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Volumn 12, Issue 8, 2012, Pages 607-614

Towards an HIV cure: A global scientific strategy

(36)  Deeks, Steven G a   Autran, Brigitte b   Berkhout, Ben c   Benkirane, Monsef d   Cairns, Scott e   Chomont, Nicolas f   Chun, Tae Wook g   Churchill, Melissa h   Mascio, Michele Di g   Katlama, Christine i   Lafeuillade, Alain j   Landay, Alan k   Lederman, Michael l   Lewin, Sharon R h   Maldarelli, Frank m   Margolis, David n   Markowitz, Martin o   Martinez Picado, Javier p   Mullins, James I q   Mellors, John r   more..


Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CELL MARKER; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; VIRUS DNA; VIRUS RNA;

EID: 84864345953     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri3262     Document Type: Review
Times cited : (446)

References (80)
  • 1
    • 57349124803 scopus 로고    scopus 로고
    • The role of HIV in serious diseases other than AIDS
    • Phillips, A. N., Neaton, J. & Lundgren, J. D. The role of HIV in serious diseases other than AIDS. AIDS 22, 2409-2418 (2008).
    • (2008) AIDS , vol.22 , pp. 2409-2418
    • Phillips, A.N.1    Neaton, J.2    Lundgren, J.D.3
  • 3
    • 80051633217 scopus 로고    scopus 로고
    • Prevention of hiv-1 infection with early antiretroviral therapy
    • Cohen, M. S. et al. Prevention of HIV-1 infection with early antiretroviral therapy. N. Engl. J. Med. 365, 493-505 (2011).
    • (2011) N. Engl. J. Med , vol.365 , pp. 493-505
    • Cohen, M.S.1
  • 4
    • 62249095476 scopus 로고    scopus 로고
    • The challenge of finding a cure for HIV infection
    • Richman, D. D. et al. The challenge of finding a cure for HIV infection. Science 323, 1304-1307 (2009).
    • (2009) Science , vol.323 , pp. 1304-1307
    • Richman, D.D.1
  • 5
    • 77954633050 scopus 로고    scopus 로고
    • HIV persistence and the prospect of long-term drug-free remissions for hiv-infected individuals
    • Trono, D. et al. HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals. Science 329, 174-180 (2010).
    • (2010) Science , vol.329 , pp. 174-180
    • Trono, D.1
  • 6
    • 79956049416 scopus 로고    scopus 로고
    • The emerging race to cure HIV infections
    • Cohen, J. The emerging race to cure HIV infections. Science 332, 784-789 (2011).
    • (2011) Science , vol.332 , pp. 784-789
    • Cohen, J.1
  • 8
    • 78549245806 scopus 로고    scopus 로고
    • Effect of raltegravir-containing intensification on HIV burden and t-cell activation in multiple gut sites of hiv-positive adults on suppressive antiretroviral therapy
    • Yukl, S. A. et al. Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy. AIDS 24, 2451-2460 (2010).
    • (2010) AIDS , vol.24 , pp. 2451-2460
    • Yukl, S.A.1
  • 9
    • 77950537810 scopus 로고    scopus 로고
    • Hiv-1 replication and immune dynamics are affected by raltegravir intensification of haart-suppressed subjects
    • Buzon, M. J. et al. HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects. Nature Med. 16, 460-465 (2010).
    • (2010) Nature Med , vol.16 , pp. 460-465
    • Buzon, M.J.1
  • 11
    • 78649612566 scopus 로고    scopus 로고
    • + T cells are persistent HIV type 1-Infected reservoirs in individuals receiving antiretroviral therapy
    • + T cells are persistent HIV type 1-infected reservoirs in individuals receiving antiretroviral therapy. J. Infect. Dis. 202, 1738-1748 (2010).
    • (2010) J. Infect. Dis , vol.202 , pp. 1738-1748
    • Wightman, F.1
  • 12
    • 0030760250 scopus 로고    scopus 로고
    • CXCR4 expression during lymphopoiesis: Implications for human immunodeficiency virus type 1 infection of the thymus
    • Kitchen, S. G. & Zack, J. A. CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus. J. Virol. 71, 6928-6934 (1997). (Pubitemid 27355356)
    • (1997) Journal of Virology , vol.71 , Issue.9 , pp. 6928-6934
    • Kitchen, S.G.1    Zack, J.A.2
  • 13
    • 77950531446 scopus 로고    scopus 로고
    • Hiv-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs
    • Carter, C. C. et al. HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs. Nature Med. 16, 446-451 (2010).
