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Volumn 6, Issue 4, 1997, Pages 361-369

Making the T cell receptor go the distance: A topological view of T cell activation

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; T LYMPHOCYTE RECEPTOR;

EID: 0030927323     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80279-4     Document Type: Review
Times cited : (357)

References (58)
  • 2
    • 0021968677 scopus 로고
    • Binding of immunogenic peptides to ia histocompatibility molecules
    • Babbitt, B.P., Allen, P.M., Matsueda, G., Haber, E., and Unanue, E. (1985). Binding of immunogenic peptides to Ia histocompatibility molecules. Nature 317, 359-361.
    • (1985) Nature , vol.317 , pp. 359-361
    • Babbitt, B.P.1    Allen, P.M.2    Matsueda, G.3    Haber, E.4    Unanue, E.5
  • 3
    • 0021250906 scopus 로고
    • Cell adhesion: Competition between nonspecific repulsion and specific binding
    • Bell, G.I., Dembo, M., and Bongrand, P. (1984). Cell adhesion: competition between nonspecific repulsion and specific binding. Biophys. J. 45, 1051-1064.
    • (1984) Biophys. J. , vol.45 , pp. 1051-1064
    • Bell, G.I.1    Dembo, M.2    Bongrand, P.3
  • 4
    • 0029125639 scopus 로고
    • Protein tyrosine phosphatases as adhesion receptors
    • Brady, K.S., and Tonks, N.K. (1995). Protein tyrosine phosphatases as adhesion receptors. Curr. Opin. Cell Biol. 7, 650-657.
    • (1995) Curr. Opin. Cell Biol. , vol.7 , pp. 650-657
    • Brady, K.S.1    Tonks, N.K.2
  • 5
    • 0030175744 scopus 로고    scopus 로고
    • Regulation of antigen receptor signal transduction by protein tyrosine kinases
    • Chan, A.C., and Shaw, A.S. (1996). Regulation of antigen receptor signal transduction by protein tyrosine kinases. Curr. Opin. Immunol. 8, 394-401.
    • (1996) Curr. Opin. Immunol. , vol.8 , pp. 394-401
    • Chan, A.C.1    Shaw, A.S.2
  • 6
    • 0026046515 scopus 로고
    • Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2
    • Chan, P.Y., Lawrence, M.B., Dustin, M.L., Ferguson, L.M., Golan, D.E., and Springer, T.A. (1991). Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2. J. Cell Biol. 115, 245-255.
    • (1991) J. Cell Biol. , vol.115 , pp. 245-255
    • Chan, P.Y.1    Lawrence, M.B.2    Dustin, M.L.3    Ferguson, L.M.4    Golan, D.E.5    Springer, T.A.6
  • 7
    • 0141544141 scopus 로고
    • Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation
    • Cooper, J.A., and MacAuley, A. (1988). Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation. Proc. Natl. Acad. Sci. USA 85, 4232-4236.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 4232-4236
    • Cooper, J.A.1    MacAuley, A.2
  • 9
    • 0028313992 scopus 로고
    • Assembly, transport, and function of MHC class II molecules
    • Cresswell, P. (1994). Assembly, transport, and function of MHC class II molecules. Annu. Rev. Immunol. 12, 259-293.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 259-293
    • Cresswell, P.1
  • 10
    • 0026021936 scopus 로고
    • The dimensions of the T lymphocyte glycoprotein leukosialin and identification of linear protein epitopes that can be modified by glycosylation
    • Cyster, J.G., Shotton, D.M., and Williams, A.F. (1991). The dimensions of the T lymphocyte glycoprotein leukosialin and identification of linear protein epitopes that can be modified by glycosylation. EMBO J. 10, 893-902.
    • (1991) EMBO J. , vol.10 , pp. 893-902
    • Cyster, J.G.1    Shotton, D.M.2    Williams, A.F.3
  • 11
    • 0029930984 scopus 로고    scopus 로고
    • The structure and ligand interations of CD2: Implications for T cell function
    • Davis, S.J., and van der Merwe, P.A. (1996). The structure and ligand interations of CD2: implications for T cell function. Immunol. Today 17, 177-187.
    • (1996) Immunol. Today , vol.17 , pp. 177-187
    • Davis, S.J.1    Van Der Merwe, P.A.2
  • 12
    • 0025182003 scopus 로고
    • The minimal number of class II MHC-antigen complexes needed for T cell activation
    • Demotz, S., Grey, H.M., and Sette, A. (1990). The minimal number of class II MHC-antigen complexes needed for T cell activation. Science 249, 1028-1030.
