylogeny estimation and hypothesis testing using maximum likelihood. Annu. Rev. Ecol. Syst. 28:437-466.
    • (1997) Annu. Rev. Ecol. Syst. , vol.28 , pp. 437-466
    • Huelsenbeck, J.P.1    Crandall, K.A.2
  • 21
    • 0030902563 scopus 로고    scopus 로고
    • Phylogenetic methods come of age: Testing hypotheses in an evolutionary context
    • Huelsenbeck, J.P., and Rannala, B. 1997. Phylogenetic methods come of age: testing hypotheses in an evolutionary context. Science. 276:227-232.
    • (1997) Science , vol.276 , pp. 227-232
    • Huelsenbeck, J.P.1    Rannala, B.2
  • 22
    • 0031773680 scopus 로고    scopus 로고
    • MODEL-TEST: Testing the model of DNA substitution
    • Posada, D., and Crandall, K.A. 1998. MODEL-TEST: testing the model of DNA substitution. Bioinformatics. 14:817-818.
    • (1998) Bioinformatics , vol.14 , pp. 817-818
    • Posada, D.1    Crandall, K.A.2
  • 23
    • 0024341852 scopus 로고
    • A cladistic measure of gene flow inferred from the phylogenies of alleles
    • Slatkin, M., and Maddison, W.P. 1989. A cladistic measure of gene flow inferred from the phylogenies of alleles. Genetics. 123:603-613.
    • (1989) Genetics , vol.123 , pp. 603-613
    • Slatkin, M.1    Maddison, W.P.2
  • 24
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
    • Perelson, A.S., Neumann, A.U., Markowitz, M., Leonard, J.M., and Ho, D.D. 1996. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science. 271:1582-1586.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5
  • 25
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1-infected compartments during combination therapy
    • Perelson, A.S., et al. 1997. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature. 387:188-191.
    • (1997) Nature , vol.387 , pp. 188-191
    • Perelson, A.S.1
  • 26
    • 0026054892 scopus 로고
    • Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection
    • Bukrinsky, M.I., Stanwick, T.L., Dempsey, M.P., and Stevenson, M. 1991. Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection. Science. 254:423-427.
    • (1991) Science , vol.254 , pp. 423-427
    • Bukrinsky, M.I.1    Stanwick, T.L.2    Dempsey, M.P.3    Stevenson, M.4
  • 27
    • 0030913366 scopus 로고    scopus 로고
    • Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
    • Chun, T.W., et al. 1997. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature. 387:183-188.
    • (1997) Nature , vol.387 , pp. 183-188
    • Chun, T.W.1
  • 28
    • 0033613070 scopus 로고    scopus 로고
    • Latent reservoirs of HIV: Obstacles to the eradication of virus
    • Chun, T.W., and Fauci, A.S. 1999. Latent reservoirs of HIV: obstacles to the eradication of virus. Proc. Natl. Acad. Sci. U. S. A. 96:10958-10961.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 10958-10961
    • Chun, T.W.1    Fauci, A.S.2
  • 29
    • 0033797161 scopus 로고    scopus 로고
    • Genetic characterization of rebounding HIV-1 after cessation of highly active antiretroviral therapy
    • Zhang, L., et al. 2000. Genetic characterization of rebounding HIV-1 after cessation of highly active antiretroviral therapy. J. Clin. Invest. 106:839-845.
    • (2000) J. Clin. Invest. , vol.106 , pp. 839-845
    • Zhang, L.1
  • 30
    • 0037111060 scopus 로고    scopus 로고
    • Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy
    • Kulkosky, J., et al. 2002. Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy. J. Infect. Dis. 186:1403-1411.
    • (2002) J. Infect. Dis. , vol.186 , pp. 1403-1411
    • Kulkosky, J.1
  • 31
    • 13744259064 scopus 로고    scopus 로고
    • IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART
    • doi:10.1172/JCI200522574
    • Wang, F.X., et al. 2005. IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART. J. Clin. Invest. 115:128-137. doi:10.1172/JCI200522574.
    • (2005) J. Clin. Invest. , vol.115 , pp. 128-137
    • Wang, F.X.1
  • 32
    • 0029979690 scopus 로고    scopus 로고
    • Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1
    • Stanley, S.K., et al. 1996. Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1. N. Engl. J. Med. 334:1222-1230.
    • (1996) N. Engl. J. Med. , vol.334 , pp. 1222-1230
    • Stanley, S.K.1
  • 33
    • 0032490570 scopus 로고    scopus 로고
    • Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines
    • Chun, T.W., Engel, D., Mizell, S.B., Ehler, L.A., and Fauci, A.S. 1998. Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines. J. Exp. Med. 188:83-91.
    • (1998) J. Exp. Med. , vol.188 , pp. 83-91
    • Chun, T.W.1    Engel, D.2    Mizell, S.B.3    Ehler, L.A.4    Fauci, A.S.5
  • 34
    • 0033942250 scopus 로고    scopus 로고
    • Effects of mycophenolic acid on human immunodeficiency virus infection in vitro and in vivo
    • Chapuis, A.G., et al. 2000. Effects of mycophenolic acid on human immunodeficiency virus infection in vitro and in vivo. Nat Med. 6:762-768.
    • (2000) Nat Med. , vol.6 , pp. 762-768
    • Chapuis, A.G.1
  • 35
    • 0032555117 scopus 로고    scopus 로고
    • Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection
    • Chun, T.W., et al. 1998. Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection. Proc. Natl. Acad. Sci. U. S. A. 95:8869-8873.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 8869-8873
    • Chun, T.W.1
  • 36
    • 0033031218 scopus 로고    scopus 로고
    • Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy
    • Chun, T.W., et al. 1999. Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy. Nat. Med. 5:651-655.
    • (1999) Nat. Med. , vol.5 , pp. 651-655
    • Chun, T.W.1


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