    • (2010) Nature Med , vol.16 , pp. 446-451
    • Carter, C.C.1
  • 14
    • 70149099556 scopus 로고    scopus 로고
    • Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia
    • Churchill, M. J. et al. Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia. Ann. Neurol. 66, 253-258 (2009).
    • (2009) Ann. Neurol , vol.66 , pp. 253-258
    • Churchill, M.J.1
  • 19
    • 71849085382 scopus 로고    scopus 로고
    • An in vitro system to model the establishment and reactivation of hiv-1 latency
    • Marini, A., Harper, J. M. & Romerio, F. An in vitro system to model the establishment and reactivation of HIV-1 latency. J. Immunol. 181, 7713-7720 (2008).
    • (2008) J. Immunol , vol.181 , pp. 7713-7720
    • Marini, A.1    Harper, J.M.2    Romerio, F.3
  • 20
    • 0037446948 scopus 로고    scopus 로고
    • HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
    • DOI 10.1093/emboj/cdg188
    • Jordan, A., Bisgrove, D. & Verdin, E. HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J. 22, 1868-1877 (2003). (Pubitemid 36460143)
    • (2003) EMBO Journal , vol.22 , Issue.8 , pp. 1868-1877
    • Jordan, A.1    Bisgrove, D.2    Verdin, E.3
  • 22
    • 77951954237 scopus 로고    scopus 로고
    • Hiv-1 tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snrnp
    • Sobhian, B. et al. HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. Mol. Cell 38, 439-451 (2010).
    • (2010) Mol. Cell , vol.38 , pp. 439-451
    • Sobhian, B.1
  • 23
    • 79960380793 scopus 로고    scopus 로고
    • Negative regulation of hiv-1 transcription by a heterodimeric nf-κb1/p50 and c-terminally truncated stat5 complex
    • Della Chiara, G. et al. Negative regulation of HIV-1 transcription by a heterodimeric NF-κB1/p50 and C-terminally truncated STAT5 complex. J. Mol. Biol. 410, 933-943 (2011).
    • (2011) J. Mol. Biol , vol.410 , pp. 933-943
    • Della Chiara, G.1
  • 24
    • 77953313393 scopus 로고    scopus 로고
    • + cells is due to epigenetic transcriptional silencing and P-TEFb restriction
    • + cells is due to epigenetic transcriptional silencing and P-TEFb restriction. J. Virol. 84, 6425-6437 (2010).
    • (2010) J. Virol , vol.84 , pp. 6425-6437
    • Tyagi, M.1    Pearson, R.J.2    Karn, J.3
  • 25
    • 30444431914 scopus 로고    scopus 로고
    • NF-κB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation
    • DOI 10.1038/sj.emboj.7600900, PII 7600900
    • Williams, S. A. et al. NF-κB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J. 25, 139-149 (2006). (Pubitemid 43077303)
    • (2006) EMBO Journal , vol.25 , Issue.1 , pp. 139-149
    • Williams, S.A.1    Chen, L.-F.2    Kwon, H.3    Ruiz-Jarabo, C.M.4    Verdin, E.5    Greene, W.C.6
  • 26
    • 33646130853 scopus 로고    scopus 로고
    • Requirement for swi/snf chromatin-remodeling complex in tat-mediated activation of the hiv-1 promoter
    • Treand, C. et al. Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter. EMBO J. 25, 1690-1699 (2006).
    • (2006) EMBO J , vol.25 , pp. 1690-1699
    • Treand, C.1
  • 27
    • 70049090006 scopus 로고    scopus 로고
    • Cpg methylation controls reactivation of HIV from latency
    • Blazkova, J. et al. CpG methylation controls reactivation of HIV from latency. PLoS Pathog. 5, e1000554 (2009).
    • (2009) PLoS Pathog , vol.5
    • Blazkova, J.1
  • 29
    • 0029919356 scopus 로고    scopus 로고
    • Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation
    • Van Lint, C., Emiliani, S., Ott, M. & Verdin, E. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J. 15, 1112-1120 (1996). (Pubitemid 26077840)
    • (1996) EMBO Journal , vol.15 , Issue.5 , pp. 1112-1120
    • Van Lint, C.1    Emiliani, S.2    Ott, M.3    Verdin, E.4
  • 30
    • 48649085472 scopus 로고    scopus 로고
    • Orientation-dependent regulation of integrated hiv-1 expression by host gene transcriptional readthrough
    • Han, Y. et al. Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough. Cell Host Microbe 4, 134-146 (2008).
    • (2008) Cell Host Microbe , vol.4 , pp. 134-146
    • Han, Y.1
  • 31
    • 68349139711 scopus 로고    scopus 로고
    • HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    • Chomont, N. et al. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nature Med. 15, 893-900 (2009).