    • (1990) Science , vol.249 , pp. 1028-1030
    • Demotz, S.1    Grey, H.M.2    Sette, A.3
  • 13
    • 0016680698 scopus 로고
    • Sialic acids and sialyltransferases in murine lymphoid cells: Indicators of T cell maturation
    • Despont, J.P., Abel, C.A., and Grey, H.M. (1975). Sialic acids and sialyltransferases in murine lymphoid cells: indicators of T cell maturation. Cell. Immunol. 17, 487-494.
    • (1975) Cell. Immunol. , vol.17 , pp. 487-494
    • Despont, J.P.1    Abel, C.A.2    Grey, H.M.3
  • 14
    • 0023676777 scopus 로고
    • Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells
    • Dustin, M.L., and Springer, T.A. (1988). Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells. J. Cell Biol. 107, 321-331.
    • (1988) J. Cell Biol. , vol.107 , pp. 321-331
    • Dustin, M.L.1    Springer, T.A.2
  • 15
    • 0030061494 scopus 로고    scopus 로고
    • Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area
    • Dustin, M.L., Ferguson, L.M., Chan, P.Y., Springer, T.A., and Golan, D. (1996a). Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area. J. Cell Biol. 132, 465-474.
    • (1996) J. Cell Biol. , vol.132 , pp. 465-474
    • Dustin, M.L.1    Ferguson, L.M.2    Chan, P.Y.3    Springer, T.A.4    Golan, D.5
  • 16
    • 0030239667 scopus 로고    scopus 로고
    • T cell receptor mediated adhesion of T cell hybridomas to planar bilayers containing purified MHC class II/peptide complexes and receptor shedding during detachment
    • Dustin, M.L., Miller, J.M., Ranganath, S., Vignali, D.A.A., Viner, N.J., Nelson, C.A., and Unanue, E.R. (1996b). T cell receptor mediated adhesion of T cell hybridomas to planar bilayers containing purified MHC class II/peptide complexes and receptor shedding during detachment. J. Immunol. 157, 2014-2021.
    • (1996) J. Immunol. , vol.157 , pp. 2014-2021
    • Dustin, M.L.1    Miller, J.M.2    Ranganath, S.3    Vignali, D.A.A.4    Viner, N.J.5    Nelson, C.A.6    Unanue, E.R.7
  • 17
    • 0029834552 scopus 로고    scopus 로고
    • The CD43 130-kD peripheral T-cell activation antigen is downregulated in thymic positive selection
    • Ellies, L.G., Tao, W., Fellinger, W., Teh, H.S., and Ziltener, H.J. (1996). The CD43 130-kD peripheral T-cell activation antigen is downregulated in thymic positive selection. Blood 88, 1725-1732.
    • (1996) Blood , vol.88 , pp. 1725-1732
    • Ellies, L.G.1    Tao, W.2    Fellinger, W.3    Teh, H.S.4    Ziltener, H.J.5
  • 18
    • 0027333348 scopus 로고
    • Tickling the TCR: Selective T-cell functions stimulated by altered peptide ligands
    • Evavold, B.D., Sloan-Lancaster, J., and Allen, P.M. (1993). Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands. Immunol. Today 14, 602-609.
    • (1993) Immunol. Today , vol.14 , pp. 602-609
    • Evavold, B.D.1    Sloan-Lancaster, J.2    Allen, P.M.3
  • 19
    • 0025855156 scopus 로고
    • Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
    • Falk, K., Rötzchke, O., Stevanovic, S., Jung, G., and Rammensee, H.G. (1991). Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351, 290-296.
    • (1991) Nature , vol.351 , pp. 290-296
    • Falk, K.1    Rötzchke, O.2    Stevanovic, S.3    Jung, G.4    Rammensee, H.G.5
  • 20
    • 0030445778 scopus 로고    scopus 로고
    • Tripping the switch fantastic: How a protein kinase cascade can convert graded inputs into switch-like outputs
    • Ferrell, J.E.J. (1996). Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. Trends Biol. Sci. 21, 460-466.
    • (1996) Trends Biol. Sci. , vol.21 , pp. 460-466
    • Ferrell, J.E.J.1
  • 21
    • 0026437895 scopus 로고
    • Tyrosine phosphatases and their possible interplay with tyrosine kinases
    • Fischer, E.H., Charbonneau, H., Cool, D.E., and Tonks, N.K. (1992). Tyrosine phosphatases and their possible interplay with tyrosine kinases. Ciba Foundation Symp. 164, 132-140.