    • (2009) Nature Med , vol.15 , pp. 893-900
    • Chomont, N.1
  • 34
    • 79958136377 scopus 로고    scopus 로고
    • + T cell model without inducing global T cell activation
    • + T cell model without inducing global T cell activation. J. Virol. 85, 6060-6064 (2011).
    • (2011) J. Virol , vol.85 , pp. 6060-6064
    • Xing, S.1
  • 35
    • 60849127627 scopus 로고    scopus 로고
    • Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid
    • Archin, N. M. et al. Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid. AIDS Res. Hum. Retroviruses 25, 207-212 (2009).
    • (2009) AIDS Res. Hum. Retroviruses , vol.25 , pp. 207-212
    • Archin, N.M.1
  • 36
    • 65449148344 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells
    • Contreras, X. et al. Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells. J. Biol. Chem. 284, 6782-6789 (2009).
    • (2009) J. Biol. Chem , vol.284 , pp. 6782-6789
    • Contreras, X.1
  • 37
    • 84864286769 scopus 로고    scopus 로고
    • + haart-treated patients
    • 19 May doi:10.1097/QAD.0b013e32835535f5
    • + HAART-treated patients. AIDS 19 May 2012 (doi:10.1097/QAD.0b013e32835535f5).
    • (2012) AIDS
    • Bouchat, S.1
  • 38
    • 78149417719 scopus 로고    scopus 로고
    • Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy
    • Yukl, S. A. et al. Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy. J. Infect. Dis. 202, 1553-1561 (2010).
    • (2010) J. Infect. Dis , vol.202 , pp. 1553-1561
    • Yukl, S.A.1
  • 39
    • 80054995389 scopus 로고    scopus 로고
    • Human immunodeficiency virus infects human seminal vesicles in vitro and in vivo
    • Deleage, C. et al. Human immunodeficiency virus infects human seminal vesicles in vitro and in vivo. Am. J. Pathol. 179, 2397-2408 (2011).
    • (2011) Am. J. Pathol , vol.179 , pp. 2397-2408
    • Deleage, C.1
  • 40
    • 84855767273 scopus 로고    scopus 로고
    • Lymph nodes harbor viral reservoirs that cause rebound of plasma viremia in siv-infected macaques upon cessation of combined antiretroviral therapy
    • Horiike, M. et al. Lymph nodes harbor viral reservoirs that cause rebound of plasma viremia in SIV-infected macaques upon cessation of combined antiretroviral therapy. Virology 423, 107-118 (2012).
    • (2012) Virology , vol.423 , pp. 107-118
    • Horiike, M.1
  • 41
    • 77956906960 scopus 로고    scopus 로고
    • Effect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusion
    • Bourry, O. et al. Effect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusion. Retrovirology 7, 78 (2010).
    • (2010) Retrovirology , vol.7 , pp. 78
    • Bourry, O.1
  • 42
    • 77649117525 scopus 로고    scopus 로고
    • Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS
    • North, T. W. et al. Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS. J. Virol. 84, 2913-2922 (2010).
    • (2010) J. Virol , vol.84 , pp. 2913-2922
    • North, T.W.1
  • 46
    • 0036786355 scopus 로고    scopus 로고
    • The central nervous system as a reservoir for simian immunodeficiency virus (SIV): Steady-state levels of SIV DNA in brain from acute through asymptomatic infection
    • Clements, J. E. et al. The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection. J. Infect. Dis. 186, 905-913 (2002).
    • (2002) J. Infect. Dis , vol.186 , pp. 905-913
    • Clements, J.E.1
  • 47
    • 79952216365 scopus 로고    scopus 로고
    • Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in hiv-1 and SIV infections
    • Zeng, M. et al. Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections. J. Clin. Invest. 121, 998-1008 (2011).
    • (2011) J. Clin. Invest , vol.121 , pp. 998-1008
    • Zeng, M.1
  • 49
    • 79955028940 scopus 로고    scopus 로고
    • + T cell recovery on antiretroviral therapy
    • + T cell recovery on antiretroviral therapy. J. Infect. Dis. 203, 1474-1483 (2011).
    • (2011) J. Infect. Dis , vol.203 , pp. 1474-1483
    • Hunt, P.W.1
  • 50
    • 27644524761 scopus 로고    scopus 로고
    • Hiv-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
    • Chun, T. W. et al. HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir. J. Clin. Invest. 115, 3250-3255 (2005).
    • (2005) J. Clin. Invest , vol.115 , pp. 3250-3255
    • Chun, T.W.1
  • 51
    • 79551614790 scopus 로고    scopus 로고
    • HIV infection, inflammation, immunosenescence, and aging
    • Deeks, S. G. HIV infection, inflammation, immunosenescence, and aging. Annu. Rev. Med. 62, 141-155 (2011).
    • (2011) Annu. Rev. Med , vol.62 , pp. 141-155
    • Deeks, S.G.1
  • 52
    • 84863337769 scopus 로고    scopus 로고
    • Stimulation of hiv-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation
    • Shan, L. et al. Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity 36, 491-501 (2012).
    • (2012) Immunity , vol.36 , pp. 491-501
    • Shan, L.1
  • 53
    • 77953916829 scopus 로고    scopus 로고
    • Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary hiv-1 infection
    • Hocqueloux, L. et al. Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infection. AIDS 24, 1598-1601 (2010).
    • (2010) AIDS , vol.24 , pp. 1598-1601
    • Hocqueloux, L.1
  • 54
    • 79957618772 scopus 로고    scopus 로고
    • Profound early control of highly pathogenic SIV by an effector memory t-cell vaccine
    • Hansen, S. G. et al. Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473, 523-527 (2011).
    • (2011) Nature , vol.473 , pp. 523-527
    • Hansen, S.G.1
  • 55
    • 84858982531 scopus 로고    scopus 로고
    • New tools for quantifying hiv-1 reservoirs: Plasma RNA single copy assays and beyond
    • Hilldorfer, B. B., Cillo, A. R., Besson, G. J., Bedison, M. A. & Mellors, J. W. New tools for quantifying HIV-1 reservoirs: plasma RNA single copy assays and beyond. Curr. HIV/AIDS Rep. 9, 91-100 (2012).
    • (2012) Curr. HIV/AIDS Rep , vol.9 , pp. 91-100
    • Hilldorfer, B.B.1    Cillo, A.R.2    Besson, G.J.3    Bedison, M.A.4    Mellors, J.W.5
  • 56
    • 79954664166 scopus 로고    scopus 로고
    • HIV cure and eradication: How will we get from the laboratory to effective clinical trials?
    • Lewin, S. R. & Rouzioux, C. HIV cure and eradication: how will we get from the laboratory to effective clinical trials? AIDS 25, 885-897 (2011).
    • (2011) AIDS , vol.25 , pp. 885-897
    • Lewin, S.R.1    Rouzioux, C.2
  • 58
    • 67249121143 scopus 로고    scopus 로고
    • Treatment intensification does not reduce residual hiv-1 viremia in patients on highly active antiretroviral therapy
    • Dinoso, J. B. et al. Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc. Natl Acad. Sci. USA 106, 9403-9408 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 9403-9408
    • Dinoso, J.B.1
  • 59
    • 77956856393 scopus 로고    scopus 로고
    • The effect of raltegravir intensification on low-level residual viremia in hiv-infected patients on antiretroviral therapy: A randomized controlled trial
    • Gandhi, R. T. et al. The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial. PLoS Med. 7, e1000321 (2010).
    • (2010) PLoS Med , vol.7
    • Gandhi, R.T.1
  • 60
    • 79953000877 scopus 로고    scopus 로고
    • + T cell response
    • + T cell response. J. Infect. Dis. 203, 960-968 (2011).
    • (2011) J. Infect. Dis , vol.203 , pp. 960-968
    • Hatano, H.1
  • 61
    • 80052395837 scopus 로고    scopus 로고
    • Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy
    • Sigal, A. et al. Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature 477, 95-98 (2011).
    • (2011) Nature , vol.477 , pp. 95-98
    • Sigal, A.1
  • 62
    • 80055078962 scopus 로고    scopus 로고
    • Deep molecular characterization of hiv-1 dynamics under suppressive HAART
    • Buzon, M. J. et al. Deep molecular characterization of HIV-1 dynamics under suppressive HAART. PLoS Pathog. 7, e1002314 (2011).
    • (2011) PLoS Pathog , vol.7
    • Buzon, M.J.1
  • 63
    • 77950525439 scopus 로고    scopus 로고
    • + T cell activation during HIV infection
    • + T cell activation during HIV infection. Nature Med. 16, 452-459 (2010).
    • (2010) Nature Med , vol.16 , pp. 452-459
    • Said, E.A.1
  • 64
    • 22744433225 scopus 로고    scopus 로고
    • Macrophages archive HIV-1 virions for dissemination in trans
    • DOI 10.1038/sj.emboj.7600707
    • Sharova, N., Swingler, C., Sharkey, M. & Stevenson, M. Macrophages archive HIV-1 virions for dissemination in trans. EMBO J. 24, 2481-2489 (2005). (Pubitemid 41032598)
    • (2005) EMBO Journal , vol.24 , Issue.13 , pp. 2481-2489
    • Sharova, N.1    Swingler, C.2    Sharkey, M.3    Stevenson, M.4
  • 65
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian, S. L. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454 (2012).