    • (1992) Ciba Foundation Symp. , vol.164 , pp. 132-140
    • Fischer, E.H.1    Charbonneau, H.2    Cool, D.E.3    Tonks, N.K.4
  • 22
    • 0029855347 scopus 로고    scopus 로고
    • Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
    • Garboczi, D.N., Ghosh, P., Utz, U., Fan, Q.R., Biddison, W.E., and Wiley, D.C. (1996). Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384, 134-141.
    • (1996) Nature , vol.384 , pp. 134-141
    • Garboczi, D.N.1    Ghosh, P.2    Utz, U.3    Fan, Q.R.4    Biddison, W.E.5    Wiley, D.C.6
  • 25
    • 0026574838 scopus 로고
    • lck protein tyrosine kinase: A functional complex crucial in T cell signal transduction
    • lck protein tyrosine kinase: a functional complex crucial in T cell signal transduction. Int. Immunol. 4, 1325-1330.
    • (1992) Int. Immunol. , vol.4 , pp. 1325-1330
    • Guttinger, M.1    Gassmann, M.2    Amrein, K.E.3    Burn, P.4
  • 26
    • 0025286210 scopus 로고
    • Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation
    • Harding, C.V., and Unanue, E.R. (1990). Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature 346, 574-576.
    • (1990) Nature , vol.346 , pp. 574-576
    • Harding, C.V.1    Unanue, E.R.2
  • 27
    • 0023256274 scopus 로고
    • Endocytosis and recycling of the T3-T cell receptor complex: The role of T3 phosphorylation
    • Krangel, M.S. (1987). Endocytosis and recycling of the T3-T cell receptor complex: the role of T3 phosphorylation. J. Exp. Med. 165, 1141-1159.
    • (1987) J. Exp. Med. , vol.165 , pp. 1141-1159
    • Krangel, M.S.1
  • 28
    • 0024535530 scopus 로고
    • Characterization of a monoclonal antibody which detects all murine α/β T cell receptors
    • Kubo, RT., Born, W., Kappler, J.W., Marrack, P., and Pigeon, M. (1989). Characterization of a monoclonal antibody which detects all murine α/β T cell receptors. J. Immunol. 142, 2736-2742.
    • (1989) J. Immunol. , vol.142 , pp. 2736-2742
    • Kubo, R.T.1    Born, W.2    Kappler, J.W.3    Marrack, P.4    Pigeon, M.5
  • 29
    • 0023231146 scopus 로고
    • Requirements for the simultaneous presence of phorbol esters and calcium ionophores in the expression of human T lymphocyte proliferation-related genes
    • Kumagai, N., Benedict, S.H., Mills, G.B., and Gelfand, E.W. (1987). Requirements for the simultaneous presence of phorbol esters and calcium ionophores in the expression of human T lymphocyte proliferation-related genes. J. Immunol. 139, 1393-1399.
    • (1987) J. Immunol. , vol.139 , pp. 1393-1399
    • Kumagai, N.1    Benedict, S.H.2    Mills, G.B.3    Gelfand, E.W.4
  • 31
    • 0027364840 scopus 로고
    • Direct evidence for two affinity states for lymphocyte function-associated antigen-1 on activated T cells
    • Lollo, B.A., Chan, K.W.H., Hanson, E.M., Moy, V.T., and Brian, A.A. (1993). Direct evidence for two affinity states for lymphocyte function-associated antigen-1 on activated T cells. J. Biol. Chem. 268, 21693-21700.
    • (1993) J. Biol. Chem. , vol.268 , pp. 21693-21700
    • Lollo, B.A.1    Chan, K.W.H.2    Hanson, E.M.3    Moy, V.T.4    Brian, A.A.5
  • 32
    • 0003104975 scopus 로고    scopus 로고
    • A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists
    • Lyons, D.S., Lieberman, S.A., Hampl, J., Boniface, J.J., Chien, Y., Berg, L.J., and Davis, M.M. (1996). A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5, 53-61.
    • (1996) Immunity , vol.5 , pp. 53-61
    • Lyons, D.S.1    Lieberman, S.A.2    Hampl, J.3    Boniface, J.J.4    Chien, Y.5    Berg, L.J.6    Davis, M.M.7
  • 33
    • 0029120438 scopus 로고
    • Negative regulation of T-cell adhesion and activation by CD43
    • Manjunath, N., Correa, M., Ardman, M., and Ardman, B. (1995). Negative regulation of T-cell adhesion and activation by CD43. Nature 377, 535-538.
    • (1995) Nature , vol.377 , pp. 535-538
    • Manjunath, N.1    Correa, M.2    Ardman, M.3    Ardman, B.4
  • 34
    • 0019154473 scopus 로고
    • The kinetics of antibody binding to membrane antigens in solution and at the cell surface
    • Mason, D.W., and Williams, A.F. (1980). The kinetics of antibody binding to membrane antigens in solution and at the cell surface. Biochem. J. 187, 1-20.
    • (1980) Biochem. J. , vol.187 , pp. 1-20
    • Mason, D.W.1    Williams, A.F.2
  • 35
    • 0028589333 scopus 로고
    • Kinetics of T-cell receptor binding to peptide/I-Ek complexes: Correlation of the dissociation rate with T-cell responsiveness
    • Matsui, K., Boniface, J.J., Steffner, P., Reay, P.A., and Davis, M.M. (1994). Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness. Proc. Natl. Acad. Sci. USA 91, 12862-12866.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12862-12866
    • Matsui, K.1    Boniface, J.J.2    Steffner, P.3    Reay, P.A.4    Davis, M.M.5
  • 36
    • 0029063148 scopus 로고
    • Kinetic proofreading in T-cell receptor signal transduction
    • McKeithan, T.W. (1995). Kinetic proofreading in T-cell receptor signal transduction. Proc. Natl. Acad. Sci. USA 92, 5042-5046.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5042-5046
    • McKeithan, T.W.1
  • 39
    • 0028064707 scopus 로고
    • Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell
    • Nelson, C.A., Petzold, S.J., and Unanue, E.R. (1994). Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell. Nature 371, 250-252.
    • (1994) Nature , vol.371 , pp. 250-252
    • Nelson, C.A.1    Petzold, S.J.2    Unanue, E.R.3
  • 40
    • 0026008413 scopus 로고
    • Cytoskeletal function in CD8- and T cell receptor-mediated interaction of cytotoxic T lymphocytes with class I protein
    • O'Rourke, A.M., Apgar, J.R., Kane, K.P., Martz, E., and Mescher, M.F. (1991). Cytoskeletal function in CD8- and T cell receptor-mediated interaction of cytotoxic T lymphocytes with class I protein. J. Exp. Med. 173, 241-249.
    • (1991) J. Exp. Med. , vol.173 , pp. 241-249
    • O'Rourke, A.M.1    Apgar, J.R.2    Kane, K.P.3    Martz, E.4    Mescher, M.F.5
  • 42
    • 0024416009 scopus 로고
    • Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation
    • Pingel, J.T., and Thomas, M.L. (1989). Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation. Cell 58, 1055-1065.
    • (1989) Cell , vol.58 , pp. 1055-1065
    • Pingel, J.T.1    Thomas, M.L.2
  • 44
    • 0028851581 scopus 로고
    • Tyrosine-phosphorylated T cell receptor ζ chain associates with the actin cytoskeleton upon activation of mature T lymphocytes
    • Rozdzial, M.M., Malissen, B., and Finkel, T.H. (1995). Tyrosine-phosphorylated T cell receptor ζ chain associates with the actin cytoskeleton upon activation of mature T lymphocytes. Immunity 3, 623-633.
    • (1995) Immunity , vol.3 , pp. 623-633
    • Rozdzial, M.M.1    Malissen, B.2    Finkel, T.H.3
  • 45
    • 0028807566 scopus 로고
    • Molecular recognition of antigen involves lattice formation between CD4, MHC class II and TCR molecules
    • Sakihama, T., Smolyar, A., and Reinherz, E.L. (1995). Molecular recognition of antigen involves lattice formation between CD4, MHC class II and TCR molecules. Immunol. Today 16, 581-587.
    • (1995) Immunol. Today , vol.16 , pp. 581-587
    • Sakihama, T.1    Smolyar, A.2    Reinherz, E.L.3
  • 47
    • 0023069478 scopus 로고
    • The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: Cell adhesion receptors of the immune system
    • Springer, T.A., Dustin, M.L., Kishimoto, T.K., and Marlin, S.D. (1987). The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system. Annu. Rev. Immunol. 5, 223-252.
    • (1987) Annu. Rev. Immunol. , vol.5 , pp. 223-252
    • Springer, T.A.1    Dustin, M.L.2    Kishimoto, T.K.3    Marlin, S.D.4
  • 48
    • 0028291525 scopus 로고
    • JNK is involved in signal integration during costimulation of T lymphocytes
    • Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y. (1994). JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77, 727-736.