    • (2012) N. Engl. J. Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1
  • 66
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter, D. L., Levine, B. L., Kalos, M., Bagg, A. & June, C. H. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N. Engl. J. Med. 365, 725-733 (2011).
    • (2011) N. Engl. J. Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 69
    • 79751500441 scopus 로고    scopus 로고
    • A therapeutic dendritic cell-based vaccine for HIV-1 infection
    • Garcia, F. et al. A therapeutic dendritic cell-based vaccine for HIV-1 infection. J. Infect. Dis. 203, 473-478 (2011).
    • (2011) J. Infect. Dis , vol.203 , pp. 473-478
    • Garcia, F.1
  • 70
    • 84859393693 scopus 로고    scopus 로고
    • Immune-correlates analysis of an hiv-1 vaccine efficacy trial
    • Haynes, B. F. et al. Immune-correlates analysis of an HIV-1 vaccine efficacy trial. N. Engl. J. Med. 366, 1275-1286 (2012).
    • (2012) N. Engl. J. Med , vol.366 , pp. 1275-1286
    • Haynes, B.F.1
  • 71
    • 65249105408 scopus 로고    scopus 로고
    • Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment
    • Levy, Y. et al. Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J. Clin. Invest. 119, 997-1007 (2009).
    • (2009) J. Clin. Invest , vol.119 , pp. 997-1007
    • Levy, Y.1
  • 72
    • 70449377960 scopus 로고    scopus 로고
    • Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation
    • Yang, H. C. et al. Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation. J. Clin. Invest. 119, 3473-3486 (2009).
    • (2009) J. Clin. Invest , vol.119 , pp. 3473-3486
    • Yang, H.C.1
  • 73
    • 77958485320 scopus 로고    scopus 로고
    • + T cells depends on chemokine-induced changes in the actin cytoskeleton
    • + T cells depends on chemokine-induced changes in the actin cytoskeleton. Proc. Natl Acad. Sci. USA 107, 16934-16939 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 16934-16939
    • Cameron, P.U.1
  • 74
    • 84855927237 scopus 로고    scopus 로고
    • Generation of HIV latency in humanized BLT mice
    • Denton, P. W. et al. Generation of HIV latency in humanized BLT mice. J. Virol. 86, 630-634 (2012).
    • (2012) J. Virol , vol.86 , pp. 630-634
    • Denton, P.W.1
  • 75
    • 60549090253 scopus 로고    scopus 로고
    • Long-term control of HIV by ccr5 delta32/delta32 stem-cell transplantation
    • Hutter, G. et al. Long-term control of HIV by CCR5 delta32/delta32 stem-cell transplantation. N. Engl. J. Med. 360, 692-698 (2009).
    • (2009) N. Engl. J. Med , vol.360 , pp. 692-698
    • Hutter, G.1
  • 76
    • 79953117041 scopus 로고    scopus 로고
    • Evidence for the cure of HIV infection by ccr5δ32/δ32 stem cell transplantation
    • Allers, K. et al. Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation. Blood 117, 2791-2799 (2011).
    • (2011) Blood , vol.117 , pp. 2791-2799
    • Allers, K.1
  • 77
    • 84859250847 scopus 로고    scopus 로고
    • Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection
    • Ananworanich, J. et al. Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. PLoS ONE 7, e33948 (2012).
    • (2012) PLoS ONE , vol.7
    • Ananworanich, J.1
  • 78
    • 84862189831 scopus 로고    scopus 로고
    • + cell hiv-1 infection without accelerating the decay of latent infection
    • + cell HIV-1 infection without accelerating the decay of latent infection. Proc. Natl Acad. Sci. USA 109, 9523-9528 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 9523-9528
    • Archin, N.M.1
  • 79
    • 78650735673 scopus 로고    scopus 로고
    • Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to ccr5 control hiv-1 in vivo
    • Holt, N. et al. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nature Biotech. 28, 839-847 (2010).
    • (2010) Nature Biotech , vol.28 , pp. 839-847
    • Holt, N.1
  • 80
    • 77955608799 scopus 로고    scopus 로고
    • + cells in patients undergoing transplantation for AIDS-related lymphoma
    • + cells in patients undergoing transplantation for AIDS-related lymphoma. Sci. Transl. Med. 2, 36ra43 (2010).
    • (2010) Sci. Transl. Med. , vol.2
    • Digiusto, D.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.