    • (1994) Cell , vol.77 , pp. 727-736
    • Su, B.1    Jacinto, E.2    Hibi, M.3    Kallunki, T.4    Karin, M.5    Ben-Neriah, Y.6
  • 49
    • 0030006284 scopus 로고    scopus 로고
    • Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
    • Symons, M., Derry, J.M.J., Karlak, B., Jiang, S., Lemahieu, V., McCormick, F., Francke, U., and Abo, A. (1996). Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 84, 723-734.
    • (1996) Cell , vol.84 , pp. 723-734
    • Symons, M.1    Derry, J.M.J.2    Karlak, B.3    Jiang, S.4    Lemahieu, V.5    McCormick, F.6    Francke, U.7    Abo, A.8
  • 50
    • 0024327898 scopus 로고
    • The leukocyte common antigen family
    • Thomas, M.L. (1989). The leukocyte common antigen family. Annu. Rev. Immunol. 7, 339-369.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 339-369
    • Thomas, M.L.1
  • 51
    • 0021550018 scopus 로고
    • Antigen-presenting function of the macrophage
    • Unanue, E.R. (1984). Antigen-presenting function of the macrophage. Annu. Rev. Immunol. 2, 395-428.
    • (1984) Annu. Rev. Immunol. , vol.2 , pp. 395-428
    • Unanue, E.R.1
  • 52
    • 0015415283 scopus 로고
    • Ligand-induced movement of lymphocyte membrane macromolecules. I. Analysis by immunofluorescence and ultrastructural radioautography
    • Unanue, E.R., Perkins, W.D., and Karnovsky, M.J. (1972). Ligand-induced movement of lymphocyte membrane macromolecules. I. Analysis by immunofluorescence and ultrastructural radioautography. J. Exp. Med. 136, 885-906.
    • (1972) J. Exp. Med. , vol.136 , pp. 885-906
    • Unanue, E.R.1    Perkins, W.D.2    Karnovsky, M.J.3
  • 53
    • 0029037210 scopus 로고
    • Serial triggering of many T-cell receptors by a few peptide-MHC complexes
    • Valitutti, S., Muller, S., Cella, M., Padovan, E., and Lanzavecchia, A. (1995). Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375, 148-151.
    • (1995) Nature , vol.375 , pp. 148-151
    • Valitutti, S.1    Muller, S.2    Cella, M.3    Padovan, E.4    Lanzavecchia, A.5
  • 54
    • 0027977974 scopus 로고
    • Transient intercellular adhesion: The importance of weak protein-protein interactions
    • van der Merwe, P.A., and Barclay, A.N. (1994). Transient intercellular adhesion: the importance of weak protein-protein interactions. Trends Biol. Sci. 19, 354-360.
    • (1994) Trends Biol. Sci. , vol.19 , pp. 354-360
    • Van Der Merwe, P.A.1    Barclay, A.N.2
  • 55
    • 0027500841 scopus 로고
    • Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD2 and CD48
    • van der Merwe, P.A., Brown, M.H., Davis, S.J., and Barclay, A.N. (1993). Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD2 and CD48. EMBO J. 12, 4945-4954.
    • (1993) EMBO J. , vol.12 , pp. 4945-4954
    • Van Der Merwe, P.A.1    Brown, M.H.2    Davis, S.J.3    Barclay, A.N.4
  • 56
    • 0027932728 scopus 로고
    • Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59
    • van der Merwe, P.A., Barclay, A.N., Mason, D.W., Davies, E.A., Morgan, B.P., Tone, M., Krishnam, A.K., Ianelli, C., and Davis, S.J. (1994). Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59. Biochemistry 33, 10149-10160.
    • (1994) Biochemistry , vol.33 , pp. 10149-10160
    • Van Der Merwe, P.A.1    Barclay, A.N.2    Mason, D.W.3    Davies, E.A.4    Morgan, B.P.5    Tone, M.6    Krishnam, A.K.7    Ianelli, C.8    Davis, S.J.9
  • 57
    • 0030057218 scopus 로고    scopus 로고
    • T cell activation determined by T cell receptor number and tunable thresholds
    • Viola, A., and Lanzavecchia, A. (1996). T cell activation determined by T cell receptor number and tunable thresholds. Science 273, 104-106.
    • (1996) Science , vol.273 , pp. 104-106
    • Viola, A.1    Lanzavecchia, A.2
  • 58
    • 0023156442 scopus 로고
    • Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene
    • Weiss, A., Shields, R., Newton, M., Manger, B., and Imboden, J. (1987). Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene. J. Immunol. 138, 2169-2176.
    • (1987) J. Immunol. , vol.138 , pp. 2169-2176
    • Weiss, A.1    Shields, R.2    Newton, M.3    Manger, B.4    Imboden, J.5


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